JP2016503030A - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP2016503030A
JP2016503030A JP2015548025A JP2015548025A JP2016503030A JP 2016503030 A JP2016503030 A JP 2016503030A JP 2015548025 A JP2015548025 A JP 2015548025A JP 2015548025 A JP2015548025 A JP 2015548025A JP 2016503030 A JP2016503030 A JP 2016503030A
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JP
Japan
Prior art keywords
compound
isopropyl
cyclopenta
pentamethyl
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015548025A
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English (en)
Japanese (ja)
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JP2016503030A5 (https=
Inventor
カイ，シェンシェン
ジョーンズ，ブライアン，アルヴィン
スパルテンステイン，アンドリュー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of JP2016503030A publication Critical patent/JP2016503030A/ja
Publication of JP2016503030A5 publication Critical patent/JP2016503030A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2015548025A 2012-12-14 2013-12-14 医薬組成物 Pending JP2016503030A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261737177P 2012-12-14 2012-12-14
US61/737,177 2012-12-14
PCT/US2013/075196 WO2014093941A1 (en) 2012-12-14 2013-12-14 Pharmaceutical compositions

Publications (2)

Publication Number Publication Date
JP2016503030A true JP2016503030A (ja) 2016-02-01
JP2016503030A5 JP2016503030A5 (https=) 2017-02-02

Family

ID=50935020

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015548025A Pending JP2016503030A (ja) 2012-12-14 2013-12-14 医薬組成物

Country Status (20)

Country Link
US (2) US9795619B2 (https=)
EP (1) EP2931285A4 (https=)
JP (1) JP2016503030A (https=)
KR (1) KR20150093819A (https=)
CN (1) CN104902905A (https=)
AU (1) AU2013358897B2 (https=)
BR (1) BR112015013695A2 (https=)
CA (1) CA2893959A1 (https=)
CL (1) CL2015001660A1 (https=)
CR (1) CR20150313A (https=)
EA (1) EA201590862A1 (https=)
HK (1) HK1209638A1 (https=)
IL (1) IL238807A0 (https=)
MA (1) MA38182A1 (https=)
MX (1) MX2015007563A (https=)
PE (1) PE20151326A1 (https=)
PH (1) PH12015501156A1 (https=)
SG (2) SG11201503807TA (https=)
WO (1) WO2014093941A1 (https=)
ZA (1) ZA201503594B (https=)

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JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
KR20150093819A (ko) * 2012-12-14 2015-08-18 글락소스미스클라인 엘엘씨 약제 조성물
EA030003B1 (ru) 2012-12-21 2018-06-29 Джилид Сайэнс, Инк. Полициклическое карбамоилпиридоновое соединение и его фармацевтическое применение для лечения вич-инфекции
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
SI3019503T1 (sl) 2013-07-12 2017-11-30 Gilead Sciences, Inc. Policiklične karbamoilpiridonske spojine in njihova uporaba za zdravljenje HIV infekcij
NO2865735T3 (https=) 2013-07-12 2018-07-21
NO2717902T3 (https=) 2014-06-20 2018-06-23
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
US10092523B2 (en) 2014-09-26 2018-10-09 Glaxosmithkline Intellectual Property (No. 2) Limited Long acting pharmaceutical compositions
TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
JP6402259B2 (ja) 2015-04-02 2018-10-10 ギリアード サイエンシーズ， インコーポレイテッド 多環式カルバモイルピリドン化合物およびそれらの薬学的使用
WO2018042332A1 (en) * 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
WO2018042331A1 (en) * 2016-08-31 2018-03-08 Glaxosmithkline Intellectual Property (No.2) Limited Combinations and uses and treatments thereof
KR20200031658A (ko) 2017-07-21 2020-03-24 비이브 헬쓰케어 컴퍼니 Hib 감염 및 aids를 치료하기 위한 요법

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WO2008057420A2 (en) * 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
JP2010533148A (ja) * 2007-07-12 2010-10-21 テイボテク・フアーマシユーチカルズ （ｅ）４−［［４−［［４−（２−シアノエテニル）−２，６−ジメチルフェニル］アミノ］−２−ピリミジニル］アミノ］ベンゾニトリルの結晶形
JP2011508747A (ja) * 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のｃ−２１ケトルパン誘導体、それらの調製および使用
WO2011100308A1 (en) * 2010-02-11 2011-08-18 Glaxosmithkline Llc Derivatives of betulin
WO2012037320A2 (en) * 2010-09-16 2012-03-22 Glaxosmithkline Llc Pharmaceutical compositions
WO2013090664A1 (en) * 2011-12-16 2013-06-20 Glaxosmithkline Llc Derivatives of betulin

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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008057420A2 (en) * 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
JP2010533148A (ja) * 2007-07-12 2010-10-21 テイボテク・フアーマシユーチカルズ （ｅ）４−［［４−［［４−（２−シアノエテニル）−２，６−ジメチルフェニル］アミノ］−２−ピリミジニル］アミノ］ベンゾニトリルの結晶形
JP2011508747A (ja) * 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のｃ−２１ケトルパン誘導体、それらの調製および使用
WO2011100308A1 (en) * 2010-02-11 2011-08-18 Glaxosmithkline Llc Derivatives of betulin
WO2012037320A2 (en) * 2010-09-16 2012-03-22 Glaxosmithkline Llc Pharmaceutical compositions
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Also Published As

Publication number Publication date
US9795619B2 (en) 2017-10-24
EP2931285A4 (en) 2016-06-01
EA201590862A1 (ru) 2016-05-31
CL2015001660A1 (es) 2015-10-02
US20150313917A1 (en) 2015-11-05
SG10201704467SA (en) 2017-06-29
IL238807A0 (en) 2015-06-30
HK1209638A1 (en) 2016-04-08
PH12015501156A1 (en) 2015-08-10
MX2015007563A (es) 2015-10-14
KR20150093819A (ko) 2015-08-18
BR112015013695A2 (pt) 2017-07-11
WO2014093941A1 (en) 2014-06-19
CA2893959A1 (en) 2014-06-19
CR20150313A (es) 2015-10-19
EP2931285A1 (en) 2015-10-21
CN104902905A (zh) 2015-09-09
AU2013358897B2 (en) 2017-01-05
MA38182A1 (fr) 2018-04-30
US20180042944A1 (en) 2018-02-15
PE20151326A1 (es) 2015-10-12
AU2013358897A1 (en) 2015-07-02
ZA201503594B (en) 2018-11-28
SG11201503807TA (en) 2015-06-29

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