JP2016518438A - ＤＰＰ−４阻害薬とα−グルコシダーゼ阻害薬との組合せ - Google Patents

ＤＰＰ−４阻害薬とα−グルコシダーゼ阻害薬との組合せ Download PDF

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JP2016518438A
JP2016518438A JP2016513398A JP2016513398A JP2016518438A JP 2016518438 A JP2016518438 A JP 2016518438A JP 2016513398 A JP2016513398 A JP 2016513398A JP 2016513398 A JP2016513398 A JP 2016513398A JP 2016518438 A JP2016518438 A JP 2016518438A
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Japan
Prior art keywords
glp
combination
dpp
inhibitor
food
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JP2016513398A
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English (en)
Japanese (ja)
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JP2016518438A5 (cg-RX-API-DMAC10.html
Inventor
トーマス クライン
トーマス クライン
マルク　ミヒャエル
ミヒャエル マルク
Original Assignee
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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Publication of JP2016518438A publication Critical patent/JP2016518438A/ja
Publication of JP2016518438A5 publication Critical patent/JP2016518438A5/ja
Priority to JP2019044858A priority Critical patent/JP7382147B2/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016513398A 2013-05-17 2014-05-16 ＤＰＰ−４阻害薬とα−グルコシダーゼ阻害薬との組合せ Pending JP2016518438A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019044858A JP7382147B2 (ja) 2013-05-17 2019-03-12 ＤＰＰ－４阻害薬とα－グルコシダーゼ阻害薬との組合せ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13168375.7 2013-05-17
EP13168375 2013-05-17
PCT/EP2014/060160 WO2014184376A1 (en) 2013-05-17 2014-05-16 Combination of a dpp-4 inhibitor and an alpha-glucosidase inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019044858A Division JP7382147B2 (ja) 2013-05-17 2019-03-12 ＤＰＰ－４阻害薬とα－グルコシダーゼ阻害薬との組合せ

Publications (2)

Publication Number Publication Date
JP2016518438A true JP2016518438A (ja) 2016-06-23
JP2016518438A5 JP2016518438A5 (cg-RX-API-DMAC10.html) 2017-06-22

Family

ID=48430599

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016513398A Pending JP2016518438A (ja) 2013-05-17 2014-05-16 ＤＰＰ−４阻害薬とα−グルコシダーゼ阻害薬との組合せ
JP2019044858A Active JP7382147B2 (ja) 2013-05-17 2019-03-12 ＤＰＰ－４阻害薬とα－グルコシダーゼ阻害薬との組合せ

Family Applications After (1)

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JP2019044858A Active JP7382147B2 (ja) 2013-05-17 2019-03-12 ＤＰＰ－４阻害薬とα－グルコシダーゼ阻害薬との組合せ

Country Status (4)

Country Link
US (1) US20140343014A1 (cg-RX-API-DMAC10.html)
EP (1) EP2996724A1 (cg-RX-API-DMAC10.html)
JP (2) JP2016518438A (cg-RX-API-DMAC10.html)
WO (1) WO2014184376A1 (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
EA034869B1 (ru) 2009-11-27 2020-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Лечение генотипированных пациентов с диабетом ингибиторами дпп-4, такими как линаглиптин
MX341025B (es) 2010-05-05 2016-08-04 Boehringer Ingelheim Int Gmbh * Terapia de combinacion.
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
CN109310697A (zh) 2016-06-10 2019-02-05 勃林格殷格翰国际有限公司 利格列汀和二甲双胍的组合
US20240358055A1 (en) * 2023-04-18 2024-10-31 Richard Clark Kaufman Dietary supplements for weight management and glycemic control

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008000133A1 (es) * 2007-01-19 2008-05-23 Boehringer Ingelheim Int Composicion farmaceutica que comprende un compuesto derivado de pirazol-o-glucosido combinado con al menos un segundo agente terapeutico; y uso de la composicion para el tratamiento de diabetes mellitus, cataratas, neuropatia, infarto de miocardio, e
MX339194B (es) * 2009-02-13 2016-05-16 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de sglt2, un inhibidor de dpp-iv y opcionalmente otro agente antidiabetico, y usos de la misma.
WO2010092163A2 (en) 2009-02-13 2010-08-19 Boehringer Ingelheim International Gmbh Antidiabetic medications
US9034883B2 (en) * 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CURR. MED. RES. OPIN., 2011, VOL.27, NO.S3, PP.21-29, JPN6018010729, ISSN: 0004029851 *
DIABETES OBES. METAB., 2012, VOL.14, NO.4, PP.348-357, JPN6018010740, ISSN: 0004029856 *
DIABETES OBES. METAB., 2013, VOL.15, NO.9, PP.833-843, JPN6018010738, ISSN: 0004029855 *
J. DIABETES INVESTIG., 2011, VOL.2, NO.3, PP.200-203, JPN6018010734, ISSN: 0004029853 *
J. DIABETES INVESTIG., 2013, VOL.4, NO.4, PP.393-398, JPN6018010732, ISSN: 0004029852 *
J. PHARMACOL. SCI., 2007, VOL.104, NO.1, PP.29-38, JPN6018010736, ISSN: 0004029854 *

Also Published As

Publication number Publication date
JP7382147B2 (ja) 2023-11-16
US20140343014A1 (en) 2014-11-20
JP2019108392A (ja) 2019-07-04
EP2996724A1 (en) 2016-03-23
WO2014184376A1 (en) 2014-11-20

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