JP2016516757A - ニワトコ抽出物とラクトバチルス・ラムノーサスの菌株との組合せを含んでなる組成物 - Google Patents
ニワトコ抽出物とラクトバチルス・ラムノーサスの菌株との組合せを含んでなる組成物 Download PDFInfo
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- JP2016516757A JP2016516757A JP2016506936A JP2016506936A JP2016516757A JP 2016516757 A JP2016516757 A JP 2016516757A JP 2016506936 A JP2016506936 A JP 2016506936A JP 2016506936 A JP2016506936 A JP 2016506936A JP 2016516757 A JP2016516757 A JP 2016516757A
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- elderberry
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- extract
- vitamin
- lactobacillus rhamnosus
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Abstract
Description
・前記組合せを調製する工程、
・本発明による組成物中に前記組合せを添加する工程
を含む方法により調製され得る。
・限外濾過:事前に希釈されたジュースにダイアフィルトレーションを行い、その後、1〜20kDaで含まれる、好ましくは、3〜10kDaで含まれるカットオフ閾値を有する有機または無機の膜で過濃縮する工程(Girard and Fukumoto, Crit. Rev. Food Sci. Nutr. 40(2), 91-157, 2000)。
・Amberlite XADタイプの吸収性ポリマー樹脂カラムの通過。
・水−アルコール(水とCl〜C4アルコールとのあらゆる比率での混合物)または酸性pHの水溶液での抽出(Bronnum-Hansen and Flink, Int. J. Food Sci. Tech. 21(2), 605-614, 1986、 Lee and Wrolstad, J. Food Sci. 69(7), 564-573, 2004)。この抽出は、有利には、乾燥および粉砕された実でまたは新鮮な実から得られたピューレで直接行うことができる。
・ニワトコ乾燥抽出物10mg〜1g、好ましくは、20mg〜200mg、有利には、20mg〜100mg、より好ましくは、40mg〜80mg、さらに同様に有利には、20〜60mg、
・単位用量当たりラクトバチルス・ラムノーサス1.107〜1.1011、好ましくは、1.108〜1.109CFU
を含んでなる。
・ニワトコアントシアニン2mg〜200mg、好ましくは、2mg〜100mg、より好ましくは、2mg〜20mg、同様に有利には、20mg〜50mg、
・ニワトコタンパク質2mg〜100mg、好ましくは、10mg〜20mg、
および
・単位用量当たりラクトバチルス・ラムノーサス1.107〜1.1011、好ましくは、1.108〜1.109CFU
を含んでなる。
・ピルビン酸デカルボキシラーゼ複合体の補因子である、ビタミンB1またはチアミン、
・フラビンアデニンジヌクレオチドの前駆体である、ビタミンB2またはリボフラビン、
・ニコチン酸アミドアデニンジヌクレオチドの前駆体である、ビタミンB3(PP)またはニコチンアミド、
・補酵素Aの前駆体および構成要素である、ビタミンB5またはパントテン酸、
・アミノ酸およびタンパク質の代謝と関連している反応の補酵素である、ビタミンB6またはピリドキシン、
・脂肪酸、炭水化物およびアミノ酸の代謝反応の補酵素である、ビタミンB8(H)またはビオチン、
・S−アデノシルメチオニンの補因子である、ビタミンB9または葉酸およびビタミンB12またはシアノコバラミン。
・EFSA Journal 2009、 7(9): 1215 Scientific opinion on the substantiation of health claims related to iron and formation of red blood cells and haemoglobin (ID 249, ID 1589), function of the immune system (ID 252, ID 259), cognitive function (ID 253) and cell division (ID 368) pursuant to Article 13(1) of regulation (EC) n° 1924/2006.
・Huskisson E., Maggini S., Ruf M., Journal of International Medical Research 2007, 25: 277-289. The role of vitamins and minerals in energy metabolism and well-being.
・Institute of Medicine (1998), National Academy press, Washington, DC (592 pages). Dietary reference intakes for Thiamine, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic acid, Biotin, and Choline.
・医学研究所食品栄養委員会の、食事摂取基準の科学的評価と葉酸塩、他のビタミンB群、およびコリンのそのパネルに関する常任委員会、ならびに栄養素の上限基準量に関する分科委員会の報告書。
ニワトコ抽出物は、ニワトコ実のジュースから得、アントシアニンを強化し、マルトデキストリン上で乾燥させた。強化は、以下の方法による膜濾過工程によって実施した:清澄化したニワトコジュース26リットルを水284リットル(ジュース1容量に対して水11容量)で希釈する。それによって得られた310リットルを撹拌し、45℃に加熱し、その後、ジュース1容量当たり水7容量(すなわち、181L)を添加することによって第1の5kDa膜で透析濾過する。次いで、透析透過物を、5kDa膜(単位表面5.8m2の5/10kDaのパイロット膜)での限外濾過によって濃縮する。限外濾過からの保持液を真空下、50℃を超えない温度で加熱濃縮し、その後、マルトデキストリン担体上に噴霧して、マルトデキストリンの量が30%(w/w)以下になるようにする。
・アントシアニン含有量:抽出物の乾燥物質に対して10〜14重量%(Wu et al., J. Agric. Food Chem. 52(26), 7846-7856, 2004によって記載されたHPLC法によれば、シアニジン−3−グルコシドとして表される)。
・タンパク質含有量:抽出物の乾燥物質に対して5〜7重量%(ケルダール方法によれば、N×6.25)
である。
・凍結乾燥プロバイオティック菌株、ラクトバチルス・ラムノーサス:35mg、すなわち、5.108CFU、
・実施例1によるニワトコ抽出物(セイヨウニワトコ(Sambucus nigra)):50mg、
・ビタミンA:400μg、
・ビタミンB1:550μg、
・ビタミンB2:700μg、
・ビタミンB5:3mg、
・ビタミンB6:700μg、
・ビタミンB8:25μg、
・ビタミンB9:100μg、
・ビタミンB12:0.625μg、
・ビタミンC:40mg、
・ビタミンD:2.5μg、
・ビタミンE:6mg、
・鉄:2.5mg、
・亜鉛:2.5mg、
・セレン:15μg、
・クロム:12.5μg、
・マンガン:500μg、
・モリブデン:12.5μg。
・凍結乾燥プロバイオティック菌株、ラクトバチルス・ラムノーサス:35mg、すなわち、5.108CFU、
・実施例1によるニワトコ抽出物(セイヨウニワトコ):25mg、
・ビタミンC:18mg、
・ビタミンB6:600μg、
・ビタミンE:2.4mg、
・亜鉛:2.5mg、
・セレン:15μg。
材料および方法
末梢血由来単核細胞は、健常被験者から単離し、再懸濁し、24ウェルプレート中に5×105細胞/ウェルの割合で分注する。これらの細胞を、5%CO2下、37℃で18時間インキュベートする。これらの細胞は、いずれかを10μg/mlのリポ多糖類を用いて、いずれかを100μg/mlのニワトコ抽出物の存在下で、つまり、5.105ラクトバチルス・ラムノーサスを用いて、または100μg/mlのニワトコ抽出物および5.105のラクトバチルス・ラムノーサスの存在下で刺激する。培養上清を回収して、フラックスサイトメトリー(flux cytometry)により種々のサイトカインをアッセイする。それらは4℃で10分間、1600rpmで遠心分離し、アッセイまで−20℃で保存した。
サイトカインに関する各刺激条件で得られた濃度を表1および表2にまとめる。サイトカインのレベルで相乗効果が存在するためには、以下が必要である:
・プロバイオティックとニワトコ抽出物とを同時に用いて末梢血由来単核細胞を刺激することにより実験的に得られたサイトカインの濃度が、ニワトコおよびプロバイオティックを個別に用いて観察されるサイトカインの濃度の合計よりも高いこと、
・6名のドナーについての、組合せを用いて得られたサイトカインの濃度中央値が、ニワトコを用いて得られたものおよびプロバイオティックを用いて得られたものの両方と比べて著しく高いこと。
試験した条件下で、本発明者らは、ニワトコ抽出物とラクトバチルス・ラムノーサスとの組合せが、IL−1RA、IL−6、IL−10、CCL3、CCL4、CXCL8、GM−CSFの誘導に関して相乗作用を示すことを示した。この組合せは、IL−lβ、IL−1RA、IL−4、IL−6、IL−10、IL−12p70、CCL2、CCL3、CCL4、CCL5、CCL22、CXCL8、IFNγ、TNFαおよびGM−CSFの産生を誘導する。このプロファイルは、ニワトコ+ラクトバチルス・ラムノーサス組合せが、炎症部位に単球、顆粒球およびリンパ球を動員することによって免疫防御を刺激することを示唆している。1型プロフィールは、その際、特に、単球/マクロファージおよび好中球の活性化を伴うが、リンパ球増殖効果を受けずに、細胞型応答の発展を促す。炎症反応は、IL−IRAおよびIL−10の産生と、特にニワトコに関連する、CXCL10の産生阻害によって抑制される。
Claims (8)
- ニワトコ抽出物と、ラクトバチルス・ラムノーサスの少なくとも1種の菌株との組合せを含んでなる組成物であって、該ニワトコ抽出物は、その抽出物の乾燥物質に対して0.5〜25重量%で含まれるアントシアニン含有物と、その抽出物の乾燥物質に対して2〜10重量%で含まれるタンパク質含有物とを含んでなる、組成物。
- 1.107〜1.1011CFU/単位用量で含まれるある量のラクトバチルス・ラムノーサスを含んでなる、請求項1に記載の組成物。
- 食物、栄養補助食品または医薬である、請求項1または2に記載の組成物。
- カプセル剤、内服錠、チュアブル錠、発泡錠、トローチ剤、丸薬、散剤、顆粒剤、経口液剤または懸濁剤、ならびに舌下および口内の投与形態からなる群から選択される投与形での栄養補助食品である、請求項1または2に記載の組成物。
- 単位用量当たりニワトコ乾燥抽出物20mg〜200mg、好ましくは単位用量当たりニワトコ乾燥抽出物20mg〜100mg、および単位用量当たりラクトバチルス・ラムノーサス1.107〜1.1011CFU、好ましくは単位用量当たりラクトバチルス・ラムノーサス1.108〜1.109CFUで含んでなる、請求項1〜4のいずれか一項に記載の組成物。
- ビタミンおよび/または無機塩をさらに含んでなる、請求項1〜5のいずれか一項に記載の組成物。
- 免疫を刺激し、および/または免疫防御を強化し、および/または感染防御応答および/または抗炎症性応答を促進し、および/または活力の維持の補助に使用するための、請求項1〜6のいずれか一項に記載の組成物。
- 特に、インフルエンザウイルスによる感染によって引き起こされるインフルエンザ様状態の症状の治療および/または予防における使用のための、請求項1〜6のいずれか一項に記載の組成物。
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ZA201508222B (en) | 2017-01-25 |
FR3004109B1 (fr) | 2016-01-01 |
HUE043671T2 (hu) | 2019-08-28 |
RU2668126C2 (ru) | 2018-09-26 |
FR3004109A1 (fr) | 2014-10-10 |
WO2014166960A1 (fr) | 2014-10-16 |
JP6660289B2 (ja) | 2020-03-11 |
ES2711821T3 (es) | 2019-05-07 |
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