JP2016525600A5 - - Google Patents
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- Publication number
- JP2016525600A5 JP2016525600A5 JP2016526700A JP2016526700A JP2016525600A5 JP 2016525600 A5 JP2016525600 A5 JP 2016525600A5 JP 2016526700 A JP2016526700 A JP 2016526700A JP 2016526700 A JP2016526700 A JP 2016526700A JP 2016525600 A5 JP2016525600 A5 JP 2016525600A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclodextrin
- ether
- sulfoalkyl ether
- composition
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 22
- 229920000858 Cyclodextrin Polymers 0.000 claims 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 13
- 239000001116 FEMA 4028 Substances 0.000 claims 12
- 229960004853 betadex Drugs 0.000 claims 12
- 125000004964 sulfoalkyl group Chemical group 0.000 claims 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 9
- 238000006243 chemical reaction Methods 0.000 claims 9
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 9
- -1 alkyl sultone Chemical class 0.000 claims 7
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 6
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 230000004913 activation Effects 0.000 claims 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims 3
- NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- 150000008053 sultones Chemical class 0.000 claims 2
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 claims 1
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000005804 alkylation reaction Methods 0.000 claims 1
- 229960005260 amiodarone Drugs 0.000 claims 1
- 229960004372 aripiprazole Drugs 0.000 claims 1
- 238000010923 batch production Methods 0.000 claims 1
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 claims 1
- 229960002438 carfilzomib Drugs 0.000 claims 1
- 108010021331 carfilzomib Proteins 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 231100000957 no side effect Toxicity 0.000 claims 1
- MHYFEEDKONKGEB-UHFFFAOYSA-N oxathiane 2,2-dioxide Chemical compound O=S1(=O)CCCCO1 MHYFEEDKONKGEB-UHFFFAOYSA-N 0.000 claims 1
- 230000008663 renal system process Effects 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
- 229960000607 ziprasidone Drugs 0.000 claims 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361847509P | 2013-07-17 | 2013-07-17 | |
| GBGB1312737.8A GB201312737D0 (en) | 2013-07-17 | 2013-07-17 | Cyclodextrin |
| GB1312737.8 | 2013-07-17 | ||
| US61/847,509 | 2013-07-17 | ||
| PCT/GB2014/052173 WO2015008066A1 (en) | 2013-07-17 | 2014-07-16 | Cyclodextrin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016525600A JP2016525600A (ja) | 2016-08-25 |
| JP2016525600A5 true JP2016525600A5 (https=) | 2016-10-06 |
Family
ID=49081370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016526700A Pending JP2016525600A (ja) | 2013-07-17 | 2014-07-16 | シクロデキストリン |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11117978B2 (https=) |
| EP (1) | EP3022231B1 (https=) |
| JP (1) | JP2016525600A (https=) |
| KR (1) | KR20160031019A (https=) |
| CN (1) | CN105431458A (https=) |
| AP (1) | AP2016008975A0 (https=) |
| AU (1) | AU2014291800A1 (https=) |
| CA (1) | CA2919501A1 (https=) |
| CL (1) | CL2016000082A1 (https=) |
| GB (3) | GB201312737D0 (https=) |
| HU (1) | HUE038911T2 (https=) |
| MX (1) | MX2016000553A (https=) |
| PT (1) | PT3022231T (https=) |
| WO (1) | WO2015008066A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10532102B2 (en) | 2016-08-19 | 2020-01-14 | Foresee Pharmaceuticals Co., Ltd. | Pharmaceutical composition and methods of uses |
| WO2018140856A1 (en) | 2017-01-30 | 2018-08-02 | Bio-Rad Laboratories, Inc. | Emulsion compositions and methods of their use |
| WO2018146698A1 (en) | 2017-02-07 | 2018-08-16 | Biophore India Pharmaceuticals Pvt. Ltd. | Improved method for the preparation of sulfobutylether beta cyclodextrin sodium |
| CN112557541B (zh) * | 2020-12-08 | 2022-07-12 | 河北科技大学 | 一种枸橼酸马罗匹坦及其有关物质的检测方法 |
| CN112370451A (zh) * | 2020-12-08 | 2021-02-19 | 河北科技大学 | 一种枸橼酸马罗匹坦包合物、注射液及制备方法 |
| CN114369177A (zh) * | 2021-12-31 | 2022-04-19 | 贵州省欣紫鸿药用辅料有限公司 | 一种采用管道反应器制备磺丁基醚-β-环糊精的方法 |
| WO2025229196A1 (en) | 2024-05-03 | 2025-11-06 | Aalborg Universitet | Primary side modified sulfoalkyl ether- and hydroxypropyl-cyclodextrins, synthesis and use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5874418A (en) | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| GB9713149D0 (en) | 1997-06-21 | 1997-08-27 | Pfizer Ltd | Pharmaceutical formulations |
| ES2257795T3 (es) * | 1997-07-01 | 2006-08-01 | Pfizer Products Inc. | Procedimiento para producir una ciclodextrina. |
| US6337380B1 (en) * | 1998-12-01 | 2002-01-08 | Fuji Photo Film Co., Ltd. | Polymer having sulfonic acid group and silver halide photographic photosensitive material using the polymer |
| US6869939B2 (en) | 2002-05-04 | 2005-03-22 | Cydex, Inc. | Formulations containing amiodarone and sulfoalkyl ether cyclodextrin |
| CN100503647C (zh) | 2005-11-02 | 2009-06-24 | 南京师范大学 | 羟丙基-磺丁基-β-环糊精及其制备方法、分析方法以及在药学上的应用 |
| CN101686681B (zh) * | 2007-04-27 | 2015-04-01 | 锡德克斯药物公司 | 包含氯吡格雷和磺基烷基醚环糊精的制剂和其使用方法 |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| DK3702374T3 (da) * | 2012-02-15 | 2022-06-27 | Cydex Pharmaceuticals Inc | Fremsgangsmåde til fremstilling for cyclodextrin-derivater |
| PH12012502259A1 (en) | 2012-05-08 | 2019-07-03 | Onyx Therapeutics Inc | Cylodextrin complexation methods for formulating peptide proteasome inhibitors |
-
2013
- 2013-07-17 GB GBGB1312737.8A patent/GB201312737D0/en not_active Ceased
-
2014
- 2014-07-16 HU HUE14742322A patent/HUE038911T2/hu unknown
- 2014-07-16 GB GB1412644.5A patent/GB2519832B/en active Active
- 2014-07-16 JP JP2016526700A patent/JP2016525600A/ja active Pending
- 2014-07-16 CN CN201480040709.2A patent/CN105431458A/zh active Pending
- 2014-07-16 AP AP2016008975A patent/AP2016008975A0/xx unknown
- 2014-07-16 EP EP14742322.2A patent/EP3022231B1/en active Active
- 2014-07-16 CA CA2919501A patent/CA2919501A1/en not_active Abandoned
- 2014-07-16 AU AU2014291800A patent/AU2014291800A1/en not_active Abandoned
- 2014-07-16 WO PCT/GB2014/052173 patent/WO2015008066A1/en not_active Ceased
- 2014-07-16 PT PT147423222T patent/PT3022231T/pt unknown
- 2014-07-16 US US14/333,417 patent/US11117978B2/en active Active
- 2014-07-16 KR KR1020167003973A patent/KR20160031019A/ko not_active Withdrawn
- 2014-07-16 GB GB2015609.7A patent/GB2586104B/en active Active
- 2014-07-16 MX MX2016000553A patent/MX2016000553A/es unknown
-
2015
- 2015-09-30 US US14/871,649 patent/US10239961B2/en active Active
-
2016
- 2016-01-14 CL CL2016000082A patent/CL2016000082A1/es unknown
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