JP2016131619A - Transdermal administration device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a transdermal administration device that enables handleability of the transdermal administration device to be increased.SOLUTION: A transdermal administration device has a supporting surface 11S for supporting a pressure sensitive adhesive sheet 21, and includes a base body 11 having rigidity higher than that of a pressure sensitive adhesive sheet 21. Any one of the pressure sensitive adhesive sheet 21 and the base body 11 is a fitting body, and a part other than the fitting body among the pressure sensitive adhesive sheet 21 and the base body 11 is a fitted body. The fitting body includes fitting protrusions 12 extending toward the fitted body, and the fitted body includes recesses 21Hb loosely fitted with the fitting protrusions 12.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a transdermal administration device having a microprojection that forms a passage in the skin for administering an administration substance.

  The transdermal administration device described above includes an administration sheet having microprojections and an adhesive sheet that supports the administration sheet. The administration sheet includes a projection forming surface and an adherend surface opposite to the projection forming surface, and a plurality of minute projections are arranged on the projection forming surface. The pressure-sensitive adhesive sheet includes a pressure-sensitive adhesive surface and a back surface opposite to the pressure-sensitive adhesive surface, and the adherend surface of the administration sheet is bonded to a part of the pressure-sensitive adhesive surface.

  When the transdermal administration device is used, an adhesive surface located around the administration sheet is attached to the surface of the skin, and the back surface of the adhesive sheet is lightly pressed with a finger or the like toward the surface of the skin. Through sticking of such an adhesive sheet, the projection forming surface of the administration sheet is pressed against the surface of the skin, and a passage for administering the drug is formed on the skin by the microprojections (see, for example, Patent Document 1).

JP 2014-28108 A

  By the way, in order for the above-mentioned passage to have a depth required for administration of the administration substance, the adhesion between the skin surface and the adhesive sheet is maintained for a predetermined time, and each of the plurality of microprotrusions is formed on the skin surface. It is preferable to be sufficiently stabbed. In order to maintain the adhesion between the surface of the skin and the adhesive sheet, in general, in addition to measures to increase the adhesive strength of the adhesive surface, follow-up of the shape that changes the shape of the sheet according to the shape change of the skin surface Measures to improve the nature are adopted.

  The conformability of the shape in each sheet can be enhanced by, for example, reducing the thickness of the sheet or increasing the flexibility of the sheet. However, if the thickness of the sheet is reduced or the flexibility of the sheet is increased, each sheet is likely to be folded erroneously before the surface of the skin and the adhesive sheet are bonded. Adhesion and adhesion between adhesive surfaces will be invited.

Thus, increasing the conformability of the shape in each sheet is useful for improving the adhesion between the skin surface and the adhesive surface, but before the adhesive surface is adhered to the skin surface, This is a factor that lowers the handleability of the skin administration device.
An object of the present invention is to provide a transdermal administration device capable of improving the handleability of the transdermal administration device.

  In order to solve the above-mentioned problem, a transdermal administration device has a projection forming surface and a surface to be bonded which is a surface opposite to the projection forming surface, and a microprojection is located on the projection forming surface. An adhesive sheet, an adhesive surface, and a supported surface that is a surface opposite to the adhesive surface, wherein the adhesive surface is bonded to a part of the adhesive surface, and the adhesive sheet And a base having higher rigidity than the pressure-sensitive adhesive sheet. One of the pressure-sensitive adhesive sheet and the base body is a fitting body, and a part other than the fitting body among the pressure-sensitive adhesive sheet and the base body is a fitting body. And the said fitting body is equipped with the fitting protrusion extended toward the said to-be-adhered body, and the said to-be-attached body is equipped with the fitting hollow which the said fitting protrusion was loosely fitted.

  According to the transdermal administration device, in the state where the surface of the skin and the adhesive surface of the adhesive sheet are not bonded and the support surface of the substrate supports the supported surface of the adhesive sheet, the supported surface with respect to the support surface Is suppressed by the loose fitting of the fitting projection with respect to the fitting depression. On the other hand, in the state where the surface of the skin and the adhesive surface of the adhesive sheet are adhered, the adhesive sheet is positioned with respect to the surface of the skin, and the supported surface can be pulled away from the support surface. Therefore, until the surface of the skin and the adhesive sheet are bonded together, the shape of the adhesive sheet and the administration sheet is approximately maintained by the substrate having high rigidity, and the adhesive sheet and the administration sheet are inadvertently deformed. It can be suppressed. As a result, the handleability of the transdermal administration device is enhanced before the skin surface and the adhesive sheet are bonded.

  In the transdermal administration device, the fitting is the base, the fitting protrusion is located on the support surface, the fitting is the pressure-sensitive adhesive sheet, and the fitting depression is It is preferable that it is a hollow formed in the said supported surface.

  According to the transdermal administration device, since the base having higher rigidity than the pressure-sensitive adhesive sheet includes the fitting protrusion, buckling of the fitting protrusion can be suppressed as compared with the configuration in which the pressure-sensitive adhesive sheet includes the fitting protrusion. It is possible to prevent the loose fitting of the fitting protrusion from being inadvertently released.

  In the transdermal administration device, it is preferable that the fitting depression is a through-hole penetrating the adhesive sheet from the supported surface to the adhesive surface, and the fitting projection protrudes from the adhesive surface.

  According to the transdermal administration device, since the fitting body is loosely fitted to the fitting body in such a manner that the fitting protrusion protrudes from the pressure-sensitive adhesive surface, the pressure-sensitive adhesive sheet until the pressure-sensitive adhesive sheet is attached to the surface of the skin. Is further suppressed.

In the transdermal administration device, it is preferable that the fitting protrusion protrudes from the minute protrusion on the basis of the adhesive surface.
According to the transdermal administration device, since the fitting protrusion protrudes from the microprojection in the height direction with respect to the adhesive surface, contact between an external obstacle other than the transdermal administration device and the tip of the microprotrusion Is suppressed by contact between an external obstacle and the tip of the fitting protrusion.

In the transdermal administration device, an index relating to the use of the transdermal administration device is attached to the distal end surface of the fitting protrusion.
According to the transdermal administration device, since the index relating to the use of the transdermal administration device is attached to the surface protruding from the adhesive surface, the convenience in using the transdermal administration device is enhanced.

In the transdermal administration device, the distal end surface of the fitting protrusion preferably has a curvature that is convex toward the distal end.
According to the transdermal administration device, since it is easy to pass the fitting protrusion through the through hole formed in the adhesive sheet, the load is reduced in the manufacturing process of combining the adhesive sheet and the substrate.

  In the transdermal administration device, the device includes a plurality of fitting protrusions and a plurality of fitting depressions, and the plurality of fitting protrusions are arranged at positions sandwiching the administration sheet, and the plurality of fitting depressions are It is preferable that the administration sheet is disposed at a position sandwiching the administration sheet.

  According to the transdermal administration device, the plurality of fitting protrusions are arranged at positions sandwiching the administration sheet, and the plurality of fitting depressions are also arranged at positions sandwiching the administration sheet. It is possible to prevent the adhesive sheet from being inadvertently deformed at the portion where the

  The transdermal administration device includes a release sheet that covers the adhesive surface, and the release sheet is attached to a portion of the adhesive surface other than the portion facing the adherend surface.

  According to the transdermal administration device, since the administration sheet and the release sheet cover the adhesive surface, before the release sheet is peeled off, the microprojections and the adhesive surface are bonded, or the adhesive surfaces are bonded together. Is reliably suppressed.

  According to the present invention, the handleability of the transdermal administration device is improved.

It is a disassembled perspective view which shows the disassembled perspective structure of a transdermal administration device in one Embodiment of a transdermal administration device. It is sectional drawing which shows the cross-section of the transdermal administration device in one Embodiment. It is an operation figure showing an operation of a transdermal administration device in one embodiment, and is a sectional view for explaining a state where a transdermal administration device is placed on the surface of the skin. It is operation drawing which shows the effect | action of the transdermal administration device in one Embodiment, Comprising: It is sectional drawing for demonstrating the state by which the administration sheet was pressed on the surface of skin. It is an operation view showing an operation of a transdermal administration device in one embodiment, and is a sectional view for explaining a state where a substrate is removed from the transdermal administration device. It is a disassembled perspective view which shows the disassembled perspective structure of a transdermal administration device in the modification of the transdermal administration device in one Embodiment. It is a disassembled perspective view which shows the disassembled perspective structure of a transdermal administration device in the other modification of the transdermal administration device in one Embodiment.

  An embodiment of a transdermal administration device will be described with reference to FIGS.

  As shown in FIG. 1, the transdermal administration device includes a substrate 11 that is an example of an insertion body, an adhesive sheet 21 that is an example of an attachment body, an administration sheet 31, and a release sheet 41. . An adhesive sheet 21 is placed on the substrate 11, and an administration sheet 31 and a release sheet 41 are placed on the adhesive sheet 21.

  The substrate 11 is a resin plate member having higher rigidity than the pressure-sensitive adhesive sheet 21 and has a disk shape. The base 11 has a support surface 11S that is a flat surface facing the pressure-sensitive adhesive sheet 21, and a back surface that is a surface opposite to the support surface 11S. The base body 11 has a thickness that allows the base body 11 to bend by receiving pressure from the user's finger or the like on the back surface. Two fitting wearing protrusions 12 extending from the support surface 11S toward the adhesive sheet 21 are located on the support surface 11S.

  The two fitting protrusions 12 are ridges having an arc shape along a virtual ring surrounding the central portion of the support surface 11S, and are disposed at positions sandwiching the central portion of the support surface 11S. The two fitting projections 12 have a structure in which a part of the base body 11 is folded back so as to be convex toward the adhesive sheet 21, and are formed by, for example, pressing a resin plate member. The portion of the fitting projection 12 that is connected to the support surface 11S is the base end, and the distal end surface 12S of the fitting projection 12 is a curved surface having a curvature that is convex toward the tip of the fitting projection 12.

  An index relating to the use of the transdermal administration device is attached to the distal end surface 12S of the fitting protrusion 12. The index relating to the use of the transdermal administration device is, for example, a character or code indicating the serial number or production date of the transdermal administration device. In addition, the index related to the use of the transdermal administration device is, for example, characters or symbols indicating which part of the administration sheet 31 is to be placed around the eyes when the administration target surface is the cheek surface.

  The resin material forming the base 11 is, for example, a polyester resin such as polyethylene terephthalate (PET) or polyethylene naphthalate (PEN), a polyolefin resin such as polyethylene or polypropylene, a polystyrene resin, a polyamide resin, a polycarbonate resin, Polyacrylonitrile resin, polyimide resin, or the like is used. These resin materials may be stretched or unstretched as long as they have a higher rigidity than the pressure-sensitive adhesive sheet 21.

  The pressure-sensitive adhesive sheet 21 includes a resin base sheet 22 and a pressure-sensitive adhesive layer 23, and has a lower rigidity than the base 11. The base material sheet 22 has a disk shape having an edge that coincides with the edge of the support surface 11S. Of the two surfaces of the base sheet 22, the flat surface facing the substrate 11 is a supported surface 21 </ b> S <b> 2 that is the back surface of the adhesive sheet 21. The supported surface 21S2 is a surface in contact with the support surface 11S and is supported by the base 11. Since the supported surface 21S2 is superimposed on the support surface 11S so that the entire supported surface 21S2 faces the entire support surface 11S, the entire pressure-sensitive adhesive sheet 21 is supported by the base body 11.

  An adhesive layer 23 is formed on the surface facing the supported surface 21S2 among the two surfaces of the base sheet 22. The surface of the pressure-sensitive adhesive layer 23 is a pressure-sensitive adhesive surface 21S1 that is the surface of the pressure-sensitive adhesive sheet 21, and has a function of adhering to the surface of the skin to be administered. A central portion showing a circular shape in the adhesive surface 21S1 is a first adhesion portion Sa that is a region to which the administration sheet 31 is adhered. The part other than the first adhesive part Sa in the adhesive surface 21S1 is a second adhesive part Sb that is an area to be adhered to the surface of the skin. The adhesive sheet 21 has two fitting recesses 21Hb penetrating from the supported surface 21S2 to the second adhesive portion Sb.

  As seen from the direction facing the adhesive surface 21S1, the two fitting recesses 21Hb sandwich the first adhesive portion Sa, and the inner edges of the two fitting recesses 21Hb are in an arc shape along the outer edge of the fitting projection 12 Is formed. In each of the two fitting recesses 21Hb, the through hole formed in the base sheet 22 and the through hole formed in the adhesive layer 23 have the same shape as viewed from the direction facing the supported surface 21S2. Such a fitting recess 21Hb is formed by punching the adhesive sheet 21, for example.

  Separate fitting fitting protrusions 12 are loosely fitted in the two fitting depressions 21Hb. And since the two fitting protrusions 12 are separately loosely fitted in the fitting recess 21Hb, the position of the adhesive sheet 21 is displaced along the support surface 11S, and the position of the adhesive sheet 21 is the support surface 11S. It is suppressed from leaving. As a result, the adhesive sheet 21 can be prevented from being folded erroneously.

  The resin material forming the base sheet 22 is, for example, a polyester resin such as polyethylene terephthalate (PET) or polyethylene naphthalate (PEN), a polyolefin resin such as polyethylene or polypropylene, a polystyrene resin, a polyamide resin, or a polycarbonate resin. Resin, polyacrylonitrile resin, polyimide resin and the like are used. These resin materials may be stretched or unstretched as long as they have a lower rigidity than that of the substrate 11.

  The pressure-sensitive adhesive composition for forming the pressure-sensitive adhesive layer 23 is, for example, a plasticizer, a filler, a stabilizer, a tackifier, or the like mixed with a pressure-sensitive adhesive such as an acrylic resin, a silicon-based resin, natural rubber, or synthetic rubber. Is.

  The administration sheet 31 is a resin plate member having rigidity lower than that of the base 11, and has a disk shape having an edge aligned with the edge of the first adhesive portion Sa. The administration sheet 31 has an adherend surface 31S2 that is a flat surface facing the adhesive surface 21S1, and a projection forming surface 31S1 that is a surface opposite to the adherend surface 31S2. A plurality of minute protrusions 32 having a conical shape are located on the protrusion forming surface 31S1. The plurality of minute protrusions 32 are equally arranged on a concentric ring centering on the center of the adherend surface 31S2.

  The length of the minute protrusion 32 is the length from the protrusion forming surface 31S1 to the tip of the minute protrusion 32. The length of the microprotrusions 32 is such that the passage formed by the microprotrusions 32 has a depth necessary for administration of the administration substance, or an effect to be expressed by puncture of the microprotrusions 32 is obtained. These are set as appropriate, and are preferably 10 μm or more and 1000 μm or less.

  For example, when the bottom of the passage formed by the microprojections 32 is set in the stratum corneum, the length of the microprojections 32 is preferably 10 μm or more and 300 μm or less, and more preferably 30 μm or more and 200 μm or less. preferable. When the bottom of the passage formed by the microprotrusions 32 is set to a depth that penetrates the stratum corneum and does not reach the nerve layer, the length of the microprotrusions 32 is preferably 200 μm or more and 700 μm or less. More preferably, it is 200 μm or more and 500 μm or less, and further preferably 200 μm or more and 300 μm or less. When the passage formed by the microprotrusions 32 reaches the dermis, the length of the microprotrusions 32 is preferably 200 μm or more and 500 μm or less.

  The width | variety which the microprotrusion 32 has is the maximum value of the length which the microprotrusion 32 has in the direction parallel to the protrusion formation surface 31S1, Comprising: It is the diameter of the circle | round | yen divided by the bottom part of the microprotrusion 32. The width of the microprojections 32 is preferably 1 μm or more and 300 μm or less. The ratio of the length of the microprojections 32 to the width of the microprojections 32 is an aspect ratio, and the aspect ratio of the microprojections 32 is preferably 1 or more and 10 or less. The angle of the tip of the microprojection 32 is preferably 5 ° or more and 30 ° or less, and more preferably 10 ° or more and 20 ° or less. Note that the width, aspect ratio, and tip angle of the microprotrusions 32 are determined according to the volume required for the passage that is a hole formed by the microprotrusions 32.

  The administration sheet 31 is formed from, for example, a biocompatible water-soluble polymer or a thermoplastic resin. Water-soluble polymer materials include carboxymethylcellulose (CMC), methylcellulose (MC), hydroxypropylcellulose (HPC), hydroxypropylmethylcellulose (HPMC), polyvinyl alcohol (PVA), polyacrylic acid polymer, polyacrylamide (PAM) , Polyethylene oxide (PEO), pullulan, alginate, pectin and the like. Examples of the thermoplastic resin material include polylactic acid, cycloolefin copolymer, polyethylene, polypropylene, polycarbonate, and polyglycolic acid.

  The microprotrusion 32 is a protrusion that forms a passage for administering a substance to be administered, and may or may not hold a drug to be administered. As a configuration in which the microprojection 32 holds the drug, the microprojection 32 may be formed of a water-soluble polymer, and the drug may be included in the microprojection 32. Alternatively, the microprojections 32 may be formed from a thermoplastic resin, and the administration substance may be applied to the surface of the microprojections 32. Note that the water-soluble polymer itself constituting the microprotrusions 32 may function as an administration substance.

  The kind of the administration substance is not particularly limited as long as it is a substance that functions by being administered intradermally. Examples of the drug include various proteins, pharmacologically active substances, cosmetic compositions, and the like, and are appropriately selected depending on the purpose of administration.

  Examples of the pharmacologically active substance include vaccines such as influenza, analgesics for cancer patients and the like, insulin, biologics, gene therapy drugs, injections, oral preparations, and skin application preparations. In transdermal administration using a transdermal administration device, an administration substance is administered into a passage formed in the skin. Therefore, transdermal administration using a transdermal administration device can be used for administration of pharmacologically active substances that require subcutaneous injection in addition to the pharmacologically active substances used in conventional transdermal administration. In particular, transdermal administration using a transdermal administration device is suitable for administration of injections such as vaccines to children because it does not cause pain during administration. In addition, transdermal administration using a transdermal administration device is suitable for administration of oral preparations for children who are difficult to take oral preparations, since it is not necessary to take the medicine at the time of administration.

  A cosmetic composition is a composition used as a cosmetic or a cosmetic. Examples of the cosmetic composition include a moisturizer, a colorant, a fragrance, or a physiologically active substance that exhibits a beauty effect such as an improvement effect on wrinkles, acne, pregnancy lines, and an improvement effect on hair loss. When a material having a fragrance is used as a cosmetic composition, an odor can be imparted to the transdermal administration device, so that a transdermal administration device suitable for cosmetics can be obtained.

  The release sheet 41 is a sheet that can be easily peeled from the adhesive surface 21S1, and has a disk shape having an edge aligned with the edge of the first adhesive portion Sa. The release sheet 41 is formed with an administration insertion hole 41Ha that is a circular hole through which the administration sheet 31 passes and a protrusion insertion hole 41Hb that is an arc hole through which the fitting projection 12 passes. The release sheet 41 has a shape that follows the second adhesive portion Sb other than the portion facing the administration sheet 31 in the adhesive surface 21S1, and is attached to the second adhesive portion Sb.

  As shown in FIG. 2, the distance between the tip of the fitting protrusion 12 and the adhesive surface 21S1 is the fitting protrusion amount T1, and the distance between the tip of the minute protrusion 32 and the adhesive surface 21S1 is for administration. The protrusion amount T2. The fitting protrusion amount T1 is larger than the administration protrusion amount T2, that is, the fitting protrusion 12 protrudes from the minute protrusion 32 with reference to the adhesive surface 21S1. If the fitting protrusion 12 protrudes from the minute protrusion 32, it is easy to read the index attached to the tip surface 12S of the fitting protrusion 12. Further, if the fitting protrusion 12 protrudes from the minute protrusion 32, the front end surface 12 </ b> S of the fitting protrusion 12 can also have a function of supporting the cover of the minute protrusion 32.

An example of an administration mode using a transdermal administration device will be described.
First, in a state where the base body 11 is positioned below the adhesive sheet 21 in the vertical direction, the edge of the base body 11 is sandwiched between fingers, and the release sheet 41 covering the adhesive face 21S1 is peeled off from the adhesive face 21S1. And the adhesive sheet 21 and the administration sheet 31 are carried to the surface of the skin while the adhesive sheet 21 is supported by the substrate 11.

  During this time, the displacement of the position of the pressure-sensitive adhesive sheet 21 with respect to the base body 11 is suppressed by loose fitting of the fitting protrusion 12 with respect to the fitting depression 21Hb. As a result, in the operation in which the release sheet 41 is peeled from the adhesive surface 21S1 or the operation in which the adhesive sheet 21 and the administration sheet 31 are carried, the adhesive sheet 21 is folded over and overlapped with the adhesive sheet 21 itself, or the adhesive sheet 21 is administered. It is possible to prevent the sheet 31 from being folded and overlapped.

  Next, as shown in FIG. 3, the base 11 is disposed above the adhesive sheet 21 in the vertical direction so that the administration sheet 31 faces the skin surface Sc. Then, the transdermal administration device is brought close to the surface of the skin until the distal end surface 12S of the fitting protrusion 12 contacts the surface Sc of the skin.

  During this time, the displacement of the position of the pressure-sensitive adhesive sheet 21 with respect to the base body 11 is suppressed by loose fitting of the fitting protrusion 12 with respect to the fitting depression 21Hb and further electrostatic adsorption between the support surface 11S and the supported surface 21S2. . As a result, in the operation in which the fitting protrusion 12 is pressed against the surface Sc of the skin, the pressure-sensitive adhesive sheet 21 can be prevented from being folded on the pressure-sensitive adhesive sheet 21 itself, and the pressure-sensitive adhesive sheet 21 can be prevented from being folded on the administration sheet 31.

  It should be noted that in the state where the tip surface 12S of the fitting projection 12 is in contact with the skin surface Sc, the tip of the microprojection 32 may be separated from the skin surface Sc, or the skin surface Sc faces the microprojection 32. In the case of a protruding shape, the tip of the fine protrusion 32 may be stabbed into the skin surface Sc. Moreover, even if an electrostatic attraction force does not act between the support surface 11S and the supported surface 21S2, the posture of the pressure-sensitive adhesive sheet 21 can be changed to the pressure-sensitive adhesive surface 21S1 only by loosely fitting the fitting protrusions 12 into the fitting depressions 21Hb. It is easy to keep the entire surface of the skin and the surface Sc of the skin facing each other. As a result, the pressure-sensitive adhesive sheet 21 can be prevented from folding over the pressure-sensitive adhesive sheet 21 itself, and the pressure-sensitive adhesive sheet 21 from being folded over to the administration sheet 31.

  Next, as shown in FIG. 4, a portion corresponding to the upper side in the vertical direction of the administration sheet 31 in the back surface of the base body 11 is pushed out toward the surface Sc of the skin. And the microprotrusion 32 is inserted into the surface Sc of the skin, and the protrusion forming surface 31S1 of the administration sheet 31 is pressed against the surface Sc of the skin.

  During this time, the base body 11 is deformed so that the base end of the fitting protrusion 12 is spread, and the deformation of the base body 11 promotes the loose fitting of the fitting protrusion 12 to the fitting depression 21Hb. Further, the adhesion between the second adhesive portion Sb on the adhesive surface 21S1 and the skin surface Sc is particularly promoted around the administration sheet 31, and through the adhesion between the adhesive surface 21S1 and the skin surface Sc, the fitting depression 21Hb The loose fitting of the fitting wearing protrusion 12 with respect to is almost released. As a result, while the loose fitting of the fitting protrusion 12 with respect to the fitting depression 21Hb is maintained, the adhesive sheet 21 also folds over the adhesive sheet 21 itself or the adhesive sheet 21 folds over the administration sheet 31 again. It can be suppressed.

  Note that the loose fitting of the fitting protrusion 12 to the fitting depression 21Hb is performed depending on the degree of contact between the fitting depression 21Hb and the fitting protrusion 12 even if the fitting protrusion 12 is not deformed. 31 may be released only by its own weight or may be prompted to release by adhesion between the adhesive surface 21S1 and the skin surface Sc.

  As shown in FIG. 5, the base 11 is separated from the adhesive sheet 21 so that the distal end surface 12 </ b> S of the fitting protrusion 12 is separated from the skin surface Sc. Then, all of the supported surface 21S2 of the adhesive sheet 21 is exposed, and all of the adhesive surface 21S1 can be pressed against the skin surface Sc.

As mentioned above, the transdermal administration device in the said embodiment has an effect enumerated below.
(1) The displacement of the pressure-sensitive adhesive sheet 21 with respect to the base body 11 is suppressed by the loose fitting of the fitting projection 12 with respect to the fitting depression 21Hb. As a result, before the skin surface Sc and the pressure-sensitive adhesive sheet 21 are bonded, the handleability of the transdermal administration device is improved.

  (2) Since the base body 11 having higher rigidity than the pressure-sensitive adhesive sheet 21 includes the fitting protrusion 12, buckling of the fitting protrusion 12 is suppressed, and loose fitting of the fitting protrusion 12 is inadvertently released. It can be suppressed.

  (3) Since the base 11 is loosely fitted to the pressure-sensitive adhesive sheet 21 in such a manner that the fitting protrusion 12 protrudes from the pressure-sensitive adhesive surface 21S1, the pressure-sensitive adhesive sheet 21 is deformed until the pressure-sensitive adhesive sheet 21 is attached to the surface Sc of the skin. It is further suppressed.

  (4) Since the fitting protrusion 12 protrudes from the microprotrusion 32 in the height direction with respect to the adhesive surface 21S1, the contact between the external obstacle other than the transdermal administration device and the tip of the microprotrusion 32 is It is suppressed by contact between an external obstacle and the tip of the fitting projection 12.

  (5) Since the index regarding the use of the transdermal administration device is attached to the distal end surface 12S protruding from the adhesive surface 21S1, the convenience in using the transdermal administration device is enhanced.

  (6) The front end surface 12S of the fitting projection 12 is an arc surface, and the fitting projection 12 is easily passed through the fitting depression 21Hb that is a through hole formed in the adhesive sheet 21. . Therefore, the load is reduced in the manufacturing process in which the adhesive sheet 21 and the base body 11 are combined.

  (7) The two fitting projections 12 are arranged at a position sandwiching the administration sheet 31, and the two fitting depressions 21 </ b> Hb are also arranged at a position sandwiching the administration sheet 31. Therefore, the adhesive sheet 21 can be prevented from being inadvertently deformed particularly in the portion where the administration sheet 31 is located in the adhesive sheet 21.

  (8) Since the administration sheet 31 and the release sheet 41 cover the adhesive surface 21S1, the microprojections 32 and the adhesive surface 21S1 adhere to each other or the adhesive surfaces 21S1 adhere to each other until the release sheet 41 is peeled off. This is definitely suppressed.

The above embodiment can be implemented with the following modifications.
[Substrate 11]
-The shape which the base | substrate 11 has is not restricted to a plate shape, For example, a rectangular parallelepiped shape may be sufficient, and the ellipsoid shape which has a magnitude | size which can be grasped by a user's hand may be sufficient. The base 11 has a shape that includes a support surface that supports the pressure-sensitive adhesive sheet, and in the configuration in which the pressure-sensitive adhesive sheet 21 is a body to be fitted, as long as the shape has a fitting protrusion, and the pressure-sensitive adhesive sheet 21 is a body to be fitted. In the configuration, any shape may be used as long as a fitting depression is formed.

  The support surface 11S is not limited to a flat surface, and may be, for example, an uneven surface or a curved surface that matches the shape of the administration target surface. The support surface 11 </ b> S only needs to have a shape that can support the pressure-sensitive adhesive sheet 21, and may be a combination of a plurality of different shapes such as a combination of an uneven surface and a curved surface.

  -The number of the fitting protrusions 12 is not limited to two, for example, it may be one or three or more. In addition, in the viewpoint from which the shift | offset | difference of the position of the adhesive sheet 21 with respect to the base | substrate 11 is suppressed, it is preferable that the number of the fitting protrusions 12 is three or more. On the other hand, from the viewpoint of reducing the load required for the design of the transdermal administration device and from the viewpoint of enhancing the productivity of the transdermal administration device, the position of the fitting protrusion 12 and the position of the fitting depression 21Hb are matched. It is preferable that the number of the fitting protrusions 12 is one because the labor required for the reduction is reduced.

  The shape of the fitting protrusion 12 is not limited to the curved shape extending along the support surface 11S when viewed from the direction facing the support surface 11S, and may be a hemispherical shape or a rectangular parallelepiped shape. However, it may be a polygonal line shape. The shape of the fitting protrusion 12 may be a combination of a plurality of different shapes. At this time, the molding method of the fitting protrusion 12 may be extrusion molding or injection molding.

  -The position of the fitting protrusion 12 may be biased on a virtual ring surrounding the central part of the support surface 11S, or may be equally distributed along the circumferential direction of the ring. Further, the position of the fitting protrusion 12 may be the center portion of the support surface 11S, or a combination of the center portion and a virtual ring surrounding the center portion of the support surface 11S. In short, the position of the fitting protrusion 12 may be a position facing the fitting depression 21Hb formed on the supported surface 21S2. In addition, it is preferable that the fitting protrusion 12 is disposed at a position facing the edge of the pressure-sensitive adhesive sheet 21 from the viewpoint that the displacement of the position of the pressure-sensitive adhesive sheet 21 with respect to the substrate 11 is suppressed in almost the entire pressure-sensitive adhesive sheet 21.

  For example, as shown in FIG. 6, the two fitting protrusions 12 are equally distributed along the circumferential direction of the base 11 at the edge of the base 11 and are disposed at positions facing the edge of the adhesive sheet 21. A fitting recess 21 </ b> Hb that is recessed toward the inside in the radial direction of the pressure-sensitive adhesive sheet 21 is formed at a position facing the fitting protrusion 12 on the peripheral surface of the pressure-sensitive adhesive sheet 21. Each of the two fitting projections 12 has a size that is loosely fitted in the fitting depression 21Hb that faces the fitting projection 12. According to such a fitting mode, the displacement of the position of the pressure-sensitive adhesive sheet 21 with respect to the base body 11 is suppressed in almost the whole pressure-sensitive adhesive sheet 21.

  The distal end surface 12S of the fitting protrusion 12 may be a flat surface, a curved surface having a curvature that is convex toward the proximal end, or an uneven surface. In the configuration in which the fitting protrusion 12 protrudes from the minute protrusion 32 with the adhesive surface 21S1 as a reference, the distal end surface 12S of the fitting protrusion 12 functions as a support portion that supports the cover of the minute protrusion 32. Also good. At this time, it is preferable that the front end surface 12S of the fitting protrusion 12 has a shape aligned with a portion of the cover that contacts the front end surface 12S. For example, when the portion of the cover that contacts the distal end surface 12S has a convex shape, the distal end surface 12S of the fitting projection 12 preferably has a convex shape. With such a shape of the tip surface 12S, the position of the cover can be prevented from shifting with respect to the tip surface 12S.

  The fitting protrusion amount T1 may be equal to the administration protrusion amount T2, or may be smaller than the administration protrusion amount T2. That is, the fitting protrusion 12 may protrude to the same extent as the minute protrusion 32 with the adhesive surface 21 </ b> S <b> 1 as a reference, or may not protrude beyond the minute protrusion 32. Furthermore, the front end surface 12S of the fitting projection 12 does not protrude from the adhesive surface 21S1, that is, the front end surface 12S of the fitting projection 12 is located inside the adhesive sheet 21 in the thickness direction of the adhesive sheet 21. May be. Even in such a fitting mode, as long as the fitting protrusion 12 is loosely fitted in the fitting depression 21Hb, the position of the adhesive sheet 21 can be suppressed from shifting with respect to the base 11.

[Adhesive sheet 21]
The area of the supported surface 21S2 may be smaller than the area of the supporting surface 11S, or may be larger than the area of the supporting surface 11S. Further, the shape of the supported surface 21S2 may be different from that of the supporting surface 11S.

  From the viewpoint of expanding the portion of the pressure-sensitive adhesive sheet 21 supported by the substrate 11, the area of the supported surface 21S2 is equal to or larger than the area of the supporting surface 11S, and the shape of the supported surface 21S2 is the supporting surface. It is preferably similar to 11S.

  On the other hand, if a part of the second adhesive portion Sb on the adhesive surface 21S1 protrudes from the support surface 11S, the second adhesive portion Sb is covered when the second adhesive portion Sb is attached to the skin surface Sc. The user can also press the support surface 21S2 directly toward the surface Sc of the skin. Therefore, from the viewpoint of improving the handleability when adhering the adhesive sheet 21 and the skin surface Sc, the area of the supported surface 21S2 is smaller than the area of the supporting surface 11S, or the supported surface 21S2 has. The shape is preferably different from the support surface 11S.

  -The number of fitting depressions 21Hb is not limited to two, and may be one or three or more as long as it is equal to or more than the number of fitting projections 12. In addition, in the viewpoint which suppresses that the rigidity of the adhesive sheet 21 becomes low too much, it is preferable that the number of the fitting depressions 21Hb is two or less.

  -The shape of the fitting recess 21Hb is not limited to the curved shape extending along the supported surface 21S2 when viewed from the direction facing the supported surface 21S2, but is a shape in which the fitting protrusion 12 is loosely fitted. A circular shape, a rectangular shape, or a polygonal line shape may be sufficient.

  -The shape which fitting hollow 21Hb has may be a multistage through-hole in the thickness direction of adhesive sheet 21. At this time, the size of the hole formed in the base material sheet 22 and the size of the hole formed in the adhesive layer 23 may be different from each other in the fitting recess 21Hb. A through hole may be formed. Further, the shape of the fitting recess 21Hb may be a bottomed hole or groove. At this time, the fitting recess 21Hb may be a hole or a groove formed only in the base sheet 22, or formed only in a part of the base sheet 22 in the thickness direction of the base sheet 22. It may be a hole or a groove.

  Among these fitting recesses 21Hb, the adhesive layer 23 can be formed prior to the formation of the fitting recess 21Hb if the fitting recess 21Hb penetrates the base sheet 22 and the adhesive layer 23. Since it is possible, it is also easy to employ the punching process for the pressure-sensitive adhesive sheet 21.

  -The position of the fitting recess 21Hb may be biased on the virtual ring surrounding the first adhesive portion Sa as long as the fitting protrusion 12 can be loosely fitted, and the circumferential direction of the ring It may be equally distributed along. Further, the position of the fitting recess 21Hb may be the first bonding portion Sa, or may be both on the virtual ring surrounding the first bonding portion Sa and the first bonding portion Sa.

[Administration sheet 31]
The shape of the microprotrusions 32 is not limited to a conical shape, and may be, for example, a pyramid shape, a frustum shape, a prismatic shape, a cylindrical shape, and different from each other. It may be a combination of shapes. The microprotrusions 32 may have a shape in which two or more solids are combined, for example, a shape in which cones are stacked on a pillar, and constrictions and steps are formed on the side walls of the microprotrusions 32. It may be.

  The shape of the microprojections 32 is not limited to a needle shape, and may be a blade shape. For example, the microprojection has a triangular prism extending along one direction, one of three rectangular side surfaces of the triangular prism is in contact with the projection forming surface, and one side shared by the two side surfaces is microscopic. The protrusion 32 may have a shape that functions as a blade.

  -The several microprotrusion 32 may be comprised from the single shape, and may be comprised from the mutually different shape. In short, the plurality of microprotrusions 32 only need to have a shape that allows a passage for administering the administration substance to be formed in the skin.

-The number of the microprotrusions 32 positioned on the protrusion forming surface 31S1 is appropriately set from one or more ranges as the number that ensures the dose of the medicine.
Each of the plurality of microprotrusions 32 is appropriately arranged in an arrangement suitable for drug administration, and may be regularly arranged on the protrusion forming surface 31S1 or may be irregularly arranged. Good.

  The mode in which the microprotrusions hold the administration substance is, for example, that grooves or holes are formed in the microprotrusions 32, and this groove or hole is filled with a powdery or liquid administration substance or a freeze-dried administration substance. It may be.

  In addition, for example, a connection passage that connects a hole penetrating the microprojections 32 and a syringe or the like may be separately provided, and the administration substance may be administered into the skin from the syringe through this connection passage. In the case of such administration, the microprotrusions 32 do not have to hold the administration substance until the microprotrusions 32 are stabbed into the skin. At this time, the connection passage may be connected to the administration sheet 31 through the through hole formed in the base body 11 or the through hole formed in the adhesive sheet 21, or the connection passage is directly connected to the administration sheet 31 and connected. The adhesive sheet 21 and the substrate 11 may be located at a position where the passage is removed.

[Fitting body and adherend]
The base body 11 may be a fitting body in which a fitting recess is formed, and the adhesive sheet 21 may be a fitting body having a fitting protrusion.
For example, as shown in FIG. 7, a fitting recess 11 </ b> H that is two recesses is formed on the support surface 11 </ b> S of the base 11. On the supported surface 21S2 of the pressure-sensitive adhesive sheet 21, a fitting projection 21T that is a projection loosely fitted in the fitting depression 11H protrudes toward the base 11.

  Also by the loose fitting of the fitting protrusion 21T with respect to the fitting depression 11H, the displacement of the adhesive sheet 21 with respect to the base body 11 is suppressed by the loose fitting of the fitting protrusion 12 with respect to the fitting depression 21Hb.

  The pressure-sensitive adhesive sheet 21 includes both a fitting projection 21T located on the supported surface 21S2 and a fitting depression 21Hb formed on the supported surface 21S2, and the base 11 is a fitting projection located on the supporting surface 11S. 12 and a fitting recess 11H formed on the support surface 11S may be provided. Then, the fitting projection 21T located on the supported surface 21S2 is loosely fitted in the fitting depression 11H formed on the supporting surface 11S, and the fitting projection 12 formed on the supporting surface 11S is supported by the supported surface 21S2. It may be loosely fitted in the fitting recess 21Hb formed in the.

  DESCRIPTION OF SYMBOLS 11 ... Base | substrate, 11H ... Fitting recess, 11S ... Support surface, 12 ... Fitting protrusion, 21 ... Adhesive sheet, 21Hb ... Fitting recess, 21S1 ... Adhesive surface, 21S2 ... Supported surface, 21T ... Fitting protrusion, 31 An administration sheet, 31S1, a projection forming surface, 31S2, an adherend surface, 32, a minute projection, 41, a release sheet.

Claims (8)

A dosing sheet having a projection forming surface and a surface to be bonded which is a surface opposite to the projection forming surface, and a microprojection is located on the projection forming surface;
A pressure-sensitive adhesive sheet, and a pressure-sensitive adhesive sheet having a supported surface that is opposite to the pressure-sensitive adhesive surface, and a part of the pressure-sensitive adhesive surface to which the surface to be bonded of the administration sheet is bonded;
A support surface that supports the pressure-sensitive adhesive sheet, and a substrate having higher rigidity than the pressure-sensitive adhesive sheet;
With
Either one of the pressure-sensitive adhesive sheet and the base body is a fitting body,
Other than the fitting body among the pressure-sensitive adhesive sheet and the base body, it is an adherend,
The fitting body includes a fitting projection extending toward the fitting body,
The said to-be-adhered body is provided with the hollow for fitting by which the said fitting protrusion was loosely fitted. The fitting body is the base body,
The fitting projection is located on the support surface;
The adherend is the pressure-sensitive adhesive sheet,
The transdermal administration device according to claim 1, wherein the fitting depression is a depression formed in the supported surface. The fitting recess is a through hole that penetrates the adhesive sheet from the supported surface to the adhesive surface,
The transdermal administration device according to claim 2, wherein the fitting protrusion protrudes from the adhesive surface. Based on the adhesive surface,
The transdermal administration device according to claim 3, wherein the fitting protrusion protrudes beyond the minute protrusion. The transdermal administration device according to claim 2 or 3, wherein an index relating to use of the transdermal administration device is attached to a distal end surface of the fitting protrusion. The transdermal administration device according to any one of claims 1 to 5, wherein a distal end surface of the fitting projection has a curvature that is convex toward the distal end. A plurality of the above-mentioned fitting projections;
A plurality of the fitting depressions,
The plurality of fitting projections are arranged at positions sandwiching the administration sheet,
The transdermal administration device according to any one of claims 1 to 6, wherein the plurality of fitting depressions are disposed at positions sandwiching the administration sheet. Further comprising a release sheet covering the adhesive surface,
The transdermal administration device according to any one of claims 1 to 7, wherein the release sheet is attached to a portion other than a portion facing the adherend surface in the adhesive surface.

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