JP2016515611A - 朝鮮人参の実抽出物を含む脳活性化組成物 - Google Patents
朝鮮人参の実抽出物を含む脳活性化組成物 Download PDFInfo
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- JP2016515611A JP2016515611A JP2016506227A JP2016506227A JP2016515611A JP 2016515611 A JP2016515611 A JP 2016515611A JP 2016506227 A JP2016506227 A JP 2016506227A JP 2016506227 A JP2016506227 A JP 2016506227A JP 2016515611 A JP2016515611 A JP 2016515611A
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- ginseng
- composition
- extract
- ginseng fruit
- fruit extract
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Abstract
Description
かかる認知機能の障害は様々な原因によって誘発することがある。該認知機能の障害には、例えば痴ほう、パーキンソン病、脳卒中、及びハンチングトン舞踏病等を含む退行性脳疾患による認知機能障害、アルコール性認知機能障害、老化による認知機能障害、事故等による脳機能損失、脳出血による障害、ADHD(注意力欠乏過剰行動障害)、精神分裂、及び慢性疲労症候群による認知機能障害が挙げられる。代表的な退行性脳疾患である痴ほうは、全般的な認知機能の障害を示す脳疾患であって、通常、慢性または進行性脳疾患によって発病し、記憶、思考、理解、計算、学習、及び言語判断等の様々な高次脳機能に障害が現われる。また老化の場合、年を取るにつれて生じる衰退的な変化現象であって、脳の機能が徐々に減退していき、その結果、認知能力の低下が生じるようになる。
本発明の目的は、朝鮮人参の実抽出物を含む脳活性化用、慢性疲労症候群の改善、治療又は予防用、又は認知能力の改善用組成物を提供することである。
(1)朝鮮人参の実を、水、有機溶媒、又はこれらの組み合わせで抽出して朝鮮人参の実抽出物を得る段階を含む製造方法によって調製されていてよい。
(i)朝鮮人参の実を、水、有機溶媒、又はこれらの組み合わせで抽出する段階;及び
(ii)前記抽出物から脂溶性成分を除去する段階;を含む製造方法によって製造されていてよい。
(a)朝鮮人参の実を前処理する段階;及び
(b)前記段階で前処理した朝鮮人参の実を、水、有機溶媒、又はこれらの組み合わせで抽出して朝鮮人参の実抽出物を得る段階;を含む製造方法によって製造されていてよい。
(d)脂溶性成分を除去する段階をさらに含んでいてよい。
(e)脂溶性成分の除去後に有機溶媒を加えて抽出する段階をさらに含んでいてよい。
1)朝鮮人参の実の前処理:生の朝鮮人参(Panax ginseng C.A. Meyer)の実を収穫して種子を分離し除去してから朝鮮人参の実の果肉と果皮を日光乾燥または熱風乾燥することで朝鮮人参の実原料を製造した。
生の朝鮮人参(Panax ginseng C.A. Meyer)の実を収穫して種子を分離し除去してから朝鮮人参の実の果汁、果肉、及び果皮を混合することで朝鮮人参の実原料を製造した。そのようにして製造された朝鮮人参の実原料1kgにエタノール3Lを加え、70℃で4時間にかけて還流抽出してからろ過した後、45℃で減圧濃縮することで朝鮮人参の実抽出物30gを得た。
前記実施例1において朝鮮人参の実の代わりに朝鮮人参の根を用いたことを除いては実施例1と同法にて朝鮮人参の根抽出物を製造し、朝鮮人参の根抽出物300gを得た。
1.朝鮮人参の実と根のジンセノサイド(朝鮮人参のサポニン)成分の分析
実施例1、実施例2及び比較例1に従い製造した朝鮮人参の実抽出物及び朝鮮人参の根抽出物にエーテル(ether)処理を施して脂溶性成分を除去した後にブタノール(BuOH)で粗サポニンを抽出し、次いで、該粗サポニンを濃縮してHPLCによるジンセノ−イド成分の分析を実施した。その結果を図1及び下の表1に表した。
実施例1及び実施例2に従い製造した朝鮮人参の実抽出物が朝鮮人参とは異なる「果実」としての特徴を持つことを確認するために、ビタミンを始めとしたミネラル成分の分析を実施し、その結果を下の表2に表した。
朝鮮人参の実抽出物を含む組成物の効果を確認するために、次のような実験を実施した。このような実験の実施に際して正常対照群(以下、正常群)と実験群を募集し設定して、実験例2、3、及び4を実施した。
実験群及び正常群の被検者らの慢性疲労度及び憂鬱感に関する自己認知程度を評価するために、次のような方法にてアンケート調査をした。慢性疲労症候群の深刻度(severity)を評価するために神経繊維疲労スケール(FibroFatigue Scale)(Zachrisson et al.、2002)を実施し、また憂鬱及び不安症状が検査の実施に及ぼす影響を調べるために、ベック抑うつ評価尺度(Beck Depression Inventory;Beck et al.、1996))及びベック不安尺度(Beck Anxiety Inventory;Beck and Steer、1990)を用いた。
適切な反応をするためには典型的且つ自動的な反応を抑制する努力が必要となるため、注意統制が要求される。近年、認知訓練ゲームのうち、「緑」という文字が赤色で書かれている場合、赤色のボタンを押すというゲームがある。これをストループ検査(Stroop task)と言うが、不一致状況で自動的な反射を抑制するための相当な統制が要求される課題であると知られている。したがって、このストループ検査を実施して反応の正確度や問題解決時間を測定することで、情報処理能力や認知能力に関する状態を評価することができる。
機能的磁気共鳴画像(functional MRI:fMRI)は、リアルタイムで脳をスキャンすることで脳の各領域に対する血流量の変化を画像にて示す装備である。血流量が多くなった部位と少ない部位の脳血流量の強度を示すことで、脳活性化程度の差異を比べることができる。
実施例1または実施例2に従う朝鮮人参の実抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、パーム油2mg、植物性硬化油8mg、黄鉛4mg及びレシチン9mgを混合し、通常の方法にて混合して軟質カプセル充填液を製造する。1カプセル当たり400mgずつ充填して軟質カプセルを製造する。そして、前記とは別に、ゼラチン66重量部、グリセリン24重量部及びソルビトール液10重量部の割合で軟質カプセルシートを製造し、前記充填液を充填して、本明細書に係る朝鮮人参の実抽出物400mgが含有された軟質カプセルを製造する。
実施例1または実施例2に従う朝鮮人参の実抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、ガラクトオリゴ糖200mg、乳糖60mg及び麦芽糖140mgを混合し、流動層乾燥機を利用して顆粒に造粒した後、糖エステル(sugar ester)6mgを添加する。これらの組成物500mgを通常の方法にて打錠して錠剤を製造する。
実施例1または実施例2に従う朝鮮人参の実抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、ブドウ糖10g、クエン酸0.6g、及び液状オリゴ糖25gを混合し、これに精製水300mlを加えて、各ビンに200mlずつ充填する。ビンに充填した後、130℃で4〜5秒間殺菌してドリンク剤を製造する。
実施例1または実施例2に従う朝鮮人参の実抽出物8mg、ビタミンE 9mg、ビタミンC 9mg、無水結晶ブドウ糖250mg及び澱粉550mgを混合し、流動層顆粒機を使用して顆粒に造粒し、包みに充填して顆粒剤を製造する。
下記の表3に表した組成にて通常の方法で注射剤を製造した。
下記の表4に表した組成にて通常の方法で健康機能食品を製造した。
下記の表5に表した組成にて通常の方法で健康飲料を製造した。
Claims (11)
- 朝鮮人参の実抽出物を有効成分として含む脳活性化用組成物。
- 朝鮮人参の実抽出物を有効成分として含む認知機能改善用組成物。
- 朝鮮人参の実抽出物を有効成分として含む慢性疲労症候群の改善、治療又は予防用、又は慢性疲労症候群の症状改善用薬学組成物。
- 朝鮮人参の実抽出物を有効成分として含む慢性疲労症候群の改善又は予防用、又は慢性疲労症候群の症状改善用食品組成物。
- 慢性疲労症候群の症状は、脳活性化の低下、脳血流量の減少、認知機能の低下、中枢神経障害、集中力障害、注意力障害、記憶力障害、憂鬱感、及びストレス抵抗性の減少からなる群から選択された一つ以上である、請求項3または4に記載の組成物。
- 朝鮮人参の実抽出物は、プロトパナキシジオール系ジンセノサイド(PD)及びプロトパナキシトリオール系ジンセノサイド(PT)の重量比(PD/PT)が、0.1〜1.5の範囲である、請求項1乃至4のいずれかに記載の組成物。
- 朝鮮人参の実抽出物は、組成物の総重量に対して0.01〜100重量%の範囲の量で含まれる、請求項1乃至4のいずれかに記載の組成物。
- 朝鮮人参の実抽出物は、粗サポニンの含量が朝鮮人参の実抽出物の総重量を基準にして20重量%以上である、請求項1乃至4のいずれかに記載の組成物。
- 朝鮮人参の実抽出物は、水又はC1〜C6の低級アルコールの抽出物である、請求項1乃至4のいずれかに記載の組成物。
- 朝鮮人参の実抽出物は、ジンセノサイドReを朝鮮人参の実抽出物の総重量に対して5〜30重量%の範囲で含む、請求項1乃至4のいずれかに記載の組成物。
- 組成物は、散剤、顆粒剤、錠剤、軟質または硬質カプセル剤、及びドリンク剤からなる群から選択された剤形である、請求項1乃至4のいずれかに記載の組成物。
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Also Published As
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WO2014163328A1 (ko) | 2014-10-09 |
CN113244282A (zh) | 2021-08-13 |
KR20140120264A (ko) | 2014-10-13 |
US10555983B2 (en) | 2020-02-11 |
KR102200012B1 (ko) | 2021-01-08 |
JP6648004B2 (ja) | 2020-02-14 |
CN104095894A (zh) | 2014-10-15 |
EP2982376A1 (en) | 2016-02-10 |
EP2982376A4 (en) | 2017-01-04 |
US20160051605A1 (en) | 2016-02-25 |
EP2982376B1 (en) | 2019-08-14 |
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