JP2016065006A - Ｄｐ１アゴニストとステロイドとを含有する外用剤 - Google Patents
Ｄｐ１アゴニストとステロイドとを含有する外用剤 Download PDFInfo
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- JP2016065006A JP2016065006A JP2014194053A JP2014194053A JP2016065006A JP 2016065006 A JP2016065006 A JP 2016065006A JP 2014194053 A JP2014194053 A JP 2014194053A JP 2014194053 A JP2014194053 A JP 2014194053A JP 2016065006 A JP2016065006 A JP 2016065006A
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- Prior art keywords
- steroid
- agonist
- external preparation
- propionate
- day
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Non-Patent Citations (3)
| Title |
|---|
| BR. J. PHARMACOL., vol. Vol.129, JPN6018021051, 2000, pages 589 - 597 * |
| J. TOXICOL. SCI., vol. 37, no. 6, JPN6018021048, 2012, pages 1127 - 1134 * |
| 日本皮膚科学会誌, vol. 119, no. 8, JPN6018021054, 2009, pages 1515 - 1534 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023088084A (ja) * | 2021-12-14 | 2023-06-26 | 株式会社ファンケル | 睡眠改善用組成物 |
| JP7776325B2 (ja) | 2021-12-14 | 2025-11-26 | 株式会社ファンケル | 睡眠改善用組成物 |
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