JP2015520768A - 強皮症の処置用の抗−ccl2抗体 - Google Patents

強皮症の処置用の抗−ccl2抗体 Download PDF

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Publication number
JP2015520768A
JP2015520768A JP2015514149A JP2015514149A JP2015520768A JP 2015520768 A JP2015520768 A JP 2015520768A JP 2015514149 A JP2015514149 A JP 2015514149A JP 2015514149 A JP2015514149 A JP 2015514149A JP 2015520768 A JP2015520768 A JP 2015520768A
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antibody
ccl2
scleroderma
fragment
ccl2 antibody
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JP2015520768A5 (enExample
Inventor
パオロ ジー.ブイ. マルティーニ,
パオロ ジー.ブイ. マルティーニ,
マドフスダン ナタラジャン,
マドフスダン ナタラジャン,
パトリック アントニー ジョン ハスレット,
パトリック アントニー ジョン ハスレット,
アルバート バーンズ シーモア,
アルバート バーンズ シーモア,
Original Assignee
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド
シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド
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Publication of JP2015520768A publication Critical patent/JP2015520768A/ja
Publication of JP2015520768A5 publication Critical patent/JP2015520768A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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JP2015514149A 2012-05-22 2013-05-22 強皮症の処置用の抗−ccl2抗体 Pending JP2015520768A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650149P 2012-05-22 2012-05-22
US61/650,149 2012-05-22
PCT/US2013/042196 WO2013177264A1 (en) 2012-05-22 2013-05-22 Anti-ccl2 antibodies for treatment of scleroderma

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017151434A Division JP2017193588A (ja) 2012-05-22 2017-08-04 強皮症の処置用の抗−ccl2抗体

Publications (2)

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JP2015520768A true JP2015520768A (ja) 2015-07-23
JP2015520768A5 JP2015520768A5 (enExample) 2016-06-30

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JP2015514149A Pending JP2015520768A (ja) 2012-05-22 2013-05-22 強皮症の処置用の抗−ccl2抗体
JP2017151434A Pending JP2017193588A (ja) 2012-05-22 2017-08-04 強皮症の処置用の抗−ccl2抗体

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JP2017151434A Pending JP2017193588A (ja) 2012-05-22 2017-08-04 強皮症の処置用の抗−ccl2抗体

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US (3) US20150158942A1 (enExample)
EP (1) EP2852411A4 (enExample)
JP (2) JP2015520768A (enExample)
CN (2) CN105854015A (enExample)
AU (2) AU2013266340A1 (enExample)
BR (1) BR112014029013A2 (enExample)
CA (1) CA2874031A1 (enExample)
EA (1) EA201491957A1 (enExample)
HK (2) HK1208819A1 (enExample)
IN (1) IN2014DN09951A (enExample)
MX (2) MX2014014290A (enExample)
WO (1) WO2013177264A1 (enExample)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
AU2014268316B2 (en) 2013-05-23 2019-10-10 Takeda Pharmaceutical Company Limited Anti-CCL2 and anti-LOXL2 combination therapy for treatment of scleroderma
SI3094353T1 (sl) 2014-01-15 2020-07-31 Medimmune, Llc RSY-specifična protitelesa in njihovi funkcionalni deli

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005530720A (ja) * 2002-04-10 2005-10-13 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 線維化疾患の治療および/または予防のためのオステオプロテゲリンの使用
US20100166757A1 (en) * 2001-11-30 2010-07-01 Biogen Idec Ma Inc. Antibodies against monocyte chemotactic proteins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1272647T3 (en) * 2000-04-11 2014-12-15 Genentech Inc Multivalent antibodies and uses thereof
US8114964B2 (en) * 2005-05-19 2012-02-14 Centocor, Inc. Anti-MCP-1 antibodies, compositions, methods and uses
PA8675801A1 (es) * 2005-05-19 2006-12-07 Centocor Inc Anticuerpos anti-mcp-1, composiciones, metodos y usos
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
AU2007319660A1 (en) * 2006-10-05 2008-05-22 Centocor Ortho Biotech Inc. CCR2 antagonists for treatment of fibrosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100166757A1 (en) * 2001-11-30 2010-07-01 Biogen Idec Ma Inc. Antibodies against monocyte chemotactic proteins
JP2005530720A (ja) * 2002-04-10 2005-10-13 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 線維化疾患の治療および/または予防のためのオステオプロテゲリンの使用

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Publication number Publication date
CA2874031A1 (en) 2013-11-28
US20150158942A1 (en) 2015-06-11
CN105854015A (zh) 2016-08-17
MX2014014290A (es) 2015-05-12
JP2017193588A (ja) 2017-10-26
CN104487091A (zh) 2015-04-01
EP2852411A1 (en) 2015-04-01
US20160289319A1 (en) 2016-10-06
EP2852411A4 (en) 2016-01-13
HK1208825A1 (en) 2016-03-18
EA201491957A1 (ru) 2015-04-30
MX2019006676A (es) 2019-08-21
WO2013177264A1 (en) 2013-11-28
IN2014DN09951A (enExample) 2015-08-14
AU2013266340A1 (en) 2014-12-04
HK1208819A1 (en) 2016-03-18
BR112014029013A2 (pt) 2017-09-19
US20180179275A1 (en) 2018-06-28
AU2018200834A1 (en) 2018-02-22

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