JP2016175842A - Ghg-containing composition, and fat absorption inhibitor using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a GHG-containing composition containing GHG at high concentration, the composition being derived from a natural product, and to provide a production method thereof.SOLUTION: The characteristics of the invention for solving the above-mentioned subject are as follows. 1. A 1, 2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-b-D-glucose-containing composition characterized by being obtained from purple tea from Kenya (Scientific Name: Camellia Sinensis, Cultivar Name: TRFK306) and containing 3-99% of 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-b-D-glucose. 2. A production method of a 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-b-D-glucose-containing composition characterized by immersing a purple tea from Kenya (Scientific Name: Camellia Sinensis, Cultivar Name: TRFK306) into a polar solvent (including also water), subsequently, heating and refluxing it to extract 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-b-D-glucose into a solvent. 3. A fat absorption inhibitor containing purple tea from Kenya (Scientific Name: Camellia sinensis, Cultivar Name: TRFK306) and/or extract thereof as an active ingredient.SELECTED DRAWING: None

Description

  The present invention relates to a composition derived from a plant and containing GHG at a high concentration and a fat absorption inhibitor using the composition. The present invention is widely used for pharmaceuticals, foods and drinks, cosmetics, and the like.

1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose (hereinafter abbreviated as “GHG”) is an antioxidant action (DPPH radical scavenging action, SOD ²⁾ and tyrosinase inhibitory action ³⁾ have already been reported (Non-patent document 1, Non-patent document 2, Non-patent document 3).
When GHG is blended in food and drink such as functional foods and health foods, it is preferably derived from natural products from the general concept of food safety. However, a conventionally known natural product containing GHG has a low content, and only a very low content GHG composition can be obtained. Moreover, even if it is contained in a high concentration, it is difficult to obtain a high concentration GHG composition because it is a wild species that is not suitable for cultivation and is difficult to obtain.

  On the other hand, in recent years, the number of people with so-called hyperlipidemia, in which the neutral fat in the blood exceeds the normal value, has increased rapidly due to overeating, lack of exercise, and increased intake of animal fat. Hyperlipidemia is known to cause diseases such as arteriosclerosis, hypertension, myocardial infarction, and cerebrovascular disorder. To prevent these diseases, an increase in the amount of neutral fat in the blood is caused. It is important for modern people to suppress and even lower the elevated blood neutral fat content to the normal range. Therefore, it is desired to develop an edible material that can be ingested or administered on a daily basis and is effective in adjusting the neutral fat in the blood. As such a material, for example, an extract of bitter gourd is known (Patent Document 1).

JP 2006-117658 Gazette

Fukuda T. et al, Phytochemistry, 63, 795-801 (2003) Gao D.F et al, J. Agric. Food Chem., 56,7517-7521 (2008)

Under such a background, the present inventor has found that GHG is contained in a high concentration in Kenya purple tea (scientific name: Camellia sinensis, variety name TRFK306), and further, Kenyan purple tea (scientific name: Camellia).
Sinensis, variety TRFK306) and its extract were found to have an action of inhibiting the absorption of fats, particularly triglycerides, into the blood, thereby completing the present invention.
That is, an object of the present invention is to provide a GHG-containing composition that is a natural product-derived composition containing a high concentration of GHG, and a method for producing the same.
Furthermore, it aims at providing the fat absorption inhibitor which uses a novel plant or its extract as an active ingredient.

The technical features of the present invention for solving the above-described problems are as follows.
1. 3-99% 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose obtained from Kenyan purple tea (scientific name: Camellia sinensis, variety TRFK306) 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose-containing composition characterized by containing.
2. Soaked Kenyan purple tea (scientific name: Camellia sinensis, variety TRFK306) in a polar solvent (including water), then heated to reflux to 1,2-di-O-galloyl-4,6- 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose-containing composition characterized by extracting O- (S) -hexahydroxydiphenoyl-b-D-glucose Manufacturing method.
3. A fat absorption inhibitor containing Kenyan purple tea (scientific name: Camellia sinensis, variety TRFK306) and / or its extract as an active ingredient.

It is a HPLC chromatogram of the purple tea extract of a present Example. It is a graph which shows evaluation of the effect on the blood triglyceride raise in the olive oil load mouse | mouth in the purple tea extract of a present Example. It is a graph which shows the body weight gain inhibitory effect in the high fat diet-fed mouse | mouth in the purple tea extract of a present Example.

  Hereinafter, the present invention will be described in detail.

The GHG-containing composition of the present invention is a Kenyan purple tea (scientific name: Camellia
sinensis, variety name TRFK306, hereinafter simply "purple tea". ), Which contains GHG at a content of 3 to 99% by mass. The shape may be liquid, solid, semi-solid, gel, etc. The solid content of GHG is preferably 3 to 99% by mass, and preferably 3 to 30% by mass. Is more preferable, and it is most preferable that it is 3-10 mass%.

  GHG is represented by the following chemical formula (1).

Purple tea is a tea tree developed by mating by the Kenyan government and is named variety name TRFK306. The tea leaves of TRFK306 contain anthocyanins and are purple due to this, so they are commonly called “purple tea” or “purple tea”. Furthermore, the present inventors have found that TRFK306 contains a specific component, GHG, at a high concentration.
The site of purple tea used in the GHG-containing composition of the present invention is not particularly limited, and leaves, stems, roots, flowers, seeds and the like can be used, but it is particularly preferable to use leaves. This is because a higher concentration of GHG can be obtained.

  The GHG-containing composition of the present invention preferably comprises, for example, pulverized raw or dried purple tea leaves (hereinafter referred to as “purple tea leaves”) and a polar solvent (including water; the same shall apply hereinafter). ) Can be used for extraction. In order to improve the extraction efficiency, the purple tea leaves may be appropriately subjected to chemical treatment such as acid or alkali decomposition, enzyme decomposition, etc., and then extracted.

Specifically, the GHG-containing composition can be produced by the method described below.
That is, first, as the purple tea leaves, raw or dried purple tea leaves may be used, and in order to further improve the extraction efficiency, chemical treatment such as acid or alkali decomposition, enzyme decomposition, etc. is appropriately performed. And then extract from it.

  Then, a polar solvent is added to the purple tea leaves and shaken or heated to reflux to extract GHG in the solvent.

At this time, although the said polar solvent is not specifically limited, Water, alcohol, and ketones can be used. These may be used alone or in combination of two or more.
Further, among these, it is particularly preferable to use a hydrous alcohol or a hydrous ketone.

  As the water-containing alcohol solvent, water-containing solvents such as ethanol, methanol, propanol and the like can be used, and water-containing ethanol is particularly preferable. Further, as the hydrous ketone solvent, hydrous solvents such as acetone, methyl ethyl ketone, diethyl ketone, chloroacetone and the like can be used, and hydrous acetone is particularly preferable.

  As the water content, in the case of water-containing ethanol, it is preferable to contain 20 to 99.9% by mass of ethanol, more preferably 30 to 99% by mass, and most preferably 40 to 80% by mass. In the case of hydrous acetone, it preferably contains 20 to 99.9% by mass of acetone. This is because the above range is excellent in GHG extraction efficiency. Hereinafter, with respect to the description of the water content of the water-containing solvent, for the sake of simplicity, for example, 80% by mass ethanol containing 20% by mass is described as “80% water-containing ethanol”.

  In the method for producing a GHG-containing composition of the present invention, the heating and refluxing can be performed by a known method using the above-mentioned hydrous alcohol solvent or hydrous ketone solvent. The heating temperature is preferably about 30 to 95 ° C., and the reflux time is preferably about 1 to 4 hours.

Moreover, in the manufacturing method of the GHG containing composition of this invention, you may perform shaking, stirring, etc. suitably as needed.

  Moreover, in the manufacturing method of the GHG containing composition of this invention, it is preferable to depressurizingly distill the said solvent after extraction. According to this, it is possible to make a composition that does not contain an organic solvent, and it can be adapted to safety standards as a food material for blending into foods and drinks such as functional foods and health foods. is there.

  In the method for producing a GHG-containing composition of the present invention, stepwise extraction can be performed with a plurality of solvents. Thereby, the GHG containing composition which contains GHG in high concentration can be manufactured with a sufficient yield.

  Specifically, for example, purple tea leaves are added with one of the above hydrous alcohol solvent and the above hydrous ketone solvent, shaken or heated to reflux, and GHG is extracted into the solvent to obtain the first extract. Get. The extract is separated into an extract and a residue not recovered as the extract by centrifugation or the like, and the other unselected solvent is added to the residue, and the mixture is shaken or heated to reflux. GHG is extracted to obtain a second extract. Then, the first extract and the second extract are mixed. Needless to say, the second extract alone can be used as an extract of purple tea leaves.

  Thus, by performing stepwise extraction with a plurality of solvents, purple tea leaves are subjected to the first extraction treatment with the above-mentioned hydrous alcohol solvent or the above hydrous ketone solvent, thereby extracting characteristics such as physical properties. In the case of using the above-mentioned hydrous alcohol solvent or the above hydrous ketone solvent, the other extraction solvent is used in the subsequent second extraction process. Even so, the extraction efficiency can be expected to be improved.

The extract obtained by the above method can be used as it is or concentrated to obtain a liquid GHG-containing composition. Furthermore, it can be pulverized by freeze-drying or spray-drying to obtain a powdery composition as a GHG-containing composition.
Moreover, it is not limited to these forms. The insoluble matter contained in the extract can be appropriately removed by filtration or the like. The insoluble material may be further pulverized into fine particles.

  The primary extract from purple tea leaves obtained as described above is fractionated and purified using GHG as an index by ion exchange, size exclusion column chromatography, HPLC, gel filtration, membrane separation, etc. This can also be used as a GHG-containing composition.

  The GHG-containing composition of the present invention may be added to a pharmaceutically acceptable base or carrier, if necessary, such as tablets, granules, powders, solutions, powders, granules, capsules, jelly-forms, etc. It can be used in the form.

In addition, the fat absorption inhibitor of the present invention is characterized by containing purple tea and / or an extract thereof as an active ingredient.
Furthermore, when using an extract of purple tea as the fat absorption inhibitor of the present invention, the extract can be obtained by the same method as the above-described GHG-containing composition.

  The GHG-containing composition of the present invention and a fat absorption inhibitor (hereinafter simply referred to as “the present composition etc.”) can be used as materials for various foods and drinks. Examples of the food and drink include edible oil (salad oil), confectionery (gum, candy, caramel, chocolate, cookie, snack, jelly, gummy, tablet confection etc.), noodles (soba, udon, ramen etc.), and dairy products ( Milk, ice cream, yogurt, etc.), seasonings (miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) and health foods (tablets , Capsules, etc.) and nutritional supplements (nutrient drinks, etc.). The composition or the like may be appropriately blended with these foods and drinks.

These foods and drinks can be blended with various ingredients depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid. Acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, Food materials such as carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. In addition, this composition having a health maintenance function includes other antioxidants and health food ingredients such as antioxidants, reduced ascorbic acid (vitamin C), vitamin E, reduced glutatin. , Tocotrienol, vitamin A derivative, lycopene, β-cryptoxanthin, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sezamin, lignans, catechin, isoflavone, chalcone, tannins, flavonoids , Coumarin, isocoumarins, blueberry extract, arbutin, tannin, anthocyanin, apple polyphenol, grape seed extract, ellagic acid, kojic acid, surge extract health food material, V. (vitamin) A, V.B1, V.B2 , V.B6, V.B12, VC, VD, VE, VP, Choline Niacin, pantothenic acid, calcium folate, EPA, oligosaccharide, dietary fiber, squalene, soy lecithin, taurine, donariella, protein, octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium, potassium, heme Iron, oyster meat extract, chitosan, chitin oligosaccharide, collagen, chondroitin, turmeric, licorice, kukoshi, keihi, hawthorn, ginger, ganoderma, swordfish extract, suppon, plantain, chamomile, chamomile, dandelion, hibiscus, honey, boren, Royal jelly, lime, lavender, rosehip, rosemary, sage, bifidobacteria, faecalis, lacris, wheat germ oil, sesame oil, perilla oil, soybean oil, medium chain fatty acid, agaricus, ginkgo biloba extract Turmeric, chondroitin, brown rice germ extract, litchi, onion, DHA, EPA, DPA, cocoon tea, cordyceps, garlic, bee, papaya, puer, propolis, mussels tree, jabushitake, royal jelly, saw palmetto, hyaluronic acid, collagen, Gabba, harp seal oil, shark cartilage, glucosamine, lecithin, phosphatidylserine, paddy carrot, mulberry leaves, soy extract, echinacea, sorghum, barley extract, olive leaf, olive fruit, gymnema, banaba, salasia, garcinia, chitosan , St. John's wort, jujube, carrot, passion flower, broccoli, placenta, pearl barley, grape seeds, peanut seed coat, bilberry, black cohosh, maria thistle, laurel, sage, rosemary, luffa, black vinegar, bitter gourdー, maca, safflower, flax, oolong tea, flower spine, caffeine, capsaicin, xylooligosaccharide, glucosamine, buckwheat, citrus, dietary fiber, protein, prunes, spirulina, barley young leaves, nucleic acid, yeast, shiitake, plum meat, amino acids, Deep sea bream extract, noni, oyster meat, suppon, champignon, plantain, acerola, pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange, fucoidan, mesimacob, cranberry, chondroitin sulfate, zinc, iron, ceramide, silk Peptide, Glycine, Niacin, Chest Tree, Ceramide, L-Cysteine, L-Carnitine, Red Wine Leaf, Millet, Horsetail, Biotin, Centella Asiatica, Hascup, Pycnogenol, Fuki, Rhubarb, Clove, Rosemary, Catechin, Puff -Al, citric acid, brewer's yeast, merirot, black zinger, ginger, gadget, nattokinase, becouge, tocotrienol, lactoferrin, cinnamon, buckwheat, cocoa, yuzu seed extract, perilla seed extract, litchi seed extract, evening primrose extract, black rice extract , Α-lipoic acid, GABA, fresh coffee bean extract, burdock extract, kiwi seed extract, Wenzhou mandarin orange extract, red ginger extract, astaxanthin) and the like.

  As a specific production method, the present composition or the like is used as it is, and in the case of an extract, it is spray-dried or freeze-dried together with powdered dextrin, and this is easily converted into a powder, granule, tablet, or solution. ). If necessary, it can also be mixed with a binder such as gum arabic to form a powder or granules, and added to a solid food.

  You may use this composition etc. as a raw material of a chemical | medical agent (a pharmaceutical and a quasi-drug are included). It can be produced by appropriately blending the present composition with a raw material for a pharmaceutical preparation. In addition, the said chemical | medical agent may be used for a human and may be used for mammals other than a human. Examples of the preparation raw material that can be blended in the present composition include, for example, excipients (glucose, lactose, sucrose, sodium chloride, starch, calcium carbonate, kaolin, crystalline cellulose, cocoa butter, hydrogenated vegetable oil, kaolin, talc, etc.), Binder (distilled water, physiological saline, ethanol water, simple syrup, glucose solution, starch solution, gelatin solution, carboxymethylcellulose, potassium phosphate, polyvinylpyrrolidone, etc.), disintegrant (sodium alginate, agar, sodium bicarbonate, carbonate Calcium, sodium lauryl sulfate, stearic acid monoglyceride, starch, lactose, gum arabic powder, gelatin, ethanol, etc.), disintegration inhibitors (sucrose, stearin, cocoa butter, hydrogenated oil, etc.), absorption accelerators (quaternary ammonium base) , Sodium lauryl sulfate, etc.), adsorbent ( Glycerin, starch, lactose, kaolin, bentonite, silicic acid, etc.), lubricants (purified talc, stearates, polyethylene glycol, and the like) and the like.

  In general, the composition can be administered orally in the form of tablets, pills, soft / hard capsules, fine granules, powders, granules and the like. The water-soluble preparation can be administered orally as a liquid. Furthermore, parenteral administration may be used. When administered as a parenteral preparation, the composition is dispersed in an appropriate solubilizing agent such as ethanol or water, and then applied in a dosage form such as a poultice, lotion, ointment, tincture or cream. be able to. In addition, water-soluble preparations such as this composition can be used as they are or in the form of a poultice, lotion, ointment, tincture, cream, etc. with a dispersant, suspension, stabilizer, etc. added. Can be applied.

  The dose may vary depending on the administration method, medical condition, age of the patient, etc., but for adults, it can be generally administered in an amount of about 5 to 200 mg as an active ingredient per day and usually about 0.5 to 100 mg for children.

  The compounding ratio when using the composition or the like as a drug can be appropriately changed depending on the dosage form, but is usually about 0.01 to 10 wt% when administered orally or by mucosal absorption, parenterally. In the case of administration, it should be about 0.01 to 20 wt%. In addition, since the dose varies depending on various conditions, a dose smaller than the above dose may be sufficient, or it may be necessary to administer beyond the range. In addition to the present composition and the like, the pharmaceutical composition may include other compounds that are commonly used in the pharmaceutical field and compounds that are necessary for molding into a form suitable for oral administration. Examples of such compounds include lactose, starch, hydroxypropyl cellulose, kaolin, talc, calcium carbonate and the like.

Furthermore, this composition etc. can also be used as cosmetics.
Cosmetic forms that can be blended with the present composition include, for example, emulsion, soap, face wash, bath preparation, cream, emulsion, lotion, eau de cologne, shave cream, shave lotion, cosmetic oil, tanning Stop Lotion, Funny Powder, Foundation, Perfume, Pack, Nail Cream, Enamel, Enamel Remover, Eyebrow, Blusher, Eye Cream, Eye Shadow, Mascara, Eyeliner, Lipstick, Lip Cream, Shampoo, Rinse, Hair Dye, Dispersion And cleaning fee.

In addition to the present composition according to the present invention, the cosmetic material of the above-described form includes ingredients, oils, higher alcohols, fatty acids, Ultraviolet absorbers, powders, pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, and the like can be blended.
Examples are listed below, but the present invention is not limited to these examples.

(1) Examples of oil components Ester-based oil phase components: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoaralkyl neopentanoate, glyceryl tri (capryl / caprate), trimethylolpropane tri-2-ethylhexanoate, trimethylol triisostearate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isolaurate Stearyl, isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl linoleate, octyldodecyl isoleate, isopropyl isostearate Cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethyleneglycol dioctanoate , Ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, triisopalmitine Glyceryl acid, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyl decyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleic acid Ester, polyglycerol isostearate, dipropyl carbonate, charcoal Dialkyl (C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, Trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, olein Cholesteryl acid, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoyl hydroxystearate Cetyl, 12-stearoyl-hydroxystearic acid stearyl 12-stearoyl-hydroxystearic acid isostearate, and the like.
Hydrocarbon oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hydrogenated oils, and naturally occurring waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated tallow, horse oil, hydrogenated horse oil, mink oil, orange luffy oil, fish oil, hydrogenated fish oil, egg yolk oil and other animal oils and Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, kiwi seed oil, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil , Perilla oil, tea seed oil, camellia oil, corn oil, rapeseed oil, hydrogenated rapeseed oil, palm kernel oil, hydrogenated palm kernel oil, palm oil, hydrogenated palm oil, peanut oil, hydrogenated peanut oil, castor oil, hydrogenated castor oil , Vegetable oils such as sunflower oil, grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, coconut oil, hardened coconut oil and its hardened , Beeswax, high acid value beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.

(2) Examples of higher alcohols Lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like can be mentioned.

(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.

(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylic acid Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-diparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diisopropyl diisopropylcinnamic acid Stealth mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Examples include full, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, and the like, polymer derivatives, silane derivatives, and the like.

(5) Examples of powders and pigments Red 104, Red 201, Yellow 4, Blue 1, Black 401 and other dyes, Yellow 4 AL lake, Yellow 203 BA lake and other lake dyes, nylon powder , Silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polyethylene powder, yellow iron oxide, red iron oxide, black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine and bitumen, white pigments such as zinc oxide, titanium oxide and cerium oxide, extender pigments such as talc, mica, sericite, kaolin and barium sulfate plate, titanium mica Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, Inorganic powders such as Rica and alumina, metal soaps such as aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, bentonite, smectite, boron nitride, etc. It is done. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, irregular shape, flake-like, spindle-like, etc.) and particle diameter. These powders are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, The surface treatment may or may not be performed in advance by polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.

(6) Examples of surfactants Anionic surfactants: fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, alkyl sulfoacetic acid Sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate, etc. are mentioned.
Cationic surfactant: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, and the like.
Amphoteric surfactants: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE cured castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, and the like.
Natural surfactant: lecithin, saponin, sugar surfactant and the like.

(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. These chemically modified compounds can also be used.

(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoyo Chemical), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubymer) , BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubicol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, BA SF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxy vinyl polymer (Carbopol, BF Goodrich), anionic polymer compounds such as acrylic acid / alkyl methacrylate copolymer (Pemulene, BF Goodrich), and acetic acid amphoteric products of dialkylaminoethyl methacrylate polymers (Yukaformer, Mitsubishi Chemical) Amphoteric polymer compounds such as octyl acrylate acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride Cationic polymer compounds such as vinyl / vinylpyrrolidone copolymer (rubicoat, manufactured by BASF), polyvinylpyrrolidone (rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF) ), Nonionic polymer compounds such as vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP), etc. There is. Cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally derived polymer compounds such as galactan, gum karaya, gum tragacanth, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be suitably used.

(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some physiological activity to the skin when applied to the skin. For example, whitening ingredients, immunostimulants, anti-aging agents, UV protection agents, slimming agents, tanning agents, antioxidants, hair growth agents, hair restorers, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, A cooling sensation agent, a warming sensation agent, vitamins, an amino acid, a wound healing promoter, an irritation relaxation agent, an analgesic agent, a cell activator, an enzyme component, etc. are mentioned. Examples of these suitable ingredients include, for example, ashitaba extract, avocado extract, amateur extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages Extract, Echinacea leaf extract, Ogon extract, Oat extract, Oen extract, Barley extract, Hypericum extract, Oyster extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Chamomile extract, Carrot extract, Kawara mugwort extract, Licorice extract, Calcade extract, Oyster extract, Kina extract, Cucumber extract, Guanosine, Gardenia extract, Kumazasa extract, Clarae Kiss, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, saicin extract, psycho extract Extract Kizuta extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senki Sue extract, assembly extract, soybean extract, tiso extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, touki extract, toshinsen extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, hibiscus extract, bacmond extract, parsley extract, honey, hamamelis extract, parietalia extract, toad extract, bisabolol, loquat extract, dandelion extract, burdock extract, bukuro extract, butcher bloom extract, grape extract, propolis, loofah extract, Safflower extract, peppermint extract, bodaige extract, button extract, hop extract, pine extract, marronnier extract, mizubasho Kiss, Mukuroji extract, Melissa extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Artemisia extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Lotus root extract, Rose extract, Rosemary extract, Roman chamomile extract And royal jelly extract.
Biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosine, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Immunostimulants such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester Vitamins, active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, α-hydroxy acid, β-hydroxy acid, etc. Cell activators, blood circulation promoters such as γ-oryzanol and vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione, etc. Whitening agent, cephalanthin, licorice extract, red pepper tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pan Tothenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonyl acid vanillylamide, nonanoic acid vanillylamide, pyroctone Olamine, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantalis tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, monostearic acid Polyoxyethylene sorbitan, peppermint oil, Sasanishiki extract, placenta, yuzu seed extract, bull Berry extract, lingonberry extract, C. tubulosa extract, black rice extract, green coffee bean extract, resveratrol, kiwi seed extract, strawberry seed extract, and the like hair tonic such as cherry extract.

(10) Examples of antioxidants Sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolyl biguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, lignan, saponin, apple extract and clove extract.

(11) Examples of solvents Purified water, ethanol, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, next-generation chlorofluorocarbon and the like.

Examples that embody the present invention will be described below. The present invention is not limited to the following examples.
Example: Preparation of purple tea extract (GHG-containing composition) 50 g of purple tea leaves were immersed in 500 mL of 50% ethanol aqueous solution and extracted by heating at 40 ° C. for 2 hours with stirring. 400 mL of extract was obtained by suction filtration. The extract was concentrated and dried to obtain 16.6 g of purple tea extract.

Component analysis of purple tea extract As a result of HPLC analysis of purple tea extract under the following conditions, a purple tea extract not contained in common teas such as green tea, oolong tea and black tea was found at 27.5 min. The peak of the specific component was confirmed (arrow part in FIG. 1).
Sample preparation: 350 mg of purple tea extract was dissolved in 30% aqueous methanol solution, and the volume was adjusted to 20 mL with a volumetric flask. The solution was diluted 2 times, filtered and subjected to HPLC analysis. The analysis conditions of HPLC are as follows.
HPLC analysis condition flow rate: 0.7 mL / min
Mobile phase A: 0.3% TFA aqueous solution Mobile phase B: Acetonitrile gradient: As shown in Table 1 below: Column: SunFire C18, 4.6 x 150 mm (Waters) or equivalent Column temperature: 30 ° C
Sample injection volume: 10 μL
Detection wavelength: 280 nm

The above specific components were separated and purified and subjected to NMR analysis. The results are shown in Table 2. Table 2. Results, known components 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose
(GHG).

As a result of quantitative analysis by HPLC using GHG purified product as a standard substance, the purple tea extract contained 8.70% of GHG.
The purple tea extract was further adjusted twice in the same manner as described above, and the GHG content in the extract was measured by the same method. As a result, the GHG contents were 6.79% and 6.38%, respectively. Met. Thereby, it was confirmed that the purple tea extract produced by the method of this example contains about 6 to 9% GHG.

Test Example 1: Evaluation of effect on blood triglyceride elevation in olive oil-loaded mice Blood was collected from the orbital venous sac of fasted mice (15 hours) using glass capillaries, and 30 minutes later, Tea extract (100, 200 mg / kg) was orally administered. One hour later, olive oil (5 mL / kg) was orally administered, and blood was similarly collected from the orbital venous sac at 2, 4 and 6 hours thereafter. Serum was centrifuged from the obtained blood, and triglyceride concentration was measured using an enzyme method (Triglyceride E-Test Wako, manufactured by Wako Pure Chemical Industries, Ltd.). The result is shown in FIG. Furthermore, instead of purple tea extract (100, 200 mg / kg), purple tea extract (400 mg / kg) and all-stat 5w / v% gum arabic suspension (10, 20 mg / kg) were used. A similar test was conducted. The result is shown in FIG.

Results and Effects of Examples in Test Example 1 As shown in FIG. 2A, blood triglycerides in olive oil-administered mice (control) increased compared to non-administered mice (Normal). In contrast, mice pre-administered with purple tea extract (100, 200 mg / kg) tended to suppress the increase in blood triglycerides. In addition, as shown in FIG. 2B, in the mice administered with 400 mg / kg purple tea extract, a significant decrease in blood triglycerides was observed at 4 and 6 hours after administration of olive oil. The anti-obesity drug orlistat significantly increased blood triglycerides at 10 and 20 mg / kg. From the above, it was confirmed that the purple tea extract (GHG-containing composition) of this example can be used as a fat absorption inhibitor and a blood triglyceride rise inhibitor.

Test Example 2: Inhibition of body weight gain in mice fed with a high fat diet (ICR, male, 10 weeks old) A high fat diet (High Fat Diet 32) was allowed to freely ingest and purple tea extract (200 mg / kg) ) Was orally administered once a day. The subject of comparison was a regular diet (CE-2) ad libitum. During this time, body weight was measured daily for 12 days. The result is shown in FIG.

Results and Effects of Examples in Test Example 2 As shown in FIG. 3, the body weight of the mouse (Control) fed with the high fat diet exceeded the body weight of the normal diet-fed mice from the seventh day of the experiment. In contrast, the body weight of mice that were orally dosed with purple tea extract (200 mg / kg) was significantly lower than that of the other groups. From the above, it was confirmed that the purple tea extract (GHG-containing composition) of this example has a body weight-suppressing action in high-fat diet mice, and can be used as a dieting agent (body weight-suppressing agent). It was.

The following are examples of blending purple tea extract resulting from aging according to the present invention, but the following blending examples do not limit the present invention.
Formulation Example 1: Chewing gum
53.0wt% sugar
Gum base 20.0
Glucose 10.0
Minamata 16.0
Fragrance 0.5
Purple tea extract 0.5
100.0wt%

Formulation Example 2: Gummy
Reduced water tank 40.0wt%
Granulated sugar 20.0
Glucose 20.0
Gelatin 4.7
Water 9.68
Grape juice 4.0
Grape flavor 0.6
Dye 0.02
Purple tea extract 1.0
100.0wt%

Formulation Example 3: Candy
50.0 wt% sugar
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Purple tea extract 0.4
100.0wt%

Formulation Example 4: Yogurt (hard / soft)
Milk 41.5wt%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Purple tea extract 0.4
Perfume
Water residue
100.0wt%

Formulation Example 5: Soft drink
Fructose glucose liquid sugar 30.0wt%
Emulsifier 0.5
Purple tea extract 0.05
Perfume
Purified water residue
100.0wt%

Formulation Example 6: Soft capsule
Grape seed oil 87.0wt%
Emulsifier 12.0
Purple tea extract 1.0
100.0wt%

Formulation Example 7: Tablet
Lactose 54.0wt%
Crystalline cellulose 30.0
Starch degradation product 10.0
Glycerin fatty acid ester 5.0
Purple tea extract 1.0
100.0wt%

Formulation Example 7: Granules (Pharmaceuticals)
Purple tea extract 1.0wt%
Lactose 30.0
Cornstarch 60.0
Crystalline cellulose 8.0
Polyvinylpyrrolidone 1.0
100.0wt%

Formulation Example 8: Tablet
76.4 wt% sugar
Glucose 19.0
Sucrose fatty acid ester 0.2
Purple tea extract 0.5
Purified water 3.9
100.0wt%
Formulation Example 9: Cosmetic cream
Squalane 20.0wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerol monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Purple tea extract 2.0
Preservative appropriate amount
Perfume
Purified water residue
100.0wt%

Formulation Example 10: lotion
Ethanol 5.0wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Purple tea extract 0.1
Purified water residue
100.0wt%

Formulation Example 11: Body gel
Macadamia nut oil 2.0wt%
Octyldodecyl myristate 10.0
Methylphenylpolysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative appropriate amount
Centella extract 1.0
Purple tea extract 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0wt%

Formulation Example 12: Emulsion
Squalane 4.0wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glyceryl monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Purple tea extract 0.5
Potassium hydroxide 0.1
Perfume
Purified water residue
100.0wt%

Formulation Example 13: Bath agent (liquid)
Propylene glycol 50.0wt%
Ethanol 20.0
Sodium sulfate 5.0
Purple tea extract 0.5
Lanolin 0.5
Avocado oil 0.5
Dye 1.5
Fragrance 22.0
100.0wt%
Formulation Example 14: Shampoo Sodium polyoxyethylene alkyl ether sulfate
(E.O2 mol) 15.0
Palm oil aliphatic diethanolamide 5.0
Glycerin 3.0
Purple tea extract 0.4
Ethanol 5.0
Perfume and preservatives
Ion exchange water
Total 100wt%

Formulation Example 15: Hair Cream
Liquid paraffin 20.0wt%
Solid paraffin 3.0
Polyoxyethylene cetyl ether
(E.O15 mol) 2.0
Sorbitan sesquioleate 1.0
Purple tea extract 0.2
Ethanol 10.0
Potassium hydroxide 0.1
Glycerin 3.0
Perfume and preservatives
Total 100wt%

Formulation Example 16: Ointment
White beeswax 5.0wt%
Purified lanolin 5.0
Purple tea extract 1.0
Fragrance 0.1
Vaseline residue
Total 100 wt%

  As described above, the present invention can provide a GHG-containing composition that is a natural product-derived composition containing GHG at a high concentration, and a method for producing the same. Furthermore, the fat absorption inhibitor which uses a novel plant or its extract as an active ingredient can be provided.

Claims (3)

3-99% 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose obtained from Kenyan purple tea (scientific name: Camellia sinensis, variety TRFK306) 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose-containing composition characterized by containing. Soaked Kenyan purple tea (scientific name: Camellia sinensis, variety TRFK306) in a polar solvent (including water), then heated to reflux to 1,2-di-O-galloyl-4,6- 1,2-di-O-galloyl-4,6-O- (S) -hexahydroxydiphenoyl-b-D-glucose-containing composition characterized by extracting O- (S) -hexahydroxydiphenoyl-b-D-glucose Manufacturing method. A fat absorption inhibitor containing Kenyan purple tea (scientific name: Camellia sinensis, variety TRFK306) and / or its extract as an active ingredient.

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