JP2009196969A - Skin preparation for external use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin preparation for external use formulated from an extract having the three functions of cell activation, anti-inflammatory action, and antibacterial activity, being not problematic in stability and pharmaceutical incompatibility, and satisfying comfortableness in use. <P>SOLUTION: A skin preparation for external use containing an extract of Asparagopsis Armata is provided. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a skin external preparation containing an extract of seaweed asparagopsis almata (red algae). More specifically, the present invention relates to a skin external preparation excellent in cell activation, anti-inflammatory action, and antibacterial properties. The skin external preparation as used in the present invention includes cosmetics such as skin care cosmetics, makeup cosmetics, body cosmetics and the like.

  In recent years, functions required for external preparations for skin, particularly skin care cosmetics, have come to include a variety of functions such as moisturizing, softening, blood circulation promotion, whitening, cell activation, anti-inflammatory, antioxidant, anti-aging, antibacterial and the like.

  In this trend, cosmetic engineers select and formulate ingredients and drugs that meet each required function, and pursue formulation that is stable and sufficiently functional in the base. ing.

  For example, various types of polyhydric alcohols, saccharides, amino acids, etc. for “moisturizing”, ascorbic acid derivatives, arbutin, licorice extract, etc. for “whitening”, benzoic acid derivatives, sorbic acid, phenoxyethanol for “antibacterial” At present, the formulation is being promoted while confirming that it is not contraindicated by selecting multiple types of raw materials and drugs.

  However, it has been very difficult to formulate such a plurality of raw materials / drugs with no problems in terms of stability, contraindications, function expression, and satisfaction in use.

  In addition, when a plurality of these raw materials and medicines are used, a proportionally expensive prescription must be obtained.

  The present invention has been made under the circumstances as described above, and is excellent in three functions of cell activation, anti-inflammatory action, and antibacterial action by blending an extract of asparagopsis almata (red algae). It was found that a topical skin preparation could be obtained and completed.

  The present invention is an external preparation for skin characterized by containing an extract of Asparagopsis Armata.

  The skin external preparation of the present invention is a skin external preparation having three types of functions of cell activation, anti-inflammatory action, and antibacterial, and is characterized in that the three types of functions are exhibited by blending one raw material. There is.

  The external preparation for skin of the present invention also has a certain antibacterial and antiseptic property even if so-called preservatives are not included in the ingredients, so that the amount of so-called preservatives can be reduced or removed.

  FIG. 1 shows the inhibitory effect of an asparagopsis almata extract on bacteria, yeast and mold. A challenge test under an environment of pH 5 or less shows that the inhibitory effect has already been developed one day later.

  FIG. 2 shows the cell activation effect of an extract of Asparagopsis almata. It can be seen that the activity increases in proportion to the concentration of the extract of Asparagopsis almata.

  FIG. 3 shows the anti-inflammatory effect of an extract of Asparagopsis almata. It can be seen that the inhibitory activity of IL-1α is increased in proportion to the concentration of the extract of Asparagopsis almata, and an anti-inflammatory effect is expressed.

  Hereinafter, the present invention will be described in detail. Asparagopsis Armata used in the present invention is an extract of red algae called coral seaweed that grows mainly on the Atlantic coast. The extract contains a protide, a nitrogen-containing organic substance, a reducing sugar, mannitol, a silicon compound, a trace element compound such as Na, K, Ca, Mg, and Cu, a halogen (Br, I, Cl) compound, and the like.

  In the present invention, it is considered that these components contained in the extract individually or synergistically exert three functions of cell activation, anti-inflammatory action, and antibacterial action, and particularly halides contribute to antibacterial action. However, the detailed mechanism of action has not been elucidated.

スアルマタエキス ９０％以上）として市販されている。The extract can be obtained as a tan water-soluble powder, for example, Excimol

SUARMATA extract 90% or more) is commercially available.

  The compounding amount of the extract of asparagopsis almata of the present invention is 0.01 to 90.0% by weight, preferably 0.1 to 10.0% by weight, based on the total amount of the external preparation for skin. When the amount is less than 0.01% by weight, the above function is not exhibited, and even if the amount exceeds 90.0% by weight, a function commensurate with the amount cannot be expected.

  As long as the dosage form of the external preparation for skin of the present invention is a form used as a normal external preparation for skin, such as liquid, emulsion, cream, gel, aerosol foam, mist / spray, solid, powder dispersion, etc. It can also take the form.

  In addition to the above essential components, other components that are usually used in skin external preparations such as cosmetics and pharmaceuticals can be blended in the external preparation for skin of the present invention. Examples of such other components include the following components. The external preparation for skin of the present invention is produced according to a conventional method by blending one or two or more of these essential ingredients.

  The following can be mentioned as an oil-based component. Olive oil, camellia oil, macadamia nut oil, castor oil, avocado oil, wheat germ oil, safflower oil, moringa oil, cottonseed oil, soybean oil, tea seed oil, sunflower oil, evening primrose oil, palm oil, palm oil, palm kernel oil, Fats and oils such as beef tallow, horse fat, cacao butter, owl, carnauba wax, candelilla wax, jojoba oil, beeswax, lanolin and other waxes, liquid paraffin, paraffin, petrolatum, ceresin, microcrystalline wax, squalane hydrocarbons, Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, batyl alcohol Lanolin alcohol, cholesterol Alcohol, higher alcohols such as phytosterol, isopropyl myristate, 2-octyldodecyl myristate, cetyl octanoate, cetyl 2-ethylhexanoate, pentaerythritol tetraester, diisostearyl malate, triethyl citrate, cholesteryl stearate, Esters such as phytostearyl isostearate, ethoxydiglycol behenate, ethoxydiglycol oleate, coconut oil fatty acid butylene glycol, methylpolysiloxane, methylphenylpolysiloxane, cyclic dimethylsilicone oil, alkyl-modified silicone, amino-modified silicone, Silicone such as three-dimensional network structure silicone and silicone rubber.

  The following can be mentioned as a polyhydric alcohol. Glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, diethylene glycol, polyethylene glycol, ethoxydiglycol, pentanediol, heptanediol, octanediol and the like.

  The following can be mentioned as saccharides. Sorbitol, mannitol, sucrose, lactose, xylitol, maltitol, trehalose, etc.

  Examples of the polymer compound include the following. Guar gum, quince seed, pectin, mannan, agar, carrageenan, xanthan gum, curdlan, gelatin, casein, collagen and other natural polymers, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, alginate, etc. Synthetic polymer, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, polyacrylic acid soda, POE / POP copolymer and other synthetic polymers, bentonite, hectorite, magnesium sodium silicate and other inorganic thickeners, amphoteric methacrylic Acid ester copolymer, cationized cellulose, polydimethylpiperidinium chloride, polyvinyl acetate, polyacrylic ester copolymer, polyvinyl acetate, nitrocellulose Scan, polymeric silicones, film-forming polymer of silicone resin or the like.

  The following can be mentioned as surfactant. Higher fatty acid soap, alkylbenzene sulfonate, alkyl sulfate, POE alkyl ether sulfate, acyl N-methyl taurate, alkyl ether phosphate, N-acyl amino acid salt, α-olefin sulfonate, POE alkyl ether Anionic surfactants such as carboxylates, cationic surfactants such as alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, benzalkonium chloride, alkyldimethylaminoacetic acid betaines, alkylamidopropyldimethylaminoacetic acid betaines, 2-alkyl-N -Amphoteric surfactants such as carboxymethyl-N-hydroxyethylimidazolinium betaine, glycerin fatty acid ester, polyglycerin fatty acid ester, POE glycerin fatty acid ester, sorbi Nonionic surfactants such as styrene fatty acid ester, POE sorbitan fatty acid ester, POE sorbite fatty acid ester, POE castor oil / hardened castor oil, POE alkyl ether, POEPOP alkyl ether, POE alkylamine / fatty acid amide, PEG fatty acid ester, alkylamine oxide Agent.

  Examples of the colorant, powder, and granule include the following. Inorganic pigments such as black iron oxide, red iron oxide, yellow iron oxide, ultramarine, carbon black, pearl pigments, organic pigments, tar dyes, natural dyes, talc, kaolin, mica, magnesium aluminum silicate, silicic acid anhydride, oxidation Granules made of inorganic powders such as titanium, mica titanium, zinc white and zeolite, organic powders such as nylon powder, polyethylene powder, cellulose powder and silk powder, nylon, polyethylene, cellulose, wax, fatty acid ester and natural products.

  The following can be mentioned as animal and plant extracts. Mucopolysaccharides such as sodium hyaluronate and chondroitin sulfate, animal extracts such as chitin / chitosan, collagen, elastin, and peptides, aloe extract, prunus extract, nettle extract, chamomile extract, licorice extract, walnut seed extract, shikon extract, birch Extract, Achillea millefolium extract, Pepper extract, Tea extract, Toki extract, Garlic extract, Carrot extract, Hamamelis extract, Hinokithiol, Loquat leaf extract, Beech tree bud extract, Loofah extract, Safflower extract, Willow extract, Caper extract , Plant extracts such as citrus nectar extract, walnut seed extract, peach leaf extract, eucalyptus extract, rose water, etc.

  The following can be mentioned as a mineral extract. Extracts such as peacock stone, rhombomanganese ore, rhombozinc ore and hematite.

  Examples of the bactericidal / preservative include the following. Benzoic acid, sodium benzoate, salicylic acid, sorbic acid, paraoxybenzoic acid ester (ethyl paraben, butyl paraben, etc.), trichlorocarbanilide, phenoxyethanol, hexachlorophene, benzalkonium chloride, chlorhexidine, zinc pyrithione, triclosan and the like.

  The following can be mentioned as antioxidant. Gallic acid ester, sodium bisulfite, etc. Examples of the antioxidant assistant include the following. Phosphoric acid, citric acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, phytic acid, EDTA, etc.

  Examples of the metal sequestering agent include the following. Edetate, hydroxyethanediphosphonic acid, phosphoric acid, citric acid, succinic acid, phytic acid, etc.

  The following can be mentioned as a ultraviolet absorber. Benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, paraaminobenzoic acid derivatives such as paraaminobenzoic acid and octylparadimethylaminobenzoate, octyl paramethoxycinnamate, diparamethoxy Methoxycinnamic acid derivatives such as mono-2-ethylhexanoic acid glyceryl cinnamate, salicylic acid derivatives such as octyl salicylate, urocanic acid and the like.

  The following can be mentioned as a pH adjuster. Sodium hydroxide, potassium hydroxide, sodium carbonate, aqueous ammonia, monoethanolamine, triethanolamine, alkali agents such as 2-amino-2-methyl-1-propanolamine, and acids such as citric acid and phosphoric acid.

  The following can be mentioned as various chemical | medical agents. Whitening agents such as arbutin, kojic acid, vitamin C, assembly extract, gamma-oryzanol, capsicum tincture, nicotinic acid benzyl ester, estradiol, ethinyl estradiol, pantothenic acid, photosensitizer 301 and other hair-growing agents, β-glycyrrhetic acid, Glycyrrhizic acid derivatives, allantoin, ε-aminocaproic acid, zinc oxide, aluminum sulfate, tannic acid, lactic acid, menthol, corticosteroids, antihistamines, and other rough skin prevention agents, sulfur, salicylic acid, resorcin, benzalkonium chloride, halocarban, etc. Anti-acne agents, chlorohydroxyaluminum, aluminum chloride, antiperspirants such as zinc oxide, vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B such as vitamin B12, vitamin B15 and its derivatives, ascorbic acid, ascorbic acid phosphate ester (salt), vitamin C such as ascorbic acid dipalmitate, α-tocopherol, β-tocopherol, γ -Vitamin E such as tocopherol, vitamin E acetate, vitamin E nicotinate, vitamins such as vitamin D, vitamin H, pantothenic acid, panthetin, glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, aspartic acid Amino acids such as asparagine, glutamine, taurine, arginine, histidine and their hydrochlorides.

  Next, the present invention will be described more specifically with reference to examples. In addition, this invention is not limited only to these Examples. Unless otherwise specified, the blending amount is expressed in weight%.

Example 1 lotion ethanol 10.00
Jojoba oil 0.50
Glycerin 4.00
Camper 0.60
Asparcid P 0.50
Fragrance Appropriate amount Pigment Appropriate amount Purified water The rest lotion containing the above ingredients was produced according to a conventional method.

Example 2 Gel Carboxyvinyl Polymer 0.45
Sodium hydroxide (10% aqueous solution) 0.90
Ethanol 3.00
Glycerin 10.00
Cetyl 2-ethylhexanoate 3.00
Tocophenol acetate 0.30
Asparcid p 0.50
Methyl benzoate 0.10
Pigment appropriate amount Fragrance appropriate amount Purified water The rest The gel containing the above ingredients was produced according to a conventional method.

Example 3 Latex Squalane 2.00
Dimethylpolysiloxane 1.50
Moringa oil 1.00
Sorbitan monooleate 3.00
Cetyl alcohol 2.00
Dipropylene glycol 5.00
Asparcid p 0.50
1,2-octanediol 2.00
Phenoxyethanol 0.10
Dye Appropriate amount Perfume Appropriate amount Purified water The rest The emulsion containing the above ingredients was produced according to a conventional method.

Example 3 Cream Stearyl Alcohol 3.00
Cetyl alcohol 2.00
Stearic acid 1.50
Liquid paraffin 8.00
Octyldodecanol 0.50
Asparcid p 5.00
1,2-octanediol 3.00
Glycerin 8.00
PEG 1500 3.00
POE (25) cetyl alcohol ether 3.00
Glycerol monostearate 2.00
Perfume Appropriate amount Purified water The rest The cream containing the above ingredients was prepared according to a conventional method.

Example 4 Cosmetic liquid Macadamia nut oil 2.00
Glycerin 5.00
Carboxyvinyl polymer 0.35
Sodium hydroxide (10% aqueous solution) 0.80
POE oleyl alcohol ether 3.00
Asparcid p 5.00
Pentylene glycol 0.50
Fragrance Appropriate amount Purified water The rest A cosmetic liquid containing the above ingredients was prepared according to a conventional method.

    FIG. 1 shows the inhibitory effect of Asparagopsis alumata extract on bacteria, yeast and mold. The results of the challenge test inoculated with various microorganisms in an environment of less than pH 5 are shown with the number of viable bacteria on the vertical axis and the day after inoculation on the horizontal axis.     FIG. 2 shows the cell activation effect of an extract of Asparagopsis alumata. The vertical axis shows the absorbance by the neutral red method, and the horizontal axis shows the concentration of the asparagopsis almata extract.     FIG. 3 shows the anti-inflammatory effect of an extract of Asparagopsis almata. The vertical axis shows the inhibitory activity of IL-1α, and the horizontal axis shows the concentration of the extract of asparagopsis almata.

Claims (1)

An external preparation for skin comprising an extract of Asparagopsis Armata.

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