JP2015518869A5 - - Google Patents
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- Publication number
- JP2015518869A5 JP2015518869A5 JP2015515488A JP2015515488A JP2015518869A5 JP 2015518869 A5 JP2015518869 A5 JP 2015518869A5 JP 2015515488 A JP2015515488 A JP 2015515488A JP 2015515488 A JP2015515488 A JP 2015515488A JP 2015518869 A5 JP2015518869 A5 JP 2015518869A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- acid
- lactide
- glycolide
- hydroxybutyric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 4
- 229920001432 poly(L-lactide) Polymers 0.000 claims 3
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 2
- JRHWHSJDIILJAT-UHFFFAOYSA-N 2-hydroxypentanoic acid Chemical compound CCCC(O)C(O)=O JRHWHSJDIILJAT-UHFFFAOYSA-N 0.000 claims 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 2
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims 2
- 229940005605 valeric acid Drugs 0.000 claims 2
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 claims 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657049P | 2012-06-08 | 2012-06-08 | |
| US61/657,049 | 2012-06-08 | ||
| PCT/EP2013/061343 WO2013182503A1 (en) | 2012-06-08 | 2013-06-03 | Rapamycin 40-o-cyclic hydrocarbon esters, compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015518869A JP2015518869A (ja) | 2015-07-06 |
| JP2015518869A5 true JP2015518869A5 (https=) | 2017-03-09 |
| JP6101346B2 JP6101346B2 (ja) | 2017-03-22 |
Family
ID=48577737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015515488A Active JP6101346B2 (ja) | 2012-06-08 | 2013-06-03 | ラパマイシン−４０−ｏ−環状炭化水素エステル、組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9408884B2 (https=) |
| EP (1) | EP2859001B1 (https=) |
| JP (1) | JP6101346B2 (https=) |
| CN (1) | CN104203959B (https=) |
| AU (1) | AU2013270798B2 (https=) |
| CA (1) | CA2869102C (https=) |
| DK (1) | DK2859001T3 (https=) |
| ES (1) | ES2574522T3 (https=) |
| PL (1) | PL2859001T3 (https=) |
| SG (1) | SG11201405777YA (https=) |
| WO (1) | WO2013182503A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10751450B2 (en) * | 2012-06-08 | 2020-08-25 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
| US9408884B2 (en) * | 2012-06-08 | 2016-08-09 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
| US11395853B2 (en) | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
| CN107759616B (zh) * | 2016-08-23 | 2020-11-17 | 上海微创医疗器械（集团）有限公司 | 一种化合物及其制备方法和用途 |
| US12453624B2 (en) | 2016-09-19 | 2025-10-28 | Biotronik Ag | Polymer-free drug eluting vascular stents |
| CN109996569B (zh) * | 2016-12-22 | 2022-05-03 | 百多力股份公司 | 用于医疗装置的药物释放涂层及其制备方法 |
| WO2019110600A1 (en) * | 2017-12-06 | 2019-06-13 | Biotronik Ag | Intracranial drug delivery materials and methods |
| EP4699663A2 (en) * | 2018-02-23 | 2026-02-25 | Biotronik Ag | Parenteral formulation materials and methods for 40-o-cyclic hydrocarbon esters and related structures |
| EP3613449A1 (de) * | 2018-08-23 | 2020-02-26 | Biotronik Ag | Verbesserung der polymerschicht bei degradierbaren vorrichtungen |
| US20220088278A1 (en) * | 2019-01-30 | 2022-03-24 | Biotronik Ag | Covered Stent For Local Drug Delivery |
| EP3708176A1 (en) | 2019-03-15 | 2020-09-16 | Centre National De La Recherche Scientifique -Cnrs- | Mutant vsv ectodomain polypeptide and uses thereof |
| WO2022023414A2 (en) * | 2020-07-29 | 2022-02-03 | Biotronik Ag | Pharmaceutical microsphere compositions and methods |
| EP4259100A1 (en) * | 2020-12-14 | 2023-10-18 | Biotronik Ag | Materials and methods for treating viral and other medicinal conditions |
| CN119907670A (zh) * | 2022-09-30 | 2025-04-29 | 百多力股份公司 | 用于血管通路瘘、移植物和其它血管疾病的血管周围医学治疗的大环三烯免疫抑制化合物 |
| US20260102380A1 (en) * | 2022-09-30 | 2026-04-16 | Biotronik Ag | Synthesis and Characterization of Cyclic Hydrocarbon Esters of Everolimus |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| ZA892859B (en) | 1988-04-22 | 1989-12-27 | Advanced Polymer Systems Inc | Porous particles in preparations involving immiscible phases |
| US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5138051A (en) | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
| US5102876A (en) | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5120725A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Bicyclic rapamycins |
| US5120727A (en) | 1991-05-29 | 1992-06-09 | American Home Products Corporation | Rapamycin dimers |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5310903A (en) | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
| WO1995014023A1 (en) * | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US5385910A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
| DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
| US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| CN101467921B (zh) * | 2001-11-05 | 2012-08-15 | 生物传感器国际集团有限公司 | 药物洗脱支架的生产方法 |
| US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
| JP2007505658A (ja) | 2003-09-15 | 2007-03-15 | アトリウム メディカル コーポレーション | 拡張可能医療用具を用いた治療物質の組織部位への塗布 |
| WO2005042567A1 (en) * | 2003-11-03 | 2005-05-12 | Altachem Pharma Ltd. | Rapamycin peptides conjugates: synthesis and uses thereof |
| JP4224115B2 (ja) * | 2004-04-14 | 2009-02-12 | ワイス | ラパマイシン４２−エステル誘導体の位置特異的合成 |
| US7214759B2 (en) | 2004-11-24 | 2007-05-08 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same |
| US8021678B2 (en) * | 2006-02-10 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics |
| US7678901B2 (en) * | 2006-02-28 | 2010-03-16 | Wyeth | Rapamycin analogs containing an antioxidant moiety |
| MX2008011458A (es) * | 2006-03-07 | 2008-09-24 | Wyeth Corp | Procedimiento para preparar conjugados de polietilenglicol solubles en agua de inmunosupresores de macrolidos. |
| EP2083834B1 (en) * | 2006-09-13 | 2017-06-21 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| US20110098241A1 (en) * | 2008-04-14 | 2011-04-28 | Poniard Pharmaceuticals, Inc. | Rapamycin analogs as anti-cancer agents |
| EP2601201B1 (en) * | 2010-08-04 | 2014-09-24 | Meril Life Sciences Pvt. Ltd. | Process for preparation of novel 42-0-(heteroalkoxyalkyl) rapamycin compounds with anti-proliferative properties" |
| CN102018996B (zh) * | 2010-12-14 | 2013-03-06 | 中国医学科学院生物医学工程研究所 | 一种表面固定有抗体的药物血管支架的制备方法 |
| DE102011010539A1 (de) | 2011-02-07 | 2012-08-09 | Airbus Operations Gmbh | Aufrüstvorrichtung und Verfahren zur Herstellung einer aus einem Faserverbundwerkstoff bestehenden Rumpftonne für ein Luftfahrzeug |
| US9408884B2 (en) * | 2012-06-08 | 2016-08-09 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
-
2013
- 2013-06-03 US US14/406,198 patent/US9408884B2/en active Active
- 2013-06-03 EP EP13727586.3A patent/EP2859001B1/en active Active
- 2013-06-03 ES ES13727586.3T patent/ES2574522T3/es active Active
- 2013-06-03 JP JP2015515488A patent/JP6101346B2/ja active Active
- 2013-06-03 WO PCT/EP2013/061343 patent/WO2013182503A1/en not_active Ceased
- 2013-06-03 CA CA2869102A patent/CA2869102C/en active Active
- 2013-06-03 AU AU2013270798A patent/AU2013270798B2/en active Active
- 2013-06-03 DK DK13727586.3T patent/DK2859001T3/da active
- 2013-06-03 PL PL13727586T patent/PL2859001T3/pl unknown
- 2013-06-03 CN CN201380010936.6A patent/CN104203959B/zh active Active
- 2013-06-03 SG SG11201405777YA patent/SG11201405777YA/en unknown
-
2016
- 2016-07-18 US US15/212,987 patent/US9867911B2/en active Active
-
2017
- 2017-12-01 US US15/829,012 patent/US20180078683A1/en not_active Abandoned
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