JP2016514697A - 酸化ストレス障害の処置のためのフェナジン−３−オンおよびフェノチアジン−３−オン誘導体 - Google Patents

酸化ストレス障害の処置のためのフェナジン−３−オンおよびフェノチアジン−３−オン誘導体 Download PDF

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JP2016514697A
JP2016514697A JP2016503226A JP2016503226A JP2016514697A JP 2016514697 A JP2016514697 A JP 2016514697A JP 2016503226 A JP2016503226 A JP 2016503226A JP 2016503226 A JP2016503226 A JP 2016503226A JP 2016514697 A JP2016514697 A JP 2016514697A
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alkyl
compound
disease
deficiency
mitochondrial
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JP2016514697A5 (enExample
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アンドリュー ダブリュー． ヒンマン，
アンドリュー ダブリュー． ヒンマン，
ダナ デイヴィス，
ダナ デイヴィス，
ウィリアム ディー． シュレイダー，
ウィリアム ディー． シュレイダー，
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エジソン ファーマシューティカルズ， インコーポレイテッド
エジソン ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP2016503226A 2013-03-15 2014-03-14 酸化ストレス障害の処置のためのフェナジン−３−オンおよびフェノチアジン−３−オン誘導体 Pending JP2016514697A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/838,372 US20140275045A1 (en) 2013-03-15 2013-03-15 Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
US13/838,372 2013-03-15
PCT/US2014/029811 WO2014145119A1 (en) 2013-03-15 2014-03-14 Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders

Publications (2)

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JP2016514697A true JP2016514697A (ja) 2016-05-23
JP2016514697A5 JP2016514697A5 (enExample) 2017-04-27

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US (1) US20140275045A1 (enExample)
EP (1) EP2970151A1 (enExample)
JP (1) JP2016514697A (enExample)
CA (1) CA2906154A1 (enExample)
HK (1) HK1220450A1 (enExample)
WO (1) WO2014145119A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019093379A1 (ja) 2017-11-07 2019-05-16 学校法人自治医科大学 ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2564843B1 (en) 2005-06-01 2018-12-26 Bioelectron Technology Corporation Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
DK2220030T3 (en) 2007-11-06 2016-04-11 Edison Pharmaceuticals Inc 4- (P-QUINONYL) -2-HYDROXYBUTANAMIDDERIVATER TO TREAT mitochondrial
EP2237664A4 (en) 2008-01-08 2013-05-22 Edison Pharmaceuticals Inc (HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
MX363223B (es) 2008-09-10 2019-03-15 Bioelectron Tech Corp Tratamiento de trastornos generalizados del desarrollo con terapeuticos con actividad redox.
ES2553557T3 (es) 2008-10-28 2015-12-10 Edison Pharmaceuticals, Inc. Proceso para la producción de alfa-tocotrienol y derivados
PL2424495T3 (pl) 2009-04-28 2018-06-29 Bioelectron Technology Corporation Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu
US9464016B2 (en) 2011-06-14 2016-10-11 Edison Pharmaceuticals, Inc. Catechol derivatives for treatment of oxidative stress diseases
JP2014520894A (ja) 2011-07-19 2014-08-25 エジソン ファーマシューティカルズ， インコーポレイテッド 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法
EP2892516A1 (en) 2012-09-07 2015-07-15 Edison Pharmaceuticals, Inc. Quinone derivatives for use in the modulation of redox status of individuals
US9868711B2 (en) 2013-03-15 2018-01-16 Bioelectron Technology Corporation Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders
EP2970158B1 (en) 2013-03-15 2019-02-20 BioElectron Technology Corporation Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders
US9670170B2 (en) 2013-03-15 2017-06-06 Bioelectron Technology Corporation Resorufin derivatives for treatment of oxidative stress disorders
PL3233786T3 (pl) 2014-12-16 2022-06-13 Ptc Therapeutics, Inc. Polimorficzne i amorficzne postacie (r)-2-hydroksy-2-metylo-4-(2,4,5-trimetylo-3,6-dioksocykloheksa-1,4-dienylo)butanoamidu
WO2016133995A1 (en) 2015-02-17 2016-08-25 Arizona Board Of Regents On Behalf Of Arizona State University Phenothiazine analogues as mitochondrial therapeutic agents
AU2016220153B2 (en) 2015-02-17 2020-07-02 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
EP3390377A1 (en) 2015-12-16 2018-10-24 BioElectron Technology Corporation Improved methods for enriching alpha-tocotrienol from mixed tocol compositions
WO2017106803A1 (en) 2015-12-17 2017-06-22 Bioelectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
WO2018039487A1 (en) * 2016-08-25 2018-03-01 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US11390605B2 (en) 2016-08-25 2022-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Substituted pyrimidine compounds as multifunctional radical quenchers and their uses
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
BR112021007153A2 (pt) 2018-10-17 2021-07-20 Ptc Therapeutics, Inc. 2,3,5-trimetil-6-nonilcicloexa-2,5-dieno-1,4-diona para a supressão e tratamento de a-sinucleinopatias, tauopatias e outros distúrbios
WO2023283466A1 (en) 2021-07-08 2023-01-12 Ptc Therapeutics, Inc. Pharmaceutical compositions comprising 2,3,5-trimethyl-6-nonylcyclohexa-2,5-diene-1,4-dione

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59144774A (ja) * 1983-01-21 1984-08-18 メルク　フロスト　カナダ，インコーポレーテッド フエノチアゾン誘導体及び類似体
WO1984004679A1 (en) * 1983-05-25 1984-12-06 John W Eaton Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
JPS60209520A (ja) * 1984-03-19 1985-10-22 メルク　エンド　カムパニー　インコーポレーテツド リポキシゲナーゼ阻害剤の細胞保護的使用
WO2012138713A2 (en) * 2011-04-04 2012-10-11 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Multifunctional radical quenchers for the treatment of mitochondrial dysfunction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4667032A (en) * 1983-01-21 1987-05-19 Merck Frosst Canada, Inc. Phenothiazone derivatives and analogs
NZ513547A (en) 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)
GB0204232D0 (en) 2002-02-22 2002-04-10 Isis Innovation Assay
DE60211875T2 (de) 2002-07-01 2006-10-26 Santhera Pharmaceuticals (Schweiz) Ag Screeningverfahren und Verbindungen zur Behandlung von Friedreich ataxia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59144774A (ja) * 1983-01-21 1984-08-18 メルク　フロスト　カナダ，インコーポレーテッド フエノチアゾン誘導体及び類似体
WO1984004679A1 (en) * 1983-05-25 1984-12-06 John W Eaton Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
JPS60501408A (ja) * 1983-05-25 1985-08-29 イ−トン，ジヨン　ダブリユ−． 酸化剤ストレス誘導抗生物質に対する動物許容度を増加させる方法及び薬剤
JPS60209520A (ja) * 1984-03-19 1985-10-22 メルク　エンド　カムパニー　インコーポレーテツド リポキシゲナーゼ阻害剤の細胞保護的使用
WO2012138713A2 (en) * 2011-04-04 2012-10-11 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Multifunctional radical quenchers for the treatment of mitochondrial dysfunction

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HASEGAWA, K. ET AL.: "The Carbon-13 NMR Spectra and Electronic Structure of 3H-phenothiazin-3-one and Its Methyl Derivativ", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 57(2), JPN6018002285, 1984, pages 510 - 517, ISSN: 0003726070 *
SUZUKI, JOSEPH K. ET AL.: "The Synthesis of 6,9-Dioxo-, 6,9- and 7,9-Dihydroxychlorpromazines, Possible Metabolites of Chlorpro", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 16(6), JPN6018002286, 1979, pages 1227 - 1232, ISSN: 0003726071 *
UENO, Y.: "Synthesis of Dimethyl- and Trimethyl-3H-phenothiazin-3-ones", PHARMAZIE, vol. 39(5), JPN6018002288, 1984, pages 355 - 356, ISSN: 0003726072 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019093379A1 (ja) 2017-11-07 2019-05-16 学校法人自治医科大学 ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途
US11369615B2 (en) 2017-11-07 2022-06-28 Jichi Medical University Agent for improving mitochondrial dysfunction, preventative or therapeutic agent for diseases or symptoms caused by mitochondrial dysfunction, and applications therefor

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