JP2016501236A5 - - Google Patents
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- JP2016501236A5 JP2016501236A5 JP2015545609A JP2015545609A JP2016501236A5 JP 2016501236 A5 JP2016501236 A5 JP 2016501236A5 JP 2015545609 A JP2015545609 A JP 2015545609A JP 2015545609 A JP2015545609 A JP 2015545609A JP 2016501236 A5 JP2016501236 A5 JP 2016501236A5
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- JP
- Japan
- Prior art keywords
- composition
- active agent
- treated
- condition
- aqa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 21
- GIXWDMTZECRIJT-UHFFFAOYSA-N aurintricarboxylic acid Chemical compound C1=CC(=O)C(C(=O)O)=CC1=C(C=1C=C(C(O)=CC=1)C(O)=O)C1=CC=C(O)C(C(O)=O)=C1 GIXWDMTZECRIJT-UHFFFAOYSA-N 0.000 claims description 10
- 201000004384 Alopecia Diseases 0.000 claims description 9
- 201000002996 androgenic alopecia Diseases 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 4
- FYEHYMARPSSOBO-UHFFFAOYSA-N Aurin Chemical compound C1=CC(O)=CC=C1C(C=1C=CC(O)=CC=1)=C1C=CC(=O)C=C1 FYEHYMARPSSOBO-UHFFFAOYSA-N 0.000 claims description 3
- 241001060848 Carapidae Species 0.000 claims description 3
- 208000006926 Discoid Lupus Erythematosus Diseases 0.000 claims description 3
- 208000010201 Exanthema Diseases 0.000 claims description 3
- 241000721454 Pemphigus Species 0.000 claims description 3
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 208000004631 alopecia areata Diseases 0.000 claims description 3
- -1 aurin hexacarboxylic acid Chemical class 0.000 claims description 3
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 claims description 3
- 201000005884 exanthem Diseases 0.000 claims description 3
- 206010037844 rash Diseases 0.000 claims description 3
- 230000037390 scarring Effects 0.000 claims description 3
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 3
- 206010068168 androgenetic alopecia Diseases 0.000 claims description 2
- 230000024203 complement activation Effects 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 238000011200 topical administration Methods 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 10
- 208000017520 skin disease Diseases 0.000 claims 4
- 231100000360 alopecia Toxicity 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010062639 Herpes dermatitis Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N hexane carboxylic acid Natural products CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 206010000496 acne Diseases 0.000 description 7
- 201000008937 atopic dermatitis Diseases 0.000 description 6
- 208000002874 Acne Vulgaris Diseases 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 4
- 206010012434 Dermatitis allergic Diseases 0.000 description 3
- 206010012438 Dermatitis atopic Diseases 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 230000000172 allergic effect Effects 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 239000004342 Benzoyl peroxide Substances 0.000 description 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010042496 Sunburn Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000019400 benzoyl peroxide Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 241000195940 Bryophyta Species 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/694,484 US8877808B2 (en) | 2012-12-06 | 2012-12-06 | Protection against skin diseases by aurin tricarboxylic acid and its derivatives |
| US13/694,484 | 2012-12-06 | ||
| PCT/CA2013/050488 WO2014085920A1 (en) | 2012-12-06 | 2013-06-21 | Methods for preventing and treating inflammatory skin conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016501236A JP2016501236A (ja) | 2016-01-18 |
| JP2016501236A5 true JP2016501236A5 (https=) | 2016-05-26 |
Family
ID=50881631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545609A Pending JP2016501236A (ja) | 2012-12-06 | 2013-06-21 | 炎症性皮膚状態の予防および治療のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8877808B2 (https=) |
| EP (1) | EP2928460B1 (https=) |
| JP (1) | JP2016501236A (https=) |
| KR (1) | KR20150090920A (https=) |
| CN (1) | CN104902886A (https=) |
| CA (1) | CA2893966C (https=) |
| WO (1) | WO2014085920A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10588879B2 (en) | 2011-08-01 | 2020-03-17 | Aurin Biotech Inc. | Treatment of age-related macular degeneration |
| ES2774776T3 (es) | 2013-11-18 | 2020-07-22 | Aurin Biotech Inc | Dímeros de ácido acetilsalicílico, síntesis de los mismos, y usos de los mismos para prevenir y tratar trastornos mediados por complemento |
| US11013750B2 (en) | 2017-01-20 | 2021-05-25 | Aurin Biotech Inc. | Methods for treating and preventing nociceptive pain |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007270A (en) | 1975-11-18 | 1977-02-08 | American Cyanamid Company | Complement inhibitors |
| US5030442A (en) | 1987-03-30 | 1991-07-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition |
| DE4222534A1 (de) * | 1992-07-09 | 1994-01-13 | Behringwerke Ag | Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura |
| US5434185A (en) | 1993-05-17 | 1995-07-18 | The University Of Kentucky Research Foundation | Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts |
| US6770633B1 (en) * | 1999-10-26 | 2004-08-03 | Immusol, Inc. | Ribozyme therapy for the treatment of proliferative skin and eye diseases |
| JP2003530309A (ja) | 1999-10-26 | 2003-10-14 | イミューソル インコーポレイテッド | 増殖性皮膚疾患又は増殖性眼疾患を治療するリボザイム療法 |
| WO2001057184A2 (en) | 2000-02-01 | 2001-08-09 | Vanderbilt University | Use of platelet activity modulators for inhibiting complement activation |
| JP2003525243A (ja) * | 2000-02-28 | 2003-08-26 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 炎症性疾患の治療のための組成物及び方法 |
| US20110189310A1 (en) | 2008-10-08 | 2011-08-04 | Cornell University | Small molecule modulators of prongf uptake |
| US20130035392A1 (en) | 2011-08-01 | 2013-02-07 | Mcgeer Patrick L | Selective inhibition of the membrane attack complex of complement and C3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex |
| US10966945B2 (en) | 2011-08-01 | 2021-04-06 | Aurin Biotech Inc. | Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic synthetic complex |
| WO2014009779A1 (en) * | 2012-07-13 | 2014-01-16 | Aurin Biotech Inc. | Selective inhibition of the membrane attack complex of complement and c3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex |
-
2012
- 2012-12-06 US US13/694,484 patent/US8877808B2/en active Active
-
2013
- 2013-06-21 EP EP13860898.9A patent/EP2928460B1/en not_active Not-in-force
- 2013-06-21 JP JP2015545609A patent/JP2016501236A/ja active Pending
- 2013-06-21 WO PCT/CA2013/050488 patent/WO2014085920A1/en not_active Ceased
- 2013-06-21 CN CN201380069919.XA patent/CN104902886A/zh active Pending
- 2013-06-21 CA CA2893966A patent/CA2893966C/en active Active
- 2013-06-21 KR KR1020157017948A patent/KR20150090920A/ko not_active Withdrawn
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