JP2016084472A - Hazardous substance deposition inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide simple means that prevents the deposition of hazardous substance such as pollen, house dust.SOLUTION: A hazardous substance deposition inhibitor comprising hydroxyalkyl chitosan or a salt thereof as an active ingredient is deposited on a target surface to prevent the deposition of hazardous substance.SELECTED DRAWING: None

Description

  The present invention relates to a harmful substance adhesion preventing agent, and more particularly to a harmful substance adhesion preventing agent containing hydroxyalkyl chitosan or a salt thereof as an active ingredient.

  In recent years, there has been a growing interest in harmful substances such as pollen and other allergens, viruses such as influenza virus, and particulate matter such as PM2.5, and many products have been developed to prevent them from being taken into the human body. Has been. For example, masks that prevent these harmful substances from being taken into the body and air purifiers that remove these harmful substances from the air in the living environment are widely used.

  However, wearing a mask imposes a burden on the user, such as blocking breathing, and thus means that can protect against harmful substances without such a burden is required. In addition, in the case of using an air cleaner, protection from harmful substances is possible only in a limited space, but means that enables protection from harmful substances in every space of daily life is required.

  Focusing on these demands, many of the harmful substances are charged, and charged particles such as cationized cellulose are attached to the periphery of the nostrils or the face and adsorbed or repelled by the harmful substances. Proposals have been made for products that suppress the uptake of food. In addition, a product has been proposed in which a substance that destroys or inactivates harmful substances such as titanium oxide along with charged particles is attached to the periphery of the nostril or the face, and the harmful substances adsorbed on the charged particles are further inactivated (patent) References 1 and 2).

  However, since these products electrically attach harmful substances to the body surface, there is a possibility that harmful effects may occur on the body surface. In addition, harmful substances may be separated from the body surface by some physical force and taken into the body. Furthermore, from the same point, harmful substances attached to the body surface can be brought into the room, separated from the body surface, then floated in the air again, and can be attached to the body surface or taken into the body again.

JP 2014-58479 A JP 2014-57247 A

  An object of the present invention is to prevent adhesion of harmful substances to the body and clothes by a simple method such as spraying, in contrast to the above-described prior art.

The present inventors have found that hydroxyalkylchitosan having no charge or a salt thereof has an effect of preventing adhesion of harmful substances, and has led to the present invention.
That is, the present invention provides a harmful substance adhesion preventing agent containing hydroxyalkyl chitosan or a salt thereof as an active ingredient.
Also provided is a method for preventing harmful substance adhesion by attaching hydroxyalkylchitosan or a salt thereof to a target surface.

The harmful substance adhesion preventive agent according to the present invention can prevent harmful substances such as pollen, influenza virus, and PM2.5 from adhering to the body surface and / or clothes, thus reducing harmful substances taken into the body. can do. Further, hydroxyalkyl chitosan or a salt thereof as an active ingredient can prevent the attachment of harmful substances regardless of the charged state of the harmful substances, so that the intake of various harmful substances into the body can be reduced. As shown in the examples described later, the harmful substance adhesion preventing agent according to the present invention has an excellent adhesion preventing effect as compared with the case where a charged substance is used as an active ingredient.
In addition, the harmful substance adhesion preventive agent according to the present invention does not drop makeup even if it is applied to a makeup face, and even if it is a target surface coated with a chemical other than the harmful substance adhesion preventive effect Can also be exhibited and has an advantage of excellent usability.

FIG. 1 is a graph showing the adhesion prevention rate of harmful substances between the sample of Example 1 and the samples of Comparative Examples 1 to 3. FIG. 2 is a graph showing the results of an answer when a subject who regularly suffers from hay fever was asked about the degree of the symptom improvement effect of hay fever after the sample of Example 2 was used once. FIG. 3 is a graph showing an answer result when a subject who regularly suffers from hay fever was asked about the degree of symptom improvement effect of hay fever after the sample of Example 2 was used continuously. FIG. 4 is a graph showing a result of an answer when a female subject sprayed with the sample of Example 2 in the long-term continuous test was inquired about makeup removal.

  The hazardous substance adhesion preventing agent according to the present invention contains hydroxyalkylchitosan or a salt thereof as an active ingredient in order to prevent adhesion of harmful substances to the target surface.

The harmful substances targeted for prevention of adhesion to the body and the like by the harmful substance adhesion preventing agent of the present invention include various substances harmful to the human body, such as pollen, house dust, fungi and allergens, influenza viruses, etc. And microparticulate materials called PM2.5, PM10, and the like. These harmful substances are usually in the form of particles and are suspended in the air. Many harmful substances are charged particles, and often have a positive or negative charge. Since the harmful substance adhesion preventive agent according to the present invention can prevent adhesion regardless of the presence or absence of electric charge, it is effective for both charged and uncharged particles, and can reduce the intake of various harmful substances into the body. . Therefore, according to the harmful substance adhesion preventing agent of the present invention, the symptoms caused by the above-mentioned harmful substances can be prevented. For example, to prevent symptoms such as allergies caused by hay fever, house dust, fungi, etc., influenza, other viral infections, and respiratory diseases such as bronchitis and asthma caused by PM2.5, PM10, etc. It is valid.
The harmful substance adhesion preventive agent of the present invention is particularly excellent in the effect of preventing the adhesion of pollen. Ginkgo biloba pollen, chickpea pollen, damselfly pollen, red linden pollen, zelkova pollen, blue whale pollen and mugwort pollen are targeted.

  “Hydroxyalkylchitosan” contained as an active ingredient in the present invention is an oxidized alkene adduct of chitosan. After removing calcium carbonate and protein from crustacean shells such as crabs, shrimp and krill, and insect shells such as beetles and grasshoppers to obtain chitin, the resulting chitin can be deacetylated. It can be obtained by adding alkene oxide to chitosan.

  Hydroxyalkyl chitosan or a salt thereof preferably contains 0.01 to 0.5% by mass of nitrogen, more preferably 0.05 to 0.5% by mass of nitrogen, and particularly preferably 0.1 to 0.5% by mass. Contains 0.25% by weight of nitrogen.

  The hydroxyalkyl group may have a linear, branched, or cyclic alkyl group, but a linear or branched hydroxyalkyl group having 1 to 8 carbon atoms is preferable in terms of solubility in water. A linear or branched hydroxyalkyl group having 1 to 6 carbon atoms is more preferable, and a linear or branched hydroxyalkyl group having 2 to 4 carbon atoms is particularly preferable.

  Specifically, as the hydroxyalkyl chitosan contained as an active ingredient in the present invention, for example, hydroxymethyl chitosan, hydroxyethyl chitosan, hydroxypropyl chitosan, hydroxybutyl chitosan, hydroxyisopropyl chitosan, hydroxypentane chitosan, hydroxyhexane chitosan, Examples thereof include hydroxyethyl hydroxypropyl chitosan, hydroxypropyl hydroxybutyl chitosan, dihydroxypropyl chitosan and salts thereof. Among these, hydroxypropyl chitosan is particularly preferable.

  Examples of the salt of hydroxyalkyl chitosan include monocarboxylates such as acetate, trifluoroacetate, butyrate, palmitate and stearate; polyvalent carboxylates such as fumarate and maleate; Oxycarboxylates such as lactate, tartrate, citrate, succinate, malonate; organic acid salts such as methanesulfonate, toluenesulfonate, tosylate; hydrochloride, sulfate, nitrate Inorganic salts such as hydrobromides and phosphates; salts with organic bases such as ammonium salts; alkali metal salts such as sodium and potassium; alkaline earth metal salts such as calcium and magnesium; metals such as aluminum And a salt with an inorganic base such as a salt thereof.

  Hydroxyalkyl chitosan generally has a weight average molecular weight in a wide range of 1 to 10 million, but the harmful substance adhesion preventing agent of the present invention may contain any hydroxyalkyl chitosan having any weight average molecular weight. However, those having an effect of preventing adhesion of harmful substances in the present invention are preferably those having a weight average molecular weight of 10 to 5 million, more preferably those having a weight average molecular weight of 10 to 2 million.

Hydroxyalkyl chitosan may be a commercially available product. For example, hydroxyethyl chitosan liquid (trade name: Aqua Cluster, manufactured by Ichimaru Falcos Co., Ltd.), hydroxypropyl chitosan liquid (trade name: manufactured by Chitofilmer, manufactured by Ichimaru Falcos Co., Ltd.) Hydroxypropyl chitosan (trade name: hydroxypropyl chitosan, manufactured by Dainichi Seika Kogyo Co., Ltd.), hydroxybutyl chitosan (trade name: hydroxybutyl chitosan, manufactured by Dainichi Seika Kogyo Co., Ltd.), and the like.
The harmful substance adhesion preventing agent according to the present invention may contain one hydroxyalkyl chitosan or two or more hydroxyalkyl chitosans.

  Examples of the solvent contained in the harmful substance adhesion preventing agent of the present invention include water, lower alcohols such as methanol, ethanol, and propanol, and polyvalents such as glycerin, propylene glycol, sorbitol, polyethylene glycol, and 1,3-butylene glycol. Other organic solvents such as alcohols and hexane are exemplified. These may be used alone or in combination of two or more, and may be appropriately selected in consideration of the dosage form and compatibility with other components. As the solvent contained in the harmful substance adhesion preventing agent of the present invention, one or a combination of water and ethanol is particularly preferable.

  The harmful substance adhesion preventive agent of the present invention includes alcohols, polyhydric alcohols, fats and oils depending on compatibility with active ingredients, dosage forms, usage methods, application targets, etc., in addition to the active ingredient hydroxyalkylchitosan. , Surfactants, humectants, pH adjusters, thickeners, essential oils and fragrances, refreshing agents, preservatives, pigments, dyes, inorganic salts and inorganic acids.

  Examples of alcohols include lower alcohols such as ethanol, isopropyl alcohol, butanol, and isobutyl alcohol; cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, hexyldecanol, isostearyl alcohol, 2- And higher alcohols such as octyldodecanol.

  Examples of the polyhydric alcohols include propylene glycol, 1,3-propanediol, dipropylene glycol, glycerin, diglycerin, 1,3-butylene glycol, 1,2-pentanediol, 1,5-pentanediol, and isoprene. Examples include glycol, sorbitol, hexylene glycol, 1,2-hexanediol, 1,6-hexanediol, maltitol, and polyethylene glycol.

  Examples of fats and oils include soybean oil, almond oil, paraffin, cetanol, avocado oil, olive oil, jojoba oil, coconut oil, palm oil, nuka oil, egg yolk oil, castor oil, squalane, lanolin, liquid paraffin, white petrolatum, etc. Vegetable fats and oils; animal fats and oils such as beef tallow, pork tallow, horse fat, turtle oil, mink oil, perserine oil, and squalane; and synthetic fats and oils such as methylpolysiloxane, glyceryl tricaprate, glyceryl trioctanoate, and liquid paraffin .

  Examples of the surfactant include glycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene castor oil, polyglycerin fatty acid ester, block polymer such as polyoxyethylene polyoxypropylene glycol, polyoxyethylene alkyl ether, polyethylene glycol fatty acid ester, Nonionic surfactants such as polyoxyethylene sorbitan fatty acid ester and polyoxyethylene hydrogenated castor oil; anions such as sodium α-olefin sulfonate, sodium lauryl sulfate, sodium polyoxyethylene lauryl sulfate, sodium coconut oil fatty acid methyl taurine Surfactants: alkylbetaines, alkylamidopropylbetaines, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium Amphoteric surfactants such as betaines, alkyl amine salts, cationic surfactants such as quaternary ammonium salts.

  Examples of moisturizing agents include cetyl octoate, myristyl lactate, isopropyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, and the like; ceramides such as ceramide, ceramide derivatives, and ceramide-like substances; collagen, elastin Proteins such as keratin, mucin, placenta extract, royal jelly and derivatives thereof, hydrolysates and salts; mucopolysaccharides and salts thereof such as hyaluronic acid and chondroitin sulfate; vitamin A, vitamin B group, vitamin D, vitamin E, Vitamins and derivatives thereof such as tocopherol acetate, sodium ascorbate and magnesium ascorbate; amino acids such as glycine, alanine, arginine, cysteine, glutamic acid, sarcosine, and salts thereof That.

  Examples of the thickener include carboxymethylcellulose, sodium carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, carboxyvinyl polymer, polyvinyl alcohol, sodium alginate, polyvinylpyrrolidone, locust bean gum, carrageenan, xanthan gum and the like.

  Examples of pH adjusters include organic acids such as citric acid, succinic acid, fumaric acid, lactic acid, salicylic acid, tartaric acid, malic acid, benzoic acid, sodium citrate, sodium monohydrogen phosphate, and potassium dihydrogen phosphate, inorganic Examples thereof include acids and salts thereof.

  Examples of essential oils and fragrances include lavender oil, jasmine oil, rose oil, lemon oil, orange oil, mint oil, thyme oil, ginger oil, fennel oil, cedar oil, hiba oil, cypress oil, eucalyptus oil, camphor, Natural and synthetic fragrances such as peppermint oil, spearmint oil, geraniol, citronellal, eugenol, limonene, mandarin oil, spruce, citronellol and the like can be mentioned. Moreover, menthol etc. are mentioned as a refreshing agent.

  Examples of the preservative include paraoxybenzoic acid esters such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben, phenoxyethanol, ethanol, and dehydroacetic acid.

  Examples of the pigment include yellow iron oxide, black iron oxide, titanium oxide, zinc oxide, mica, talc, bentonite and the like.

  Examples of the dye include Blue No. 1, Blue No. 2, Red No. 102, Red No. 106, Red No. 227, Red No. 230, Yellow No. 4, Yellow No. 5, Yellow No. 202, Green No. 3, chlorophyll, riboflavin, For example, safflower.

  Examples of inorganic salts and inorganic acids include sodium chloride, potassium chloride, ammonium chloride, sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, boric acid, borax, sodium sulfate, magnesium sulfate, ammonium sulfate, sodium sulfide, potassium sulfide, Examples thereof include sodium nitrate, calcium nitrate, sodium thiosulfate, calcium thiosulfate, sulfur, calcium hydrogen phosphate, sodium phosphate, sodium polyphosphate, anhydrous silicic acid, and metasilicic acid.

  In the harmful substance adhesion preventing agent of the present invention, the hydroxyalkyl chitosan or a salt thereof may be contained in an amount capable of exhibiting an adhesion preventing effect when applied to an object, and usually depends on the dosage form, but usually a harmful substance adhesion preventing agent. What is necessary is just to contain 0.00001 mass% or more with respect to all the components. Moreover, it is preferable to contain at 1.0 mass% or less from the ease of formulation.

  The harmful substance adhesion preventing agent of the present invention is not particularly limited with respect to its dosage form, and a suitable dosage form can be appropriately selected according to its use and application site. For example, various forms such as a solid agent, a liquid agent, a cream agent, an aerosol agent, and a gel agent can be used. Moreover, the form at the time of use can also be selected suitably. For example, it can be used by being sprayed with an aerosol agent, a pumping agent or the like, or impregnated into a liquid such as lotion, lotion, emulsion, etc. on a substrate such as cotton or nonwoven fabric.

  The harmful substance adhesion preventing agent of the present invention exerts its effect by adhering to a desired target surface. For example, the effect is exerted by adhering to a part of the body including the face and hair or the whole body, and in some cases to clothes. At this time, cosmetics, hairdressing agents, sunscreen agents, or the like may be applied to a part of the body including the face or hair or the whole body, or a waterproofing agent may be applied to the clothes. The harmful substance adhesion preventing agent of the present invention exhibits an adhesion preventing effect even on a target surface coated with a chemical other than the harmful substance adhesion preventing agent. In addition, the harmful substance adhesion preventing agent of the present invention is typically used in humans, but is not limited thereto. For example, it is used in other animals such as dogs and cats to cause symptoms caused by harmful substances. Can be prevented. In addition to clothes, portable products such as handkerchiefs, towels, masks, etc., and indoor products such as curtains, carpets, futons, sofas, etc., reduce the uptake of harmful substances through these indoor products into the body. can do. In addition, for the articles that can cover the mouth such as handkerchiefs, towels, masks, etc. and can reduce the uptake of harmful substances into the body by covering the mouth, the harmful substance adhesion preventing agent of the present invention is attached. Thus, it is possible to further reduce the intake of harmful substances into the body.

  Hydroxyalkyl chitosan or a salt thereof, which is an active ingredient of the harmful substance adhesion preventing agent of the present invention, can be effectively adhered to a part of the body or the whole body including the face and hair, and in some cases to clothes. This is a preferred embodiment for reducing the uptake of. In such an embodiment, the aerosol agent and the pump agent are preferable, and the aerosol agent is more preferable in that the harmful substance adhesion preventing agent can be adhered to the target surface without any problem. Here, the aerosol agent in the present specification is an agent that encloses the harmful substance adhesion preventing agent of the present invention in an aerosol container together with a propellant composed of liquefied gas or compressed gas, and sprays the harmful substance adhesion preventing agent together with the propellant. It is.

  As the propellant, known ones can be widely used, for example, liquefied gas such as dimethyl ether, liquefied petroleum gas, fluorocarbon, liquefied carbon dioxide gas; and nitrogen gas, carbon dioxide gas, mixed gas thereof, compressed air, nitrous oxide, etc. A compressed gas is mentioned.

  In the case of compressed gas, the propellant is preferably charged in an amount of 0.001 to 10% by mass, more preferably 0.05 to 5.0% by mass, based on the total content. In addition, the liquefied gas is preferably contained in an amount of 10 to 90% by mass, more preferably 20 to 80% by mass, based on the total content to be filled.

The amount of use at the time of spraying is preferably 0.3 to 30 g in terms of efficiently attaching the harmful substance adhesion preventing agent to the target surface. Similarly, the particle size of the spray is preferably 1 to 500 μm, more preferably 10 to 300 μm. In addition, the injection amount is preferably 0.5 to 50 g / 10 seconds, and more preferably 1 to 10 g / 10 seconds. When pressure-filling the harmful substance adhesion preventing agent and the propellant, the internal pressure of the aerosol container is preferably 0.1 to 1.0 MPa (3 to 10 kg / cm ² , 25 ° C.).

  Specific examples of aerosol products include, for example, a stem diameter of 0.1 to 1.0 mm, a housing diameter of 0.1 to 3.0 mm, and a propellant with or without a vapor tap when the propellant is a liquefied gas. In the case of compressed gas, an aerosol container having a valve without a vapor tap and a wide-angle injection type button (for example, a mechanical break button) having a nozzle hole diameter of 0.1 to 2.0 mm can be used. Although there is no restriction | limiting in particular about the material of an aerosol container, For example, an aluminum can, a tin can, a plastic container, a special container (double structure container) etc. are mentioned. The aerosol container may have an inner surface coated with a polyamideimide resin or a polyethylene terephthalate resin.

  Hereinafter, although an example is given and explained concretely, the present invention is not limited at all by these.

1. Preparation of samples Samples shown in Table 1 were prepared. As Example 1, purified water was added to chitofilmer (manufactured by Ichimaru Falcos Co., Ltd., weight average molecular weight 800,000) so that the content of hydroxypropylchitosan was 0.0004% by mass to prepare a solution. In addition, as Comparative Example 1 and Comparative Example 2, Katchinal LC-100 (manufactured by Toho Chemical Industry Co., Ltd., another name: cationized cellulose, degree of cationization: about 1.1), Katchinal HC-100 (manufactured by Toho Chemical Industry Co., Ltd.) , Also known as cationized cellulose, degree of cationization: about 1.8), and purified water was added so that each content was 0.0004% by mass to prepare each solution. As Comparative Example 3, only purified water was used.

2. Basic test 2-1. Test Method A 5 cm × 5 cm polyester cloth (JIS L 0803 compliant code No. 670110) was used as an object to be adhered, impregnated with 200 μl of the solution obtained in each example and comparative example, and air-dried. Next, the surface of the polyester cloth was rubbed once with commercially available tissue paper. After that, the thread and adhesive tape are placed so that they are located in the center of a cardboard box (25 cm × 25 cm × 22 cm) containing 0.5 g of pseudo-pollen Ishimatsuko (spore of beige pods, APPIE standard powder) as harmful substances Used to hang a polyester cloth. The corrugated cardboard box was turned upside down 10 times continuously (about 18 seconds), and the harmful substances were soared in the box to promote the adhesion of the harmful substances to the surface of the polyester cloth. As a control, a similar test was performed using an untreated polyester cloth not impregnated with the solution. After the treatment, the number of harmful substances adhering to the polyester cloth was observed with a microscope (observed monitor area: 5.8 mm × 8.0 mm = 46.4 mm ² ), and the number of harmful substances adhering on the surface of the polyester cloth was counted. did. The test was repeated three times to determine the average number of harmful substances adhered, and the harmful substance adhesion prevention rate was determined by the following formula. Hereinafter, the average number of harmful substances is defined as the average number of adhesions, and the harmful substance adhesion prevention rate is defined as the adhesion prevention ratio.
[Equation 1]
Hazardous substance prevention rate (%) = [(average number of untreated harmful substances-average number of harmful substances on the specimen) / average number of untreated harmful substances] x 100

2-2. Test results The test results are shown in Table 2 below and FIG.

As shown in Table 2 and FIG. 1, in the anti-adhesion agent of Example 1 containing hydroxypropyl chitosan as an active ingredient, the anti-adhesion rate was 94.5%. On the other hand, the anti-adhesive agent of Comparative Example 1 containing cationized cellulose having a low degree of cationization as an active ingredient does not show any harmful substance adhesion preventing effect, and is a comparative example using cationized cellulose having a high degree of cationization as an active ingredient. In the anti-adhesive agent No. 2, the anti-adhesion rate was 22.3%, which was slightly effective in preventing harmful substance adhesion, but no significant effect as in Example 1 was observed. Therefore, it was shown that the anti-adhesion agent of the present invention has a very high effect of preventing the adhesion of harmful substances as compared with an anti-adhesion agent containing a substance having a charge as an active ingredient.

3. Actual use test 3-1. Test sample (Example 2)
Chitofilmer (Ichimaru Falcos Co., Ltd.), ethanol, floral fragrance and preservatives (methylparaben, phenoxyethanol) were added to purified water, and a stock solution of Example 2 was prepared with the composition shown in Table 3 below. 75 ml of the obtained stock solution is made of aluminum with a stem diameter of 0.5 mm, a housing diameter of 0.4 mm, a mechanical break button with a nozzle diameter of 0.3 mm, φ40 mm × H118 mm, and the inside of the container coated with polyamideimide resin Was filled in an aerosol container having a capacity of 133 mL, and the internal pressure was adjusted to about 0.7 MPa with nitrogen gas.

3-2. Single use test (implemented in 2014)
A. Test method The test was carried out in early May 2014 with a relatively large amount of pollen, and was conducted on 8 subjects who suffered from hay fever on a daily basis.
As a test method, the test sample of Example 2 was sprayed from above the subject's head for about 5 seconds so as to bathe the upper body including the face and hair. When converted to a spray amount, this corresponds to an average of 3.7 g. After spraying, the subject was allowed to live normally, and after about 7 hours had passed, the question of the following evaluation items was asked and an answer was obtained.
[Evaluation item]
Question 1: “Did you feel the symptom improvement effect of hay fever using the sample?”
Answer options:
1. I felt 2. I didn't feel

B. Test results As shown in FIG. 2, 6 subjects replied “feel”, 2 subjects replied “not felt”, 6 out of 8 subjects, that is, 75% of test subjects improved. “I felt” the effect. Thereby, it was confirmed that the test sample of Example 2 prevented the adhesion of harmful substances to the surface of the subject, and the pollen taken into the body of the subject was reduced.

3-3. Long-term continuous test (performed in 2015)
A. Test Method The test was conducted on 30 people suffering from hay fever between the beginning of April 2015 and the end of May 2015, where pollen is relatively high.
As a test method, the test sample of Example 2 was sprayed from above the subject's head for about 5 seconds so as to bathe the upper body including the face and hair. The spray amount corresponds to 1.7 to 5.1 g. In addition, 20 female subjects out of 30 were sprayed with the test sample with makeup applied as usual. The subjects were allowed to live for 2 weeks or more and live as usual. After continuous use, we asked questions about the following evaluation items and obtained answers.
[Evaluation item]
Question 2: “Did you feel the symptom-improving effect of hay fever with the samples?”
Answer options:
1. I felt 2. 2. I didn't feel much. I didn't feel

Question 3 (20 female subjects only): “Did you use a sample to remove makeup?”
1. I did not remove my makeup. 2. I lost my makeup. I do not understand

B. Test Results As shown in FIG. 3, 68% of the subjects answered “feel” to Question 2. It has been found that even if the number of subjects increases, not only the single use of the test conducted in 2014 but also the long-term continuous use does not decrease the effect and the effect can be continuously obtained. Therefore, even in this continuous test, it was confirmed that the test sample of Example 2 prevented harmful substances from adhering to the surface of the subject and reduced pollen taken into the subject's body.
In addition, as shown in FIG. 4, all the female subjects answered “no makeup was removed” even when the test sample was sprayed in a state where makeup was performed as usual, as shown in FIG. 4. Therefore, it was confirmed that even if the target surface was coated with a chemical other than the harmful substance adhesion preventing agent, the adhesion preventing effect was obtained, and that it could be used without a sense of incompatibility even when applying makeup.

  As described above, the present invention can provide simple means that can prevent harmful substances from adhering to the target surface and reduce the uptake into the body when away from home.

Claims (2)

  A harmful substance adhesion preventive agent comprising hydroxyalkyl chitosan or a salt thereof as an active ingredient.   A method for preventing adhesion of harmful substances, wherein hydroxyalkylchitosan or a salt thereof is adhered to a target surface.