JP2016520122A5 - - Google Patents
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- Publication number
- JP2016520122A5 JP2016520122A5 JP2016516309A JP2016516309A JP2016520122A5 JP 2016520122 A5 JP2016520122 A5 JP 2016520122A5 JP 2016516309 A JP2016516309 A JP 2016516309A JP 2016516309 A JP2016516309 A JP 2016516309A JP 2016520122 A5 JP2016520122 A5 JP 2016520122A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- preparing
- alkylation
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 238000004519 manufacturing process Methods 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- 230000029936 alkylation Effects 0.000 claims 2
- 238000005804 alkylation reaction Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000010933 acylation Effects 0.000 claims 1
- 238000005917 acylation reaction Methods 0.000 claims 1
- 150000001345 alkine derivatives Chemical group 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1881/MUM/2013 | 2013-05-28 | ||
| IN1881MU2013 | 2013-05-28 | ||
| PCT/IN2014/000359 WO2014192027A1 (en) | 2013-05-28 | 2014-05-28 | Methods for treatment of inflammatory conditions using s-[4-(3-fluoro-3-methylbutyryloxy) but-2-ynyl] 6alpha, 9alpha-difluoro-17alpha-(furan-2-yl) carbonyloxy-11beta -hydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta -carbothioate. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520122A JP2016520122A (ja) | 2016-07-11 |
| JP2016520122A5 true JP2016520122A5 (cg-RX-API-DMAC7.html) | 2017-06-08 |
| JP6366696B2 JP6366696B2 (ja) | 2018-08-01 |
Family
ID=51300796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516309A Expired - Fee Related JP6366696B2 (ja) | 2013-05-28 | 2014-05-28 | Ｓ−［４−（３−フルオロ−３−メチルブチリルオキシ）ブタ−２−イニル］６α，９α−ジフルオロ−１７α−（フラン−２−イル）カルボニルオキシ−１１β−ヒドロキシ−１６α−メチル−３−オキソアンドロスタ−１，４−ジエン−１７β−カルボチオアートを使用する炎症性病態の治療の方法 |
Country Status (18)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY179214A (en) | 2013-05-28 | 2020-11-02 | Sun Pharma Advanced Res Co Ltd | Methods for treatment of inflammatory conditions using s-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl]6alpha, 9alpha- difluoro-17alpha-(furan-2-yl)carbonyloxy-11beta-hydroxy-16alpha- methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate |
| CA2975363A1 (en) | 2015-01-31 | 2016-08-04 | Jiten Ranchhodbhai Patel | Crystalline forms of s-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl]6.alpha.,9.alpha.-difluoro-17.alpha.-(furan-2-yl)carbonyloxy-11.beta.-hydroxy-16.alpha.-methyl-3-oxoandrosta-1,4-diene-17.beta.-carbothioate |
| CN106279341A (zh) * | 2015-05-11 | 2017-01-04 | 正大天晴药业集团股份有限公司 | 一种糠酸氟替卡松的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4335121A (en) | 1980-02-15 | 1982-06-15 | Glaxo Group Limited | Androstane carbothioates |
| AU2003263575A1 (en) | 2002-06-20 | 2004-01-06 | Sun Pharmaceutical Industries Limited | Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-diene-17beta-carbothioate |
| GB0225287D0 (en) | 2002-10-30 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| AR059216A1 (es) * | 2006-01-27 | 2008-03-19 | Sun Pharmaceutical Ind Ltd | 11b-hidroxiandrosta-4-eno-3-onas |
| MY179214A (en) | 2013-05-28 | 2020-11-02 | Sun Pharma Advanced Res Co Ltd | Methods for treatment of inflammatory conditions using s-[4-(3-fluoro-3-methylbutyryloxy)but-2-ynyl]6alpha, 9alpha- difluoro-17alpha-(furan-2-yl)carbonyloxy-11beta-hydroxy-16alpha- methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate |
-
2014
- 2014-05-28 MY MYPI2015704326A patent/MY179214A/en unknown
- 2014-05-28 SG SG11201509680TA patent/SG11201509680TA/en unknown
- 2014-05-28 KR KR1020157033778A patent/KR20160030085A/ko not_active Withdrawn
- 2014-05-28 CN CN201480030607.2A patent/CN105431445A/zh active Pending
- 2014-05-28 MX MX2015016283A patent/MX2015016283A/es unknown
- 2014-05-28 US US14/893,655 patent/US9458187B2/en not_active Expired - Fee Related
- 2014-05-28 CA CA2912400A patent/CA2912400A1/en not_active Abandoned
- 2014-05-28 ES ES14750012.8T patent/ES2664019T3/es active Active
- 2014-05-28 AU AU2014272640A patent/AU2014272640B2/en not_active Ceased
- 2014-05-28 WO PCT/IN2014/000359 patent/WO2014192027A1/en not_active Ceased
- 2014-05-28 BR BR112015029530A patent/BR112015029530A8/pt not_active Application Discontinuation
- 2014-05-28 EP EP14750012.8A patent/EP3004133B1/en not_active Not-in-force
- 2014-05-28 JP JP2016516309A patent/JP6366696B2/ja not_active Expired - Fee Related
- 2014-05-28 UA UAA201512888A patent/UA117248C2/uk unknown
- 2014-05-28 EA EA201592283A patent/EA027831B9/ru not_active IP Right Cessation
-
2015
- 2015-11-18 IL IL242658A patent/IL242658A0/en unknown
- 2015-11-24 ZA ZA2015/08640A patent/ZA201508640B/en unknown
- 2015-11-26 PH PH12015502652A patent/PH12015502652A1/en unknown