JP2016503398A5 - - Google Patents
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- Publication number
- JP2016503398A5 JP2016503398A5 JP2015539751A JP2015539751A JP2016503398A5 JP 2016503398 A5 JP2016503398 A5 JP 2016503398A5 JP 2015539751 A JP2015539751 A JP 2015539751A JP 2015539751 A JP2015539751 A JP 2015539751A JP 2016503398 A5 JP2016503398 A5 JP 2016503398A5
- Authority
- JP
- Japan
- Prior art keywords
- gdf11
- antagonist
- pharmaceutical composition
- patient
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 28
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims 28
- 239000005557 antagonist Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 230000007423 decrease Effects 0.000 claims 5
- 230000003247 decreasing effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000007502 anemia Diseases 0.000 claims 1
- 208000005980 beta thalassemia Diseases 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000011132 hemopoiesis Effects 0.000 claims 1
- 210000004005 intermediate erythroblast Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 210000003924 normoblast Anatomy 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 230000004952 protein activity Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718128P | 2012-10-24 | 2012-10-24 | |
| US61/718,128 | 2012-10-24 | ||
| PCT/US2013/066353 WO2014066487A2 (en) | 2012-10-24 | 2013-10-23 | Methods for treating anemia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018131952A Division JP2018184430A (ja) | 2012-10-24 | 2018-07-12 | 貧血の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503398A JP2016503398A (ja) | 2016-02-04 |
| JP2016503398A5 true JP2016503398A5 (Direct) | 2016-12-08 |
| JP6401172B2 JP6401172B2 (ja) | 2018-10-10 |
Family
ID=50545463
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539751A Active JP6401172B2 (ja) | 2012-10-24 | 2013-10-23 | 貧血の治療方法 |
| JP2018131952A Pending JP2018184430A (ja) | 2012-10-24 | 2018-07-12 | 貧血の治療方法 |
| JP2020108654A Withdrawn JP2020183390A (ja) | 2012-10-24 | 2020-06-24 | 貧血の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018131952A Pending JP2018184430A (ja) | 2012-10-24 | 2018-07-12 | 貧血の治療方法 |
| JP2020108654A Withdrawn JP2020183390A (ja) | 2012-10-24 | 2020-06-24 | 貧血の治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20150266950A1 (Direct) |
| EP (2) | EP3527219A1 (Direct) |
| JP (3) | JP6401172B2 (Direct) |
| CN (3) | CN104981250A (Direct) |
| AU (4) | AU2013334660B2 (Direct) |
| CA (1) | CA2889286A1 (Direct) |
| HK (1) | HK1214504A1 (Direct) |
| NZ (1) | NZ747350A (Direct) |
| WO (1) | WO2014066487A2 (Direct) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160137665A (ko) | 2005-11-23 | 2016-11-30 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 골 성장을 촉진하기 위한 이들의 용도 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| JP5237970B2 (ja) | 2007-02-01 | 2013-07-17 | アクセルロン ファーマ， インコーポレイテッド | 乳癌を治療または予防するためのアクチビンＡｃｔＲＩＩａアンタゴニストおよび使用 |
| TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| JP5574711B2 (ja) | 2007-02-09 | 2014-08-20 | アクセルロン ファーマ， インコーポレイテッド | 癌患者における骨成長を促進するためのアクチビン−ａｃｔｒｉｉａアンタゴニストおよびその使用 |
| US7960343B2 (en) | 2007-09-18 | 2011-06-14 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion |
| SI3750552T1 (sl) | 2008-08-14 | 2023-10-30 | Acceleron Pharma Inc. | GDF pasti |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| EP3845239A1 (en) | 2009-06-08 | 2021-07-07 | Acceleron Pharma Inc. | Use of anti-actriib proteins for increasing thermogenic adipocytes |
| WO2010151426A1 (en) | 2009-06-12 | 2010-12-29 | Acceleron Pharma Inc. | Truncated actriib-fc fusion proteins |
| CA2781152A1 (en) | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| KR20130132824A (ko) | 2010-11-08 | 2013-12-05 | 악셀레론 파마 인코포레이티드 | Actriia 결합제 및 이의 용도 |
| CN104981250A (zh) * | 2012-10-24 | 2015-10-14 | 细胞基因公司 | 用于治疗贫血的方法 |
| NZ707477A (en) | 2012-11-02 | 2019-09-27 | Celgene Corp | Activin-actrii antagonists and uses for treating bone and other disorders |
| MA39722A (fr) * | 2014-03-21 | 2021-06-02 | Acceleron Pharma Inc | Composition pour son utilisation dans une methode de traitement ou de prevention de l'anemie par l'inhibition de l'activine b et du gdf11 |
| MA40008A (fr) | 2014-06-13 | 2021-05-05 | Acceleron Pharma Inc | Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| MA41119A (fr) * | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
| TWI773117B (zh) | 2014-12-03 | 2022-08-01 | 美商西建公司 | 活化素-actrii拮抗劑及治療貧血之用途 |
| EP3256148A1 (en) * | 2015-02-12 | 2017-12-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| TN2017000468A1 (en) * | 2015-05-13 | 2019-04-12 | Acceleron Pharma Inc | TREATMENT OF BETA-THALASSEMIA USING ACTRIl LIGAND TRAPS. |
| HK1252174A1 (zh) | 2015-05-20 | 2019-05-17 | 细胞基因公司 | 使用II型活化素受体配体阱的用於β-地中海贫血的体外细胞培养方法 |
| US11123430B2 (en) | 2015-11-04 | 2021-09-21 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels and treating ineffective erythropoiesis |
| RS62011B1 (sr) | 2016-07-15 | 2021-07-30 | Acceleron Pharma Inc | Kompozicije koje sadrže polipeptide actriia za upotrebu u lečenju plućne hipertenzije |
| HRP20240974T1 (hr) | 2016-07-27 | 2024-10-25 | Acceleron Pharma Inc. | Pripravci za uporabu u liječenju mijelofibroze |
| JP7139326B2 (ja) | 2016-11-10 | 2022-09-20 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物 |
| CN107011430B (zh) * | 2017-04-07 | 2020-09-01 | 哈尔滨医科大学 | 一种具有生物学活性的截短的生长分化因子11及其制备方法 |
| US11484573B2 (en) | 2017-11-09 | 2022-11-01 | Keros Therapeutics, Inc. | Activin receptor type IIa variants and methods of use thereof |
| IL275936B2 (en) | 2018-01-12 | 2025-09-01 | Keros Therapeutics Inc | Activin receptor type iib variants and methods of using them |
| EP3790572A4 (en) * | 2018-05-09 | 2022-03-16 | Keros Therapeutics, Inc. | ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOF |
| WO2020257587A1 (en) * | 2019-06-19 | 2020-12-24 | Cornell University | Methods of promoting erythropoiesis and overcoming erythropoitein resistance in patients |
| EP4121088A4 (en) | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| CA3176735A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Activin receptor type ii chimeras and methods of use thereof |
| US12186370B1 (en) | 2020-11-05 | 2025-01-07 | Celgene Corporation | ACTRIIB ligand trap compositions and uses thereof |
| CN113801880B (zh) * | 2021-07-27 | 2024-11-01 | 浙江大学 | 一种通过靶向敲除基因建立的早衰细胞模型及其sgRNA、构建方法和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| DK0776337T3 (da) * | 1994-07-08 | 2005-12-12 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-11 |
| US7795202B2 (en) | 1997-08-04 | 2010-09-14 | Neurorepair, Inc. | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) |
| AU765832B2 (en) * | 1998-07-28 | 2003-10-02 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-11 |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| BR0307871A (pt) | 2002-02-21 | 2005-04-12 | Wyeth Corp | Proteìnas contendo domìnio de folistatina |
| AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| ES2551852T3 (es) | 2004-07-23 | 2015-11-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| CN101309698A (zh) * | 2005-03-30 | 2008-11-19 | 惠氏公司 | 通过施用bmp来刺激毛发生长的方法 |
| US7612040B2 (en) * | 2005-07-01 | 2009-11-03 | Acceleron Pharma Inc. | Lefty polypeptides and derivatives thereof |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| ES2396734T3 (es) * | 2006-12-18 | 2013-02-25 | Acceleron Pharma, Inc. | Antagonistas de ACTIVINA-ACTRII y sus usos para tratar la anemia |
| TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| TW201718635A (zh) | 2007-03-06 | 2017-06-01 | 安美基公司 | 變異之活動素受體多肽及其用途 |
| WO2008109779A2 (en) | 2007-03-07 | 2008-09-12 | The Johns Hopkins University | Use of follistatin-like related gene (flrg) to increase muscle mass |
| US7960343B2 (en) | 2007-09-18 | 2011-06-14 | Acceleron Pharma Inc. | Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion |
| ES2852699T3 (es) * | 2008-06-26 | 2021-09-14 | Acceleron Pharma Inc | Antagonistas de ActRIIb y usos para aumentar los niveles de glóbulos rojos |
| SI3750552T1 (sl) * | 2008-08-14 | 2023-10-30 | Acceleron Pharma Inc. | GDF pasti |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| CN105561295B (zh) * | 2009-08-13 | 2020-03-20 | 阿塞勒隆制药公司 | Gdf捕获物和促红细胞生成素受体激活剂联合应用以增加红细胞水平 |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| WO2012027065A2 (en) * | 2010-08-27 | 2012-03-01 | Celgene Corporation | Combination therapy for treatment of disease |
| KR20130132824A (ko) * | 2010-11-08 | 2013-12-05 | 악셀레론 파마 인코포레이티드 | Actriia 결합제 및 이의 용도 |
| CN104981250A (zh) * | 2012-10-24 | 2015-10-14 | 细胞基因公司 | 用于治疗贫血的方法 |
-
2013
- 2013-10-23 CN CN201380067832.9A patent/CN104981250A/zh active Pending
- 2013-10-23 EP EP19151143.5A patent/EP3527219A1/en not_active Withdrawn
- 2013-10-23 CN CN202011542063.1A patent/CN112957462A/zh active Pending
- 2013-10-23 NZ NZ747350A patent/NZ747350A/en unknown
- 2013-10-23 AU AU2013334660A patent/AU2013334660B2/en active Active
- 2013-10-23 US US14/438,127 patent/US20150266950A1/en not_active Abandoned
- 2013-10-23 CN CN202011541918.9A patent/CN112933223A/zh active Pending
- 2013-10-23 HK HK16102359.3A patent/HK1214504A1/zh unknown
- 2013-10-23 EP EP13849960.3A patent/EP2911682A4/en not_active Withdrawn
- 2013-10-23 WO PCT/US2013/066353 patent/WO2014066487A2/en not_active Ceased
- 2013-10-23 JP JP2015539751A patent/JP6401172B2/ja active Active
- 2013-10-23 CA CA2889286A patent/CA2889286A1/en not_active Abandoned
-
2018
- 2018-07-12 JP JP2018131952A patent/JP2018184430A/ja active Pending
- 2018-11-02 AU AU2018256635A patent/AU2018256635A1/en not_active Abandoned
-
2020
- 2020-05-15 AU AU2020203198A patent/AU2020203198B2/en active Active
- 2020-06-24 JP JP2020108654A patent/JP2020183390A/ja not_active Withdrawn
-
2022
- 2022-03-21 AU AU2022201923A patent/AU2022201923A1/en not_active Abandoned
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