JP2015502829A5 - - Google Patents
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- Publication number
- JP2015502829A5 JP2015502829A5 JP2014548646A JP2014548646A JP2015502829A5 JP 2015502829 A5 JP2015502829 A5 JP 2015502829A5 JP 2014548646 A JP2014548646 A JP 2014548646A JP 2014548646 A JP2014548646 A JP 2014548646A JP 2015502829 A5 JP2015502829 A5 JP 2015502829A5
- Authority
- JP
- Japan
- Prior art keywords
- peg
- arm
- hydrated gel
- photopolymerization
- natural polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001223 polyethylene glycol Polymers 0.000 claims description 93
- 239000000499 gel Substances 0.000 claims description 71
- 239000012528 membrane Substances 0.000 claims description 66
- 239000007788 liquid Substances 0.000 claims description 35
- 239000000654 additive Substances 0.000 claims description 34
- 230000000996 additive effect Effects 0.000 claims description 33
- 229920000642 polymer Polymers 0.000 claims description 33
- 229920005615 natural polymer Polymers 0.000 claims description 32
- 102000008186 Collagen Human genes 0.000 claims description 20
- 108010035532 Collagen Proteins 0.000 claims description 20
- 229960005188 collagen Drugs 0.000 claims description 20
- 229920001436 collagen Polymers 0.000 claims description 20
- 125000000524 functional group Chemical group 0.000 claims description 18
- 239000003999 initiator Substances 0.000 claims description 18
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 17
- 238000006065 biodegradation reaction Methods 0.000 claims description 17
- 229920002674 hyaluronan Polymers 0.000 claims description 17
- 229960003160 hyaluronic acid Drugs 0.000 claims description 17
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 14
- 210000000988 bone and bone Anatomy 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 239000011259 mixed solution Substances 0.000 claims description 12
- 230000015556 catabolic process Effects 0.000 claims description 11
- 230000007547 defect Effects 0.000 claims description 11
- 238000006731 degradation reaction Methods 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 230000001678 irradiating effect Effects 0.000 claims description 8
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 claims description 7
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- 229920001661 Chitosan Polymers 0.000 claims description 7
- 229920002307 Dextran Polymers 0.000 claims description 7
- 229920002971 Heparan sulfate Polymers 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 229940072056 alginate Drugs 0.000 claims description 7
- 229920000615 alginic acid Polymers 0.000 claims description 7
- 235000010443 alginic acid Nutrition 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 7
- 229940045110 chitosan Drugs 0.000 claims description 7
- 229960002086 dextran Drugs 0.000 claims description 7
- 230000000977 initiatory effect Effects 0.000 claims description 7
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 7
- 229940113082 thymine Drugs 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims description 6
- 229940048053 acrylate Drugs 0.000 claims description 6
- 229940114081 cinnamate Drugs 0.000 claims description 6
- 229940063557 methacrylate Drugs 0.000 claims description 6
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 6
- 238000000354 decomposition reaction Methods 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 230000036571 hydration Effects 0.000 claims description 2
- 238000006703 hydration reaction Methods 0.000 claims description 2
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 230000010478 bone regeneration Effects 0.000 description 7
- 210000004872 soft tissue Anatomy 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000005548 dental material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020110139849A KR101269423B1 (ko) | 2011-12-22 | 2011-12-22 | 체내 분해 속도 조절이 가능한 수화젤 및 그 제조 방법 |
| KR10-2011-0139849 | 2011-12-22 | ||
| PCT/KR2012/008017 WO2013094858A1 (ko) | 2011-12-22 | 2012-10-04 | 체내 분해 속도 조절이 가능한수화젤 및 그 제조 방법 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502829A JP2015502829A (ja) | 2015-01-29 |
| JP2015502829A5 true JP2015502829A5 (enExample) | 2015-03-19 |
| JP5837996B2 JP5837996B2 (ja) | 2015-12-24 |
Family
ID=48667186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548646A Active JP5837996B2 (ja) | 2011-12-22 | 2012-10-04 | 水和ゲル及び水和ゲルメンブレイン並びにそれらの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20150005395A1 (enExample) |
| EP (1) | EP2796486A4 (enExample) |
| JP (1) | JP5837996B2 (enExample) |
| KR (1) | KR101269423B1 (enExample) |
| CN (1) | CN104011113B (enExample) |
| WO (1) | WO2013094858A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102492730B1 (ko) * | 2015-10-02 | 2023-01-27 | 삼성디스플레이 주식회사 | 유기 발광 표시 장치 |
| KR102063210B1 (ko) * | 2017-12-19 | 2020-01-08 | 주식회사 테라시온 바이오메디칼 | 일시적 혈관폐쇄 용구의 제조방법 |
| AU2020267858B2 (en) * | 2019-05-07 | 2025-09-04 | National University Of Singapore | Novel polysaccharide-based hydrogel scaffolds for wound care |
| CN116195991B (zh) * | 2023-02-10 | 2025-10-31 | 华中科技大学 | 界面黏性光控可调的表皮式运动状态监测混合电子系统 |
| JPWO2024219027A1 (enExample) * | 2023-04-21 | 2024-10-24 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69329594T2 (de) | 1992-02-28 | 2001-05-31 | Board Of Regents, The University Of Texas System | Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung |
| US5904927A (en) * | 1997-03-14 | 1999-05-18 | Northeastern University | Drug delivery using pH-sensitive semi-interpenetrating network hydrogels |
| CA2430130A1 (en) * | 2000-11-28 | 2002-06-06 | Focal, Inc. | Polyalkylene glycol viscosity-enhancing polymeric formulations |
| CA2444880C (en) * | 2001-04-23 | 2009-11-24 | Wisconsin Alumni Research Foundation | Bifunctional-modified hydrogels |
| EP1951331A4 (en) * | 2005-11-14 | 2010-03-24 | Seoul Nat Univ Ind Foundation | METHOD FOR PRODUCING A COLLAGEN / APATITE COMPOSITE MEMBRANE FOR THE PURPOSE OF REGULATING BONE REGENERATION |
| US20070212385A1 (en) * | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
| US7935363B2 (en) * | 2006-12-12 | 2011-05-03 | Synthasome, Inc. | Composite material for tissue repair |
| US20110104280A1 (en) * | 2009-05-20 | 2011-05-05 | Olexander Hnojewyj | Wound treatment systems, devices, and methods using biocompatible synthetic hydrogel compositions |
| US8697111B2 (en) * | 2010-05-12 | 2014-04-15 | Covidien Lp | Osteochondral implant comprising osseous phase and chondral phase |
| US8591950B2 (en) * | 2010-05-27 | 2013-11-26 | Covidien Lp | Hydrogel implants with varying degrees of crosslinking |
| US9265830B2 (en) * | 2011-04-20 | 2016-02-23 | Warsaw Orthopedic, Inc. | Implantable compositions and methods for preparing the same |
-
2011
- 2011-12-22 KR KR1020110139849A patent/KR101269423B1/ko active Active
-
2012
- 2012-10-04 EP EP12860012.9A patent/EP2796486A4/en not_active Withdrawn
- 2012-10-04 CN CN201280063874.0A patent/CN104011113B/zh active Active
- 2012-10-04 US US14/367,906 patent/US20150005395A1/en not_active Abandoned
- 2012-10-04 JP JP2014548646A patent/JP5837996B2/ja active Active
- 2012-10-04 WO PCT/KR2012/008017 patent/WO2013094858A1/ko not_active Ceased
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