JP2015502352A5 - - Google Patents
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- Publication number
- JP2015502352A5 JP2015502352A5 JP2014542593A JP2014542593A JP2015502352A5 JP 2015502352 A5 JP2015502352 A5 JP 2015502352A5 JP 2014542593 A JP2014542593 A JP 2014542593A JP 2014542593 A JP2014542593 A JP 2014542593A JP 2015502352 A5 JP2015502352 A5 JP 2015502352A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- alcohol
- malignant
- perillyl alcohol
- patent document
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- NDTYTMIUWGWIMO-UHFFFAOYSA-N perillyl alcohol Chemical compound CC(=C)C1CCC(CO)=CC1 NDTYTMIUWGWIMO-UHFFFAOYSA-N 0.000 description 16
- 229930007631 (-)-perillyl alcohol Natural products 0.000 description 8
- 235000005693 perillyl alcohol Nutrition 0.000 description 8
- 206010018338 Glioma Diseases 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 208000005017 glioblastoma Diseases 0.000 description 3
- 208000029824 high grade glioma Diseases 0.000 description 3
- 201000011614 malignant glioma Diseases 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 229910052805 deuterium Inorganic materials 0.000 description 2
- 229930003658 monoterpene Natural products 0.000 description 2
- 150000002773 monoterpene derivatives Chemical class 0.000 description 2
- 235000002577 monoterpenes Nutrition 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- NDTYTMIUWGWIMO-SNVBAGLBSA-N (-)-perillyl alcohol Chemical compound CC(=C)[C@H]1CCC(CO)=CC1 NDTYTMIUWGWIMO-SNVBAGLBSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010003571 Astrocytoma Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 206010002224 anaplastic astrocytoma Diseases 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 201000007455 central nervous system cancer Diseases 0.000 description 1
- 230000002113 chemopreventative effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- -1 for example Chemical compound 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562105P | 2011-11-21 | 2011-11-21 | |
| US61/562,105 | 2011-11-21 | ||
| US13/566,731 | 2012-08-03 | ||
| US13/566,731 US8916545B2 (en) | 2010-08-27 | 2012-08-03 | Pharmaceutical compositions comprising POH derivatives |
| PCT/US2012/066379 WO2013119304A2 (en) | 2011-11-21 | 2012-11-21 | Pharmaceutical compositions comprising deuterium-enriched perillyl alcohol, iso-perillyl alcohol and derivatives thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017161091A Division JP2018035148A (ja) | 2011-11-21 | 2017-08-24 | 重水素強化ペリリルアルコール、イソペリリルアルコール、及びその誘導体を含む医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502352A JP2015502352A (ja) | 2015-01-22 |
| JP2015502352A5 true JP2015502352A5 (enExample) | 2015-11-26 |
Family
ID=48948152
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542593A Pending JP2015502352A (ja) | 2011-11-21 | 2012-11-21 | 重水素強化ペリリルアルコール、イソペリリルアルコール、及びその誘導体を含む医薬組成物 |
| JP2017161091A Pending JP2018035148A (ja) | 2011-11-21 | 2017-08-24 | 重水素強化ペリリルアルコール、イソペリリルアルコール、及びその誘導体を含む医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017161091A Pending JP2018035148A (ja) | 2011-11-21 | 2017-08-24 | 重水素強化ペリリルアルコール、イソペリリルアルコール、及びその誘導体を含む医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2782894A4 (enExample) |
| JP (2) | JP2015502352A (enExample) |
| KR (1) | KR20150000469A (enExample) |
| CN (1) | CN103946202A (enExample) |
| BR (1) | BR112014012180A2 (enExample) |
| CA (1) | CA2856403A1 (enExample) |
| HK (1) | HK1201253A1 (enExample) |
| WO (1) | WO2013119304A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104945335B (zh) * | 2014-03-27 | 2018-02-16 | 沈阳药科大学 | 紫苏胺类化合物及其制备和应用 |
| CN104945334B (zh) * | 2014-03-27 | 2018-02-16 | 沈阳药科大学 | 紫苏醇衍生物及其制备和应用 |
| CN104945333B (zh) * | 2014-03-27 | 2018-02-02 | 沈阳药科大学 | 紫苏醇类似物及其制备和应用 |
| CN104945336B (zh) * | 2014-03-27 | 2018-02-16 | 沈阳药科大学 | 紫苏酸甲酯含氮衍生物及其制备和应用 |
| JP7325425B2 (ja) * | 2018-02-08 | 2023-08-14 | ネオンク テクノロジーズ インク． | 血液脳関門を透過性にする方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272441A (en) * | 1980-03-13 | 1981-06-09 | Fmc Corporation | Preparation of carbamates |
| US7816398B2 (en) * | 2001-03-23 | 2010-10-19 | Luitpold Pharmaceuticals, Inc. | Fatty alcohol drug conjugates |
| AU2002360547A1 (en) * | 2001-12-11 | 2003-07-24 | Dor Biopharma, Inc. | Monoterpene compositions and uses thereof |
| BR0107262B1 (pt) | 2001-12-17 | 2014-04-22 | Da Fonseca Clovis Orlando Pereira | Composição farmacêutica inalatória |
| CA2570754A1 (en) * | 2004-06-23 | 2006-01-05 | Robert F. Hofmann | Use of targeted oxidative therapeutic formulation in treatment of burns |
| US7601355B2 (en) | 2005-06-01 | 2009-10-13 | Northwestern University | Compositions and methods for altering immune function |
| US20100168228A1 (en) * | 2006-10-13 | 2010-07-01 | Reliance Life Sciences Pvt. Ltd. | Novel chemotherapeutic agents against inflammation and cancer |
| CN104523661A (zh) * | 2009-02-06 | 2015-04-22 | 南加利福尼亚大学 | 含有单萜的治疗组合物 |
| US9499461B2 (en) * | 2010-08-27 | 2016-11-22 | Neonc Technologies, Inc. | Pharmaceutical compositions comprising POH derivatives |
| CN101979378B (zh) * | 2010-10-13 | 2012-06-27 | 中国科学院上海有机化学研究所 | 一种手性γ-内酰胺化合物的合成方法 |
-
2012
- 2012-11-21 CN CN201280057166.6A patent/CN103946202A/zh active Pending
- 2012-11-21 WO PCT/US2012/066379 patent/WO2013119304A2/en not_active Ceased
- 2012-11-21 HK HK15101876.0A patent/HK1201253A1/xx unknown
- 2012-11-21 EP EP12867815.8A patent/EP2782894A4/en not_active Withdrawn
- 2012-11-21 CA CA2856403A patent/CA2856403A1/en not_active Abandoned
- 2012-11-21 KR KR20147016865A patent/KR20150000469A/ko not_active Withdrawn
- 2012-11-21 BR BR112014012180A patent/BR112014012180A2/pt not_active IP Right Cessation
- 2012-11-21 JP JP2014542593A patent/JP2015502352A/ja active Pending
-
2017
- 2017-08-24 JP JP2017161091A patent/JP2018035148A/ja active Pending
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