JP2015520612A5 - - Google Patents
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- Publication number
- JP2015520612A5 JP2015520612A5 JP2015514061A JP2015514061A JP2015520612A5 JP 2015520612 A5 JP2015520612 A5 JP 2015520612A5 JP 2015514061 A JP2015514061 A JP 2015514061A JP 2015514061 A JP2015514061 A JP 2015514061A JP 2015520612 A5 JP2015520612 A5 JP 2015520612A5
- Authority
- JP
- Japan
- Prior art keywords
- clostridium
- per gram
- produced cells
- fermentation medium
- potassium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 24
- 238000000855 fermentation Methods 0.000 claims 19
- 230000004151 fermentation Effects 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 241000193403 Clostridium Species 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 8
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 7
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 6
- 239000010941 cobalt Substances 0.000 claims 5
- 229910017052 cobalt Inorganic materials 0.000 claims 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 229910052742 iron Inorganic materials 0.000 claims 4
- 239000011777 magnesium Substances 0.000 claims 4
- 229910052749 magnesium Inorganic materials 0.000 claims 4
- 229910052759 nickel Inorganic materials 0.000 claims 4
- 239000011593 sulfur Substances 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 3
- 241001656809 Clostridium autoethanogenum Species 0.000 claims 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 3
- 235000019270 ammonium chloride Nutrition 0.000 claims 3
- 239000000908 ammonium hydroxide Substances 0.000 claims 3
- 239000011574 phosphorus Substances 0.000 claims 3
- 229910052698 phosphorus Inorganic materials 0.000 claims 3
- 239000011591 potassium Substances 0.000 claims 3
- 229910052700 potassium Inorganic materials 0.000 claims 3
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 3
- 229910052721 tungsten Inorganic materials 0.000 claims 3
- 239000010937 tungsten Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000193401 Clostridium acetobutylicum Species 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 244000061457 Solanum nigrum Species 0.000 claims 2
- 241000186339 Thermoanaerobacter Species 0.000 claims 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims 2
- 235000011009 potassium phosphates Nutrition 0.000 claims 2
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 2
- 229960003495 thiamine Drugs 0.000 claims 2
- 235000019157 thiamine Nutrition 0.000 claims 2
- 239000011721 thiamine Substances 0.000 claims 2
- 241001468161 Acetobacterium Species 0.000 claims 1
- 239000004254 Ammonium phosphate Substances 0.000 claims 1
- 241000880298 Baculum Species 0.000 claims 1
- 241001464894 Blautia producta Species 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 241001656810 Clostridium aceticum Species 0.000 claims 1
- 241001468167 Clostridium magnum Species 0.000 claims 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 claims 1
- 102100030787 ERI1 exoribonuclease 2 Human genes 0.000 claims 1
- 241000186398 Eubacterium limosum Species 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 241001135750 Geobacter Species 0.000 claims 1
- 101000941690 Homo sapiens Cytochrome P450 1A1 Proteins 0.000 claims 1
- 101000938751 Homo sapiens ERI1 exoribonuclease 2 Proteins 0.000 claims 1
- 241000205276 Methanosarcina Species 0.000 claims 1
- 241000205275 Methanosarcina barkeri Species 0.000 claims 1
- 229910021586 Nickel(II) chloride Inorganic materials 0.000 claims 1
- 241000178986 Oxobacter Species 0.000 claims 1
- 241000191992 Peptostreptococcus Species 0.000 claims 1
- 230000000789 acetogenic effect Effects 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 claims 1
- 235000019289 ammonium phosphates Nutrition 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 229940041514 candida albicans extract Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- GVPFVAHMJGGAJG-UHFFFAOYSA-L cobalt dichloride Chemical group [Cl-].[Cl-].[Co+2] GVPFVAHMJGGAJG-UHFFFAOYSA-L 0.000 claims 1
- AVWLPUQJODERGA-UHFFFAOYSA-L cobalt(2+);diiodide Chemical compound [Co+2].[I-].[I-] AVWLPUQJODERGA-UHFFFAOYSA-L 0.000 claims 1
- BZRRQSJJPUGBAA-UHFFFAOYSA-L cobalt(ii) bromide Chemical compound Br[Co]Br BZRRQSJJPUGBAA-UHFFFAOYSA-L 0.000 claims 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims 1
- AAQNGTNRWPXMPB-UHFFFAOYSA-N dipotassium;dioxido(dioxo)tungsten Chemical compound [K+].[K+].[O-][W]([O-])(=O)=O AAQNGTNRWPXMPB-UHFFFAOYSA-N 0.000 claims 1
- 229960002089 ferrous chloride Drugs 0.000 claims 1
- 239000011790 ferrous sulphate Substances 0.000 claims 1
- 235000003891 ferrous sulphate Nutrition 0.000 claims 1
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 claims 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- 235000011147 magnesium chloride Nutrition 0.000 claims 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 1
- 239000004137 magnesium phosphate Substances 0.000 claims 1
- 229960002261 magnesium phosphate Drugs 0.000 claims 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims 1
- 235000010994 magnesium phosphates Nutrition 0.000 claims 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims 1
- 235000019341 magnesium sulphate Nutrition 0.000 claims 1
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 claims 1
- LGQLOGILCSXPEA-UHFFFAOYSA-L nickel sulfate Chemical compound [Ni+2].[O-]S([O-])(=O)=O LGQLOGILCSXPEA-UHFFFAOYSA-L 0.000 claims 1
- 229910000363 nickel(II) sulfate Inorganic materials 0.000 claims 1
- KBJMLQFLOWQJNF-UHFFFAOYSA-N nickel(ii) nitrate Chemical compound [Ni+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O KBJMLQFLOWQJNF-UHFFFAOYSA-N 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 239000004323 potassium nitrate Substances 0.000 claims 1
- 235000010333 potassium nitrate Nutrition 0.000 claims 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims 1
- 229910052939 potassium sulfate Inorganic materials 0.000 claims 1
- 235000011151 potassium sulphates Nutrition 0.000 claims 1
- 229910052979 sodium sulfide Inorganic materials 0.000 claims 1
- GRVFOGOEDUUMBP-UHFFFAOYSA-N sodium sulfide (anhydrous) Chemical compound [Na+].[Na+].[S-2] GRVFOGOEDUUMBP-UHFFFAOYSA-N 0.000 claims 1
- XMVONEAAOPAGAO-UHFFFAOYSA-N sodium tungstate Chemical compound [Na+].[Na+].[O-][W]([O-])(=O)=O XMVONEAAOPAGAO-UHFFFAOYSA-N 0.000 claims 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 claims 1
- 239000012138 yeast extract Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261650093P | 2012-05-22 | 2012-05-22 | |
| US201261650098P | 2012-05-22 | 2012-05-22 | |
| US61/650,098 | 2012-05-22 | ||
| US61/650,093 | 2012-05-22 | ||
| US201261726225P | 2012-11-14 | 2012-11-14 | |
| US61/726,225 | 2012-11-14 | ||
| US13/890,777 US10100338B2 (en) | 2012-05-22 | 2013-05-09 | Method of operation of a syngas fermentation process |
| US13/890,777 | 2013-05-09 | ||
| PCT/US2013/041250 WO2013176948A2 (en) | 2012-05-22 | 2013-05-15 | Method of operation of a syngas fermentation process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520612A JP2015520612A (ja) | 2015-07-23 |
| JP2015520612A5 true JP2015520612A5 (https=) | 2016-07-07 |
| JP6228596B2 JP6228596B2 (ja) | 2017-11-08 |
Family
ID=49621897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015514061A Active JP6228596B2 (ja) | 2012-05-22 | 2013-05-15 | シンガス発酵プロセスの操作方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10100338B2 (https=) |
| EP (1) | EP2852675B1 (https=) |
| JP (1) | JP6228596B2 (https=) |
| KR (2) | KR102046677B1 (https=) |
| CN (2) | CN108841874B (https=) |
| AR (1) | AR091109A1 (https=) |
| AU (2) | AU2013266676B2 (https=) |
| BR (2) | BR122021020217B1 (https=) |
| CA (1) | CA2874086C (https=) |
| RU (1) | RU2623170C2 (https=) |
| TW (1) | TWI650422B (https=) |
| WO (1) | WO2013176948A2 (https=) |
| ZA (1) | ZA201409445B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9885063B2 (en) * | 2013-06-10 | 2018-02-06 | Ineos Bio Sa | Process for fermenting co-containing gaseous substrates in a low phosphate medium effective for reducing water usage |
| US9850503B2 (en) * | 2013-06-10 | 2017-12-26 | Ineos Bio Sa | Control of conductivity in anaerobic fermentation |
| US9617566B2 (en) | 2014-07-11 | 2017-04-11 | Lanzatech New Zealand Limited | Control of bioreactor processes |
| US9765408B2 (en) * | 2014-08-12 | 2017-09-19 | Ineos Bio Sa | Process for controlling fermentation of co-containing substrates |
| EP3050967A1 (en) * | 2015-01-28 | 2016-08-03 | Evonik Degussa GmbH | A method of producing higher alcohols |
| CN107779477B (zh) * | 2016-08-25 | 2021-10-12 | 中国科学院天津工业生物技术研究所 | 一种食气厌氧菌利用合成气发酵产醇的培养体系和培养方法 |
| CN106399387A (zh) * | 2016-09-20 | 2017-02-15 | 江南大学 | 一种混合菌发酵合成气产乙醇的氮缺陷调控方法 |
| US11333607B2 (en) | 2018-10-02 | 2022-05-17 | Electronics And Telecommunications Research Institute | Fluorescent signal detection apparatus using diagnostic kit |
| KR102722662B1 (ko) | 2021-09-17 | 2024-10-29 | 한국과학기술연구원 | 합성 가스로부터 알코올을 제조하기 위한 에탄올 포함하는 배지 조성물 및 이를 이용한 알코올 생산 방법 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| JPH11341947A (ja) * | 1998-06-02 | 1999-12-14 | Yakult Honsha Co Ltd | 発酵管理方法 |
| US5972661A (en) | 1998-09-28 | 1999-10-26 | Penn State Research Foundation | Mixing systems |
| WO2000068407A1 (en) | 1999-05-07 | 2000-11-16 | Bioengineering Resources, Inc. | Clostridium strains which produce ethanol from substrate-containing gases |
| WO2001025467A1 (en) * | 1999-09-30 | 2001-04-12 | Cognis Corporation | Improved fermentation process |
| EP2960325B1 (en) * | 2000-01-28 | 2017-09-27 | DSM IP Assets B.V. | Enhanced production of lipids containing polyenoic fatty acids by high density cultures of eukaryotic microbes in fermentors |
| WO2002008438A2 (en) * | 2000-07-25 | 2002-01-31 | Bioengineering Resources, Inc. | Methods for increasing the production of ethanol from microbial fermentation |
| EP1584680A1 (en) * | 2004-04-08 | 2005-10-12 | Boehringer Ingelheim Austria GmbH | Fed-batch fermentation process for the production of plasmid DNA |
| NZ546496A (en) | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
| US20070275447A1 (en) | 2006-05-25 | 2007-11-29 | Lewis Randy S | Indirect or direct fermentation of biomass to fuel alcohol |
| WO2008086466A1 (en) * | 2007-01-11 | 2008-07-17 | Danisco Us Inc., Genencor Division | Enzyme production in culture medium comprising raw glycerol |
| CN102016052B (zh) | 2007-08-15 | 2015-04-29 | 朗泽科技新西兰有限公司 | 生产醇的工艺 |
| US8852918B2 (en) * | 2007-11-13 | 2014-10-07 | Lanzatech New Zealand Limited | Bacteria and methods of use thereof |
| JP5600296B2 (ja) | 2007-11-13 | 2014-10-01 | ランザテク・ニュージーランド・リミテッド | 新規細菌及びその使用法 |
| US9034618B2 (en) | 2009-03-09 | 2015-05-19 | Ineos Bio Sa | Method for sustaining microorganism culture in syngas fermentation process in decreased concentration or absence of various substrates |
| BRPI0909841B1 (pt) | 2008-03-10 | 2019-02-05 | Ineos Bio Sa | métodos de sustentação e de prevenção de perda rápida de cultura de microorganismos em reator de fermentação de singás em concentração diminuída ou ausência de vários substratos |
| EA019266B1 (ru) | 2008-03-12 | 2014-02-28 | Ланзатек Нью Зиленд Лимитед | Микробиологический способ производства спирта |
| RU2418070C2 (ru) * | 2009-07-06 | 2011-05-10 | Общество с ограниченной ответственностью "Фирма Атлас" | Способ преобразования газообразного углеводородного сырья в жидкое топливо |
| EP2646561B1 (en) | 2010-12-03 | 2019-07-24 | Jupeng Bio (HK) Limited | Method of operation of fermentation of carbon monoxide and hydrogen containing gaseous substrate |
| BR112013013407B1 (pt) | 2010-12-03 | 2021-01-19 | Jupeng Bio Sa | processo para aumentar a densidade celular em fermentação microbiana de substrato gasoso compreendendo hidrogênio |
| WO2013090769A2 (en) * | 2011-12-14 | 2013-06-20 | Kiverdi, Inc. | Method and apparatus for growing microbial cultures that require gaseous electron donors, electron acceptors, carbon sources, or other nutrients |
-
2013
- 2013-05-09 US US13/890,777 patent/US10100338B2/en active Active
- 2013-05-15 RU RU2014151620A patent/RU2623170C2/ru not_active IP Right Cessation
- 2013-05-15 CA CA2874086A patent/CA2874086C/en active Active
- 2013-05-15 JP JP2015514061A patent/JP6228596B2/ja active Active
- 2013-05-15 KR KR1020147035891A patent/KR102046677B1/ko active Active
- 2013-05-15 CN CN201810500522.6A patent/CN108841874B/zh active Active
- 2013-05-15 WO PCT/US2013/041250 patent/WO2013176948A2/en not_active Ceased
- 2013-05-15 EP EP13728863.5A patent/EP2852675B1/en active Active
- 2013-05-15 KR KR1020197033343A patent/KR102142234B1/ko active Active
- 2013-05-15 BR BR122021020217-6A patent/BR122021020217B1/pt active IP Right Grant
- 2013-05-15 AU AU2013266676A patent/AU2013266676B2/en active Active
- 2013-05-15 CN CN201380026747.8A patent/CN104822836B/zh active Active
- 2013-05-15 BR BR112014028956-5A patent/BR112014028956B1/pt active IP Right Grant
- 2013-05-21 AR ARP130101753 patent/AR091109A1/es unknown
- 2013-05-21 TW TW102117885A patent/TWI650422B/zh active
-
2014
- 2014-12-19 ZA ZA2014/09445A patent/ZA201409445B/en unknown
-
2016
- 2016-05-12 AU AU2016203101A patent/AU2016203101B2/en active Active
-
2018
- 2018-10-12 US US16/158,508 patent/US10858672B2/en active Active
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