JP2016520313A5 - - Google Patents

Info

Publication number

JP2016520313A5

JP2016520313A5 JP2016515304A JP2016515304A JP2016520313A5 JP 2016520313 A5 JP2016520313 A5 JP 2016520313A5 JP 2016515304 A JP2016515304 A JP 2016515304A JP 2016515304 A JP2016515304 A JP 2016515304A JP 2016520313 A5 JP2016520313 A5 JP 2016520313A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

antibody

acid sequence

chain variable

Prior art date

2014-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
• 239000012634 fragment Substances 0.000 claims description 9
• 150000007523 nucleic acids Chemical class 0.000 claims description 9
• 102000039446 nucleic acids Human genes 0.000 claims description 9
• 108020004707 nucleic acids Proteins 0.000 claims description 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
• 208000024781 Immune Complex disease Diseases 0.000 claims description 2
• 206010061218 Inflammation Diseases 0.000 claims description 2
• 208000004221 Multiple Trauma Diseases 0.000 claims description 2
• 206010063837 Reperfusion injury Diseases 0.000 claims description 2
• 206010040047 Sepsis Diseases 0.000 claims description 2
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• 206010052779 Transplant rejections Diseases 0.000 claims description 2
• 206010047115 Vasculitis Diseases 0.000 claims description 2
• 206010000891 acute myocardial infarction Diseases 0.000 claims description 2
• 208000007502 anemia Diseases 0.000 claims description 2
• 230000002612 cardiopulmonary effect Effects 0.000 claims description 2
• 230000004054 inflammatory process Effects 0.000 claims description 2
• 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 2
• 230000001404 mediated effect Effects 0.000 claims description 2
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• 238000007631 vascular surgery Methods 0.000 claims description 2
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• 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
• 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
• 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 1
• 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 1
• 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
• 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
• 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
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