JP2016030748A - Hair restoration and scalp improving agent by oral administration - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hair restoration and scalp improving agent which can maintain or increase the hair by oral administration, and which is concurrently capable of improving the scalp condition.SOLUTION: The invention relates to a hair restoration and scalp improving agent by oral administration characterized by containing apple polyphenol, tocotrienol, and the ovarian membrane extract of salmon species. Taking the hair restoration and scalp improving agent of the invention can promote growing of the hair, can maintain or increase the hair, to inhibit progress of thinning hair, and can also improve a scalp condition by scalp improving actions, such as scalp inflammation (rash) inhibition or dandruff generation inhibition.SELECTED DRAWING: None

Description

  The present invention relates to an orally administered hair growth and scalp improving agent, and in particular, when taken from the mouth, it is possible to suppress thinning of the hair (thin hair) due to its excellent hair growth action, and to suppress inflammation (rash) of the scalp. The present invention relates to a hair-growth and scalp-improving agent exhibiting scalp-improving action such as suppression of occurrence of dandruff and dandruff.

Hair is one of the factors that have a great influence on the person's appearance, and is very important in that it affects the appearance.
The thin hair of the hair progresses as the hair becomes thinner or the number of hair decreases, and when the symptom progresses, the portion covered with the hair decreases and the background (scalp) is exposed and becomes conspicuous.

Possible causes of thinning hair include hormonal effects, genetic factors, diet, lack of sleep time, and stress.
For example, male thin hair that has been attracting attention in the past is well known to be due to the effects of male hormones (testosterone, etc.), and typically thin hair progresses mainly in the frontal region and the top of the head.
In recent years, attention has been focused on the problem of thinning hair in women. In the case of women, for example, due to a decrease in the secretion of female hormones (estrogens, etc.), thinning of the hair, loss of elasticity, thinning of the hair progresses, and the overall volume of the hair disappears, The symptom is that the hairstyle is difficult to determine.

People with advanced thinning symptoms may experience significant stress due to differences from their appearance prior to loss of hair. In recent years, the number of people who suffer from such thinnings tends to increase, and the improvement is demanded.
Therefore, various hair growth agents for maintaining or increasing hair are known (for example, Patent Documents 1 to 3).

Japanese Patent No. 3650400 Japanese Patent No. 4172864 US Pat. No. 7,211,274

By the way, with the progress of thinning hair of the scalp, the scalp condition may worsen such as inflammation of the scalp and increased dandruff. These affect hair growth and can cause further deterioration of thinning hair.
In addition, for example, if a large amount of dandruff adheres to clothes, it may have an adverse effect on the impression to others as much as or more than thin hair.
Therefore, it is preferable that the scalp state can be improved in combination with suppressing the progress of thinning hair and maintaining or increasing the hair.

  In addition, hair growth agents are conventionally prepared in a liquid form and generally used in a form that is applied directly to the head, but it is easier to take into account the points that attract attention from others at the time of administration. Those that can be used in the above are preferred.

  This invention is made | formed based on such a situation, and it aims at providing the hair growth and scalp improving agent which can improve a scalp state while being able to maintain or increase a head hair by oral administration.

That is, the gist of the present invention is as follows.
[1] An orally administered hair-growth and scalp improving agent characterized by containing ovarian membrane extract of apple polyphenol, tocotrienol and moss.
[2] The hair-growth and scalp improving agent according to [1], wherein the apple polyphenol is contained in an amount of 1% by mass to 40% by mass based on the hair-growth and scalp improving agent.
[3] The hair growth and scalp improving agent according to [1] or [2], wherein the tocotrienol is contained in an amount of 0.5% by mass to 40% by mass with respect to the hair restoring and scalp improving agent.
[4] The ovarian membrane extract of the moss is contained in an amount of 1% by mass to 25% by mass per the hair growth and scalp improving agent, according to any one of [1] to [3] Hair growth and scalp improving agent.
[5] The hair-growth and scalp improving agent according to any one of [1] to [4], wherein the scalp ameliorating action is suppression of scalp inflammation or dandruff.
[6] The hair growth and scalp improving agent is a hair growth and scalp improving agent for women,
The hair growth according to any one of [1] to [5], further comprising flaxseed oil, ginger extract, d-α-tocopherol, pueraria mirifica powder, L-methionine and peanut seed coat extract Scalp improving agent.
[7] The hair growth and scalp improving agent is a male hair growth and scalp improving agent,
The hair-growth and scalp improving agent according to any one of [1] to [5], further comprising a saw palmetto extract and rice germ oil.
[8] It further comprises at least one of soybean extract, resveratrol-containing grape extract, camellia seed extract, liquor yeast, camellia oil, biominerals and pine ceramide [1] to [1] [7] The hair growth and scalp improving agent according to any one of [7].

ADVANTAGE OF THE INVENTION According to this invention, the hair growth and scalp improving agent which can maintain or increase scalp hair and can improve a scalp state by oral administration can be provided.
That is, by taking the hair growth and scalp improving agent of the present invention containing apple polyphenol, tocotrienol and mosquito ovary membrane extract, it promotes hair growth and maintains or increases scalp to suppress the progression of thinning hair be able to. Furthermore, the scalp state can be improved by the scalp improving action such as suppression of inflammation of the scalp and generation of dandruff.

It is a table | surface which shows the judgment result of the doctor about the hair-growth effect | action when the hair-growth and scalp improving agent of Example 1 or 2 is orally administered to a man or a woman. It is a table | surface which shows the determination result by the test subject about the extent of hair loss when the hair growth and scalp improving agent of Example 1 is orally administered to a man. It is a table | surface which shows the determination result by the test subject itself about the extent of hair loss when the hair growth and scalp improving agent of Example 2 is orally administered to a woman. It is a table | surface which shows the determination result by the test subject about hair elasticity and stiffness when the hair-growth and scalp improving agent of Example 1 was orally administered to men. It is a table | surface which shows the determination result by the test subject about hair elasticity and stiffness when the hair growth and scalp improving agent of Example 2 was orally administered to a woman. It is a table | surface which shows the determination result by the test subject about the luster of the hair when the hair growth and scalp improving agent of Example 1 is orally administered to a man. It is a table | surface which shows the determination result by the test subject itself about the luster of the hair when the hair growth and scalp improving agent of Example 2 is orally administered to a woman. It is a table | surface which shows the determination result of the doctor about inflammation (rash) when the hair growth and scalp improving agent of Example 1 is orally administered to a man. It is a table | surface which shows the doctor's determination result about inflammation (rash) when the hair growth and scalp improvement agent of Example 2 is orally administered to a woman. It is a table | surface which shows the doctor's determination result about the amount of dandruff when the hair-growth and scalp improving agent of Example 1 is orally administered to men. It is a table | surface which shows the doctor's determination result about the amount of dandruff when the hair growth and scalp improvement agent of Example 2 is orally administered to a woman. It is a table | surface which shows the doctor's determination result about the clogging of a pore when the hair growth and scalp improving agent of Example 1 is orally administered to a man. It is a table | surface which shows the doctor's determination result about the stickiness of a scalp when the hair growth and scalp improving agent of Example 1 is orally administered to a man.

Next, one embodiment of the hair growth and scalp improving agent of the present invention will be described.
The hair growth and scalp improving agent of this embodiment is characterized by containing apple polyphenol, tocotrienol, and mosquito ovary membrane extract (hereinafter also referred to as vaginal ovary membrane extract), and is taken orally. The

Apple polyphenol is a polyphenol group (epicatechin, caffeic acid, procyanidin, etc.) extracted from the fruit of apple (Malus pumila), and has an antioxidant effect and the like.
Here, the apple polyphenol is preferably contained in an amount of 1% by mass or more and 40% by mass or less, preferably 5% by mass or more and 25% by mass or less, based on the hair growth and scalp improving agent of the present embodiment, from the viewpoint of hair growth and scalp condition improvement. More preferably it is contained.
As the apple polyphenol, those extracted from apples by the method described in Patent Document 1 or Patent Document 2, for example, may be used, or a commercially available product may be used.

Tocotrienol is a vitamin E (tocopherol) homologue, a compound having three unsaturated bonds in the linear alkyl group of tocopherol, and has a strong antioxidative effect about several tens of times that of vitamin E. It is also known as a component having an action for improving hyperlipidemia.
Here, it is preferable that tocotrienol is contained in an amount of 0.5% by mass or more and 40% by mass or less, preferably 1% by mass or more and 20% by mass or less, based on the hair growth and scalp improving agent of the present embodiment from the viewpoint of hair growth and scalp condition. More preferably it is contained.
Tocotrienol can be obtained by a method such as pressing, extraction, or synthesis of natural products such as plants, and is generally extracted from the skin and / or seeds of palm plant such as palm palm. The hair growth and scalp improving agent of the present embodiment can be used from any natural product or synthetic product. Any of α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol can be used, and these may be used in combination. Moreover, in the case of being derived from a natural product, a plant extract (for example, palm palm extract) or the like can be blended in the present embodiment as a tocotrienol supply source in addition to a purified product.

The mosquito ovarian membrane extract is an extract obtained from the mosquito ovarian membrane. In addition, in this specification, moss means the organism which is a salmonid department on classification, and can specifically mention salmon, red salmon, silver salmon, rainbow trout, cherry salmon, chinook salmon, and the like.
Here, the ovarian membrane extract of moss is preferably contained in an amount of 1% by mass or more and 25% by mass or less, preferably 2% by mass or more and 12% by mass or less, per the hair growth and scalp improving agent of the present embodiment. More preferred.
As the ovarian membrane extract of moss, for example, those extracted by the method described in JP 2011-026273 A can be used, and commercially available products can also be used.

Moreover, the hair growth and scalp improving agent of this embodiment may contain other components in addition to these apple polyphenols, tocotrienol, and rabbit ovary membrane extract.
For example, when the hair growth and scalp improving agent of this embodiment is used as a female hair growth and scalp improving agent, the hair growth and scalp improving agent is added to apple polyphenol and tocotrienol and vaginal ovary membrane extract, linseed oil, It is preferable to further contain ginger extract, d-α-tocopherol, Pueraria mirifica powder, L-methionine and peanut seed coat extract. By containing the said component, the hair-restoration effect | action in a woman can further be improved.

Linseed oil is an oil (essential oil) taken from the seeds of flax (Linum usitatissimum). For example, a commercially available linseed oil may be used.
The ginger extract is an oily extract extracted from the rhizome of ginger (Zingiber officinale) with carbon dioxide or the like. As the ginger extract, a commercially available product may be used in the same manner as linseed oil.
d-α-tocopherol is a kind of vitamin E, and for example, a commercially available product may be used. Moreover, it can also be set as the aspect which mix | blends the vegetable oil containing the said d- (alpha) -tocopherol.
Pueraria mirifica powder is a powder of Pueraria mirifica, a plant that grows in Southeast Asia. As the powder, a commercially available product may be used in the same manner as linseed oil.
L-methionine is a kind of amino acid, and for example, a commercially available product can be used.
Peanut seed coat extract (Peanut seed coat extract) is an extract of peanut (Arachis hypogaea) fruit skin (seed coat). The extract can be obtained by, for example, the method described in JP-A No. 11-246562, and a commercially available product may be used in the same manner as linseed oil.

  Here, the linseed oil is preferably contained in an amount of 15% by mass to 60% by mass. Similarly, the ginger extract is preferably contained in an amount of 1% by mass to 10% by mass. It is preferable that d-α-tocopherol is contained in an amount of 0.5% by mass or more and 20% by mass or less. The Pueraria mirifica powder is preferably contained in an amount of 2 to 40% by mass. Further, L-methionine is preferably contained in an amount of 0.1% by mass or more and 10% by mass or less. The peanut seed coat extract is preferably contained in an amount of 1% by mass to 10% by mass. (Every hair growth and scalp improving agent of this embodiment)

  Moreover, the hair growth and scalp improving agent of this embodiment can also be used as the male hair growth and scalp improving agent. In the case of a male hair-growth and scalp improving agent, the hair-growth and scalp improving agent preferably further contains a saw palmetto extract and rice germ oil in addition to apple polyphenol, tocotrienol and rabbit ovary membrane extract. By containing the said component, the hair-restoration effect | action in a male can further be improved. In addition, clogging of pores and stickiness of the scalp can be suppressed.

Saw palm extract (saw palm extract) is an extract of the fruit of Serenoa repens. The extract can be obtained by, for example, a method described in JP-A-2007-063204, or a commercially available product may be used.
Rice germ oil is oil taken from rice germ. As the rice germ oil, a commercially available product may be used in the same manner as the saw palmetto extract.

  Here, the saw palmetto extract is preferably contained in an amount of 5% by mass or more and 50% by mass or less per hair growth and scalp improving agent of the present embodiment. Similarly, the rice germ oil is preferably contained in an amount of 5% by mass or more and 40% by mass or less per hair growth and scalp improving agent of the present embodiment.

Furthermore, in this embodiment, it can be made to contain the other component which contributes to the hair restoring action etc.
Specifically, it is extracted from soybean extract, resveratrol-containing grape extract (grape resveratrol powder), camellia seed extract, liquor yeast, camellia oil, plants, etc. Biological minerals that are minerals, pine ceramide (plant ceramide derived from pineapple fruit (edible part)), and the like can be mentioned. For example, in the present embodiment, one or more of these are contained. can do. Furthermore, for example, tocopherol may be included in a hair growth and scalp improving agent for men.

Furthermore, in this embodiment, it can be made to contain other components, such as a carrier and a base of the quantity made into 100 mass% with respect to the hair growth and scalp improving agent whole.
The carrier holds each component contained in the present embodiment dissolved or dispersed. The carrier is not particularly limited, but is preferably one that assists absorption of each component from the gastrointestinal route. Examples of suitable carriers are edible oils (eg olive oil), animal product based carriers (eg gelatin), gum arabic, sucrose, lipids, mono and diglycerides, and maltodextrins. Water can also be used as a carrier, but is usually used together with a suitable emulsifier (for example, lecithin, sorbitan monolaurate).
In addition, the mixing method of each component should just mix so that each component may disperse | distribute as uniformly as possible, and is not specifically limited. In addition to the carrier, a hardness adjusting agent or an absorption improving agent may be included.
The base can be appropriately set by those skilled in the art and is not particularly limited.

The hair growth and scalp improving agent of this embodiment can be orally administered, for example, as a pharmaceutical, a quasi-drug or a food having the form of a solution, oil, emulsion, suspension or dispersion. Suitable forms are, for example, capsules or tablets. The hair growth and scalp improving agents of this embodiment are usually provided in the form of soft gelatin capsules.
The amount taken of the hair growth and scalp improving agent of the present embodiment is not particularly limited and can be appropriately set in consideration of the dosage form of the carrier. For example, apple polyphenol 100 to 150 mg per soft gelatin capsule per day , 10 to 150 mg of tocotrienol and 25 to 100 mg of vaginal ovarian membrane extract can be set to such an amount as to be administered orally.

As described above, according to this embodiment, although there are individual differences, it is possible to provide a hair-growth and scalp improving agent capable of maintaining or increasing the hair by oral administration and improving the scalp state.
By taking the hair-growth and scalp improving agent of this embodiment containing apple polyphenol, tocotrienol, and rabbit ovary membrane extract, it can promote hair growth and maintain or increase hair and suppress the progression of thin hair it can. Furthermore, the scalp state can be improved by the scalp improving action such as suppression of scalp inflammation and dandruff.

  Furthermore, the hair-growth and scalp improving agent of the present embodiment has an excellent hair-growth effect, and exhibits a higher hair-growth effect as compared to the case where other ingredients with known hair-growth action are individually taken.

  Furthermore, since the hair-growth and scalp improving agent of this embodiment is ingested by oral administration, it can be used more easily than conventional hair-growth agents directly administered to the head. Therefore, for example, it is possible to carry it to a travel destination and use it without worrying about the eyes of others.

  Hereinafter, the hair growth and scalp improving agents of the present invention will be described more specifically by way of examples. Note that the present invention is not limited to this.

  The following ingredients were mixed to produce the hair growth and scalp improving agent of this example.

  Specifically, the ingredients described in Tables 1 and 2 are mixed and filled into gelatin capsules, and the hair growth and scalp improving agent for men is used as Example 1, and hair growth and scalp improvement for women are performed. The agent was obtained as Example 2 (one capsule was 470 mg each).

  The hair growth and scalp improving agent of Example 1 was administered to males (15 people) and the hair growth and scalp improving agent of Example 2 to females (14 people) three times a day. Changes in hair condition and scalp status 16 weeks after the start of administration are determined by three doctors (dermatologists) based on images of the heads of the panelists before and 16 weeks after the start of administration. Went. Moreover, about the hair-growth effect | action, the test subject's own determination was also performed.

In addition, the test subject's own judgment about hair growth determined the score of each test subject based on the following criteria. The significance of the determination was evaluated by the Wilcoxon test.
Degree of hair loss: "Nearly nothing (I don't care)", 2. “There is a little (I am a little worried),” 3. “I can't say either.” “Many (I'm interested)”
Harness and stiffness of hair: 1. “Yes”, 2. “If anything,” 3. “I can't say either.” “It ’s not good”, 5. "Absent"
Hair color, gloss: “Yes”, 2. “If anything,” 3. “I can't say either.” “It ’s not good”, 5. "Absent"

Moreover, the judgment by the doctor of the scalp state determined the score of each subject based on the following criteria. The significance of the determination was evaluated by the Wilcoxon test as in the case of the subject's own determination.
0 “None: no symptoms” 1 “Minor: slightly symptoms” 2 “Mild: slightly symptoms” 3 “Medium: obvious symptoms” 4 “Severe” : There are significant symptoms "

The results after 16 weeks from the start of administration are shown in FIGS.
In both cases of doctor and subject's own judgment, there are individual differences after 16 weeks from the start of administration compared to before the start of oral administration. Obtained. From the results, for example, when tocotrienol was administered alone (Lim Ai Beoy, Wong Jia Woei, Yuen Kah Hay, “Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers”, Tropical Life Sciences Research, 21 (2), 91- 99, 2010.), it can be understood that the hair growth and scalp improving agent of this embodiment has an excellent hair growth action.
In addition, with respect to the amount of inflammation and dandruff, both Examples 1 and 2 were confirmed to be improved compared to before administration. Furthermore, when the hair-growth and scalp improving agent of Example 1 was administered to men, it was confirmed that improvements were also observed in pore clogging and scalp stickiness.

Claims (8)

  An orally administered hair-growth and scalp improvement agent characterized by containing an ovarian membrane extract of apple polyphenol, tocotrienol and moss.   2. The hair growth and scalp improving agent according to claim 1, wherein the apple polyphenol is contained in an amount of 1% by mass or more and 40% by mass or less per the hair growth and scalp improving agent.   The hair growth and scalp improving agent according to claim 1 or 2, wherein the tocotrienol is contained in an amount of 0.5 mass% to 40 mass% per the hair growth and scalp improving agent.   The hair growth and scalp improving agent according to any one of claims 1 to 3, wherein the ovarian membrane extract of the moss is contained in an amount of 1% by mass or more and 25% by mass or less per the hair restoring and scalp improving agent. .   5. The hair growth and scalp improving agent according to any one of claims 1 to 4, which exhibits suppression of inflammation of the scalp or suppression of dandruff as an effect of improving the scalp. The hair growth and scalp improving agent is a hair growth and scalp improving agent for women,
The hair growth and scalp improvement according to any one of claims 1 to 5, further comprising linseed oil, ginger extract, d-α-tocopherol, pueraria mirifica powder, L-methionine and peanut seed coat extract. Agent. The hair growth and scalp improving agent is a male hair growth and scalp improving agent,
The hair-growth and scalp improving agent according to any one of claims 1 to 5, further comprising a saw palmetto extract and rice germ oil.   The soybean extract, resveratrol-containing grape stem extract, camellia seed extract, liquor yeast, camellia oil, biomineral, and pineceramide, further comprising at least one kind The hair growth and scalp improvement agent as described in any one.

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