JP2015509003A - 比色センサを有する血液培養ボトル用検出装置 - Google Patents
比色センサを有する血液培養ボトル用検出装置 Download PDFInfo
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/80—Indicating pH value
Abstract
Description
検出器_出力(信号)=0.2652-0.2554x R2=0.9963
検出器_出力(基準)= 0.5621-0.2384x R2=0.9999
表2において、xは線型変位距離(インチ)である。
上述の様に、約490nm未満の照明のピーク波長を持つ基準LED10(図3)も本検出装置に適していることが明らかとなった。一実施形態において、基準LEDは約328〜470nmの照明のピーク波長を有している。好適な実施形態において、基準LEDは約450〜470nmの照明のピーク波長を有している。ピーク波長が460nmであり、ローレンツ輝度分布であり、かつ分光幅が約25nm(全体で435〜485nm)であるOptek Technology社のOVLFB3C7青色LEDは、好適な基準LEDの一例である。
Claims (12)
- 血液培養ボトル内の試料媒体のpH又はCO2の変化による色の変化の影響を受ける、比色センサの組み込まれた血液培養ボトル用の検出装置であって、
前記比色センサを照らすセンサLEDと、
前記比色センサを照らす基準LEDと、
前記センサLED及び前記基準LEDを選択的かつ交互に作動させる制御回路と、
前記センサLED及び前記基準LEDが前記比色センサを選択的かつ交互に照らす間、前記比色センサからの反射率を測定し、強度信号を生成する光検出器とを備え、
前記基準LEDは、前記基準LEDの照明による前記光検出器の前記強度信号が前記比色センサの色の変化による影響を実質的に受けないような照明のピーク波長を持つように選択され、
前記基準LEDの照明の前記ピーク波長が約490nm未満である
検出装置。 - 請求項1に記載の検出装置において、前記基準LEDは約328と470nmとの間に照明のピーク波長を有する、検出装置。
- 請求項1に記載の検出装置において、前記基準LEDは約450と470nmとの間に照明のピーク波長を有する、検出装置。
- 請求項1に記載の検出装置において、前記強度信号を受け取るコンピュータを更に備え、該コンピュータが、前記検出装置に対する前記ボトルの原点位置からの距離の関数として、前記基準LEDの強度信号間の較正関係を保存するメモリを含む検出装置。
- 請求項4に記載の検出装置において、前記メモリが、前記ボトルの前記原点位置からの距離の関数として、前記センサLEDの強度信号間の較正関係を更に保存し、前記コンピュータが、前記センサLEDと前記基準LEDとの較正関係に従い、前記原点位置から離れて位置する前記ボトルによる、前記センサLEDの強度信号の低下を補償する検出装置。
- 血液培養ボトルに組み込まれ、該血液培養ボトル内の試料媒体のpH又はCO2の変化による色の変化の影響を受ける比色センサの検出方法であって、
センサLED及び基準LEDによって前記比色センサを交互に反復して照らすステップと、
前記センサLED及び前記基準LEDによる前記比色センサの照明による前記比色センサの反射率を、応答して強度信号を生成する光検出器によって測定するステップと、を含み、
前記基準LEDは、前記基準LEDによる照明の前記光検出器の前記強度信号が、前記比色センサの色の変化による影響を実質的に受けないようなピーク波長を持ち、前記基準LEDの照明の前記ピーク波長が約490nm未満となるように選択される
検出方法。 - 請求項6に記載の方法において、前記基準LEDは約328と470nmとの間に照明のピーク波長を有する、方法。
- 請求項6に記載の方法において、前記基準LEDは約450と470nmとの間に照明のピーク波長を有する、方法。
- 請求項6に記載の方法において、コンピュータメモリに、前記センサLED、基準LED及び光検出器に対する原点位置からの前記ボトルの距離の関数として、前記基準LEDの強度信号の較正関係を保存するステップを更に含む方法。
- 請求項6に記載の方法において、コンピュータメモリに、前記センサLED、基準LED及び光検出器に対する原点位置からの前記ボトルの距離の関数として、前記センサLEDの強度信号の較正関係を保存するステップを更に含む方法。
- 請求項10に記載の方法において、前記センサLEDと前記基準LEDの較正関係に従い、前記原点位置から離れて位置する前記ボトルによる、前記センサLEDの強度信号の低下を補償するステップを更に含む方法。
- 請求項11に記載の方法において、前記補償するステップは、前記基準LEDの前記較正関係と、前記センサLEDの前記較正関係とを用いて前記ボトルの移動値を決定し、前記光検出器の前記強度信号を調整して、前記移動値によって前記ボトルの前記移動を修正するステップを更に含む方法。
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PCT/US2012/021733 WO2013109267A1 (en) | 2012-01-18 | 2012-01-18 | Detector arrangement for blood culture bottles with colorimetric sensors |
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JP (1) | JP5919394B2 (ja) |
CN (1) | CN104053991B (ja) |
AU (1) | AU2012327180B2 (ja) |
CA (1) | CA2861301C (ja) |
ES (1) | ES2698056T3 (ja) |
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CN105093344B (zh) * | 2014-04-17 | 2019-01-11 | 湖南长沙天地人生物科技有限公司 | 培养位状态判断方法、装置及一种微生物培养系统 |
WO2016149848A1 (en) * | 2015-03-24 | 2016-09-29 | Uster Technologies Ag | Led-based fiber property measurement |
DE102016113763A1 (de) * | 2016-07-26 | 2018-02-01 | Endress+Hauser Conducta Gmbh+Co. Kg | Sensoranordnung zum Einsatz in der Prozessautomatisierung |
CN107271366B (zh) * | 2017-06-28 | 2020-01-17 | 中南民族大学 | 检测硝基苯酚的比色瓶/管 |
US20220056396A1 (en) * | 2019-01-23 | 2022-02-24 | Becton, Dickinson And Company | Devices, systems, and methods for continuous real time blood culture measurement |
WO2023150268A1 (en) * | 2022-02-04 | 2023-08-10 | Becton, Dickinson And Company | Systems and methods for calibrating instruments that measure temperature and microbial growth in blood culture bottles |
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JP5919394B2 (ja) | 2016-05-18 |
EP2805161A1 (en) | 2014-11-26 |
EP2805161B1 (en) | 2018-09-26 |
CN104053991A (zh) | 2014-09-17 |
CA2861301A1 (en) | 2013-07-25 |
AU2012327180A1 (en) | 2013-08-01 |
CN104053991B (zh) | 2016-09-14 |
ES2698056T3 (es) | 2019-01-30 |
WO2013109267A1 (en) | 2013-07-25 |
EP2805161A4 (en) | 2015-10-07 |
CA2861301C (en) | 2019-04-09 |
AU2012327180B2 (en) | 2015-05-21 |
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