JP2015511721A5 - - Google Patents
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- Publication number
- JP2015511721A5 JP2015511721A5 JP2015502555A JP2015502555A JP2015511721A5 JP 2015511721 A5 JP2015511721 A5 JP 2015511721A5 JP 2015502555 A JP2015502555 A JP 2015502555A JP 2015502555 A JP2015502555 A JP 2015502555A JP 2015511721 A5 JP2015511721 A5 JP 2015511721A5
- Authority
- JP
- Japan
- Prior art keywords
- level
- cells
- blood sample
- cd11b
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 31
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 19
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 19
- 238000000034 method Methods 0.000 claims 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 210000004369 blood Anatomy 0.000 claims 12
- 239000008280 blood Substances 0.000 claims 12
- 210000002074 inflammatory monocyte Anatomy 0.000 claims 12
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 10
- 102100022338 Integrin alpha-M Human genes 0.000 claims 10
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 9
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 9
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 9
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 8
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 8
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615465P | 2012-03-26 | 2012-03-26 | |
| US61/615,465 | 2012-03-26 | ||
| PCT/IL2013/050277 WO2013144957A1 (en) | 2012-03-26 | 2013-03-21 | Cellular markers for diagnosis of alzheimer's disease and for alzheimer's disease progression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511721A JP2015511721A (ja) | 2015-04-20 |
| JP2015511721A5 true JP2015511721A5 (enExample) | 2016-05-12 |
| JP6276252B2 JP6276252B2 (ja) | 2018-02-07 |
Family
ID=49258360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015502555A Active JP6276252B2 (ja) | 2012-03-26 | 2013-03-21 | アルツハイマー病の診断のための細胞マーカーおよびアルツハイマー病の進行の細胞マーカー |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150057176A1 (enExample) |
| EP (1) | EP2831584B1 (enExample) |
| JP (1) | JP6276252B2 (enExample) |
| KR (1) | KR20140145173A (enExample) |
| CN (1) | CN104471394B (enExample) |
| AU (1) | AU2013239070A1 (enExample) |
| CA (1) | CA2907909A1 (enExample) |
| ES (1) | ES2819174T3 (enExample) |
| IL (1) | IL234779A (enExample) |
| WO (1) | WO2013144957A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6312302B2 (ja) * | 2014-01-06 | 2018-04-18 | 公益財団法人ヒューマンサイエンス振興財団 | 脳梗塞の診断マーカー |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング，インコーポレイテッド | Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療 |
| JP6499342B2 (ja) * | 2018-03-19 | 2019-04-10 | 隆樹 日和佐 | 脳梗塞の診断マーカー |
| CN120058944A (zh) | 2019-01-30 | 2025-05-30 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| WO2020198299A1 (en) * | 2019-03-26 | 2020-10-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for characterizing and treating alzheimer's disease |
| CN111727260A (zh) * | 2019-10-15 | 2020-09-29 | 湖南乾康科技有限公司 | 中间型单核细胞在制备诊断和预测ad药物中的应用 |
| JP2023528797A (ja) | 2020-05-26 | 2023-07-06 | トゥルーバインディング，インコーポレイテッド | ガレクチン－３を遮断することにより炎症性疾患を処置する方法 |
| CN112562867A (zh) * | 2021-02-22 | 2021-03-26 | 天津迈德新医药科技有限公司 | 一种预测极早期hiv感染风险的装置、存储介质和电子装置 |
| CA3228621A1 (en) | 2021-08-09 | 2023-02-16 | Xin Huang | Compositions, kits, and methods for detecting preclinical alzheimer's disease |
| US20250009714A1 (en) * | 2021-11-02 | 2025-01-09 | Tranquis Therapeutics, Inc. | Selection and treatment of subjects having a circulating myeloid cell inflammatory phenotype |
| KR102745500B1 (ko) * | 2022-09-02 | 2024-12-23 | 한양대학교 에리카산학협력단 | 혈액 대사체를 이용한 치매 스크리닝 장치 및 방법 |
| CN116270741B (zh) * | 2023-02-28 | 2025-10-24 | 东莞市东南部中心医院 | 骨髓源性抑制细胞在制备治疗阿兹海默症药物或试剂中的应用 |
| CN117122612B (zh) * | 2023-07-07 | 2024-08-27 | 河络新图生物科技(上海)有限公司 | 外周血单个核细胞在制备治疗/预防阿尔茨海默病的药物中的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE302020T1 (de) * | 2000-01-20 | 2005-09-15 | Yeda Res & Dev | Verwendung von copolymer 1- und verwandten peptiden sowie von polypeptiden und damit behandelten t-zellen zur neuroprotektiven therapie |
| US20020137108A1 (en) * | 2000-11-08 | 2002-09-26 | Michael Mullan | CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker in alzheimer's disease |
| AU2002353486B2 (en) * | 2001-12-06 | 2009-01-15 | Yeda Research And Development Co. Ltd | Vaccine and method for treatment of motor neurone diseases |
| CN100591761C (zh) * | 2004-08-19 | 2010-02-24 | 加的夫大学学院咨询有限公司 | 呈递抗原的人γδT细胞的制备和在免疫治疗中的用途 |
| WO2010033861A1 (en) * | 2008-09-18 | 2010-03-25 | Cedars-Sinai Medical Center | Optical method for the detection of alzheimer's disease |
| JP5904953B2 (ja) * | 2010-03-10 | 2016-04-20 | イエダ リサーチ アンド ディベロップメント カンパニー リミテッド | Ａｌｓの早期診断およびａｌｓ進行のための細胞性血液マーカー |
-
2013
- 2013-03-21 CA CA2907909A patent/CA2907909A1/en not_active Abandoned
- 2013-03-21 JP JP2015502555A patent/JP6276252B2/ja active Active
- 2013-03-21 US US14/388,369 patent/US20150057176A1/en not_active Abandoned
- 2013-03-21 KR KR1020147029916A patent/KR20140145173A/ko not_active Withdrawn
- 2013-03-21 CN CN201380027520.5A patent/CN104471394B/zh active Active
- 2013-03-21 AU AU2013239070A patent/AU2013239070A1/en not_active Abandoned
- 2013-03-21 WO PCT/IL2013/050277 patent/WO2013144957A1/en not_active Ceased
- 2013-03-21 EP EP13767635.9A patent/EP2831584B1/en active Active
- 2013-03-21 ES ES13767635T patent/ES2819174T3/es active Active
-
2014
- 2014-09-22 IL IL234779A patent/IL234779A/en active IP Right Grant
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