JP2016511822A5 - - Google Patents
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- Publication number
- JP2016511822A5 JP2016511822A5 JP2015552068A JP2015552068A JP2016511822A5 JP 2016511822 A5 JP2016511822 A5 JP 2016511822A5 JP 2015552068 A JP2015552068 A JP 2015552068A JP 2015552068 A JP2015552068 A JP 2015552068A JP 2016511822 A5 JP2016511822 A5 JP 2016511822A5
- Authority
- JP
- Japan
- Prior art keywords
- astrin
- cell
- raptor
- binding fragment
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 21
- 101000618133 Homo sapiens Sperm-associated antigen 5 Proteins 0.000 claims 19
- 102100021915 Sperm-associated antigen 5 Human genes 0.000 claims 19
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 claims 16
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 claims 16
- 239000012634 fragment Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108010067902 Peptide Library Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000001114 immunoprecipitation Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000001235 sensitizing effect Effects 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 229940126586 small molecule drug Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13151022.4A EP2755027B1 (en) | 2013-01-11 | 2013-01-11 | Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy |
| EP13151022.4 | 2013-01-11 | ||
| PCT/EP2014/050460 WO2014108532A1 (en) | 2013-01-11 | 2014-01-13 | Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511822A JP2016511822A (ja) | 2016-04-21 |
| JP2016511822A5 true JP2016511822A5 (enExample) | 2017-02-23 |
| JP6494112B2 JP6494112B2 (ja) | 2019-04-03 |
Family
ID=47563201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552068A Expired - Fee Related JP6494112B2 (ja) | 2013-01-11 | 2014-01-13 | アストリンとラプターの相互作用調節因子、及びその癌治療での用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10041933B2 (enExample) |
| EP (1) | EP2755027B1 (enExample) |
| JP (1) | JP6494112B2 (enExample) |
| ES (1) | ES2588778T3 (enExample) |
| WO (1) | WO2014108532A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11237168B2 (en) | 2019-06-26 | 2022-02-01 | St. Jude Children's Research Hospital | Method for identifying modulators of G3BP activity |
| CN110476877A (zh) * | 2019-08-15 | 2019-11-22 | 上海交通大学医学院附属瑞金医院 | 一种β细胞中特异性Raptor敲除同时GFP示踪的小鼠的制备方法 |
| CN113125747B (zh) * | 2021-03-15 | 2022-06-14 | 天津医科大学 | 一种isPLA-Seq的高通量检测蛋白质相互作用的方法和试剂盒及其应用 |
-
2013
- 2013-01-11 EP EP13151022.4A patent/EP2755027B1/en active Active
- 2013-01-11 ES ES13151022.4T patent/ES2588778T3/es active Active
-
2014
- 2014-01-13 US US14/758,461 patent/US10041933B2/en not_active Expired - Fee Related
- 2014-01-13 WO PCT/EP2014/050460 patent/WO2014108532A1/en not_active Ceased
- 2014-01-13 JP JP2015552068A patent/JP6494112B2/ja not_active Expired - Fee Related
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