JP2015518819A - 立体構造的に特異的なウイルス免疫原 - Google Patents

立体構造的に特異的なウイルス免疫原 Download PDF

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JP2015518819A
JP2015518819A JP2015511675A JP2015511675A JP2015518819A JP 2015518819 A JP2015518819 A JP 2015518819A JP 2015511675 A JP2015511675 A JP 2015511675A JP 2015511675 A JP2015511675 A JP 2015511675A JP 2015518819 A JP2015518819 A JP 2015518819A
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viral protein
protein complex
viral
protein
virus
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JP2015518819A5 (enExample
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マーシャル，クリストファー，パトリック
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G01N33/56988—HIV or HTLV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
JP2015511675A 2012-05-09 2013-05-09 立体構造的に特異的なウイルス免疫原 Pending JP2015518819A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261644830P 2012-05-09 2012-05-09
US61/644,830 2012-05-09
PCT/US2013/040228 WO2013169961A1 (en) 2012-05-09 2013-05-09 Conformationally specific viral immunogens

Related Child Applications (1)

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JP2018088600A Division JP6692853B2 (ja) 2012-05-09 2018-05-02 立体構造的に特異的なウイルス免疫原

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JP2015518819A true JP2015518819A (ja) 2015-07-06
JP2015518819A5 JP2015518819A5 (enExample) 2016-06-30

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JP2015511675A Pending JP2015518819A (ja) 2012-05-09 2013-05-09 立体構造的に特異的なウイルス免疫原
JP2018088600A Expired - Fee Related JP6692853B2 (ja) 2012-05-09 2018-05-02 立体構造的に特異的なウイルス免疫原
JP2020073065A Pending JP2020125323A (ja) 2012-05-09 2020-04-15 立体構造的に特異的なウイルス免疫原
JP2022128985A Active JP7472209B2 (ja) 2012-05-09 2022-08-12 立体構造的に特異的なウイルス免疫原

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JP2018088600A Expired - Fee Related JP6692853B2 (ja) 2012-05-09 2018-05-02 立体構造的に特異的なウイルス免疫原
JP2020073065A Pending JP2020125323A (ja) 2012-05-09 2020-04-15 立体構造的に特異的なウイルス免疫原
JP2022128985A Active JP7472209B2 (ja) 2012-05-09 2022-08-12 立体構造的に特異的なウイルス免疫原

Country Status (7)

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US (6) US20130302366A1 (enExample)
EP (2) EP3483174A1 (enExample)
JP (4) JP2015518819A (enExample)
AU (5) AU2013259548A1 (enExample)
CA (1) CA2873048C (enExample)
IN (1) IN2014DN09445A (enExample)
WO (1) WO2013169961A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3024483B1 (en) 2013-07-25 2020-01-15 Calder Biosciences Inc. Conformationally stabilized rsv pre-fusion f proteins
EP3027640B1 (en) 2013-08-03 2018-03-07 Avatar Medical, LLC Influenza hemagglutinin proteins and methods of use thereof
AU2018313000B2 (en) 2017-08-07 2025-07-03 Calder Biosciences Inc. Conformationally stabilized RSV pre-fusion F proteins
WO2019178521A1 (en) 2018-03-16 2019-09-19 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compositions and methods for vaccination against respiratory syncitial virus infection
WO2021231651A2 (en) * 2020-05-12 2021-11-18 The Regents Of The University Ofcalifornia Sars-cov2 neutralizing single domain antibody constructs

Citations (3)

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US20020061549A1 (en) * 1999-10-15 2002-05-23 Marshall Christopher P. Stabilized proteins
JP2007537133A (ja) * 2003-07-03 2007-12-20 アバター バイオテクノロジーズ，インク． 免疫原性を低減した分子の取得方法
US20110076298A1 (en) * 2006-06-19 2011-03-31 Olson William C Soluble stabilized trimeric hiv env proteins and uses thereof

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US7311920B1 (en) * 1999-10-08 2007-12-25 University Of Maryland Biotechnology Institute Virus coat protein/receptor chimeras and methods of use
JP2003511420A (ja) * 1999-10-13 2003-03-25 カイロン コーポレイション タンパク質から細胞性免疫応答を得る方法
US6465425B1 (en) 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US7179468B1 (en) * 2000-06-08 2007-02-20 Cornell Research Foundation, Inc. Antigen for developing neutralizing antibodies to human immunodeficiency virus
EP1463521A4 (en) 2001-12-17 2009-06-24 Us Gov Health & Human Serv INHIBITOR OF GP41
US20080206264A1 (en) 2003-02-04 2008-08-28 New York University Constrained Hiv V3 Loop Peptides as Novel Immunogens and Receptor Antagonists
WO2005118886A2 (en) * 2004-06-01 2005-12-15 Merck & Co., Inc. Stable peptide mimetic of hiv gp41 fusion intermediate
CN105566450A (zh) * 2007-07-27 2016-05-11 伊玛提克斯生物技术有限公司 免疫疗法的新型免疫抗原表位
BRPI0815416A2 (pt) 2007-08-15 2014-10-21 Amunix Inc Composições e métodos para modificar propriedades de polipeptídeos biologicamente ativos
US20090246191A1 (en) * 2007-10-11 2009-10-01 University Of Tennessee Research Foundation Preparation of Purified Covalently Cross-linked Abeta Oligomers and Uses Thereof
SMT202000101T1 (it) * 2008-10-10 2020-03-13 Childrens Medical Center Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
US20110123556A1 (en) 2009-11-24 2011-05-26 Sanjay Phogat Immunogen prioritization for vaccine design
EP2572196A4 (en) 2010-05-18 2014-04-23 Christopher P Marshall ANTIGEN IDENTIFICATION TEST THAT ACTIVATES B-CELL RECEPTORS COMPRISING NEUTRALIZING ANTIBODIES
US20130149336A1 (en) * 2011-10-27 2013-06-13 Brian L. Hjelle Methods for Screening Viral Like Particles and Identifying Neutralizing Epitopes and Related Vaccines, Constructs, and Libraries
EP2804948B1 (en) 2012-01-20 2020-04-15 The Government of The Hong Kong Special Administrative Region of The People's Republic of China A novel paramyxovirus and uses thereof

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US20020061549A1 (en) * 1999-10-15 2002-05-23 Marshall Christopher P. Stabilized proteins
JP2007537133A (ja) * 2003-07-03 2007-12-20 アバター バイオテクノロジーズ，インク． 免疫原性を低減した分子の取得方法
US20110076298A1 (en) * 2006-06-19 2011-03-31 Olson William C Soluble stabilized trimeric hiv env proteins and uses thereof

Non-Patent Citations (3)

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Title
FOUTS ET AL: "Crosslinked HIV-1 Envelope-CD4 Receptor Complexes Elicit Broadly Cross-Reactive Neutralizing Antibod", PNAS, vol. 99, JPN6017011486, 2002, pages 11842 - 11847, XP001204529, ISSN: 0003534476, DOI: 10.1073/pnas.182412199 *
HOROWITZ E ET AL: "Tyrosine Cross-Linking Reveals Interfacial Dynamics in Adeno-Associated Viral Capsids during Infecti", ACS CHEMICAL BIOLOGY, vol. 7, no. 6, JPN6017011481, 29 March 2012 (2012-03-29), pages 1059 - 1066, ISSN: 0003534474 *
SANDERS, RW ET AL: "Stabilization Of The Soluble, Cleaved, Trimeric Form OF The Envelope Glycoprotein Complex OF Human I", J.VIROL, vol. 76, JPN6017011484, 2002, pages 8875 - 8889, XP002600070, ISSN: 0003534475, DOI: 10.1128/JVI.76.17.8875-8889.2002 *

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Publication number Publication date
US11752191B2 (en) 2023-09-12
AU2019216695A1 (en) 2019-09-05
AU2021204169A1 (en) 2021-07-15
JP2020125323A (ja) 2020-08-20
AU2018200502A1 (en) 2018-02-15
JP2018150330A (ja) 2018-09-27
EP2846828B1 (en) 2018-11-21
AU2024201200A1 (en) 2024-03-14
AU2021204169B2 (en) 2023-11-23
US20190105368A1 (en) 2019-04-11
US10155023B2 (en) 2018-12-18
JP7472209B2 (ja) 2024-04-22
US20130302366A1 (en) 2013-11-14
US20130317205A1 (en) 2013-11-28
US20180117116A1 (en) 2018-05-03
JP6692853B2 (ja) 2020-05-13
AU2018200502B2 (en) 2019-10-03
JP2022163180A (ja) 2022-10-25
CA2873048A1 (en) 2013-11-14
US20210322512A1 (en) 2021-10-21
EP2846828A4 (en) 2015-07-01
AU2013259548A1 (en) 2014-11-27
WO2013169961A1 (en) 2013-11-14
EP2846828A1 (en) 2015-03-18
EP3483174A1 (en) 2019-05-15
US20240238369A1 (en) 2024-07-18
IN2014DN09445A (enExample) 2015-07-17
CA2873048C (en) 2020-10-27

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