JP2015501644A5 - - Google Patents

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Publication number
JP2015501644A5
JP2015501644A5 JP2014546158A JP2014546158A JP2015501644A5 JP 2015501644 A5 JP2015501644 A5 JP 2015501644A5 JP 2014546158 A JP2014546158 A JP 2014546158A JP 2014546158 A JP2014546158 A JP 2014546158A JP 2015501644 A5 JP2015501644 A5 JP 2015501644A5
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JP
Japan
Prior art keywords
individual
cell receptor
gene segment
profile
immune activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014546158A
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English (en)
Japanese (ja)
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JP2015501644A (ja
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Publication date
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Priority claimed from PCT/US2012/068631 external-priority patent/WO2013086462A1/en
Publication of JP2015501644A publication Critical patent/JP2015501644A/ja
Publication of JP2015501644A5 publication Critical patent/JP2015501644A5/ja
Pending legal-status Critical Current

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JP2014546158A 2011-12-09 2012-12-07 免疫活性化を測定する方法 Pending JP2015501644A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568850P 2011-12-09 2011-12-09
US61/568,850 2011-12-09
PCT/US2012/068631 WO2013086462A1 (en) 2011-12-09 2012-12-07 Method of measuring immune activation

Publications (2)

Publication Number Publication Date
JP2015501644A JP2015501644A (ja) 2015-01-19
JP2015501644A5 true JP2015501644A5 (cg-RX-API-DMAC7.html) 2017-01-26

Family

ID=48574963

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014546158A Pending JP2015501644A (ja) 2011-12-09 2012-12-07 免疫活性化を測定する方法

Country Status (4)

Country Link
US (1) US20140342360A1 (cg-RX-API-DMAC7.html)
EP (1) EP2788507A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015501644A (cg-RX-API-DMAC7.html)
WO (1) WO2013086462A1 (cg-RX-API-DMAC7.html)

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Publication number Priority date Publication date Assignee Title
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
GB2483810B (en) 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population
EP2387627B1 (en) 2009-01-15 2016-03-30 Adaptive Biotechnologies Corporation Adaptive immunity profiling and methods for generation of monoclonal antibodies
US20100330571A1 (en) 2009-06-25 2010-12-30 Robins Harlan S Method of measuring adaptive immunity
US9043160B1 (en) 2009-11-09 2015-05-26 Sequenta, Inc. Method of determining clonotypes and clonotype profiles
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
AU2012325791B2 (en) 2011-10-21 2018-04-05 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
EP3904536B1 (en) 2011-12-09 2025-10-29 Adaptive Biotechnologies Corporation Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2823060B1 (en) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Determining paired immune receptor chains from frequency matched subunits
BR112014027309A2 (pt) 2012-05-08 2017-07-11 Adaptive Biotechnologies Corp composições e métodos para medir e calibrar a tendên-cia de amplificação em reações de pcr multiplexadas
CN105189779B (zh) 2012-10-01 2018-05-11 适应生物技术公司 通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
ES2741740T3 (es) 2014-03-05 2020-02-12 Adaptive Biotechnologies Corp Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US10392663B2 (en) 2014-10-29 2019-08-27 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
ES2858306T3 (es) 2015-02-24 2021-09-30 Adaptive Biotechnologies Corp Método para determinar el estado de HLA mediante secuenciación del repertorio inmunitario
AU2016242967B2 (en) 2015-04-01 2021-07-01 Adaptive Biotechnologies Corp. Method of identifying human compatible T cell receptors specific for an antigenic target
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
CN112689682A (zh) 2019-05-31 2021-04-20 伊鲁米纳公司 从流动池中的生物样品获取信息
CN116635948A (zh) * 2020-12-07 2023-08-22 Absci公司 用于产生疾病相关蛋白质组合物的系统和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4416189A (en) * 1988-10-06 1990-05-01 T Cell Sciences, Inc. Therapeutic and diagnostic methods using soluble t cell surface molecules
AU736742B2 (en) * 1996-06-03 2001-08-02 Governors Of The University Of Alberta, The Methods for detection of rearranged DNA
US20020136722A1 (en) * 1997-06-18 2002-09-26 Heath Andrew William Vaccination method
WO2005115449A1 (en) * 2004-05-28 2005-12-08 Alk-Abelló A/S Method of treating allergy and infection by eliciting an iga antibody response
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
WO2008026927A2 (en) * 2006-08-30 2008-03-06 Academisch Medisch Centrum Process for displaying t- and b-cell receptor repertoires
US8748103B2 (en) * 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
GB2483810B (en) * 2008-11-07 2012-09-05 Sequenta Inc Methods for correlating clonotypes with diseases in a population

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