JP2015511226A - 低酸素活性化プロドラッグ療法のための予測バイオマーカー - Google Patents

低酸素活性化プロドラッグ療法のための予測バイオマーカー Download PDF

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JP2015511226A
JP2015511226A JP2014554975A JP2014554975A JP2015511226A JP 2015511226 A JP2015511226 A JP 2015511226A JP 2014554975 A JP2014554975 A JP 2014554975A JP 2014554975 A JP2014554975 A JP 2014554975A JP 2015511226 A JP2015511226 A JP 2015511226A
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cancer
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ハート，チャールズ
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スレッショルド ファーマシューティカルズ，インコーポレイテッド
スレッショルド ファーマシューティカルズ，インコーポレイテッド
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  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014554975A 2012-01-31 2013-01-30 低酸素活性化プロドラッグ療法のための予測バイオマーカー Pending JP2015511226A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261593249P 2012-01-31 2012-01-31
US61/593,249 2012-01-31
PCT/US2013/023921 WO2013116385A1 (en) 2012-01-31 2013-01-30 Predictive biomarker for hypoxia-activated prodrug therapy

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JP2017214327A Division JP2018052956A (ja) 2012-01-31 2017-11-07 低酸素活性化プロドラッグ療法のための予測バイオマーカー

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JP2015511226A5 JP2015511226A5 (https=) 2016-03-17

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US (1) US20150005264A1 (https=)
EP (1) EP2810076A4 (https=)
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Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
EP1896040B1 (en) 2005-06-29 2012-08-01 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
EP2793882A4 (en) 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
WO2015025283A2 (en) * 2013-08-20 2015-02-26 Stichting Maastricht Radiation Oncology "Maastro-Clinic" Dual action carbonic anhydrase inhibitors
WO2015069489A1 (en) * 2013-11-06 2015-05-14 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
US10760130B2 (en) 2014-11-19 2020-09-01 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
US20210369746A1 (en) * 2016-08-01 2021-12-02 Molecular Templates, Inc. Administration of hypoxia activated prodrugs in combination with immune modulatory agents for treating cancer
WO2023025312A1 (zh) 2021-08-27 2023-03-02 深圳艾欣达伟医药科技有限公司 使用th-302治疗parp抑制剂耐药的患者
CN117651548B (zh) 2021-08-27 2026-03-03 深圳艾欣达伟医药科技有限公司 冻干制剂溶液及冻干制剂、方法和用途
US20250186468A1 (en) 2022-03-15 2025-06-12 Ascentawits Pharmaceuticals, Ltd. Method for treating patient with brca-mutated cancer
CN119384281A (zh) 2022-04-15 2025-01-28 深圳艾欣达伟医药科技有限公司 使用th-302单药或联用parp抑制剂治疗癌症的方法
CN119233822A (zh) 2022-05-23 2024-12-31 深圳艾欣达伟医药科技有限公司 烷化剂前药与细胞周期抑制剂联用治疗癌症的方法
CN119894521A (zh) 2022-09-22 2025-04-25 深圳艾欣达伟医药科技有限公司 乏氧激活的化合物在制备治疗癌症患者的药物中的用途
KR20250160163A (ko) 2023-02-27 2025-11-11 아센타위츠 파마슈티컬즈 리미티드 용액, 동결건조 제형, 동결건조 제형 단위 패키지, 주사제, 및 주사제 제조 방법
WO2025026214A1 (zh) 2023-07-28 2025-02-06 深圳艾欣达伟医药科技有限公司 治疗p53基因突变或缺陷阴性癌症、肿瘤患者

Citations (1)

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WO2012009288A2 (en) * 2010-07-12 2012-01-19 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer

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HUE026218T2 (en) * 2002-02-21 2016-05-30 Inst Virology MN / CA IX-Specific Monoclonal Antibodies and Methods for MN / CA IX Deficient Mice
EP1743038A4 (en) * 2004-05-04 2007-11-21 Bayer Healthcare MN / CA IX / CA9 AND KIDNEY CANCER PROGNOSIS

Patent Citations (1)

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WO2012009288A2 (en) * 2010-07-12 2012-01-19 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer

Non-Patent Citations (6)

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WO2013116385A1 (en) 2013-08-08
EP2810076A4 (en) 2015-07-01
US20150005264A1 (en) 2015-01-01
JP2018052956A (ja) 2018-04-05

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