JP2015501645A - 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 - Google Patents
肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 Download PDFInfo
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- JP2015501645A JP2015501645A JP2014546169A JP2014546169A JP2015501645A JP 2015501645 A JP2015501645 A JP 2015501645A JP 2014546169 A JP2014546169 A JP 2014546169A JP 2014546169 A JP2014546169 A JP 2014546169A JP 2015501645 A JP2015501645 A JP 2015501645A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569237P | 2011-12-10 | 2011-12-10 | |
| US61/569,237 | 2011-12-10 | ||
| PCT/US2012/068736 WO2013086489A1 (en) | 2011-12-10 | 2012-12-10 | Mirnas useful to reduce lung cancer tumorigenesis and chemotherapy resistance and related compositons and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154487A Division JP2017006137A (ja) | 2011-12-10 | 2016-08-05 | 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015501645A true JP2015501645A (ja) | 2015-01-19 |
| JP2015501645A5 JP2015501645A5 (enExample) | 2015-02-26 |
Family
ID=48574974
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546169A Pending JP2015501645A (ja) | 2011-12-10 | 2012-12-10 | 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 |
| JP2016154487A Pending JP2017006137A (ja) | 2011-12-10 | 2016-08-05 | 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016154487A Pending JP2017006137A (ja) | 2011-12-10 | 2016-08-05 | 肺がんの腫瘍発生および化学療法耐性を低減するために有用なmiRNAならびに関連する組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140351963A1 (enExample) |
| EP (1) | EP2788486A4 (enExample) |
| JP (2) | JP2015501645A (enExample) |
| CN (1) | CN104302767A (enExample) |
| AU (1) | AU2012347498A1 (enExample) |
| CA (1) | CA2858382A1 (enExample) |
| WO (1) | WO2013086489A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016152754A1 (ja) * | 2015-03-20 | 2016-09-29 | アンジェスMg株式会社 | c-Met陽性癌の判定方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1838852A2 (en) | 2004-11-12 | 2007-10-03 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| EP2968567A2 (en) * | 2013-03-15 | 2016-01-20 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing micrornas and egfr-tki inhibitors |
| US20140308274A1 (en) * | 2013-03-15 | 2014-10-16 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing synthetic oligonucleotides and egfr-tki inhibitors |
| US9530095B2 (en) * | 2013-06-26 | 2016-12-27 | International Business Machines Corporation | Method and system for exploring the associations between drug side-effects and therapeutic indications |
| CN104784703A (zh) * | 2015-04-20 | 2015-07-22 | 北京工业大学 | 一种基于适配体靶向递送microRNA的纳米载体及其制备方法与应用 |
| CN105950753B (zh) * | 2016-06-16 | 2019-10-01 | 朱伟 | 一种与肺腺癌辅助诊断相关的血浆miRNA标志物及其应用 |
| JP2020510027A (ja) * | 2017-03-08 | 2020-04-02 | アリアド ファーマシューティカルズ,インコーポレーテッド | 5−クロロ−n4−[2−(ジメチルホスホリル)フェニル]−n2−{2−メトキシ−4−[4−(4−メチルピペラジン−1−イル)ピペリジン−1−イル]フェニル}ピリミジン−2,4−ジアミンを含む医薬製剤 |
| KR102132222B1 (ko) * | 2018-11-27 | 2020-07-09 | 강원대학교산학협력단 | 항암제 내성 진단 마커로서의 miR-143-3p 및 miR-373-5p, 및 이의 이용 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100298410A1 (en) * | 2007-10-04 | 2010-11-25 | Santaris Pharma A/S | MICROMIRs |
| US20110077288A1 (en) * | 2008-03-07 | 2011-03-31 | Santaris Pharma A/S | Pharmaceutical Compositions for Treatment of MicroRNA Related Diseases |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005013901A2 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| EP1797183B1 (en) * | 2004-09-02 | 2012-08-01 | Yale University | Regulation of oncogenes by micrornas |
| EP1838852A2 (en) * | 2004-11-12 | 2007-10-03 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| EP2796554A3 (en) * | 2005-09-12 | 2014-12-10 | The Ohio State University Research Foundation | Compositions for use in treating BCL2-associated cancers |
| CN103361424A (zh) * | 2006-01-05 | 2013-10-23 | 俄亥俄州立大学研究基金会 | 胰腺内分泌和腺泡肿瘤中的微小rna表达异常 |
| EP2468895B1 (en) * | 2006-01-05 | 2014-09-24 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| EP2111408A4 (en) * | 2007-01-17 | 2010-02-03 | Univ Johns Hopkins | COMPOSITIONS AND METHODS OF microRNA FOR THE TREATMENT OF NEOPLASIA |
| CN101861401B (zh) * | 2007-10-11 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 用于诊断和治疗食管腺癌的方法和组合物 |
| CA2717030A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | Microrna signatures associated with cytogenetics and prognosis in acute myeloid leukemia (aml) and uses thereof |
| AU2009219197B2 (en) * | 2008-02-28 | 2014-04-10 | The Govt. Of The U.S.A. As Represented By The Secretary Of The Dep. Of Health And Human Services | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of prostate related disorders |
| US20110107440A1 (en) * | 2008-06-04 | 2011-05-05 | Andor Pivarcsi | Skin cancer associated micrornas |
| AU2010218147A1 (en) * | 2009-02-26 | 2011-10-20 | The Government Of The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services | MicroRNAs in never-smokers and related materials and methods |
| JP2011093892A (ja) * | 2009-09-30 | 2011-05-12 | Japan Health Science Foundation | がん抑制的マイクロrnaを含む腫瘍増殖抑制剤 |
| EP2504452A4 (en) * | 2009-11-23 | 2014-06-11 | Univ Ohio State Res Found | MATERIALS AND METHODS FOR INFLUENCING GROWTH, MIGRATION AND INVASION OF TUMOR CELLS |
-
2012
- 2012-12-10 JP JP2014546169A patent/JP2015501645A/ja active Pending
- 2012-12-10 WO PCT/US2012/068736 patent/WO2013086489A1/en not_active Ceased
- 2012-12-10 AU AU2012347498A patent/AU2012347498A1/en not_active Abandoned
- 2012-12-10 CA CA2858382A patent/CA2858382A1/en not_active Abandoned
- 2012-12-10 US US14/364,163 patent/US20140351963A1/en not_active Abandoned
- 2012-12-10 CN CN201280067179.1A patent/CN104302767A/zh active Pending
- 2012-12-10 EP EP12855814.5A patent/EP2788486A4/en not_active Withdrawn
-
2016
- 2016-08-05 JP JP2016154487A patent/JP2017006137A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100298410A1 (en) * | 2007-10-04 | 2010-11-25 | Santaris Pharma A/S | MICROMIRs |
| US20110077288A1 (en) * | 2008-03-07 | 2011-03-31 | Santaris Pharma A/S | Pharmaceutical Compositions for Treatment of MicroRNA Related Diseases |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016152754A1 (ja) * | 2015-03-20 | 2016-09-29 | アンジェスMg株式会社 | c-Met陽性癌の判定方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104302767A (zh) | 2015-01-21 |
| WO2013086489A1 (en) | 2013-06-13 |
| AU2012347498A1 (en) | 2014-06-26 |
| JP2017006137A (ja) | 2017-01-12 |
| EP2788486A1 (en) | 2014-10-15 |
| CA2858382A1 (en) | 2013-06-13 |
| EP2788486A4 (en) | 2015-08-12 |
| US20140351963A1 (en) | 2014-11-27 |
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