JP2016108306A - External preparation composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve the problem that formulating and designing tea tree oil essential oil in an external preparation composition is limited because the tea tree oil is oily and is water-insoluble.SOLUTION: The invention can solve the subject by the means of (1) an external preparation composition characterized by containing a micro emulsion liquid of tea tree oil; and (2) the external preparation composition described in (1) wherein 0.001-95.0 mass% of the micro emulsion liquid of tea tree oil is contained.

Description

  The present invention relates to an external preparation composition containing a microemulsion liquid of tea tree oil. Here, the topical composition is a cosmetic such as shampoo, rinse, facial cleansing foam, etc., basic cosmetics such as creams, lotions, cosmetics, makeup cosmetics such as foundations and lipsticks, hair cosmetics such as hair styling agents and hair restorers. , Aromatic cosmetics, body cosmetics and other cosmetics, quasi drugs and pharmaceuticals.

  Oil preparations are blended in external preparation compositions such as cleaning agents, cosmetics, and pharmaceuticals for the purpose of suppressing the transpiration of moisture from the skin, setting the hair, and improving the feeling of use. Essential oils extracted from plants are blended for the purpose of antioxidant, cell activation, antipruritic, antibacterial, and the like.

  Among these essential oils, tea tree oil has been widely used as a traditional medicine among indigenous people because it is obtained mainly from shrubs native to Australia and has strong antibacterial properties. However, since this tea tree oil is oily and insoluble in water, it becomes an unstable composition that easily separates even if it is forcibly blended into an aqueous external preparation composition, or even when a surfactant is used in combination. In some cases, it is difficult to select the optimum one, and there are limitations in designing the formulation as an external preparation composition.

  The present invention has been made under the circumstances as described above, and attempts to solve the restrictions on the tea tree oil formulation design by blending tea tree oil as a microemulsion liquid compatible with water. It is.

The present invention
(1) External preparation composition characterized by containing a microemulsion liquid of tea tree oil (2) The microemulsion liquid of the tea tree oil is 0.001 to 95.0% by mass (1) The above-mentioned problems are solved by the means for external preparation.

  The tea tree oil microemulsion liquid of the present invention is a water mixture in a very stable state by making it a “microemulsion liquid”. Therefore, the antibacterial, photoaging and anti-inflammatory functions of the tea tree oil itself It is possible to design and manufacture a stable composition for external use with a wide range of dosage forms.

  Moreover, since it mix | blends as a "microemulsion liquid", it can design and manufacture the external preparation composition with a refreshing use feeling, although the main component is an essential oil.

Hereinafter, the present invention will be described in detail.
The tea tree oil used in the “tea tree oil microemulsion solution” of the present invention is obtained as an essential oil by steam distillation of leaves of a shrub (scientific name Melaleuca alternifolia), which is called a tea tree that grows mainly in Australia. This "microemulsion liquid" of tea tree oil can be obtained by adding a surfactant, a stabilizer and water and using a conventional method for producing a microemulsion.
For example, 50 parts of tea tree oil can be obtained by mixing polysorbate 20, 30 parts of PEG-40 hydrogenated castor oil, stabilizers such as tocopherols, chelating agents, and the remainder of purified water. It can be obtained under the trade name “Merafresh T10-WS”, a commercially available raw material from Southern Cross Botanicals of the country.

  In the external preparation composition of the present invention, the preferred blending amount of the tea tree oil microemulsion liquid depends on its dosage form and function, but is 0.001 to 95.0 mass%, more preferably 0 in the external preparation composition. 0.1 to 10.0% by mass. If it is less than 0.001 mass%, it is insufficient to exhibit the function as an antibacterial component. Moreover, even if it mixes exceeding 95.0 mass%, the effect corresponding to a compounding quantity cannot be expected.

  In addition to the above essential components, the external preparation composition of the present invention can be blended with other components usually used in external preparation compositions such as cosmetics and pharmaceuticals. Examples of such other components include the following components. The external preparation composition of the present invention is produced according to a conventional method by blending one or more of these essential components with the above essential components.

  The following can be mentioned as an oil-based component. Olive oil, camellia oil, wild tea flower oil, macadamia nut oil, castor oil, avocado oil, wheat germ oil, safflower oil, moringa oil, cottonseed oil, soybean oil, tea seed oil, sunflower oil, evening primrose oil, palm oil, palm oil, palm Oils such as nuclear oil, beef tallow, horse fat, cacao butter, owl, etc., waxes such as carnauba wax, candelilla wax, jojoba oil, beeswax, lanolin, liquid paraffin, paraffin, petrolatum, ceresin, microcrystalline wax, squalane, etc. Higher fatty acids such as hydrocarbon, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, Batyl alcohol, lanolin al Alcohol, cholesterol, phytosterol and other higher alcohols, isopropyl myristate, 2-octyldodecyl myristate, cetyl octanoate, cetyl 2-ethylhexanoate, pentaerythritol tetraester, diisostearyl malate, triethyl citrate, stearic acid Esters such as cholesteryl, phytostearyl isostearate, ethoxydiglycol behenate, ethoxydiglycol oleate, coconut oil fatty acid butylene glycol, methylpolysiloxane, methylphenylpolysiloxane, cyclic dimethylsilicone oil, alkyl-modified silicone, amino-modified Silicone such as silicone, three-dimensional network structure silicone, and silicone rubber.

  The following can be mentioned as a polyhydric alcohol. Glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, diethylene glycol, polyethylene glycol, ethoxydiglycol, pentanediol, hexanediol, heptanediol, octanediol and the like.

  The following can be mentioned as saccharides. Sorbitol, mannitol, sucrose, lactose, xylitol, maltitol, trehalose, etc.

  Examples of the polymer compound include the following. Natural polymers such as guar gum, quince seed, pectin, mannan, agar, carrageenan, xanthan gum, curdlan, gelatin, casein, collagen, alkaligenes acidic polysaccharide, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, stearoxyhydroxypropylmethylcellulose , Semi-synthetic polymers such as carboxymethyl cellulose and alginate, synthetic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, sodium polyacrylate, POE / POP copolymer, bentonite, hectorite, sodium magnesium silicate, etc. Inorganic thickeners, amphoteric methacrylate copolymers, cationized cellulose, polydimethylpiperidinium chloride, Vinyl acetate, polyacrylic acid ester copolymer, polyvinyl acetate, nitrocellulose, polymeric silicones, film-forming polymer of silicone resin or the like.

  The following can be mentioned as surfactant. Higher fatty acid soap, alkylbenzene sulfonate, alkyl sulfate, POE alkyl ether sulfate, acyl N-methyl taurate, alkyl ether phosphate, N-acyl amino acid salt, α-olefin sulfonate, POE alkyl ether Anionic surfactant such as carboxylate, cationic surfactant such as alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, benzalkonium chloride, alkyldimethylaminoacetic acid betaine, alkylamidopropyldimethylaminoacetic acid betaine, 2-alkyl -N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lecithin, lysolecithin and other amphoteric surfactants, glycerin fatty acid ester, polyglycerin fatty acid ester, POE glycerin Phosphorus fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE castor oil / hardened castor oil, POE alkyl ether, POEPOP alkyl ether, POE alkylamine / fatty acid amide, PEG fatty acid ester, alkylamine oxide, etc. Nonionic surfactant.

  Examples of the colorant, powder, and granule include the following. Inorganic pigments such as black iron oxide, red iron oxide, yellow iron oxide, ultramarine, carbon black, pearl pigments, organic pigments, tar dyes, natural dyes, talc, kaolin, mica, magnesium aluminum silicate, silicic acid anhydride, oxidation Granules made of inorganic powders such as titanium, mica titanium, zinc white and zeolite, organic powders such as nylon powder, polyethylene powder, cellulose powder and silk powder, nylon, polyethylene, cellulose, wax, fatty acid ester and natural products.

  The following can be mentioned as animal and plant extracts. Mucopolysaccharides such as sodium hyaluronate, chondroitin sulfate sodium, animal extracts such as chitin / chitosan, collagen, elastin, peptides, asparagopsis armata extract, aloe extract, psyllium extract, barbet extract, barley extract, bark extract, kakadu plum Extract, chamomile extract, licorice extract, yellow rose sennici extract, caviar lime extract, walnut seed extract, caper extract, chicory extract, birch extract, yarrow extract, mint extract, tasmanian pepper fruit extract, tea Extract, Toki Extract, Garlic Extract, Carrot Extract, Camelis Extract, Hinokithiol, Loquat Leaf Extract, Beech Tree Bud Extract, Loofah Extract, Safflower Extract, Manuka Yl, peach leaf extract, Yanagiran extract, eucalyptus extract, plant extract rose water and the like.

  The following can be mentioned as a mineral extract. Extracts such as peacock stone, rhombomanganese ore, rhombozinc ore and hematite.

  Examples of the bactericidal / preservative include the following. Benzoic acid, sodium benzoate, salicylic acid, sorbic acid, paraoxybenzoic acid ester (methylparaben, ethylparaben, butylparaben, etc.), trichlorocarbanilide, phenoxyethanol, hexachlorophene, benzalkonium chloride, chlorhexidine, zinc pyrithione, triclosan, methylchloro Isothiazolinone, methylisothiazolinone, etc.

  The following can be mentioned as antioxidant. Gallic acid ester, sodium bisulfite, etc., phosphoric acid, citric acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, phytic acid, etc.

  The following can be mentioned as a metal sequestering agent. Edetate, hydroxyethanediphosphonic acid, phosphoric acid, citric acid, succinic acid, phytic acid, etc.

  The following can be mentioned as a ultraviolet absorber. Benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, paraaminobenzoic acid derivatives such as paraaminobenzoic acid and octylparadimethylaminobenzoate, ethylhexyl paramethoxycinnamate, diparamethoxy Methoxycinnamic acid derivatives such as mono-2-ethylhexanoic acid glyceryl cinnamate, salicylic acid derivatives such as octyl salicylate, urocanic acid and the like.

  The following can be mentioned as a pH adjuster. Alkaline agents such as sodium hydroxide, potassium hydroxide, sodium carbonate, aqueous ammonia, monoethanolamine, triethanolamine, aminomethylpropanol, and acids such as citric acid and phosphoric acid.

  Examples of various drugs include the following. Whitening agents such as arbutin, kojic acid, vitamin C, assembly extract, γ-oryzanol, capsicum tincture, nicotinic acid benzyl ester, estradiol, ethinyl estradiol, pantothenic acid, photosensitizing agent 301 and other hair growth agents, β-glycyrrhetinic acid, Glycyrrhizic acid derivatives, allantoin, ε-aminocaproic acid, zinc oxide, aluminum sulfate, tannic acid, lactic acid, menthol, corticosteroids, antihistamines and other rough skin prevention agents, sulfur, salicylic acid, resorcin, benzalkonium chloride, halocarban, etc. Anti-acne agents, chlorohydroxyaluminum, aluminum chloride, antiperspirants such as zinc oxide, vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B such as vitamin B12, vitamin B15 and its derivatives, ascorbic acid, ascorbic acid phosphate (salt), vitamin C such as ascorbic acid dipalmitate, α-tocopherol, β-tocopherol, γ -Vitamin E such as tocopherol, vitamin E acetate, vitamin E nicotinate, vitamins such as vitamin D, vitamin H, pantothenic acid, panthetin, glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, aspartic acid Amino acids such as asparagine, glutamine, taurine, arginine, histidine and their hydrochlorides.

  The dosage form of the external preparation composition of the present invention can take a form usually used as an external preparation composition, such as liquid, emulsion, cream, gel, aerosol foam, solid, and powder dispersion.

  Next, the present invention will be described more specifically with reference to examples. In addition, this invention is not limited only to these Examples. Unless otherwise specified, the amount is shown in mass%.

Example 1 Acne Skin Cream 1,3-BG 5.0
Glycerin 3.0
Xanthan gum 0.3
Cetanol 3.0
Macadamia nut oil 5.0
Jojoba oil 3.0
Octyldodecyl myristate 3.0
Dimethicone 0.5
Glyceryl monostearate 2.0
POE glyceryl isostearate 2.0
Merafresh T10-WS ^{* 1)} 8.0
Preservative appropriate amount Chelating agent appropriate amount Fragrance appropriate amount
Purified water remaining
100.0
* 1) "Merafresh T10-WS": Tea tree oil microemulsion (product of Southern Cross Botanicals)

Example 2 Latex Glycerin 4.0
1,3-BG 6.0
Dimethicone 5.0
Cyclomethicone 5.0
Squalane 5.0
Carboxyvinyl polymer 0.1
Acrylic acid / methacrylic acid acrylic copolymer 0.1
Potassium hydroxide (10% aqueous solution) appropriate amount Polyglyceryl myristate-10 2.0
Lecithin 0.3
Merafresh T10-WS ^{* 1)} 3.0
Preservative appropriate amount Chelating agent appropriate amount Fragrance appropriate amount
Purified water remaining
100.0

Example 3 lotion 1,3-BG 6.0
Glycerin 4.0
Jojoba oil 0.1
POE (20) sorbitan monolaurate 0.5
POE (15) lauryl alcohol ether 0.5
Ethanol 10.0
Merafresh T10-WS ^{* 1)} 0.1
Preservative appropriate amount Chelating agent appropriate amount Fragrance appropriate amount
Purified water remaining
100.0

Example 4 Cosmetic liquid Macadamia nut oil 2.00
Glycerin 5.00
Carboxyvinyl polymer 0.35
Sodium hydroxide (10% aqueous solution) appropriate amount POE oleyl alcohol ether 3.00
Merafresh T10-WS ^{* 1)} 5.00
Pentylene glycol 0.50
Chelating agent appropriate amount perfume appropriate amount
Purified water remaining
100.00

Example 5 Acne Skin Gel Dipropylene Glycol 7.0
PEG1500 8.0
Carboxyvinyl polymer 0.4
Methylcellulose 0.2
POE (15) oleyl alcohol ether 1.0
Potassium hydroxide (10% aqueous solution) appropriate amount Merafresh T10-WS ^{* 1)} 0.8
Preservative appropriate amount Chelating agent appropriate amount Fragrance appropriate amount
Purified water remaining
100.0

Example 6 Hair Tonic 1,3-BG 3.0
Glycerin 0.5
Ethanol 40.0
Merafresh T10-WS ^{* 1)} 2.0
Chelating agent appropriate amount perfume appropriate amount
Purified water remaining
100.0

Example 7 Shampoo Lauryl polyoxyethylene (3) sulfate
Triethanolamine salt (30% solution) 10.0
Lauryl polyoxyethylene (3) sulfate
Sodium salt (30% solution) 20.0
Lauryl sulfate sodium salt (30% solution) 5.0
Lauroyl monoethanolamide 3.0
Lauryldimethylaminoacetic acid betaine (35% solution) 7.0
Ethylene glycol distearyl 2.0
Propylene glycol 5.0
Merafresh T10-WS ^{* 1)} 6.0
Preservative appropriate amount Chelating agent appropriate amount Fragrance appropriate amount
Purified water remaining
100.0

Example 8 Body Soap Glycerin 20.0
Lauric acid 2.5
Myristic acid 5.0
Palmitic acid 2.5
Oleic acid 2.5
1,3-BG 8.0
Cocoyl diethanolamide 1.0
Potassium hydroxide (10% aqueous solution) appropriate amount Merafresh T10-WS ^{* 1)} 2.0
Chelating agent appropriate amount perfume appropriate amount
Purified water remaining
100.0

Example 9 Cleansing Foam Glycerin 10.0
Sorbitol 70% solution 15.0
1,3BG 10.0
POE (20) Glycerol monostearate 2.0
Lauric acid 5.0
Myristic acid 14.0
Stearic acid 12.0
Potassium hydroxide (10% aqueous solution) appropriate amount Merafresh T10-WS ^{* 1)} 1.0
Chelating agent appropriate amount perfume appropriate amount
Purified water remaining
100.0

Example 10 Deodorant Lotion Aluminum Chlorohydrate 10.0
Ethanol 60.0
1,3BG 3.0
Benzalkonium chloride 0.2
POE (40) hydrogenated castor oil 0.5
Xanthan gum 0.3
Merafresh T10-WS ^{* 1)} 5.0
Perfume
Purified water remaining
100.0

Claims (2)

  An external preparation composition comprising a tea tree oil microemulsion solution.   The external preparation composition according to claim 1, wherein the tea tree oil microemulsion is 0.001 to 95.0 mass%.