JP2015192622A - Nutritional supplementary food for locomotive syndrome - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a nutritional supplementary food for locomotive syndrome for improving endurance because it is necessary to prevent deterioration of muscle mass and muscle force to take measures against locomotive syndrome, and it is therefore necessary to enhance endurance in order to perform muscle force training for a long time.SOLUTION: A nutritional supplementary food for locomotive syndrome is a combination of a protein processed product, leucine, and carnitine in a blending ratio of 20:3:0.5 to 3.

Description

  The present invention relates to a dietary supplement for locomotive syndrome for improving endurance. More specifically, the present invention relates to a dietary supplement for locomotive syndrome that can improve endurance by using a processed protein product, leucine and carnitine in combination.

  In Japan, which is said to be a super-aged society, locomotive syndrome has become a major social problem. One factor of locomotive syndrome is a decrease in muscle mass and strength associated with aging. In general, high-intensity strength training is the most effective way to prevent a decrease in muscle mass and strength, but there is a concern that elderly people may be accompanied by mental stress and cardiovascular stress. Therefore, for strength training in the elderly, muscle strength training with low strength that has low mental stress and a load on the circulatory organ has been proposed. However, it is difficult for muscle strength training with low strength to easily increase muscle mass and strength. Therefore, it is important to increase endurance and perform strength training for a long time. Under these circumstances, dietary supplements for increasing endurance exist on the market.

  A component for increasing endurance is carnitine (Non-patent Documents 1 and 2), and it is said that endurance is improved by fatigue recovery. On the other hand, there is a report that carnitine is not effective for endurance (Non-patent Document 3).

  Against this background, the development of nutritional supplements for locomotive syndromes to further improve endurance has been strongly desired.

The 26th Health Medical Science Grants, 102-109, 2011 J. et al. Appl Physiol. 75, 1595-1600, 1993 Nutrition, 20, 709-715, 2004

  The object of the present invention was made in view of the above-mentioned situation, and is to provide a dietary supplement for locomotive syndrome for improving endurance.

The present invention is a dietary supplement for locomotive syndrome that can improve endurance by combining protein processed products, leucine and carnitine in a specific blending ratio as a result of intensive studies to achieve the above object. As a result, the present invention has been completed.
That is, this invention is shown to the following (1)-(2).
(1) Nutritional supplement for improving endurance, wherein the ratio of protein processed product: leucine: carnitine is 20: 3: 0.5-3, .
(2) The dietary supplement for locomotive syndrome according to (1) above, wherein the ratio of the processed protein product: leucine: carnitine is 20: 3: 1-2.

  As described above, the present invention can provide a dietary supplement for locomotive syndrome for improving endurance by combining a protein processed product, leucine and carnitine at a specific blending ratio.

  Hereinafter, the dietary supplement for locomotive syndrome of the present invention will be described in detail. Note that the examples described in the present specification do not particularly limit the present invention.

  The term “endurance” of the present invention means that each dietary supplement is orally administered to a rat for 2 weeks, then a weight corresponding to 6% of the body weight is attached to the rat's tail, swimming in a water tank, exhausted, and continuously 7 It means the duration of swimming until no face appears on the water for a second. A mathematical statistically significant difference from the swimming duration of the comparison subject to which only purified water was orally administered was compared by t-test, and when the p value was less than 0.05, the endurance was significantly improved.

  Examples of the protein processed product used in the present invention include, for example, casein protein, α-casein, β-casein, κ-casein, whey protein, whey powder, whey protein concentrate, whey protein isolate, β-lactoglobulin, α- Examples thereof include lactalbumin, lactoferrin, egg protein, soy protein, wheat protein, meat protein, whole milk powder, skim milk powder and partially skim milk powder, and can be used alone or in combination of two or more, preferably casein protein And whey protein.

  The leucine used in the present invention may be naturally derived or synthetic, such as L-leucine, D-leucine, DL-leucine and salts acceptable as dietary supplements thereof. I.e., hydrochloride, hydrobromide, phosphate, acetate, lactate, citrate, tartrate, maleate, fumarate, sodium, potassium and calcium salts, Although it can be used 1 type or in combination of 2 or more types, L-leucine and DL-leucine are preferable, and L-leucine is more preferable.

  Examples of carnitine used in the present invention include L-carnitine magnesium citrate, acetyl-L-carnitine hydrochloride, and L-carnitine L-tartrate, and these can be used alone or in combination. . The carnitine compounding ratio of the dietary supplement for locomotive syndrome of the present invention is preferably 0.5-3, more preferably 1-2, with respect to the protein processed product 20 and leucine 3. If it is less than 0.5, significant endurance cannot be obtained, which is not preferable. On the other hand, when it is more than 3, it is not preferable because the bitter taste of carnitine becomes strong and the aftertaste is deteriorated to deteriorate the taste.

  The dietary supplement for locomotive syndrome of the present invention is not limited to the above essential components, but various components that are acceptable in producing the dietary supplement within a range not impairing the effects of the present invention, that is, excipient, disintegrant, binding An agent, a lubricant, a colorant, a sweetener, a sour agent, and the like can be appropriately blended.

  Examples of the excipient include sugars such as glucose, fructose, maltose, lactose, sucrose, dextrin, corn syrup, oligosaccharide and sugar alcohol, corn starch, potato starch, wheat starch, tapioca starch, and modified starches thereof. A starch etc. are mentioned, It can use 1 type or in combination of 2 or more types.

  Examples of the disintegrant include carboxymethylcellulose, xanthan gum, galaia gum, gum arabic, dextrin and starch, and can be used alone or in combination of two or more.

  Examples of the binder include cellulose derivatives such as hydroxypropylmethylcellulose and ethylcellulose, povidone, acrylic acid, methacrylic acid copolymers, milk derivatives such as whey, starch and derivatives thereof, and one or a combination of two or more. Can be used.

  Examples of the lubricant include polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, lecithin, enzymatically decomposed lecithin, fatty acid glyceride, polyoxyethylene sorbitan fatty acid ester, fatty acid calcium salt, fatty acid magnesium salt, hydrogenated oil and wax. Etc., and can be used alone or in combination of two or more.

  Examples of the colorant include anato, carotenoid pigment, curcumin, turmeric pigment, caramel pigment, carotene pigment, cuticle pigment, carminic pigment, carminic acid, cochineal, food tar pigment, copper chlorophyll, copper chlorophyllin sodium, monascus pigment, Examples include red potato, monascus, casamas pigment, safflower pigment, flavonoid pigment, safflower pigment, and the like, which can be used alone or in combination.

  Examples of the sweetener include aspartame, acesulfame potassium, licorice extract, xylitol, saccharin, sodium saccharin, stevia and D-sorbitol, and can be used alone or in combination of two or more.

  Examples of the acidulant include citric acid, L-tartaric acid, and lactic acid, and can be used alone or in combination of two or more.

  The form of the dietary supplement for locomotive syndrome of the present invention is not particularly limited, and examples thereof include powders, granules, solids, liquids, capsules, creams, and pastes. Are powder, granule, and solid.

  The production of the dietary supplement for locomotive syndrome of the present invention is not particularly limited, and can be produced by a conventionally known method or a method newly provided in the future.

  The dietary supplement for locomotive syndrome of the present invention can be produced, for example, by the following method.

  The method for preparing the dietary supplement for locomotive syndrome of the present invention in the form of a powder is obtained by sieving the processed protein product, leucine and carnitine, and if necessary, excipient, disintegrant, binder, lubricant, colorant, sweetness Add additives such as savory and acidulant, and mix with a cylindrical mixer, rotary container mixer, mixer with low speed stirring device, etc., and after drying, pack into bottles such as glass and resin, Alternatively, it can be produced by packaging with an aluminum film.

  The production method for granulating the dietary supplement for locomotive syndrome of the present invention is not particularly limited, and after sieving the raw material, if necessary, excipient, disintegrant, binder, lubricant, colorant, sweetener And additives such as acidulant, and after drying the product formed by stirring granulation, fluidized bed granulation, extrusion granulation, dry compaction granulation, rolling granulation, etc., to obtain uniform granules again The product obtained by sieving can be produced by packing into a bottle of glass, resin or the like, or packaging and packaging with an aluminum film.

  The production method for solidifying the dietary supplement for locomotive syndrome of the present invention is not particularly limited, and after sieving the raw material, if necessary, excipient, disintegrant, binder, lubricant, colorant, sweetener Add additives such as acidulant and mix with a cylindrical mixer, rotary container mixer, mixer with low speed stirring device, etc., if necessary, stirring granulation, fluidized bed granulation, extrusion granulation, dry type After forming by compaction granulation, rolling granulation, etc., add a lubricant to this, apply mechanical external pressure with a single tableting machine, rotary tableting machine, etc., compress and mold, if necessary The surface of polymer, sucrose, etc. alone or mixed with powder to form or laminate a film is packed into a glass or resin bottle or sealed with an aluminum film after packaging with a plastic film. Can be manufactured by Kill.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.
(Example 1)
Based on the formulation shown in Table 1, it was prepared by the method of Preparation Method 1 described later to obtain a dietary supplement 1 for locomotive syndrome of the present invention. Using the obtained dietary supplement 1 for locomotive syndrome, the swimming duration when the endurance test was conducted according to Test Example 1 was 48.4 minutes ± 5.5 minutes, compared with the comparative control. , Significantly improved endurance. The results are shown in Table 2.

(Preparation method 1)
4 g of the processed protein product, 0.6 g of leucine and 0.4 g of carnitine were mixed with powder until uniform to obtain a dietary supplement for locomotive syndrome.

(Test Example 1)
Endurance test Using the dietary supplement for locomotive syndrome of Example 1 described above, the dietary supplement for locomotive syndrome of Example 2 described later, and the dietary supplements of Comparative Examples 1 to 3 described later, and the following method An endurance test was conducted.
4-week-old male Wistar rats were preliminarily raised for 1 week, and then divided into groups of 8 animals in each group so that the average body weight was equivalent. Each test dietary supplement was dissolved in 400 mL of purified water to prepare a solution for administration. The solution for administration was orally administered every day so as to be a predetermined amount (2 w / v% of the body weight of the rat) per day, and was bred for 2 weeks. Moreover, the group which orally administered only purified water every day was reared simultaneously as a comparison control for 2 weeks. During this period, food and water were allowed to freely ingest and allowed to swim freely for 30 minutes each day without any load in order to become accustomed to the swimming exercise. After rearing under the above conditions, attach a weight equivalent to 6% of body weight to the tail of each rat, let it swim in the water tank, measure the time until it is exhausted and no longer appears on the surface for 7 seconds. It was.

(Example 2)
In Example 1, except for changing carnitine from 0.4 g to 0.2 g, the same preparation method as in Example 1 was repeated to obtain a dietary supplement 2 for locomotive syndrome. Using the obtained nutritional supplement 2 for locomotive syndrome, the average swimming time when the endurance test was conducted according to Test Example 1 was 49.8 ± 7.0 minutes, compared with the control, Endurance improved significantly. The results are shown in Table 2.

(Comparative Example 1)
In Example 1, the nutritional supplement 1 was obtained by repeating exactly the same preparation method as Example 1 except having changed carnitine from 0.4 g to 0.1 g. The swimming duration when endurance test was conducted according to Test Example 1 using the obtained dietary supplement 1 was 38.2 ± 7.4 minutes, which was significant endurance compared to the control. There was no improvement in power. The results are shown in Table 2.

(Comparative Example 2)
In Example 1, the nutritional supplement 2 was obtained by repeating exactly the same preparation method as Example 1 except not adding a protein processed product and a leucine. The swimming duration when the endurance test was conducted according to Test Example 1 using the obtained dietary supplement 2 was 35.0 ± 6.3 minutes, which was significant endurance compared to the control. There was no improvement in power. The results are shown in Table 2.

(Comparative Example 3)
In Example 1, the nutritional supplement 3 was obtained by repeating exactly the same preparation method as Example 1 except not adding carnitine. The swimming duration when the endurance test was conducted according to Test Example 1 using the obtained dietary supplement 3 was 33.3 ± 7.5 minutes, which was significant endurance compared to the control. There was no improvement in power. The results are shown in Table 2.

The present invention relates to a dietary supplement for locomotive syndrome for improving endurance by combining a processed protein product, leucine and carnitine at a specific blending ratio, and can be sufficiently used industrially.

Claims (2)

  A nutritional supplement for improving endurance, wherein the ratio of protein processed product: leucine: carnitine is 20: 3: 0.5-3. The dietary supplement for locomotive syndrome according to claim 1, wherein the ratio of the processed protein product: leucine: carnitine is 20: 3: 1-2.