JP2016523537A5 - - Google Patents

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Publication number
JP2016523537A5
JP2016523537A5 JP2016522319A JP2016522319A JP2016523537A5 JP 2016523537 A5 JP2016523537 A5 JP 2016523537A5 JP 2016522319 A JP2016522319 A JP 2016522319A JP 2016522319 A JP2016522319 A JP 2016522319A JP 2016523537 A5 JP2016523537 A5 JP 2016523537A5
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JP
Japan
Prior art keywords
sequence
human
framework region
seq
antibody
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JP2016522319A
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English (en)
Japanese (ja)
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JP6708544B2 (ja
JP2016523537A (ja
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Priority claimed from PCT/EP2014/001730 external-priority patent/WO2014206561A1/en
Publication of JP2016523537A publication Critical patent/JP2016523537A/ja
Publication of JP2016523537A5 publication Critical patent/JP2016523537A5/ja
Application granted granted Critical
Publication of JP6708544B2 publication Critical patent/JP6708544B2/ja
Active legal-status Critical Current
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JP2016522319A 2013-06-26 2014-06-26 新規抗体フレームワーク Active JP6708544B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003264.2 2013-06-26
EP13003264 2013-06-26
PCT/EP2014/001730 WO2014206561A1 (en) 2013-06-26 2014-06-26 Novel antibody frameworks

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019111990A Division JP2019201643A (ja) 2013-06-26 2019-06-17 新規抗体フレームワーク

Publications (3)

Publication Number Publication Date
JP2016523537A JP2016523537A (ja) 2016-08-12
JP2016523537A5 true JP2016523537A5 (OSRAM) 2018-01-18
JP6708544B2 JP6708544B2 (ja) 2020-06-10

Family

ID=48699516

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2016522319A Active JP6708544B2 (ja) 2013-06-26 2014-06-26 新規抗体フレームワーク
JP2019111990A Withdrawn JP2019201643A (ja) 2013-06-26 2019-06-17 新規抗体フレームワーク
JP2021169020A Pending JP2022028659A (ja) 2013-06-26 2021-10-14 新規抗体フレームワーク
JP2023199881A Pending JP2024026176A (ja) 2013-06-26 2023-11-27 新規抗体フレームワーク

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2019111990A Withdrawn JP2019201643A (ja) 2013-06-26 2019-06-17 新規抗体フレームワーク
JP2021169020A Pending JP2022028659A (ja) 2013-06-26 2021-10-14 新規抗体フレームワーク
JP2023199881A Pending JP2024026176A (ja) 2013-06-26 2023-11-27 新規抗体フレームワーク

Country Status (12)

Country Link
US (3) US10174102B2 (OSRAM)
EP (1) EP3013864A1 (OSRAM)
JP (4) JP6708544B2 (OSRAM)
KR (4) KR20240000622A (OSRAM)
CN (2) CN105579472B (OSRAM)
AU (2) AU2014301629B2 (OSRAM)
CA (1) CA2914829A1 (OSRAM)
HK (1) HK1218549A1 (OSRAM)
IL (3) IL243311B (OSRAM)
NZ (1) NZ714320A (OSRAM)
SG (2) SG10201811017QA (OSRAM)
WO (1) WO2014206561A1 (OSRAM)

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IL243311B (en) 2013-06-26 2022-07-01 Numab Therapeutics AG Novel antibody frameworks
CN115057936B (zh) 2015-06-15 2025-05-30 努玛治疗有限公司 异源二聚体多特异性抗体形式
BR112018067698A2 (pt) 2016-02-25 2019-01-08 Cell Medica Switzerland Ag células modificadas para imunoterapia
CA3011500A1 (en) 2016-03-17 2017-09-21 Numab Innovation Ag Anti-tnfalpha-antibodies and functional fragments thereof
HUE052869T2 (hu) 2016-03-17 2021-05-28 Tillotts Pharma Ag TNF-ellenes alfa-antitestek és ezek funkcionális fragmentjei
JP7184746B2 (ja) 2016-03-17 2022-12-06 ヌマブ イノヴェイション アーゲー 抗TNFα抗体およびそれらの機能的断片
LT3219726T (lt) 2016-03-17 2021-01-25 Tillotts Pharma Ag Anti-tnf alfa antikūnai ir jų funkciniai fragmentai
WO2017158101A1 (en) 2016-03-17 2017-09-21 Numab Innovation Ag ANTI-TNFα-ANTIBODIES AND FUNCTIONAL FRAGMENTS THEREOF
GB201621591D0 (en) * 2016-12-19 2017-02-01 Ucb Biopharma Sprl Antibody molecules and method
US11319371B2 (en) 2017-06-05 2022-05-03 Numab Therapeutics AG Anti-CD3 antibodies
WO2018224441A1 (en) 2017-06-05 2018-12-13 Numab Innovation Ag Novel anti-cd3 antibodies
WO2018224439A1 (en) 2017-06-05 2018-12-13 Numab Innovation Ag Novel anti-hsa antibodies
ES2967739T3 (es) 2017-06-05 2024-05-03 Numab Therapeutics AG Formato de anticuerpo heterodimérico multiespecífico dirigido al menos a CD3 y a HSA
AU2018280679B2 (en) * 2017-06-05 2025-04-24 Numab Therapeutics AG Novel anti-HSA antibodies
EP3645049A4 (en) 2017-06-25 2021-06-30 Systimmune, Inc. MULTISPECIFIC ANTIBODIES AND THE METHOD OF MANUFACTURING AND USING THEREOF
CN110799540B (zh) * 2017-06-25 2024-02-13 西雅图免疫公司 多特异性抗体及其制备和使用方法
EP3459968A1 (en) 2017-09-20 2019-03-27 Numab Innovation AG Novel stable antibody variable domain framework combinations
CN113631574B (zh) 2019-01-31 2025-03-04 努玛治疗有限公司 对TNFα和IL-17A具有特异性的多特异性抗体、靶向IL-17A的抗体及其使用方法
EP3689907A1 (en) 2019-01-31 2020-08-05 Numab Therapeutics AG Antibodies targeting il-17a and methods of use thereof
EP4271413A4 (en) * 2020-12-30 2025-07-30 Ascendo Biotechnology Inc MONOCLONAL ANTIBODY AGAINST HUMAN MAC-1 AND ITS USES
WO2022171771A1 (en) 2021-02-12 2022-08-18 Boehringer Ingelheim International Gmbh Complement c3 antigen binding proteins
CA3213283A1 (en) 2021-03-11 2022-09-15 IgGenix, Inc. Methods and systems for predicting allergic response
AR128065A1 (es) 2021-12-22 2024-03-20 Cdr Life Ag Anticuerpos anti-c3 y fragmentos de unión al antígeno de estos y sus usos para tratar enfermedades oftálmicas u oculares
WO2024098026A2 (en) * 2022-11-04 2024-05-10 Mink Therapeutics, Inc. B-cell maturation antigen (bcma) chimeric antigen receptor invariant natural killer t cells and uses thereof

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US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
AU2003259718A1 (en) 2003-08-07 2005-03-07 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
WO2008004834A1 (en) 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
FR2910896B1 (fr) * 2006-12-29 2012-11-16 Lab Francais Du Fractionnement Anticorps monoclonal dirige contre le recepteur humain des ldl
CN101868477A (zh) 2007-05-21 2010-10-20 奥尔德生物制药公司 新型兔抗体人源化方法和人源化的兔抗体
WO2009000099A2 (en) 2007-06-25 2008-12-31 Esbatech Ag Methods of modifying antibodies, and modified antibodies with improved functional properties
LT3444274T (lt) * 2008-06-25 2021-03-25 Novartis Ag Stabilūs ir tirpūs antikūnai, slopinantys tnf
BRPI0914663A2 (pt) 2008-06-25 2015-10-20 Esbatech Alcon Biomed Res Unit humanização de anticorpos de coelho usando uma estrutura de anticorpo universal
CN110372792A (zh) * 2008-06-25 2019-10-25 艾斯巴技术-诺华有限责任公司 抑制vegf的稳定和可溶的抗体
US8193235B2 (en) 2009-06-12 2012-06-05 University Of Kansas Compositions and methods for establishing and maintaining stem cells in an undifferentiated state
CA2798120A1 (en) * 2010-04-30 2011-11-03 Paul P. Tamburini Antibodies having reduced immunogenicity in a human
EP2726504A1 (en) * 2011-05-27 2014-05-07 Dutalys Antibodies with improved folding stability
IL243311B (en) 2013-06-26 2022-07-01 Numab Therapeutics AG Novel antibody frameworks
EP3459968A1 (en) * 2017-09-20 2019-03-27 Numab Innovation AG Novel stable antibody variable domain framework combinations

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