JP2016017077A - External preparation for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel external preparation for skin because the external preparation for skin contained β glycyrrhetic acid, a glycyrrhizinic acid derivative, allantoin, azulene, hydrocortisone, and the like as symptomatic treatments for skin inflammation has been used but these drugs has an insufficient sedative effect or is expensive.SOLUTION: The subject is solved by the means of (1) an external preparation for skin containing extract of Tasmanian Pepper fruits, and of (2) the external preparation for skin in the above statement (1) containing 0.1-95.0 mass% of the extract of the Tasmanian Pepper fruits.SELECTED DRAWING: Figure 1

Description

The present invention relates to a skin external preparation containing an extract of a fruit of a plant Tasmanian pepper.
The topical skin preparation as used in the present invention includes cosmetics such as basic cosmetics, makeup cosmetics, body cosmetics, quasi-drugs, and pharmaceuticals.

Skin is exposed to various stimuli such as air pollution, environmental factors such as ultraviolet rays, psychological and internal factors such as stress, fatigue, etc., or artificially received local stimuli by shaving, etc., resulting in inflammation A condition is triggered.
The present invention relates to an external preparation for skin having an effect of calming inflammation of the skin.

In recent years, there has been considerable progress in research on the mechanism of skin inflammation. I came.
However, since these drugs have insufficient sedative effects or are expensive, new effective substances have been demanded.

  This invention is made | formed under the above situations, and provides the skin external preparation containing the extract of the fruit of a plant Tasmanian pepper (Tasmanian Pepper).

The present invention
(1) A skin external preparation characterized by containing an extract of Tasmanian Pepper fruit.
(2) The external preparation for skin according to (1) above, which contains 0.1 to 95.0% by mass of a fruit extract of Tasmanian Pepper.
The above-described problem is solved by the means as described above.

  The active ingredient of the Tasmanian pepper fruit extract contained in the present invention is mainly polygodial, and additionally contains anthocyanins, rutin, minerals and the like.

  The details of the mechanism of anti-inflammatory action by the Tasmanian pepper fruit extract contained in the present invention are unclear, but the inflammatory cytokine IL-8 that is subsequently promoted by IL-1α produced in the cells It is thought that it suppresses. As a result, the skin inflammation is immediately sedated.

  In FIG. 1, as the concentration of Tasmanian pepper fruit extract (trade name “Tazman pepper”) contained in the present invention is increased from 0.05% to 0.4%, the concentration increases. IL-8 production was suppressed.

  Hereinafter, the present invention will be described in detail. Tasmanian Pepper (Tasmania Lanceolata) is a plant that grows in the southeast of Australia and in the cold regions of Tasmania. The extract contained in the present invention is extracted from the fruit of Tasmanian pepper using glycerin.

  The Tasmanian pepper fruit extract contained in the present invention is a trade name of “Tazman pepper”, a commercially available raw material of Southern Cross Botanicals of Australia as a mixed solution of glycerin, water, alcohol or alcohol-free. Can be obtained at

  In the external preparation for skin of the present invention, the preferable blending amount of the fruit extract of Tasmanian pepper is 0.1 to 95.0% by mass in the external preparation for skin, although it depends on the dosage form and function. If the amount is less than 0.1% by mass, the effect of calming inflammation is insufficient, and even if the amount exceeds 95.0% by mass, an effect commensurate with the amount cannot be expected.

  In addition to the above essential components, other components that are usually used in skin external preparations such as cosmetics and pharmaceuticals can be blended in the external preparation for skin of the present invention. Examples of such other components include the following components. The external preparation for skin of the present invention is produced according to a conventional method by blending one or two or more of these essential ingredients.

  The following can be mentioned as an oil-based component. Olive oil, camellia oil, wild tea flower oil, macadamia nut oil, castor oil, avocado oil, wheat germ oil, safflower oil, moringa oil, cottonseed oil, soybean oil, tea seed oil, sunflower oil, evening primrose oil, palm oil, palm oil, palm Oils such as nuclear oil, beef tallow, horse fat, cacao butter, owl, etc., waxes such as carnauba wax, candelilla wax, jojoba oil, beeswax, lanolin, liquid paraffin, paraffin, petrolatum, ceresin, microcrystalline wax, squalane, etc. Higher fatty acids such as hydrocarbon, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol, 2-octyldodecanol, Batyl alcohol, lanolin al Alcohol, cholesterol, phytosterol and other higher alcohols, isopropyl myristate, 2-octyldodecyl myristate, cetyl octanoate, cetyl 2-ethylhexanoate, pentaerythritol tetraester, diisostearyl malate, triethyl citrate, stearic acid Esters such as cholesteryl, phytostearyl isostearate, ethoxydiglycol behenate, ethoxydiglycol oleate, coconut oil fatty acid butylene glycol, methylpolysiloxane, methylphenylpolysiloxane, cyclic dimethylsilicone oil, alkyl-modified silicone, amino-modified Silicone such as silicone, three-dimensional network structure silicone, and silicone rubber.

  The following can be mentioned as a polyhydric alcohol. Glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, diethylene glycol, polyethylene glycol, ethoxydiglycol, pentanediol, heptanediol, octanediol and the like.

  The following can be mentioned as saccharides. Sorbitol, mannitol, sucrose, lactose, xylitol, maltitol, trehalose, etc.

  Examples of the polymer compound include the following. Guar gum, quince seed, pectin, mannan, agar, carrageenan, xanthan gum, curdlan, gelatin, casein, collagen and other natural polymers, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, alginate, etc. Synthetic polymer, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, polyacrylic acid soda, POE / POP copolymer and other synthetic polymers, bentonite, hectorite, magnesium sodium silicate and other inorganic thickeners, amphoteric methacrylic Acid ester copolymer, cationized cellulose, polydimethylpiperidinium chloride, polyvinyl acetate, polyacrylic ester copolymer, polyvinyl acetate, nitrocellulose Scan, polymeric silicones, film-forming polymer of silicone resin or the like.

  The following can be mentioned as surfactant. Higher fatty acid soap, alkylbenzene sulfonate, alkyl sulfate, POE alkyl ether sulfate, acyl N-methyl taurate, alkyl ether phosphate, N-acyl amino acid salt, α-olefin sulfonate, POE alkyl ether Anionic surfactant such as carboxylate, cationic surfactant such as alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, benzalkonium chloride, alkyldimethylaminoacetic acid betaine, alkylamidopropyldimethylaminoacetic acid betaine, 2-alkyl -N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lecithin, lysolecithin and other amphoteric surfactants, glycerin fatty acid ester, polyglycerin fatty acid ester, POE glycerin Phosphorus fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE castor oil / hardened castor oil, POE alkyl ether, POEPOP alkyl ether, POE alkylamine / fatty acid amide, PEG fatty acid ester, alkylamine oxide, etc. Nonionic surfactant.

  Examples of the colorant, powder, and granule include the following. Inorganic pigments such as black iron oxide, red iron oxide, yellow iron oxide, ultramarine, carbon black, pearl pigments, organic pigments, tar dyes, natural dyes, talc, kaolin, mica, magnesium aluminum silicate, silicic acid anhydride, oxidation Granules made of inorganic powders such as titanium, mica titanium, zinc white and zeolite, organic powders such as nylon powder, polyethylene powder, cellulose powder and silk powder, nylon, polyethylene, cellulose, wax, fatty acid ester and natural products.

  The following can be mentioned as animal and plant extracts. Mucopolysaccharides such as sodium hyaluronate, chondroitin sulfate sodium, animal extracts such as chitin / chitosan, collagen, elastin, peptides, asparagopsis armata extract, aloe extract, psyllium extract, barbet extract, barley, odorantum extract, kakadupram extract , Chamomile extract, licorice extract, yellow citrus extract, caviar lime extract, walnut seed extract, caper extract, coconut extract, birch extract, yarrow extract, mint extract, tea extract, tomato extract, garlic extract, carrot Extract, Hamamelis extract, Hinokitiol, Loquat leaf extract, Beech tree bud extract, Loofah extract, Safflower extract, Peach leaf extract, Willow extract, Eucalyptus extract It rose water, plant extracts and the like.

  The following can be mentioned as a mineral extract. Extracts such as peacock stone, rhombomanganese ore, rhombozinc ore and hematite.

  Examples of the bactericidal / preservative include the following. Benzoic acid, sodium benzoate, salicylic acid, sorbic acid, paraoxybenzoic acid ester (ethylparaben, butylparaben, etc.), trichlorocarbanilide, phenoxyethanol, hexachlorophene, benzalkonium chloride, chlorhexidine, zinc pyrithione, triclosan, methylchloroisothiazo Linone, methylisothiazolinone, etc.

  The following can be mentioned as antioxidant. Gallic acid ester, sodium bisulfite, etc., phosphoric acid, citric acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, phytic acid, etc.

  Examples of the metal sequestering agent include the following. Edetate, hydroxyethanediphosphonic acid, phosphoric acid, citric acid, succinic acid, phytic acid, etc.

  The following can be mentioned as a ultraviolet absorber. Benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, paraaminobenzoic acid derivatives such as paraaminobenzoic acid and octylparadimethylaminobenzoate, octyl paramethoxycinnamate, diparamethoxy Methoxycinnamic acid derivatives such as mono-2-ethylhexanoic acid glyceryl cinnamate, salicylic acid derivatives such as octyl salicylate, urocanic acid and the like.

  The following can be mentioned as a pH adjuster. Alkaline agents such as sodium hydroxide, potassium hydroxide, sodium carbonate, aqueous ammonia, monoethanolamine, triethanolamine, aminomethylpropanol, and acids such as citric acid and phosphoric acid.

  The following can be mentioned as various chemical | medical agents. Whitening agents such as arbutin, kojic acid, vitamin C, assembly extract, gamma-oryzanol, capsicum tincture, nicotinic acid benzyl ester, estradiol, ethinyl estradiol, pantothenic acid, photosensitizer 301 and other hair-growing agents, β-glycyrrhetic acid, Glycyrrhizic acid derivatives, allantoin, ε-aminocaproic acid, zinc oxide, aluminum sulfate, tannic acid, lactic acid, menthol, corticosteroids, antihistamines, and other rough skin prevention agents, sulfur, salicylic acid, resorcin, benzalkonium chloride, halocarban, etc. Anti-acne agents, chlorohydroxyaluminum, aluminum chloride, antiperspirants such as zinc oxide, vitamin A and its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and its derivatives, vitamin B such as vitamin B12, vitamin B15 and its derivatives, ascorbic acid, ascorbic acid phosphate ester (salt), vitamin C such as ascorbic acid dipalmitate, α-tocopherol, β-tocopherol, γ -Vitamin E such as tocopherol, vitamin E acetate, vitamin E nicotinate, vitamins such as vitamin D, vitamin H, pantothenic acid, panthetin, glycine, alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, aspartic acid Amino acids such as asparagine, glutamine, taurine, arginine, histidine and their hydrochlorides.

  The dosage form of the external preparation for skin of the present invention can take the form usually used as an external preparation for skin, such as liquid, emulsion, cream, gel, aerosol foam, solid, powder dispersion, etc. It can be manufactured as a cream, serum, gel, pack, multi-purpose foundation, hair tonic, sun care product, after sun care product.

  Next, the present invention will be described more specifically with reference to examples. In addition, this invention is not limited only to these Examples. Unless otherwise specified, the amount is shown in mass%.

Example 1 After Sun Gel Cream (I)
Purified water 80.35
Chlorophenesin 0.30
Phenoxyethanol 0.60
Na phytate / water / alcohol 0.10
Red 504 aqueous solution (0.1%) 0.50
Yellow 4 aqueous solution (0.1%) 1.50
(II)
Lecigel ^{* 1)} 1.75
(III)
Butylene glycol dicaprylate / dicaplate 3.00
Isononyl isononanoate 4.00
Capric / Capric Triglyceride 3.00
Tocopherol / Sunflower seed oil 0.20
(IV)
Tazman Pepper ^{* 2)} 2.00
Wildplum Harvest ^{* 3)} 2.00
Melitane GL 200 ^{* 4)} 0.50
(V)
Fragrance 0.20
100.00
* 1) Sodium Acrylates Copolymer (and) Lecithin: Raw material of Lucas Meyer Cosmetics * 2) Glycerin (and) Water (and) Alcohol Denat. (And) Tasmania Lanceolata Fruit Extract: Southern Cross Botanicals * 3) Glycerin (and) Water (and) Alcohol Denat. (And) Terminalia Ferdinandana Fruit Extract (and) Pleiignium Timorense Fruit Extract (and) Podocarus Elastus Fruit Extract Company raw materials Creams containing the above ingredients were prepared according to a conventional method.

Example 2 Latex Glycerin 4.0
1,3-BG 6.0
Dimethicone 5.0
Cyclomethicone 5.0
Squalane 5.0
Carboxyvinyl polymer 0.1
Acrylic acid / methacrylic acid acrylic copolymer 0.1
Potassium hydroxide appropriate amount Polyglyceryl myristate-10 2.0
Lecithin 0.3
Tazman Pepper ^{* 2)} 5.0
Preservative Appropriate amount Chelating agent Appropriate amount Fragrance Appropriate amount
Purified water balance
100.0
An emulsion containing the above components was prepared according to a conventional method.

Example 3 Lotion 1,3-BG 6.0
Glycerin 4.0
Jojoba oil 0.1
POE (20) sorbitan monolaurate 0.5
POE (15) lauryl alcohol ether 0.5
Ethanol 10.0
Tazman Pepper ^{* 2)} 0.5
Preservative Appropriate amount Chelating agent Appropriate amount Fragrance Appropriate amount
Purified water balance
100.0
A lotion containing the above ingredients was prepared according to a conventional method.

Example 4 Gel Dipropylene Glycol 7.0
PEG1500 8.0
Carboxyvinyl polymer 0.4
Methylcellulose 0.2
POE (15) oleyl alcohol ether 1.0
Potassium hydroxide appropriate amount Tazman Pepper ^{* 2)} 0.8
Preservative Appropriate amount Chelating agent Appropriate amount Fragrance Appropriate amount
Purified water balance
100.0
A gel containing the above ingredients was prepared according to a conventional method.

Claims (2)

  An external preparation for skin comprising an extract of Tasmanian Pepper fruit.   The topical skin preparation according to claim 1, comprising 0.1 to 95.0% by mass of an extract of a Tasmanian pepper fruit.

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