JP2016506861A5 - - Google Patents

Claims (20)

Sidewalls defining a range of chamber volumes;
A flexible membrane provided within the chamber volume and defining a membrane volume range;
An inlet in fluid communication with the membrane volume;
An outlet in fluid communication with the membrane volume;
A separation chamber comprising:   The separation chamber of claim 1, wherein the flexible membrane expands when a composite liquid is transferred into the membrane volume.   The separation chamber according to claim 1, wherein the flexible membrane expands and contacts an inner surface of the side wall when receiving a first centrifugal force.   The separation chamber according to claim 1, wherein the side wall includes an inner surface having a step.   The separation chamber of claim 1, further comprising a cap portion that engages the top of the sidewall and further defines a range of the chamber volume. 6. The separation chamber according to claim 5 , wherein the cap part has a first part and a second part, and at least one of the first part and the second part has a groove part. . In the separation chamber according to claim 5, wherein the exit, the separation chamber, characterized in that provided in the cap portion. In the separation chamber according to claim 5, the entering port, the separation chamber, characterized in that provided in the cap portion. In the separation chamber according to claim 1, the entering port, separation chamber, characterized in that it is fluidly connected to the blood processing vessel. In the separation chamber according to claim 1, further comprising a one-way valve that is fluidly connected to the entering opening, by the one-way valve, the composite liquid separation chamber, characterized in that it is introduced into the membrane volume. A blood processing vessel attached to the centrifuge rotor;
A flexible membrane defining a range of membrane volumes, wherein the inlet and outlet are in fluid communication with said membrane volume;
A disposable blood separation set comprising:   12. The disposable blood separation set according to claim 11, wherein the flexible membrane expands when a cell-containing liquid is transferred to the membrane volume.   12. The disposable blood separation set of claim 11, further comprising an inlet tube in fluid communication with the inlet and extending into the membrane volume.   12. The disposable blood separation set according to claim 11, wherein the flexible membrane has a cylindrical outer surface.   12. The disposable blood separation set according to claim 11, further comprising a cell separation chamber, wherein the flexible membrane is positioned in the cell separation chamber. 16. The disposable blood separation set according to claim 15 , wherein the flexible membrane expands and contacts the inner surface of the cell separation chamber when subjected to a first centrifugal force. A method for separating cellular components, the method comprising:
Transferring the whole blood-containing liquid to a blood processing container;
Separating the whole blood-containing liquid into at least a first component containing cells and a second component;
Transferring the first component to a membrane volume delimited by a flexible membrane;
Separating the cells from the first component in the membrane volume;
Removing the cells from the membrane volume;
A method for separating cellular components, characterized by comprising:   18. The method of claim 17, wherein the step of separating the whole blood containing liquid comprises applying a centrifugal force by rotating the blood processing vessel on a rotor.   18. The method of claim 17, wherein the flexible membrane expands during the step of transferring the first component to the membrane volume.   18. The method of claim 17, wherein during the step of removing the cells from the membrane volume, the membrane volume is reduced by contraction of the flexible membrane.