JP2015520143A5 - - Google Patents

Info

Publication number

JP2015520143A5

JP2015520143A5 JP2015510822A JP2015510822A JP2015520143A5 JP 2015520143 A5 JP2015520143 A5 JP 2015520143A5 JP 2015510822 A JP2015510822 A JP 2015510822A JP 2015510822 A JP2015510822 A JP 2015510822A JP 2015520143 A5 JP2015520143 A5 JP 2015520143A5

Authority

JP

Japan

Prior art keywords

alkyl

hydrogen

alkoxy

formula

attachment

Prior art date

2013-05-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
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• 229910052739 hydrogen Inorganic materials 0.000 claims 28
• 239000001257 hydrogen Substances 0.000 claims 28
• 150000001875 compounds Chemical class 0.000 claims 26
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 17
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 13
• 150000002431 hydrogen Chemical class 0.000 claims 11
• 150000001204 N-oxides Chemical class 0.000 claims 10
• 125000003277 amino group Chemical group 0.000 claims 10
• 125000004122 cyclic group Chemical group 0.000 claims 10
• 150000003839 salts Chemical class 0.000 claims 10
• 201000010099 disease Diseases 0.000 claims 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
• 229910052757 nitrogen Inorganic materials 0.000 claims 7
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
• 125000004093 cyano group Chemical group *C#N 0.000 claims 6
• 229910052736 halogen Inorganic materials 0.000 claims 5
• 150000002367 halogens Chemical class 0.000 claims 5
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 3
• 229910052731 fluorine Inorganic materials 0.000 claims 3
• 125000005842 heteroatom Chemical group 0.000 claims 3
• 230000003463 hyperproliferative effect Effects 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 229910052760 oxygen Inorganic materials 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• -1 1-6C-alkoxy Chemical class 0.000 claims 2
• 206010027476 Metastases Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 229910052794 bromium Inorganic materials 0.000 claims 2
• 230000030833 cell death Effects 0.000 claims 2
• 229910052801 chlorine Inorganic materials 0.000 claims 2
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
• 230000006698 induction Effects 0.000 claims 2
• 229910052740 iodine Inorganic materials 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 claims 1
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
• 239000003054 catalyst Substances 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 230000000973 chemotherapeutic effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
• 239000011737 fluorine Substances 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000004430 oxygen atom Chemical group O* 0.000 claims 1
• 229910052763 palladium Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
• BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
• 238000003419 tautomerization reaction Methods 0.000 claims 1
• 0 CC1(*)C=NC=CC(N(*)c2c(*)c(*)nc(-c3n[n]c4c3CCCC43CCCC3)n2)=C1 Chemical compound CC1(*)C=NC=CC(N(*)c2c(*)c(*)nc(-c3n[n]c4c3CCCC43CCCC3)n2)=C1 0.000 description 1
• ADNXCHQUIPXULO-UHFFFAOYSA-O CCOC(c1cnccc1[OH2+])=O Chemical compound CCOC(c1cnccc1[OH2+])=O ADNXCHQUIPXULO-UHFFFAOYSA-O 0.000 description 1
• JZTKRFAEIHYBNV-UHFFFAOYSA-O CN[O](CC[OH2+])(=O)=O Chemical compound CN[O](CC[OH2+])(=O)=O JZTKRFAEIHYBNV-UHFFFAOYSA-O 0.000 description 1