JP2016520361A5 - - Google Patents
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- Publication number
- JP2016520361A5 JP2016520361A5 JP2016509106A JP2016509106A JP2016520361A5 JP 2016520361 A5 JP2016520361 A5 JP 2016520361A5 JP 2016509106 A JP2016509106 A JP 2016509106A JP 2016509106 A JP2016509106 A JP 2016509106A JP 2016520361 A5 JP2016520361 A5 JP 2016520361A5
- Authority
- JP
- Japan
- Prior art keywords
- catheter
- medical device
- polymer
- polyurethane
- aliphatic polyether
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004814 polyurethane Substances 0.000 claims description 99
- 229920002635 polyurethane Polymers 0.000 claims description 99
- 229920000642 polymer Polymers 0.000 claims description 82
- 238000000034 method Methods 0.000 claims description 73
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 72
- 229920000570 polyether Polymers 0.000 claims description 72
- 125000001931 aliphatic group Chemical group 0.000 claims description 69
- 239000011248 coating agent Substances 0.000 claims description 40
- 238000000576 coating method Methods 0.000 claims description 40
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 39
- 229960003260 chlorhexidine Drugs 0.000 claims description 39
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 35
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 24
- 229940124597 therapeutic agent Drugs 0.000 claims description 24
- 229960004023 minocycline Drugs 0.000 claims description 22
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims description 22
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims description 22
- 229960001225 rifampicin Drugs 0.000 claims description 22
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 230000002792 vascular Effects 0.000 claims description 19
- 239000003242 anti bacterial agent Substances 0.000 claims description 13
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- -1 polytetrafluoroethylene Polymers 0.000 claims description 11
- 239000011527 polyurethane coating Substances 0.000 claims description 11
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 claims description 10
- 229940122388 Thrombin inhibitor Drugs 0.000 claims description 10
- 239000002738 chelating agent Substances 0.000 claims description 10
- 239000003868 thrombin inhibitor Substances 0.000 claims description 10
- 239000000017 hydrogel Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- 230000003113 alkalizing effect Effects 0.000 claims description 8
- 239000007943 implant Substances 0.000 claims description 8
- 239000003112 inhibitor Substances 0.000 claims description 8
- 238000001990 intravenous administration Methods 0.000 claims description 8
- 229940124549 vasodilator Drugs 0.000 claims description 8
- 239000003071 vasodilator agent Substances 0.000 claims description 8
- 239000004599 antimicrobial Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 230000003510 anti-fibrotic effect Effects 0.000 claims description 6
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 6
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 6
- 229960003856 argatroban Drugs 0.000 claims description 6
- KXNPVXPOPUZYGB-XYVMCAHJSA-N argatroban Chemical compound OC(=O)[C@H]1C[C@H](C)CCN1C(=O)[C@H](CCCN=C(N)N)NS(=O)(=O)C1=CC=CC2=C1NC[C@H](C)C2 KXNPVXPOPUZYGB-XYVMCAHJSA-N 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 6
- 229960002768 dipyridamole Drugs 0.000 claims description 6
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 150000004665 fatty acids Chemical class 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 238000007917 intracranial administration Methods 0.000 claims description 6
- 238000007913 intrathecal administration Methods 0.000 claims description 6
- 230000002093 peripheral effect Effects 0.000 claims description 6
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 6
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 6
- 210000001147 pulmonary artery Anatomy 0.000 claims description 6
- 238000001361 intraarterial administration Methods 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 5
- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 4
- 239000003416 antiarrhythmic agent Substances 0.000 claims description 4
- 239000000480 calcium channel blocker Substances 0.000 claims description 4
- 210000003169 central nervous system Anatomy 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000000399 orthopedic effect Effects 0.000 claims description 4
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000006 Nitroglycerin Substances 0.000 claims description 3
- 229960003711 glyceryl trinitrate Drugs 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- 230000003472 neutralizing effect Effects 0.000 claims description 3
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims description 2
- 239000002473 artificial blood Substances 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000004204 blood vessel Anatomy 0.000 claims description 2
- 239000004053 dental implant Substances 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 230000000638 stimulation Effects 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 230000002485 urinary effect Effects 0.000 claims 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 229920002118 antimicrobial polymer Polymers 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 239000002357 osmotic agent Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 239000011575 calcium Substances 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
- XHJZXCYPSJOWPV-UHFFFAOYSA-N sulfanyl ethanesulfonate Chemical compound CCS(=O)(=O)OS XHJZXCYPSJOWPV-UHFFFAOYSA-N 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- 210000001635 urinary tract Anatomy 0.000 description 4
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical group C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 3
- DSUFPYCILZXJFF-UHFFFAOYSA-N 4-[[4-[[4-(pentoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamoyloxy]butyl n-[4-[[4-(butoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamate Chemical compound C1CC(NC(=O)OCCCCC)CCC1CC1CCC(NC(=O)OCCCCOC(=O)NC2CCC(CC3CCC(CC3)NC(=O)OCCCC)CC2)CC1 DSUFPYCILZXJFF-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 229920002313 fluoropolymer Polymers 0.000 description 3
- 239000004811 fluoropolymer Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 229960002784 thioridazine Drugs 0.000 description 3
- 229960001722 verapamil Drugs 0.000 description 3
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 102100036769 Girdin Human genes 0.000 description 2
- 101710199302 Girdin Proteins 0.000 description 2
- 239000005639 Lauric acid Substances 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 229920002959 polymer blend Polymers 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- JHECKPXUCKQCSH-UHFFFAOYSA-J calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;hydrate Chemical group O.[Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O JHECKPXUCKQCSH-UHFFFAOYSA-J 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361813542P | 2013-04-18 | 2013-04-18 | |
| US61/813,542 | 2013-04-18 | ||
| PCT/US2014/034551 WO2014172569A2 (en) | 2013-04-18 | 2014-04-17 | Antimicrobial catheters |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520361A JP2016520361A (ja) | 2016-07-14 |
| JP2016520361A5 true JP2016520361A5 (enExample) | 2017-06-01 |
| JP6594295B2 JP6594295B2 (ja) | 2019-10-23 |
Family
ID=51731986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509106A Active JP6594295B2 (ja) | 2013-04-18 | 2014-04-17 | 抗菌カテーテル |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10744232B2 (enExample) |
| EP (2) | EP2986342B1 (enExample) |
| JP (1) | JP6594295B2 (enExample) |
| ES (1) | ES2984024T3 (enExample) |
| WO (1) | WO2014172569A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104548198B (zh) * | 2014-12-31 | 2016-08-24 | 胡作军 | 一种负载双嘧达莫聚氨酯抗凝血材料的制备工艺 |
| ES2959428T3 (es) | 2016-04-22 | 2024-02-26 | Lilly Co Eli | Dispositivo de infusión con componentes que comprenden un sorbente polimérico para reducir la concentración de m-cresol en la insulina |
| US10173035B2 (en) | 2016-12-27 | 2019-01-08 | Vasonics, Llc | Catheter housing |
| CN118434460A (zh) * | 2021-12-28 | 2024-08-02 | 巴德血管外围设备公司 | 具有涂层的皮下通路装置及相关方法 |
| CN114699563B (zh) * | 2022-02-22 | 2024-02-02 | 中国医科大学附属盛京医院 | 一种负载型聚醚型聚氨酯薄膜、制备方法及其应用 |
| CN116688244A (zh) * | 2023-06-21 | 2023-09-05 | 惠州市顺美医疗科技有限公司 | 中心静脉导管用抗菌涂层及其制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8517091D0 (en) * | 1985-07-05 | 1985-08-14 | Franklin Medical Ltd | Balloon catheters |
| US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| US5165952A (en) * | 1989-01-18 | 1992-11-24 | Becton, Dickinson And Company | Anti-infective and antithrombogenic medical articles and method for their preparation |
| US4925668A (en) | 1989-01-18 | 1990-05-15 | Becton, Dickinson And Company | Anti-infective and lubricious medical articles and method for their preparation |
| US5453099A (en) | 1990-03-26 | 1995-09-26 | Becton, Dickinson And Company | Catheter tubing of controlled in vivo softening |
| US5458935A (en) | 1991-12-24 | 1995-10-17 | Abbott Laboratories | Thermoplastic urethane elastomer |
| US5217493A (en) | 1992-03-11 | 1993-06-08 | Board Of Regents, The University Of Texas System | Antibacterial coated medical implants |
| US5688516A (en) * | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| JPH11500330A (ja) | 1995-01-18 | 1999-01-12 | ヴィタフォア コーポレイション | 抗菌性医療装置及び方法 |
| EP0806992B1 (en) | 1995-02-01 | 2000-04-12 | Schneider (Usa) Inc. | Material having a coating of a polyurethane-polyurea polymer hydrogel |
| US5624704A (en) * | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
| US6224579B1 (en) * | 1999-03-31 | 2001-05-01 | The Trustees Of Columbia University In The City Of New York | Triclosan and silver compound containing medical devices |
| DE60221496D1 (de) * | 2001-01-12 | 2007-09-13 | Univ Texas | Neue antiseptische derivate mit breitem antimikrobiellem wirkungsspektrum zur imprägnierung von oberflächen |
| US6582719B2 (en) | 2001-02-02 | 2003-06-24 | The Trustees Of Columbia University In The City Of New York | Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms |
| US6939554B2 (en) * | 2002-02-05 | 2005-09-06 | Michigan Biotechnology Institute | Antimicrobial polymer |
| US20060009099A1 (en) * | 2004-07-12 | 2006-01-12 | Closure Medical Corporation | Adhesive-containing wound closure device and method |
| US20070154621A1 (en) | 2005-11-18 | 2007-07-05 | Issam Raad | Methods for coating surfaces with antimicrobial agents |
| US20070129690A1 (en) * | 2005-12-02 | 2007-06-07 | Joel Rosenblatt | Catheter with polymeric coating |
| US7867547B2 (en) * | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
| US20100069854A1 (en) * | 2008-09-12 | 2010-03-18 | Onajite Okoh | Elastomeric Devices Containing Chlorhexidine/Fatty Acid Salts Made From Fatty Acids of 12 to 18 Carbons |
| US20100233288A1 (en) * | 2009-03-11 | 2010-09-16 | Teleflex Medical Incorporated | Medical devices containing nitroprusside and antimicrobial agents |
| JP2012520745A (ja) | 2009-03-20 | 2012-09-10 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 医療装置に抗菌活性を付与するための方法 |
| US20110060313A1 (en) | 2009-09-09 | 2011-03-10 | Jian-Lin Liu | Substrate surface modification utilizing a densified fluid and a surface modifier |
| US20110082499A1 (en) * | 2009-10-05 | 2011-04-07 | Tyco Healthcare Group Lp | Coatings that enhance resistance to abrasion |
| JP2012045038A (ja) * | 2010-08-24 | 2012-03-08 | Nihon Covidien Kk | 抗菌性医療用具およびその製造方法 |
| EP2734262B1 (en) * | 2011-07-20 | 2018-02-28 | Patrick F. Kiser | Intravaginal rings for drug delivery |
| EP2780051B1 (en) * | 2011-11-09 | 2018-10-24 | Arrow International, Inc. | Novel enhanced formulations for coating medical devices |
| JP6066447B2 (ja) * | 2011-12-14 | 2017-01-25 | 株式会社リコー | トナー並びにこれを用いた画像形成方法 |
-
2014
- 2014-04-17 WO PCT/US2014/034551 patent/WO2014172569A2/en not_active Ceased
- 2014-04-17 JP JP2016509106A patent/JP6594295B2/ja active Active
- 2014-04-17 EP EP14785648.8A patent/EP2986342B1/en active Active
- 2014-04-17 EP EP20191534.5A patent/EP3777977B1/en active Active
- 2014-04-17 US US14/784,747 patent/US10744232B2/en active Active
- 2014-04-17 ES ES20191534T patent/ES2984024T3/es active Active
-
2020
- 2020-07-08 US US16/924,096 patent/US11738119B2/en active Active
-
2023
- 2023-08-25 US US18/456,061 patent/US20230405191A1/en active Pending
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