JP2015522025A5 - - Google Patents

Info

Publication number

JP2015522025A5

JP2015522025A5 JP2015520512A JP2015520512A JP2015522025A5 JP 2015522025 A5 JP2015522025 A5 JP 2015522025A5 JP 2015520512 A JP2015520512 A JP 2015520512A JP 2015520512 A JP2015520512 A JP 2015520512A JP 2015522025 A5 JP2015522025 A5 JP 2015522025A5

Authority

JP

Japan

Prior art keywords

inhibitor

combination according

cancer

osc

pharmaceutical composition

Prior art date

2013-06-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 24
• 239000003112 inhibitor Substances 0.000 claims 24
• 230000015572 biosynthetic process Effects 0.000 claims 12
• 235000012000 cholesterol Nutrition 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 9
• 201000011510 cancer Diseases 0.000 claims 9
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 8
• 239000000328 estrogen antagonist Substances 0.000 claims 8
• 239000013059 antihormonal agent Substances 0.000 claims 7
• 239000000900 selective estrogen receptor beta agonist Substances 0.000 claims 6
• 239000000556 agonist Substances 0.000 claims 5
• 229940113549 Cholesterol inhibitor Drugs 0.000 claims 4
• VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 4
• 229960002258 fulvestrant Drugs 0.000 claims 4
• 229960001603 tamoxifen Drugs 0.000 claims 4
• 229940046836 anti-estrogen Drugs 0.000 claims 3
• 230000001833 anti-estrogenic effect Effects 0.000 claims 3
• MQIMZDXIAHJKQP-UHFFFAOYSA-N 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol Chemical compound N=1C2=CC(O)=CC(C=C)=C2OC=1C1=CC=C(O)C(F)=C1 MQIMZDXIAHJKQP-UHFFFAOYSA-N 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• FURUXTVZLHCCNA-UHFFFAOYSA-N Liquiritigenin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-UHFFFAOYSA-N 0.000 claims 2
• BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims 2
• KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims 2
• 229940117893 apigenin Drugs 0.000 claims 2
• XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 claims 2
• 235000008714 apigenin Nutrition 0.000 claims 2
• BAAILVWEAXFTSF-UHFFFAOYSA-N chembl188528 Chemical compound C1=CC(O)=CC=C1C1=NC2=CC(O)=CC(Br)=C2O1 BAAILVWEAXFTSF-UHFFFAOYSA-N 0.000 claims 2
• LRRMQNGSYOUANY-OMCISZLKSA-N chembl509051 Chemical compound ClC1=C(O)C(/C=N/O)=CC=C1C1=CC=C(O)C(F)=C1 LRRMQNGSYOUANY-OMCISZLKSA-N 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 claims 2
• FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 claims 2
• GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 claims 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
• 230000003388 anti-hormonal effect Effects 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 229940044683 chemotherapy drug Drugs 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1