JP2015534986A - 組合せ - Google Patents

組合せ Download PDF

Info

Publication number
JP2015534986A
JP2015534986A JP2015538098A JP2015538098A JP2015534986A JP 2015534986 A JP2015534986 A JP 2015534986A JP 2015538098 A JP2015538098 A JP 2015538098A JP 2015538098 A JP2015538098 A JP 2015538098A JP 2015534986 A JP2015534986 A JP 2015534986A
Authority
JP
Japan
Prior art keywords
cancer
chloro
methyl
administered
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015538098A
Other languages
English (en)
Japanese (ja)
Inventor
ギルマー,トナ,エム.
クマール,ラケシュ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline LLC filed Critical GlaxoSmithKline LLC
Publication of JP2015534986A publication Critical patent/JP2015534986A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
JP2015538098A 2012-10-22 2013-10-21 組合せ Pending JP2015534986A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261716780P 2012-10-22 2012-10-22
US61/716,780 2012-10-22
PCT/US2013/065827 WO2014066202A1 (en) 2012-10-22 2013-10-21 Combination

Publications (1)

Publication Number Publication Date
JP2015534986A true JP2015534986A (ja) 2015-12-07

Family

ID=50545138

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015538098A Pending JP2015534986A (ja) 2012-10-22 2013-10-21 組合せ

Country Status (12)

Country Link
US (1) US20150272952A1 (enExample)
EP (1) EP2908815A4 (enExample)
JP (1) JP2015534986A (enExample)
KR (1) KR20150074097A (enExample)
CN (1) CN104902899A (enExample)
AU (1) AU2013334943A1 (enExample)
BR (1) BR112015008924A2 (enExample)
CA (1) CA2889051A1 (enExample)
IN (1) IN2015DN03909A (enExample)
MX (1) MX2015005113A (enExample)
RU (1) RU2015119245A (enExample)
WO (1) WO2014066202A1 (enExample)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30892A1 (es) * 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
EP2485593B1 (en) * 2009-10-08 2015-01-07 GlaxoSmithKline LLC Combination
WO2011060380A1 (en) * 2009-11-14 2011-05-19 The Regents Of The University Of California Pik3ca mutation status and sash1 expression predicts synergy between lapatinib and an akt inhibitor in her2 positive breast cancer
US20130072507A1 (en) * 2010-05-21 2013-03-21 Glaxosmithkline Llc Combination
US20130004481A1 (en) * 2011-01-12 2013-01-03 Boehringer Ingelheim International Gmbh Anticancer therapy

Also Published As

Publication number Publication date
EP2908815A1 (en) 2015-08-26
AU2013334943A1 (en) 2015-05-14
US20150272952A1 (en) 2015-10-01
CA2889051A1 (en) 2014-05-01
EP2908815A4 (en) 2016-06-22
KR20150074097A (ko) 2015-07-01
BR112015008924A2 (pt) 2017-07-04
CN104902899A (zh) 2015-09-09
MX2015005113A (es) 2015-10-29
WO2014066202A1 (en) 2014-05-01
IN2015DN03909A (enExample) 2015-10-02
RU2015119245A (ru) 2016-12-10

Similar Documents

Publication Publication Date Title
US20160213672A1 (en) Combination
JP5858989B2 (ja) 組合せ
US9402846B2 (en) Combination of inhibitor of B-Raf and inhibitor of AKT in the treatment of cancer
CN102770026B (zh) 组合
JP5881607B2 (ja) 組合せ
US20130137701A1 (en) Combination
US20150272952A1 (en) Combination
US20150094283A1 (en) Combination
US20150272950A1 (en) Combination

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20151013

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20151013