JP2015505959A - 癌を有する患者に治療を選択する方法 - Google Patents

癌を有する患者に治療を選択する方法 Download PDF

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Publication number
JP2015505959A
JP2015505959A JP2014545002A JP2014545002A JP2015505959A JP 2015505959 A JP2015505959 A JP 2015505959A JP 2014545002 A JP2014545002 A JP 2014545002A JP 2014545002 A JP2014545002 A JP 2014545002A JP 2015505959 A JP2015505959 A JP 2015505959A
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cancer
pi3k
treatment
inhibitor
activation
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JP2015505959A5 (https=
Inventor
シャラット シン，
シャラット シン，
アン クーラー，
アン クーラー，
タニ アン ティー． リー，
タニ アン ティー． リー，
サスワティ ハズラール，
サスワティ ハズラール，
リチャード カークランド，
リチャード カークランド，
シンジュン リュー，
シンジュン リュー，
フィリップ キム，
フィリップ キム，
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Nestec SA
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Nestec SA
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2014545002A 2011-12-05 2012-12-05 癌を有する患者に治療を選択する方法 Pending JP2015505959A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161567085P 2011-12-05 2011-12-05
US61/567,085 2011-12-05
US201261728748P 2012-11-20 2012-11-20
US61/728,748 2012-11-20
PCT/US2012/068005 WO2013086031A1 (en) 2011-12-05 2012-12-05 Method of therapy selection for patients with cancer

Related Child Applications (1)

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JP2017191195A Division JP2018054614A (ja) 2011-12-05 2017-09-29 癌を有する患者に治療を選択する方法

Publications (2)

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JP2015505959A true JP2015505959A (ja) 2015-02-26
JP2015505959A5 JP2015505959A5 (https=) 2016-01-28

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JP2014545002A Pending JP2015505959A (ja) 2011-12-05 2012-12-05 癌を有する患者に治療を選択する方法
JP2017191195A Pending JP2018054614A (ja) 2011-12-05 2017-09-29 癌を有する患者に治療を選択する方法
JP2019182229A Pending JP2020024210A (ja) 2011-12-05 2019-10-02 癌を有する患者に治療を選択する方法

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JP2017191195A Pending JP2018054614A (ja) 2011-12-05 2017-09-29 癌を有する患者に治療を選択する方法
JP2019182229A Pending JP2020024210A (ja) 2011-12-05 2019-10-02 癌を有する患者に治療を選択する方法

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US (1) US20140273006A1 (https=)
EP (1) EP2788752B1 (https=)
JP (3) JP2015505959A (https=)
WO (1) WO2013086031A1 (https=)

Cited By (4)

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WO2017065277A1 (ja) * 2015-10-14 2017-04-20 日東紡績株式会社 ２種のプロテインキナーゼの活性測定を用いる解析方法による、薬剤感受性ヒト細胞株の判定方法
JP2018517129A (ja) * 2015-04-21 2018-06-28 ジェネンテック， インコーポレイテッド 前立腺がんの分析のための組成物及び方法
JP2022505266A (ja) * 2018-10-18 2022-01-14 メディミューン，エルエルシー 癌患者の治療を決定する方法
JP2023022111A (ja) * 2017-06-22 2023-02-14 キャンブリッジ ライフ サイエンシーズ リミテッド 抗ｅｒｂｂ３抗体治療に対する食道癌の応答を予測する方法およびキット

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RU2015127037A (ru) * 2012-12-07 2017-01-11 Дзе Дженерал Хоспитал Корпорейшн Комбинации ингибитора pi3k/akt с ингибитором her3/egfr и способы их применения
JP2016515132A (ja) * 2013-03-14 2016-05-26 ジェネンテック， インコーポレイテッド Ｍｅｋ阻害剤化合物のｈｅｒ３／ｅｇｆｒ阻害剤化合物との組み合わせ及び使用方法
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
CA2975829A1 (en) * 2014-02-20 2015-09-03 Merrimack Pharmaceuticals, Inc. Dosage and administration of anti-igf-1r, anti-erbb3 bispecific antibodies, uses thereof and methods of treatment therewith
CA2955141A1 (en) * 2014-07-23 2016-01-28 Ontario Institute For Cancer Research Systems, devices and methods for constructing and using a biomarker
DK3230736T3 (da) * 2014-12-12 2020-06-08 Celcuity Inc Fremgangsmåder til måling af ErbB-signaleringsvejsaktivitet til at diagnosticere og behandle cancerpatienter
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
HK1249866A1 (zh) * 2015-06-29 2018-11-16 豪夫迈‧罗氏有限公司 用他塞利昔布进行治疗的方法
CN109789204A (zh) * 2016-05-31 2019-05-21 雀巢产品技术援助有限公司 基于her2和her3通路亚型选择乳癌患者药物疗法的方法
US20180117029A1 (en) * 2016-11-03 2018-05-03 Beth Israel Deaconess Medical Center, Inc. Targeting Metabolic Vulnerability in Triple-Negative Breast Cancer
SG11201909218RA (en) 2017-04-03 2019-11-28 Hoffmann La Roche Antibodies binding to steap-1
KR102267593B1 (ko) * 2018-10-19 2021-06-21 주식회사 프로티나 Her2 및 her3의 헤테로다이머를 표적으로 하는 약물 및 이의 스크리닝 방법
CN111888487B (zh) * 2020-09-04 2022-05-17 山西医科大学 肿瘤靶向型光声成像引导多阶段治疗纳米探针及制备方法

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JP2010533842A (ja) * 2007-07-13 2010-10-28 プロメテウス ラボラトリーズ インコーポレイテッド 抗体アレイを用いた肺癌治療のための薬剤選択
JP2011514522A (ja) * 2008-02-25 2011-05-06 プロメテウス ラボラトリーズ インコーポレイテッド 抗体に基づくアレイを用いた乳癌療法のための薬物選択
WO2011088149A2 (en) * 2010-01-12 2011-07-21 Prometheus Laboratories Inc. Methods for predicting response of triple-negative breast cancer to therapy

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JP5718319B2 (ja) 2009-05-14 2015-05-13 ネステク ソシエテ アノニム Ｈｅｒ２標的化療法に対する乳癌細胞の感受性を決定するためのバイオマーカー
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JP2011514522A (ja) * 2008-02-25 2011-05-06 プロメテウス ラボラトリーズ インコーポレイテッド 抗体に基づくアレイを用いた乳癌療法のための薬物選択
WO2011088149A2 (en) * 2010-01-12 2011-07-21 Prometheus Laboratories Inc. Methods for predicting response of triple-negative breast cancer to therapy

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018517129A (ja) * 2015-04-21 2018-06-28 ジェネンテック， インコーポレイテッド 前立腺がんの分析のための組成物及び方法
JP2021073437A (ja) * 2015-04-21 2021-05-13 ジェネンテック， インコーポレイテッド 前立腺がんの分析のための組成物及び方法
JP7022191B2 (ja) 2015-04-21 2022-02-17 ジェネンテック， インコーポレイテッド 前立腺がんの分析のための組成物及び方法
WO2017065277A1 (ja) * 2015-10-14 2017-04-20 日東紡績株式会社 ２種のプロテインキナーゼの活性測定を用いる解析方法による、薬剤感受性ヒト細胞株の判定方法
JPWO2017065277A1 (ja) * 2015-10-14 2018-08-09 日東紡績株式会社 ２種のプロテインキナーゼの活性測定を用いる解析方法による、薬剤感受性ヒト細胞株の判定方法
US10724071B2 (en) 2015-10-14 2020-07-28 Nitto Boseki Co., Ltd. Method for determining drug-sensitive human cell lines by analysis method in which measurement of activity of two types of protein kinase is used
JP2023022111A (ja) * 2017-06-22 2023-02-14 キャンブリッジ ライフ サイエンシーズ リミテッド 抗ｅｒｂｂ３抗体治療に対する食道癌の応答を予測する方法およびキット
JP7411055B2 (ja) 2017-06-22 2024-01-10 キャンブリッジ ライフ サイエンシーズ リミテッド 抗ｅｒｂｂ３抗体治療に対する食道癌の応答を予測する方法およびキット
JP2022505266A (ja) * 2018-10-18 2022-01-14 メディミューン，エルエルシー 癌患者の治療を決定する方法

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Publication number Publication date
EP2788752A1 (en) 2014-10-15
JP2020024210A (ja) 2020-02-13
JP2018054614A (ja) 2018-04-05
EP2788752A4 (en) 2015-11-11
WO2013086031A1 (en) 2013-06-13
EP2788752B1 (en) 2018-10-03
US20140273006A1 (en) 2014-09-18

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