JP2015187119A5 - - Google Patents
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- Publication number
- JP2015187119A5 JP2015187119A5 JP2015096792A JP2015096792A JP2015187119A5 JP 2015187119 A5 JP2015187119 A5 JP 2015187119A5 JP 2015096792 A JP2015096792 A JP 2015096792A JP 2015096792 A JP2015096792 A JP 2015096792A JP 2015187119 A5 JP2015187119 A5 JP 2015187119A5
- Authority
- JP
- Japan
- Prior art keywords
- vegf
- expression
- formulation
- vegfr
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 25
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 25
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 25
- 238000009472 formulation Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 18
- 230000000694 effects Effects 0.000 claims 14
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 12
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims 8
- 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 claims 8
- 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 claims 8
- 102000009519 Vascular Endothelial Growth Factor D Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims 7
- 229940123429 VEGFR tyrosine kinase inhibitor Drugs 0.000 claims 4
- -1 VEGFR-2 nucleic acid Chemical class 0.000 claims 4
- 206010030113 Oedema Diseases 0.000 claims 3
- 108091008605 VEGF receptors Proteins 0.000 claims 3
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000053642 Catalytic RNA Human genes 0.000 claims 2
- 108090000994 Catalytic RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 239000003906 humectant Substances 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 108091092562 ribozyme Proteins 0.000 claims 2
- 239000002453 shampoo Substances 0.000 claims 2
- 230000037380 skin damage Effects 0.000 claims 2
- 239000000344 soap Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 230000000475 sunscreen effect Effects 0.000 claims 2
- 239000000516 sunscreening agent Substances 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76032806P | 2006-01-18 | 2006-01-18 | |
| US60/760,328 | 2006-01-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551385A Division JP2009523807A (ja) | 2006-01-18 | 2007-01-18 | リンパ機能を高める方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015187119A JP2015187119A (ja) | 2015-10-29 |
| JP2015187119A5 true JP2015187119A5 (enExample) | 2016-04-14 |
Family
ID=38191298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551385A Pending JP2009523807A (ja) | 2006-01-18 | 2007-01-18 | リンパ機能を高める方法 |
| JP2015096792A Pending JP2015187119A (ja) | 2006-01-18 | 2015-05-11 | リンパ機能を高める方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008551385A Pending JP2009523807A (ja) | 2006-01-18 | 2007-01-18 | リンパ機能を高める方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8367609B2 (enExample) |
| EP (2) | EP2272497B1 (enExample) |
| JP (2) | JP2009523807A (enExample) |
| KR (2) | KR101611322B1 (enExample) |
| CN (2) | CN103638522A (enExample) |
| AT (1) | ATE476986T1 (enExample) |
| DE (1) | DE602007008365D1 (enExample) |
| ES (2) | ES2396440T3 (enExample) |
| TW (1) | TWI428143B (enExample) |
| WO (1) | WO2007084599A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005107461A2 (en) * | 2004-04-07 | 2005-11-17 | The General Hospital Corporation | Modulating lymphatic function |
| MX2008002882A (es) | 2005-09-07 | 2008-03-27 | Tyco Healthcare | Aposito de herida con deposito de vacio. |
| US8580755B2 (en) * | 2008-02-19 | 2013-11-12 | University Of Rochester | Methods and compositions for treating inflammatory conditions |
| SG183562A1 (en) * | 2010-03-01 | 2012-10-30 | Mitomics Inc | Uv associated mtdna fusion transcripts and methods and uses thereof |
| US10405961B2 (en) | 2013-03-14 | 2019-09-10 | Cell and Molecular Tissue Engineering, LLC | Coated surgical mesh, and corresponding systems and methods |
| US10130288B2 (en) | 2013-03-14 | 2018-11-20 | Cell and Molecular Tissue Engineering, LLC | Coated sensors, and corresponding systems and methods |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8821A (en) * | 1852-03-23 | Machiheiiy toe | ||
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
| DK0678122T3 (da) | 1993-01-12 | 2000-03-06 | Biogen Inc | Rekombinante anti-VLA4 antistofmolekyler |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| GB9410533D0 (en) * | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | In situ hybridisation and immuno-Chemical localisation of a growth factor |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6018098A (en) * | 1995-06-16 | 2000-01-25 | Thomas Jefferson University | In vivo and in vitro model of cutaneous photoaging |
| US7727761B2 (en) * | 1995-08-01 | 2010-06-01 | Vegenics Limited | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| US6361946B1 (en) * | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| DE19541844C1 (de) | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
| US20030143204A1 (en) | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
| CA2263890C (en) | 1996-08-23 | 2013-05-14 | Ludwig Institute For Cancer Research | Recombinant vascular endothelial cell growth factor d (vegf-d) |
| FR2752734B1 (fr) | 1996-09-02 | 1998-11-06 | Cird Galderma | Utilisation de retinoides pour la preparation d'un medicament destine a traiter les affections liees a une surexpression de vegf |
| US6337320B1 (en) * | 1996-10-11 | 2002-01-08 | Thione International, Inc. | Reparatives for ultraviolet radiation skin damage |
| DE69732304T2 (de) * | 1996-11-01 | 2005-06-02 | Ark Therapeutics Ltd. | Verwendung von vegf zur herstellung eines medikaments zur behandlung oder verhinderung der intimalen hyperplasie und verabreichungsgerät |
| CA2273194C (en) | 1996-12-03 | 2011-02-01 | Abgenix, Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
| JP2002532720A (ja) * | 1998-12-11 | 2002-10-02 | エーザイ株式会社 | 血管内皮成長因子（ｖｅｇｆ）の使用 |
| CN1330555A (zh) * | 1998-12-21 | 2002-01-09 | 路德维格癌症研究所 | 抗截短的vegf－d的抗体及其应用 |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| CN1433318A (zh) * | 1999-02-08 | 2003-07-30 | 人体基因组科学有限公司 | 血管内皮生长因子2 |
| WO2000058511A1 (en) * | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
| US20020119921A1 (en) * | 1999-03-31 | 2002-08-29 | Michael Streit | Thrombospondin-2 and uses thereof |
| US6867348B1 (en) * | 1999-12-16 | 2005-03-15 | Xenogen Corporation | Methods and compositions for screening for angiogenesis modulating compounds |
| US20020102260A1 (en) * | 2000-03-02 | 2002-08-01 | Marc Achen | Methods for treating neoplastic disease characterized by vascular endothelial growth factor D expression, for screening for neoplastic disease or metastatic risk, and for maintaining vascularization of tissue |
| JP2003526367A (ja) | 2000-03-16 | 2003-09-09 | ジェネティカ インコーポレイテッド | Ｒｎａ干渉の方法とｒｎａ干渉組成物 |
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| US6511808B2 (en) | 2000-04-28 | 2003-01-28 | Sangamo Biosciences, Inc. | Methods for designing exogenous regulatory molecules |
| WO2002053202A1 (de) * | 2001-01-05 | 2002-07-11 | Gerd Hausdorf | Durch korrosion abbaubare metallische medizinische implante |
| TWI233361B (en) | 2001-04-13 | 2005-06-01 | Gen Hospital Corp | Methods of preventing UVB-induced skin damage |
| EP1572902B1 (en) | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| CU23178A1 (es) * | 2002-04-15 | 2006-09-22 | Ct Ingenieria Genetica Biotech | INMUNOTERAPIA ACTIVA ANTIANGIOGéNICA |
| WO2003093430A2 (en) | 2002-05-03 | 2003-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in preparing sirnas |
| WO2004015062A2 (en) | 2002-08-12 | 2004-02-19 | New England Biolabs, Inc. | Methods and compositions relating to gene silencing |
| WO2005097187A2 (en) * | 2004-04-01 | 2005-10-20 | The General Hospital Corporation | Methods of preventing uvb-induced skin damage |
-
2007
- 2007-01-18 JP JP2008551385A patent/JP2009523807A/ja active Pending
- 2007-01-18 TW TW096101900A patent/TWI428143B/zh active
- 2007-01-18 KR KR1020157010985A patent/KR101611322B1/ko active Active
- 2007-01-18 ES ES10172193T patent/ES2396440T3/es active Active
- 2007-01-18 DE DE602007008365T patent/DE602007008365D1/de active Active
- 2007-01-18 WO PCT/US2007/001309 patent/WO2007084599A2/en not_active Ceased
- 2007-01-18 US US11/654,776 patent/US8367609B2/en active Active
- 2007-01-18 ES ES07717966T patent/ES2350269T3/es active Active
- 2007-01-18 CN CN201310303045.1A patent/CN103638522A/zh active Pending
- 2007-01-18 AT AT07717966T patent/ATE476986T1/de not_active IP Right Cessation
- 2007-01-18 EP EP10172193A patent/EP2272497B1/en active Active
- 2007-01-18 CN CNA2007800096055A patent/CN101405408A/zh active Pending
- 2007-01-18 KR KR1020087020003A patent/KR20080087164A/ko not_active Ceased
- 2007-01-18 EP EP07717966A patent/EP1984522B1/en active Active
-
2013
- 2013-01-11 US US13/739,533 patent/US9192652B2/en active Active
-
2015
- 2015-05-11 JP JP2015096792A patent/JP2015187119A/ja active Pending
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