JP2016523275A - 多様な疾患を処置するためのjnk阻害剤分子の新規な用途 - Google Patents
多様な疾患を処置するためのjnk阻害剤分子の新規な用途 Download PDFInfo
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- JP2016523275A JP2016523275A JP2016522322A JP2016522322A JP2016523275A JP 2016523275 A JP2016523275 A JP 2016523275A JP 2016522322 A JP2016522322 A JP 2016522322A JP 2016522322 A JP2016522322 A JP 2016522322A JP 2016523275 A JP2016523275 A JP 2016523275A
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2013/001880 | 2013-06-26 | ||
| PCT/EP2013/001880 WO2014206426A1 (en) | 2013-06-26 | 2013-06-26 | New use for jnk inhibitor molecules for treatment of various diseases |
| PCT/EP2014/001737 WO2014206564A1 (en) | 2013-06-26 | 2014-06-26 | New use for jnk inhibitor molecules for treatment of various diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2016523275A true JP2016523275A (ja) | 2016-08-08 |
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| JP2016575150A Expired - Fee Related JP6843625B2 (ja) | 2013-06-26 | 2015-06-26 | 様々な疾患の処置のためのjnk阻害剤分子の新規使用 |
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| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2009143864A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases |
| WO2010072228A1 (en) | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| JP5857056B2 (ja) | 2010-10-14 | 2016-02-10 | ザイジェン インフラメーション エルティーディー | 慢性又は非慢性の炎症性眼疾患を治療するためのjnkシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
| WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| WO2015197097A1 (en) * | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2016055160A2 (en) * | 2014-10-08 | 2016-04-14 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| WO2014206426A1 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
| AU2014301631A1 (en) | 2013-06-26 | 2015-08-27 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
| WO2015200768A2 (en) * | 2014-06-26 | 2015-12-30 | Auris Medical Ag | Pharmacologic treatments of menière's disease |
| CN106714821B (zh) * | 2014-06-26 | 2021-07-23 | 埃克西金炎症有限公司 | Jnk信号转导途径的细胞穿透肽抑制剂用于治疗多种疾病的新用途 |
| JP2025069480A (ja) * | 2022-03-25 | 2025-05-01 | メスキュージェナシス株式会社 | ジンジパインに対して親和性及び/又は阻害能を有するペプチド及びその使用 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006501165A (ja) * | 2002-06-07 | 2006-01-12 | ユニバーシティ オブ ローザンヌ | Jnkシグナル伝達経路の細胞透過性ペプチド阻害剤 |
| JP2009507502A (ja) * | 2005-09-12 | 2009-02-26 | ザイジェン エス.アー. | Jnkシグナル伝達経路の細胞透過性ペプチド阻害剤 |
| JP2009538882A (ja) * | 2006-06-02 | 2009-11-12 | メルク セローノ ソシエテ アノニム | 皮膚疾患の治療のためのjnk阻害物質 |
| JP2010254672A (ja) * | 2009-03-30 | 2010-11-11 | Santen Pharmaceut Co Ltd | JNK(c−Junアミノ末端キナーゼ)阻害ペプチドを有効成分として含有する網膜疾患の予防または治療剤 |
| JP2011524861A (ja) * | 2008-05-30 | 2011-09-08 | ザイジェン エス.アー. | Jnkシグナル伝達経路に対する、細胞透過性のペプチド性阻害剤の種々の、疾病を治療するための使用 |
| WO2011160827A2 (en) * | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| WO2012048721A1 (en) * | 2010-10-14 | 2012-04-19 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013079213A1 (en) * | 2011-11-30 | 2013-06-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of dry eye syndrome |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| US5670617A (en) | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| CN1208438A (zh) | 1995-07-28 | 1999-02-17 | 玛丽·柯里癌症治疗中心 | 转运蛋白及其应用 |
| US6043083A (en) | 1997-04-28 | 2000-03-28 | Davis; Roger J. | Inhibitors of the JNK signal transduction pathway and methods of use |
| US6232289B1 (en) * | 1998-04-17 | 2001-05-15 | University Of Maryland, Baltimore | Method of treating interstitial cytitis with recombinant heparin-binding epidermal growth factor-like growth factor (HB-EGF) |
| BR0316290A (pt) * | 2002-11-15 | 2005-10-11 | Sangstat Medical Corp | Método de tratar cistite intersticial |
| US20120077753A1 (en) | 2009-06-25 | 2012-03-29 | Laxman Gangwani | Jnk inhibitors for use in treating spinal muscular atrophy |
| GB2478599B (en) * | 2010-03-12 | 2014-07-16 | Dyson Technology Ltd | A vacuum cleaning arrangement |
| WO2013091670A1 (en) * | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| WO2014206426A1 (en) * | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
| AU2014301631A1 (en) * | 2013-06-26 | 2015-08-27 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases |
-
2013
- 2013-06-26 WO PCT/EP2013/001880 patent/WO2014206426A1/en not_active Ceased
-
2014
- 2014-06-26 JP JP2016522322A patent/JP2016523275A/ja active Pending
- 2014-06-26 US US14/890,859 patent/US20160115200A1/en not_active Abandoned
- 2014-06-26 EP EP14736292.5A patent/EP3013853A1/en not_active Withdrawn
- 2014-06-26 WO PCT/EP2014/001737 patent/WO2014206564A1/en not_active Ceased
-
2015
- 2015-06-26 JP JP2016575150A patent/JP6843625B2/ja not_active Expired - Fee Related
- 2015-06-26 US US15/321,904 patent/US20170128516A1/en not_active Abandoned
-
2022
- 2022-04-12 US US17/719,068 patent/US20220280591A1/en not_active Abandoned
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006501165A (ja) * | 2002-06-07 | 2006-01-12 | ユニバーシティ オブ ローザンヌ | Jnkシグナル伝達経路の細胞透過性ペプチド阻害剤 |
| JP2009507502A (ja) * | 2005-09-12 | 2009-02-26 | ザイジェン エス.アー. | Jnkシグナル伝達経路の細胞透過性ペプチド阻害剤 |
| JP2009538882A (ja) * | 2006-06-02 | 2009-11-12 | メルク セローノ ソシエテ アノニム | 皮膚疾患の治療のためのjnk阻害物質 |
| JP2011524861A (ja) * | 2008-05-30 | 2011-09-08 | ザイジェン エス.アー. | Jnkシグナル伝達経路に対する、細胞透過性のペプチド性阻害剤の種々の、疾病を治療するための使用 |
| JP2010254672A (ja) * | 2009-03-30 | 2010-11-11 | Santen Pharmaceut Co Ltd | JNK(c−Junアミノ末端キナーゼ)阻害ペプチドを有効成分として含有する網膜疾患の予防または治療剤 |
| WO2011160827A2 (en) * | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
| WO2012048721A1 (en) * | 2010-10-14 | 2012-04-19 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
| WO2013079213A1 (en) * | 2011-11-30 | 2013-06-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of dry eye syndrome |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3013853A1 (en) | 2016-05-04 |
| JP6843625B2 (ja) | 2021-03-17 |
| WO2014206564A1 (en) | 2014-12-31 |
| US20220280591A1 (en) | 2022-09-08 |
| JP2017520569A (ja) | 2017-07-27 |
| US20170128516A1 (en) | 2017-05-11 |
| WO2014206426A1 (en) | 2014-12-31 |
| US20160115200A1 (en) | 2016-04-28 |
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