JP2015502915A - CD1dに対する抗体 - Google Patents

CD1dに対する抗体 Download PDF

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Publication number
JP2015502915A
JP2015502915A JP2014534890A JP2014534890A JP2015502915A JP 2015502915 A JP2015502915 A JP 2015502915A JP 2014534890 A JP2014534890 A JP 2014534890A JP 2014534890 A JP2014534890 A JP 2014534890A JP 2015502915 A JP2015502915 A JP 2015502915A
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JP
Japan
Prior art keywords
seq
cd1d
antigen
antibody
human
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JP2014534890A
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Japanese (ja)
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JP2015502915A5 (enExample
Inventor
ジョナサン・カンナン・ナンビアー
リン・ドロシー・ポールトン
アダム・クラーク
アンドリュー・ジェームズ・パウ
デブラ・タンヴァキス
ジョージ・コプシダス
アンソニー・ゲラルド・ドイル
マシュー・ポラード
フセイン・ムスタファ
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テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド
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Priority claimed from AU2011904190A external-priority patent/AU2011904190A0/en
Application filed by テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド filed Critical テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド
Publication of JP2015502915A publication Critical patent/JP2015502915A/ja
Publication of JP2015502915A5 publication Critical patent/JP2015502915A5/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2014534890A 2011-10-14 2012-10-15 CD1dに対する抗体 Pending JP2015502915A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161547307P 2011-10-14 2011-10-14
US61/547,307 2011-10-14
AU2011904190 2011-10-14
AU2011904190A AU2011904190A0 (en) 2011-10-14 Antibodies to CD1d
PCT/AU2012/001247 WO2013053021A1 (en) 2011-10-14 2012-10-15 ANTIBODIES TO CD1d

Publications (2)

Publication Number Publication Date
JP2015502915A true JP2015502915A (ja) 2015-01-29
JP2015502915A5 JP2015502915A5 (enExample) 2015-12-03

Family

ID=48081279

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014534890A Pending JP2015502915A (ja) 2011-10-14 2012-10-15 CD1dに対する抗体

Country Status (14)

Country Link
US (1) US20140286957A1 (enExample)
EP (1) EP2766042A4 (enExample)
JP (1) JP2015502915A (enExample)
KR (1) KR20140108520A (enExample)
CN (1) CN104144700B (enExample)
AU (1) AU2012323781B8 (enExample)
BR (1) BR112014008691A2 (enExample)
CA (1) CA2850961A1 (enExample)
EA (1) EA201400447A1 (enExample)
IL (1) IL231975A0 (enExample)
MX (1) MX2014004326A (enExample)
SG (1) SG11201400521PA (enExample)
WO (1) WO2013053021A1 (enExample)
ZA (1) ZA201401776B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022511062A (ja) * 2018-12-07 2022-01-28 ライフアーク ヒト化抗il17br抗体
JP2023538379A (ja) * 2020-08-18 2023-09-07 セファロン エルエルシー 抗par-2抗体及びそれらの使用方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201706128PA (en) 2015-01-27 2017-08-30 Lava Therapeutics B V Single domain antibodies targeting cd1d
CN109476724B (zh) * 2016-04-08 2023-04-04 艾达普特免疫有限公司 T细胞受体
DK3440105T3 (da) * 2016-04-08 2022-06-13 Immunocore Ltd T-cellereceptorer
SG11201808751SA (en) * 2016-04-08 2018-11-29 Adaptimmune Ltd T cell receptors
CN108079292A (zh) * 2016-11-23 2018-05-29 苏州盛迪亚生物医药有限公司 一种抗pd-1抗体在制备治疗肝癌的药物中的用途
AU2018234827B2 (en) * 2017-03-15 2024-04-04 Orca Biosystems Inc. Compositions and methods for hematopoietic stem cell transplants
BR112021005184A8 (pt) * 2018-09-19 2022-08-16 Lava Therapeutics B V Imunoglobulina cd1d de dupla ação
US20240050569A1 (en) * 2020-12-18 2024-02-15 Bioardis, Llc Mesothelin binding molecules and uses thereof
CN120476137A (zh) 2022-08-18 2025-08-12 英美偌科有限公司 对mage a4具有特异性的t细胞受体融合蛋白
CN116217704B (zh) * 2022-10-25 2025-08-15 南京医科大学 一种抑制肝细胞凋亡的表面分子及其应用
WO2024137789A2 (en) * 2022-12-21 2024-06-27 Board Of Regents, The University Of Texas System Cd3 and itcr expressing engineered natural killer cells with enhanced function for adoptive immunotherapy
WO2024226794A1 (en) * 2023-04-26 2024-10-31 The Trustees Of Indiana University Composition and methods for treatment of spinal cord injury and traumatic brain injury

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003092615A2 (en) * 2002-05-01 2003-11-13 Beth Israel Deaconess Medical Center Use of anti-cd1 antibodies for the modulation of immune responses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1095062B1 (en) * 1998-07-09 2006-09-13 Brian J. Nickoloff Method of treating disorders by modulating the interaction of natural killer receptors on t cells with their respective ligands
WO2008100912A1 (en) * 2007-02-12 2008-08-21 The General Hospital Corporation Methods for attenuating allergen-induced airway hyperreactivity using cd1d dependent antagonists
US8012484B2 (en) * 2007-04-12 2011-09-06 University Of Virginia Patent Foundation Method of treating ischemia reperfusion injury by inhibiting NKT cell activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003092615A2 (en) * 2002-05-01 2003-11-13 Beth Israel Deaconess Medical Center Use of anti-cd1 antibodies for the modulation of immune responses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J.MASS.SPECTROM.SOC.JPN, vol. 45, no. 3, JPN6016046412, 1997, pages 355 - 366 *
ドージンニュース, vol. no.109, JPN6016046410, 2004, pages 1 - 7 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022511062A (ja) * 2018-12-07 2022-01-28 ライフアーク ヒト化抗il17br抗体
JP2023538379A (ja) * 2020-08-18 2023-09-07 セファロン エルエルシー 抗par-2抗体及びそれらの使用方法

Also Published As

Publication number Publication date
ZA201401776B (en) 2016-01-27
CA2850961A1 (en) 2013-04-18
KR20140108520A (ko) 2014-09-11
US20140286957A1 (en) 2014-09-25
AU2012323781A1 (en) 2014-03-27
BR112014008691A2 (pt) 2017-06-13
EP2766042A1 (en) 2014-08-20
CN104144700A (zh) 2014-11-12
EA201400447A1 (ru) 2014-09-30
IL231975A0 (en) 2014-05-28
AU2012323781B8 (en) 2015-05-14
SG11201400521PA (en) 2014-08-28
AU2012323781B2 (en) 2015-04-23
CN104144700B (zh) 2016-10-19
NZ622050A (en) 2016-07-29
WO2013053021A1 (en) 2013-04-18
AU2012323781A8 (en) 2015-05-14
EP2766042A4 (en) 2015-05-27
MX2014004326A (es) 2014-09-25

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