JP2015142700A - Wristwatch type blood glucose level watch device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an inexpensive and portable wristwatch type blood glucose level watch device for detecting a blood vessel position.SOLUTION: Pulse emission means is configured of a plurality of LEDs which emit light at a prescribed plurality of timings synchronized with a watch function. Pulse light output from the pulse emission means and emitted at a prescribed plurality of timings comprises a reflection composite pulse configured of first group pulse light having a wavelength excluding near infrared ray and forming a staircase wave, and second group pulse light superposed during an apex part timing period of the top of the staircase wave of the first group pulse light, and having a wavelength of near infrared ray. A CPU sets a reference level by a difference between the staircase wave of first group reflectance pulse light among the composite pulse reflected on the skin, measures a reflectance peak level of second group reflectance pulse light, and calculates a ratio to a reference value as a variation of the reflectance peak level.

Description

  The present invention relates to a wristwatch-type blood sugar level watch device that measures changes in blood sugar level and warns of hypoglycemic symptoms and the like.

  Diabetes is a disease that increases blood sugar levels. When you eat, your blood sugar level starts to rise, and at this time, insulin, the only hypoglycemic hormone in your body, is secreted from the pancreas in response to your blood sugar level and works to lower your blood sugar level. However, if the amount of insulin secreted is small or its action is poor, the blood sugar level does not drop to the normal range and becomes high blood sugar. Diabetes is a group of metabolic diseases whose main feature is chronic hyperglycemia, and it is said that this lack of action of insulin is the main disease state.

  A hyperglycemic state is not an emergency for diabetics, but a hypoglycemic state is dangerous for the patient. Causes include overdose of insulin, excessive use of internal medicine, lack of food intake, prolonged use of medicine (or insulin administration), persistent diarrhea and vomiting, intense exercise, alcohol overdose, etc. However, in any case, it is important to monitor blood glucose level changes so as not to fall into hypoglycemic symptoms.

Symptoms of hypoglycemia change from parasympathetic symptom (rapid hunger) to central nervous symptom (headache, dizziness, nausea), and further sympathetic symptom (sweat, palpitation, tremor), If blood sugar falls too low, it can cause abnormal behavior, confusion, and convulsions, resulting in loss of consciousness (hypoglycemic coma), which can lead to dangerous situations. However, it is effective to know the change in blood glucose level regularly if possible because it may vary depending on the individual, such as the presence of neurological disorders or the type of insulin preparation, but it is effective and simple. There was no device for measuring blood glucose level.

In health management in diabetes, blood glucose level, particularly management that does not cause hypoglycemia is an important theme. In order to manage this blood glucose level, an invasive blood glucose measuring device using a portable puncture device has become widespread, but daily use of the puncture device has been mentally and physically painful.
A pulse oximeter is known as a means for measuring a blood glucose level of a diabetic patient. A pulse oximeter is a medical device that attaches a probe to a fingertip or an ear and monitors the pulse rate and percutaneous arterial oxygen saturation without invading. However, pulse oximeters that measure blood glucose levels are medical devices, are expensive, and are not usually worn.

  From the standpoint of a general diabetic patient, there is a demand for a simple blood glucose level sensor that gives an alarm when the blood glucose level is likely to become low even if the accurate blood glucose level is unknown. The inventor has invented a blood glucose level watch that detects a blood vessel position using an image sensor and an LED. This is to measure a change in blood glucose level using a composite pulse in which a near-infrared pulse and a step wave having a wavelength other than near-infrared are combined (Patent Document 1).

  On the other hand, a pulse oximeter is also known to measure arterial oxygen saturation by using a light-emitting element with a wavelength of 650 nm and a light-emitting element with a wavelength of 950 nm, driving each pulsed, and comparing and measuring the absorbance by arterial blood. (Patent Document 2).

Japanese Patent Application No. 2012-280410 Japanese Patent Laid-Open No. 5-207993

  In the above-mentioned patent document 1, since a CCD camera is used, there is a problem that the configuration is different from a conventional pulse oximeter and development takes time. On the other hand, in the pulse oximeter of Patent Document 2, paragraph (0033) states that “the light-emitting element 1 and the light-emitting element 2 pass through a part 3 of a living body such as fingers, auricles, and nose to the light-receiving element 4 in a time-sharing manner. Since it is premised on use in a medical institution that irradiates light of each wavelength, it is premised on accurate blood glucose measurement. Further, paragraph (0033) of Patent Document 2 states that “the light-emitting element 1 and the light-emitting element 2 pass through each part of the living body such as fingers, auricles, and nose of the limbs to the light-receiving element 4 in a time-sharing manner. It is designed to irradiate light, ”and is not supposed to be incorporated into a portable device. In order to warn about hypoglycemia and hyperglycemia symptoms that are a problem for diabetics, accurate numerical measurement is not necessary, and when the blood glucose level is lower than the predetermined lower limit or higher than the upper limit Knowing the time is enough for everyday use.

  Therefore, in the present invention, it is easy to manufacture like a pulse oximeter, and instead of measuring a blood glucose level, a change in the blood glucose level is detected and compared with a predetermined maximum or minimum value to generate an alarm. An object of the present invention is to provide a blood sugar level watch that detects an inexpensive simple blood vessel position.

  In order to solve the above-described problems, in the present invention, a CPU having a clock function, a memory connected to the CPU, and a light emitting unit that emits pulsed light of different wavelengths toward the wrist under the control of the CPU. And a method for detecting the blood vessel position of the skin with the light receiving means for detecting the reflected pulsed light reflected by the wrist and outputting the photoelectric conversion voltage value to the CPU, other than the near infrared ray output from the pulse light emitting means. A first group of pulse lights having a wavelength and forming a staircase wave, and a second group of pulses having a near-infrared wavelength superimposed within the uppermost vertex timing period of the staircase wave of the first group of pulse lights The composite reflected pulse light is generated by reflection from the skin by irradiating the light to the skin and reflected by the CPU. By sampling by generating a timing pulse at a portion overlapping with the second group of pulsed light, a reference is made with a step of the stepped wave of the reflected pulsed light of the first group of the composite pulses reflected by the skin. The level is set, the reflected light peak level of the reflected light of the second group is measured, the ratio of the reflected light peak level to the reference value is calculated using the reflected light peak level as a variation value, and the predetermined number of the reflected composite pulses Of the ratio to the reference value, the blood vessel for detecting the blood vessel position of the skin is detected from the relative low level region of the reflected pulse light.

  In the present invention, a method of detecting a change in blood glucose level using the same reflected composite pulse wave as in the cited document 1 is used. However, in the cited document 1, one reflected composite pulse is collectively received by a plurality of light receiving cells, for example, a CCD camera, and the blood vessel position is detected using the near-infrared reflected pulse level in the reflected composite pulse as a parameter. On the other hand, in the present invention, while having a structure similar to that of a conventional pulse oximeter, a plurality of pulse light emission sources emit light at different timings at a plurality of different positions, and the light receiving means is a single sensor, such as a conventional pulse oximeter. The infrared / near-infrared sensor used can be used. It differs from Patent Document 1 in that a near-infrared pulse is detected at a position close to a blood vessel from among a plurality of light emitting means, and is different from Patent Document 2 that uses a single light emitting source and a single light receiving means. .

  Although the structure is similar to the basic structure of a conventional pulse oximeter, the present invention can be implemented by arranging a plurality of LEDs, so that rapid spread is expected. When diabetics wear and carry this blood glucose watch as a wrist watch on a daily basis, especially in the case of hypoglycemia, a warning sound is generated not only by themselves but also by the surrounding people using the alarm function. Can report to the surroundings that it is a hypoglycemic condition.

It is a light emission timing diagram of a composite pulse. It is a functional block diagram of a blood glucose level watch device that detects a wristwatch-type blood vessel position including one light emitting means and a plurality of light receiving means. It is an example of arrangement of a plurality of LEDs. It is an example of the light emission sequence which light-emits and receives only the detection pulse of a staircase wave. 3 is a unit structure of a light emitting unit and a light receiving unit of Example 2.

In the present invention, in order to measure the blood sugar level, the blood pressure level is attached in close contact with the measurement target skin including the blood vessel of the measurement subject, and a predetermined pulse is emitted by being controlled by the clock function, the CPU, and the CPU. A wristwatch-type blood glucose level watch using near-infrared spectroscopy, comprising pulse light emitting means and light receiving means for converting the reflected pulse light emitted from the pulse light emitting means and reflected by being emitted to the skin. A device,
The pulse light emitting means is a combination of an LED having a wavelength other than near infrared and an LED having a near infrared wavelength, and is configured by a plurality of LEDs that emit light while scanning at a predetermined timing synchronized with the clock function in a predetermined direction,
The pulsed light emitted from the pulsed light emitting means at a plurality of predetermined timings includes a first group of pulsed light having a wavelength other than near infrared rays and forming a staircase wave, and a staircase wave of the first group of pulsed light A reflection composite pulse composed of a second group of pulsed light having a near-infrared wavelength superimposed within the topmost vertex timing period of
The CPU sets a reference level at the step of the stepped wave of the reflected pulse light of the first group of the composite pulses reflected by the skin, and measures the reflected light peak level of the reflected pulse light of the second group Then, the ratio of the reflected light peak level to the reference value is calculated as a fluctuation value, and the ratio from the reference value in the predetermined number of the reflected composite pulses is calculated from the relative low level region of the reflected pulse light. The blood vessel position of the skin was detected and used as the blood glucose level fluctuation parameter value of the reflex composite pulse.

  FIG. 1 is a functional block diagram of a blood glucose level watch device that detects a wristwatch type blood vessel position including one light emitting means and a plurality of light receiving means. The blood glucose level watch device 1 that detects the blood vessel position is provided with a CPU 9, and a program memory 9 a and a data memory 9 b are connected to the CPU 9. In addition, a pulse generator 2 controlled by the CPU 9 is built in, and the first light emitting circuits 3a, 3a ′ and the second light emitting circuit 3b are controlled at the pulse timing generated by the pulse generator 2, and the back surface of the wristwatch is First light emitting circuit having a wavelength other than near-infrared light Reflected light, which will be described later, is emitted from a plurality of first light emitting circuits 3a, 3a 'and a second light emitting circuit 3b arranged to form a composite reflected pulse at a plurality of different positions. The pulsed light irradiates the skin of the subject's arm and reaches the blood vessel 4.

  The pulse reflected by the blood vessel 4 of the skin is received by the light receiving means 5 as a composite reflection pulse to be described later, and the photoelectrically converted voltage and the reference value generated by the sample and hold circuit 6 of the first light emitting circuits 3a and 3a ' The fluctuation value data generated by the sample and hold circuit 7 of the light emitting circuit 3b is held, compared by the comparison circuit 8 and fed back to the CPU 9, and the result is displayed on the display unit 10 of the blood glucose level watch device 1. The comparison circuit 8 calculates the rate at which the fluctuation value B changes with respect to the reference value A. However, in the region where blood does not flow much, the rate at which the reference light is absorbed by hemoglobin is small. In order to increase the measurement accuracy, it is necessary to calculate with the reflected light irradiated on the blood vessel 4 of the skin.

  In this case, since the sugar content parameter is changed by hemoglobin detected by the blood pressure, the absolute value of the blood glucose level parameter is changed, but in the present invention, the pulse light having a wavelength other than the near infrared ray and the pulse light having the near infrared wavelength are combined and reflected. Since it detects and measures as, it becomes difficult to receive the influence of a blood flow rate.

  In addition, blood pressure is generally lowest at night and during sleep, slightly higher in the afternoon, lower at night, and tends to increase with getting up, and rises after meals, returning to the original level in about an hour. Since there is a tendency, it is necessary to manage blood glucose levels from data tailored to life patterns.

  In the above, the first light-emitting circuit 3 uses LEDs or semiconductor lasers having wavelengths other than 700 to 800 nm, such as blue and green, and the second light-emitting circuit 4 has a wavelength of about 700 to 900 nm that easily passes through the living body. It is desirable to use light of a light emitting diode or a semiconductor laser that emits light having a wavelength of infrared light (preferably 760 nm) or near infrared diffuse reflection spectrum (700 nm to 1050 nm). This reflective sensor may be arranged in a circle on the outer periphery of the wristwatch or linearly arranged in the diametrical direction, and a combination of red light having a wavelength of 660 nm, for example, infrared rays, using the infrared light of a unit adjacent to one near infrared LED.

  Further, as the light emitting means of the first light emitting circuits 3a, 3a 'as the light emitting means attached to the wristwatch and the second light emitting circuit, a light emitting diode LED or a semiconductor laser, particularly a hologram laser unit can be used as long as it can be miniaturized. Conceivable.

  When the LED is arranged on a wristwatch, a near-infrared wavelength LED and a near-infrared wavelength LED are arranged in a circle on a concentric circle, and the near-infrared wavelength LED and the near-infrared wavelength LED other than the near-infrared wavelength adjacent to the near-infrared wavelength LED are arranged. It is possible to group LEDs of wavelengths and synthesize a composite reflected pulse wave by these emission.

  For example, New Japan Radio Co., Ltd. sells a reflective sensor “NJL5501R” as one of the applications of a pulse oximeter, and uses two LEDs, a red light with a wavelength of 660 nm and a near infrared light with a wavelength of 940 nm. However, since this reflective sensor has only two LEDs, it is possible to generate infrared staircase pulses by voltage operation. It is also conceivable to use a staircase base light as the LED 3a and two adjacent red light LEDs having a wavelength of 660 nm as the light to form the step of the staircase as the LED 3a ′.

  For the light receiving unit 5, an optical sensor such as TMS320C5515 sold by Texas Instruments Inc., which is used in a conventional pulse oximeter, can be used. The difference from the conventional pulse oximeter is whether the received signal is continuous light or composite pulse reflected light.

  FIG. 2 is a light emission timing diagram of the composite pulse. The method used here includes a first group of pulsed lights that are emitted from the pulsed light emitting means at a plurality of predetermined timings and have a wavelength other than near infrared rays to form a staircase wave. This is a detection method in which the second group of pulsed light having a near-infrared wavelength superimposed within the topmost vertex timing period of the staircase wave of the pulsed light is reflected by the skin and detected as a reflected composite pulse by the light receiving means. .

  In the method, a reference level is set by a step of a stepped wave of the first group of reflected pulse lights of the composite pulse reflected by the skin, and a reflected light peak level of the second group of reflected pulse lights is determined. Measure and calculate the ratio of the reflected light peak level as the fluctuation value to the reference value, and from the relative low level region of the reflected pulse light out of the ratio to the reference value in the predetermined number of the reflected composite pulses. It is a method of detecting a blood vessel for detecting the blood vessel position of the skin.

  FIG. 2A shows a pulse 11 that forms the basis of a pulse staircase wave emitted from the main first pulse light emission circuit 3a having a wavelength other than near infrared rays. The height of the light emission pulse is A1, and the timing is from t1 to t5. In the reflection composite pulse, the staircase portion of the staircase wave emitted from the first LED 3 is formed.

FIG. 2B shows a pulse 12 that forms the upper layer of a pulse staircase having a wavelength other than near infrared. This pulse is a pulse emitted from the sub-first pulse light emission circuit 3a ′ having a wavelength other than near infrared rays. In the reflection composite pulse, the upper part of the staircase wave emitted from the first LED 3 'is formed. The height of the light emission pulse is A3, and the timing is from t2 to t5. When the height A1 and height A3 of the pulse 11 having a wavelength other than the near infrared ray are added, A2 is obtained.

 FIG. 2C shows a pulse 13 having a near infrared wavelength. This pulse is a pulse emitted from the second pulse light emission circuit 3b having a near infrared wavelength. The reflected composite pulse wave is superimposed on the top of the staircase, the height of the light emission pulse is A4, and the timing is from t3 to t4.

FIG. 2D shows a reflected composite pulse waveform 14 of pulses 11 to 13 reflected from the skin. Here, the height of the reflected wave portion of the pulse 11 emitted from the main first pulse light emission circuit 3a having a wavelength other than near infrared is a1, and the height of the reflected wave portion emitted from the sub first pulse light emission circuit 3a 'having a wavelength other than near infrared. The height of the reflected wave portion of the pulse 12 and the height of the reflected wave portion are a2, and the height of the reflected pulse is a2.

The difference between the heights a1 and a2 of the reflected pulse is h1. Further, the height of the reflected light portion of the pulse emitted from the second pulse light emitting circuit 3b having the near-infrared wavelength is h2, and when the height of the reflected pulse is a2, the peak height is a3.

  FIG. 3 is a functional block diagram of a blood glucose monitoring device that detects a wristwatch type blood vessel position including a plurality of light emitting means and one light receiving means. The blood glucose level watch device 1 that detects a wristwatch-type blood vessel position is provided with a CPU 109, and a program memory 109a and a data memory 109b are connected to the CPU 109. In addition, the pulse generator 2 controlled by the CPU 109 is built in, and the first light emitting circuits 103a and 103a ′ and the second light emitting circuit 103b are controlled at the pulse timing generated by the pulse generator 102. First light-emitting circuit having a wavelength other than near infrared rays A main first pulse light-emitting circuit 103a having a wavelength other than near-infrared, which is arranged so that reflected light, which will be described later, forms a reflection composite pulse at a plurality of different positions. The pulsed light emitted from the sub-first pulse light emission circuit 103 a ′ of the wavelength and the second pulse light emission circuit 103 b of the near infrared wavelength irradiates the subject's skin and reaches the blood vessel 104.

  The pulse reflected by the blood vessel 104 on the skin is received by the light receiving means 105 as a reflected composite pulse, and the main pulse light emitting circuit 103a having a wavelength other than near infrared in the reflected composite pulsed light and the sub-pulse emission having a wavelength other than near infrared. The reflected pulse light reflected by the skin of the circuit 103a ′ is photoelectrically converted to generate the reference value detection circuit 6 reference value. On the other hand, the reflected pulse light reflected by the skin of the second pulse issuing circuit 103b having the near-infrared wavelength in the reflected composite pulse light is photoelectrically converted, and the fluctuation value detection circuit 7 generates a fluctuation value. The reference value and the fluctuation value are ratio-calculated by the ratio calculation circuit 108 under the control of the CPU. The calculation result is stored in the data memory 109b. The calculation result is fed back to the CPU 109, and the result is displayed on the display unit 110 of the blood glucose level watch device 101.

  Here, in the conventional pulse oximeter, since the integrated light transmitted or reflected from the finger or arm is detected, post-processing is complicated. If the reflected light only from the periphery of the blood vessel can be detected, the fluctuation of the blood glucose level can be known without complicated calculation.

  The above-described methods for examining blood using near-infrared light and light other than near-infrared light have been well known in the past for measuring oxygen in blood. However, since the pulse oximeter basically uses only continuous light or single wave light pulses, there was no technical idea of providing reference values and variation parameter information using only pulses.

  In the present invention, it is an important problem to be solved to issue a warning to a subject in anticipation of becoming a hypoglycemic state or a hyperglycemic state by regularly measuring the blood sugar level instead of measuring the blood sugar level accurately. did. And the above-mentioned subject was solved by reading standard value information and blood glucose level change value information from the reflected light from the skin of the compound pulse which combined the near-infrared pulse and other wavelength pulses.

  FIG. 4 is an arrangement example of a plurality of LEDs. In FIG. 1, LEDs are arranged concentrically on the periphery of the wristwatch. However, blood vessels can be detected by arranging LEDs on a straight line that is substantially perpendicular to the blood vessels in the diameter direction of the wristwatch. The top row is an LED 103a that generates a primary first pulse of a wavelength other than near infrared, and the bottom row is an LED 103a 'that generates a secondary first pulse of a wavelength other than near infrared, and the middle row sandwiched between them is the wavelength of the near infrared The LED 103b that generates the second pulse.

Since a large output cannot be obtained with an SMD type LED, for example, an LED 18 that generates a second pulse having a near-infrared wavelength, LEDs 115 and 116 that generate a main first pulse having a wavelength other than the near-infrared, and a wavelength other than the near-infrared wavelength. The light receiving means 105 receives the reflection composite pulse by generating a pulse by combining the LEDs 121 and 122 that generate the second sub-pulse. Further, an LED 119 that generates a second pulse having a near infrared wavelength, LEDs 116 and 117 that generate a main first pulse having a wavelength other than the near infrared, and LEDs 122 and 123 that generate a sub first pulse having a wavelength other than the near infrared are included. By generating pulses in combination, the light receiving means 105 can receive the reflection composite pulse.

  When it is desired to increase the reception level of the near-infrared pulse, the LEDs 118 and 119 that generate the second pulse of the near-infrared wavelength, the LED 116 that generates the main first pulse of the wavelength other than the near-infrared, and the other than the near-infrared The light receiving means 5 receives the reflection composite pulse by generating a pulse by combining the LEDs 122 that generate the sub-first pulse of the wavelength. Further, the LEDs 119 and 120 that generate the second pulse of the near infrared wavelength, the LED 17 that generates the main first pulse of the wavelength other than the near infrared, and the LED 123 that generates the sub first pulse of the wavelength other than the near infrared are combined. The light receiving means 105 receives the reflection composite pulse by generating the pulse.

  In the second embodiment, in the wristwatch-type blood glucose level watch device of the first embodiment, the CPU uses a sampling pulse for detecting the reference level and the fluctuation value, and the first group of pulsed lights is obtained by the CPU using the reference value. The waveform is obtained by masking the light emission timing of the light emitting means using the sampling pulse for generating, and the second group of pulse lights is emitted by the light emitting means using the sampling pulse for generating the fluctuation value by the CPU. The first group of pulse lights includes a timing of a sampling pulse for generating the reference value by the CPU, has a pulse width equal to or greater than the timing pulse, and is a second group of pulses. The light includes the timing of the sampling pulse for generating the fluctuation value by the CPU. And to have a pulse width of more than the timing pulses.

  Here, in the reflection composite pulse, the pulse reflected by the blood vessel 104 of the skin is received by the light receiving means 105 as a reflection composite pulse, and a portion used for generating the reference value in the reflection composite pulse light and a fluctuation value are generated. It is also conceivable to emit light from the light emitting circuit only at the portion to be operated.

  FIG. 4 shows an example of a light emission sequence for emitting and receiving only the detection pulse of the staircase wave. In the first embodiment, only the portion received by the light receiving sensor is extracted and used in the staircase wave synthesized when the pulse light having a wavelength other than near infrared is reflected by the skin.

  FIG. 4A shows a pulse P101 included in the pulse P1 forming the base of the pulse staircase wave emitted from the main first pulse light emission circuit 3a having a wavelength other than the near infrared ray other than the near infrared ray in FIG. is there. The height of the light emission pulse is A1, and the timing is from timing pt01a to pt01b between t1 and t2 in FIG.

FIG. 4B shows pulses P102a and P102b that form the upper layer of a pulse staircase having a wavelength other than near infrared rays. This pulse is composed of two pulses included in the upper staircase wave P2 in FIG. Both these two pulses have the same amplitude A2. The amplitude A2 is an amplitude obtained by adding the height A1 and the height A3 of the pulse 11 having a wavelength other than the near infrared ray shown in FIG. The first pulse P102a in the first half is emitted during a period from timing pt02a to pt02b included in the staircase landing area. The second pulse P102b in the latter half has the same timing as the near-infrared pulse P103 shown in FIG. The height of the light emission pulse is A3, and light is emitted from timing t3 to timing t4. These are pulses emitted from the sub-first pulse light emission circuit 3a ′ having a wavelength other than near infrared rays. In the composite pulse that is reflected and synthesized by the skin, it is located at the upper part of the staircase wave P2 emitted from the first LED 3 'shown in FIG.

 FIG. 4C shows a pulse P103 having a near infrared wavelength. This pulse is the same pulse as the pulse P3 emitted from the second pulse light emitting circuit 3b having a near infrared wavelength in FIG. The reflected composite pulse wave is superimposed on the top of the staircase, the height of the light emission pulse is A4, and the timing is from t3 to t4.

FIG. 4D shows a reflected composite pulse waveform RP101 synthesized by reflecting the pulses P101, P102a, P102b, and P103 reflected by the skin. Here, the height of the reflected wave portion of the pulse P1 emitted from the main first pulse light emission circuit 3a having a wavelength other than near infrared is a1, and the height of the reflected first pulse light emission circuit 3a ′ having a wavelength other than near infrared is emitted. The height of the reflected wave portion of the pulse 12 and the height of the reflected wave portion are a2, and the height of the reflected pulse is a2.

The difference between the heights a1 and a2 of the reflected pulse is h1. Further, the height of the reflected light portion of the pulse emitted from the second pulse light emitting circuit 3b having the near-infrared wavelength is h2, and when the height of the reflected pulse is a2, the peak height is a3.

  In the case of the present embodiment, since the light emission timing by the light emitting means and the detection timing by the light receiving means are matched, the circuit design is simplified.

  In the comparison circuit, the first single reflected pulse waveform portion RP101a having a wavelength other than the near infrared ray, which is the reflected light of the pulse P101, and the second single reflected pulse waveform portion P102b having a wavelength other than the near infrared ray are used as reference values. And the fluctuation value generated by detecting the single reflected light pulse PR103c of the pulse P103 with respect to the reference value is compared, and the fluctuation of the hemoglobin amount in the blood can be observed.

  In terms of circuit, the first single reflected pulse waveform of the wavelength other than near infrared reflected by the skin of the main pulse light emitting circuit 103a having a wavelength other than near infrared and the sub-pulse light emitting circuit 103a ′ having a wavelength other than near infrared. The portions RP101a and RP101b are photoelectrically converted to generate the reference value detection circuit 6 reference value. On the other hand, the single reflected pulse portion PR101c of the near infrared wavelength reflected by the skin of the second pulse issuing circuit 103b of the near infrared wavelength in the reflected composite pulse light is photoelectrically converted and the fluctuation value is detected by the fluctuation value detecting circuit 7. Is generated. The reference value and the fluctuation value are ratio-calculated by the ratio calculation circuit 108 under the control of the CPU. The calculation result is stored in the data memory 109b. The calculation result is fed back to the CPU 109, and the result is displayed on the display unit 110 of the blood glucose level watch device 101 that detects the blood vessel position.

  FIG. 5 shows a unit structure of the light emitting means and the light receiving means of the second embodiment. The light receiving means 5 may be a device common to a plurality of units. For example, a light receiving means may be provided for each group of New Japan Radio.

  The main first pulse light emission circuit 3a having a wavelength other than the near infrared ray includes an LED 101 having a wavelength other than the near infrared ray and a switch 102 for controlling ON / OFF.

  When the control signal 108 from the CPU 9 selects the selection switch 109 under the control of the CPU 9, the switch 102 is turned on, and the pulse P1 that forms the base of the pulse staircase wave is emitted from the LED 101 having a wavelength other than the near infrared ray. .

  The main first pulse light emission circuit 3a 'having a wavelength other than the near infrared ray includes an LED 103 having a wavelength other than the near infrared ray and a switch 104 that controls ON / OFF.

  In order to generate the pulse P101, the first switch output terminal 103 is selected by the selection of the CPU 9. The control signal 101 from the pulse generation circuit is input from the switch input terminal 102 and output from the first switch output terminal 103 in the switch 101. Here, the first transistor 107 is turned on, and the current flowing through the first load resistor 108 is caused to flow to the first LED 109 that generates the main first pulse of a wavelength other than near infrared rays, thereby generating the pulse P101. .

  In order to generate the pulses P102a and P102b, the CPU 9 selects the second switch output terminal 104. The control signal 101 from the pulse generation circuit is input from the switch input terminal 102 and output from the second switch output terminal 104 in the switch 101. Here, by turning on the second transistor 111 and causing the current flowing through the second load resistor 112 to flow through the second LED 113 that generates the main second pulse having a wavelength other than near infrared rays, the pulses P102a and P102b are transmitted. generate.

  Further, the output from the second switch output terminal 104 is the main first pulse having a wavelength other than the near infrared ray by turning on the first transistor 107 via the diode 114 and passing the current flowing through the first load resistor 108. Is caused to flow through the first LED 109 for generating the pulse P101.

  To generate the pulse P103, the third switch output terminal 105 is selected by the selection of the CPU 9. The control signal 101 from the pulse generation circuit is input from the switch input terminal 102 and output from the third switch output terminal 105 in the switch 101. Here, the third transistor 116 is turned on, and a current flowing through the third load resistor 117 is caused to flow to the LED 118 that generates a near-infrared wavelength pulse, thereby generating a pulse P103.

  Further, the first transistor 107 is turned on through the diode 119 and the second transistor 111 is turned on through the diode 120.

  The pulses P101, P102a, P102b, and P103 are reflected on the skin, and using these pulse generation timings, a reflection composite pulse waveform RP101 composed of three pulses is detected by the light receiving means 5, and the first reflected pulse PR101a is detected. A reference value is generated from the second reflected pulse PR101b, a fluctuation value is further generated from the level difference between the third reflected pulse PR101c and the second reflected pulse PR101b, and the blood value is divided by dividing the fluctuation value by the reference value. A variation of medium hemoglobin is calculated.

  In the above, it is desirable that the pulse timing of the light emission pulse includes the sampling timing of the light receiving means, and the pulse width of the light emission pulse is greater than or equal to the sampling pulse width of the light receiving means.

  In addition, it is desirable that the pulsed light emitting means combine an LED having a wavelength other than near-infrared light and an LED having a near-infrared wavelength and scan in a predetermined direction at a plurality of predetermined timings synchronized with the clock function.

  In this case, the scanning direction may be a linear direction orthogonal to the arm length direction, or may be a concentric circumferential direction when the back cover of the wristwatch is circular.

  The feature of the present invention is that by selecting reflected light from a position close to the blood vessel from among a plurality of reflection composite pulse waveforms having different reflection positions, the one having the lowest fluctuation value is close to the blood vessel from among the calculated values. This is to estimate the fluctuation value of moglobin due to the reflected light from the position.

In the above, if one conventional pulse oximeter structure is used, it is possible to arrange the light receiving means 114 at the center of the back of the wristwatch and to arrange the light emitting means 3a, 3a ′, 3b around the periphery. However, there are two types of near infrared light (wavelength 940 nm) and red light (wavelength 660 nm) for applications such as pulse oximeters (oxygen saturation meters) and pulse meters such as the photo reflector NJL8801R of New Japan Radio Co., Ltd. In the case of using a photo reflector in which an LED and a phototransistor are mounted in one package, a light receiving means 114 may be provided for each photo reflector.

  Further, even if it is not a wristwatch, the first group of pulse lights having a wavelength other than the near infrared ray output from the pulse light emitting means and forming a staircase wave, and the top vertex of the staircase wave of the pulse light of the first group A second group of pulsed light having a near-infrared wavelength that is superimposed within a part timing period is applied to the skin and reflected to generate composite reflected pulsed light by reflection from the skin. The first group of the composite pulses reflected by the skin by sampling by generating a timing pulse at the landing, the uppermost front part, and the part overlapping the pulse light of the second group The reference level is set by the step of the stepped wave of the reflected pulsed light, and the reflected light peak level of the reflected pulsed light of the second group is measured. The ratio of the reference value is calculated using a bell as a fluctuation value, and the blood vessel position of the skin is detected from the relative low level region of the reflected pulse light out of the ratio to the reference value in a predetermined number of the reflected composite pulses. As a method for detecting a blood vessel to be performed, for example, the position of a blood vessel in an artery or vein under the skin can be detected by irradiating the skin such as an arm.

  By using the above method, by comparing the difference between the reference value and the fluctuation value of the reflection composite pulse in real time without using the movie, it is possible to identify the subcutaneous artery and vein that could not be identified without using the movie. It becomes easy to identify.

  The blood glucose level watch device for detecting a blood vessel position according to the present invention can be used regularly instead of a wristwatch. Since blood glucose levels can also be measured, it is possible to improve the medical system without increasing the number of precision measuring devices.

DESCRIPTION OF SYMBOLS 1 Blood glucose level watch apparatus which detects wristwatch-type blood vessel position 2 Pulse generation circuit 3a Main first pulse light emission circuit 3a 'of sub-first pulse light emission circuit 3b' of wavelengths other than near infrared Second pulse light emission circuit 4 Blood vessel in skin 5 Light receiving means 6 Reference value detection circuit 7 Fluctuation value detection circuit 8 Ratio calculation circuit 9 CPU
9 Program memory 9 Data memory 10 Display device
101 Control signal from pulse generation circuit 102 Switch input terminal 103 First switch output terminal 104 Second switch output terminal 105 Third switch output terminal 106 Diode 107 First transistor 108 First load resistor 109 Other than near infrared rays A first LED generating a main first pulse of a wavelength of
110 Diode 111 Second transistor 112 Second load resistance 113 Second LED that generates a main first pulse having a wavelength other than near infrared rays
114 Diode 115 Diode 116 Third transistor 117 Third load resistor 118 LED generating a second pulse of near-infrared wavelength
119 Diode 120 Diode P1, P101 Main first pulse waveform of wavelength other than near infrared
P2, P101a, P101b Single reflected pulse waveform of wavelength other than near infrared P3, P101c Single reflected pulse waveform of near infrared wavelength PR101 Reflected composite pulse waveform PR101a First single reflected pulse waveform of wavelength other than near infrared PR101b Second single reflection pulse waveform portion of wavelength other than near infrared ray PR101c Single reflection pulse portion of wavelength of near infrared ray

FIG. 4A shows a pulse P101 a included in the pulse P1 forming the base of the pulse staircase wave emitted from the main first pulse light emission circuit 3a having a wavelength other than the near infrared ray other than the near infrared ray in FIG. To P101c . The height of the light emitting pulses is A1, at the timing pt01a located between the timing of P101a is t1 and t2 shown in FIG. 2 (a) to Pt01b, timing P101b is the same as described later pulse P102A, Timing of P101c Is the same timing as pulses P102b and P103 described later .

Claims (2)

In order to measure the blood glucose level, it is attached in close contact with the measurement target skin including the blood vessel of the measurement subject, a clock function, a CPU, and a pulse light emitting means that emits a predetermined pulse controlled by the CPU. A wristwatch type blood glucose monitoring device using near-infrared spectroscopy comprising light receiving means for converting reflected pulsed light emitted from the pulsed light emitting means to the skin and reflected by being emitted to the skin. ,
The pulse light emitting means is composed of a plurality of LEDs that emit light while scanning in a predetermined direction at a plurality of predetermined timings synchronized with the clock function, by combining an LED having a wavelength other than near infrared and an LED having a wavelength of near infrared.
The pulsed light emitted from the pulsed light emitting means at a plurality of predetermined timings includes a first group of pulsed light having a wavelength other than near infrared rays and forming a staircase wave, and a staircase wave of the first group of pulsed light A reflection composite pulse composed of a second group of pulsed light having a near-infrared wavelength superimposed within the topmost vertex timing period of
The CPU sets a reference level at the step of the stepped wave of the reflected pulse light of the first group of the composite pulses reflected by the skin, and measures the reflected light peak level of the reflected pulse light of the second group Then, the ratio of the reflected light peak level to the reference value is calculated as a fluctuation value, and the ratio from the reference value in the predetermined number of the reflected composite pulses is calculated from the relative low level region of the reflected pulse light. A wristwatch-type blood glucose monitoring device characterized by detecting a blood vessel position on a skin and using it as a blood glucose level fluctuation parameter value of a reflection composite pulse. The wristwatch-type blood sugar level watch device according to claim 1, wherein the CPU uses a sampling pulse for detecting the reference level and the fluctuation value,
The first group of pulsed light is a waveform in which the light emission timing of the light emitting means is masked using a sampling pulse for generating the reference value by the CPU,
The second group of pulsed light is a waveform in which the light emission timing of the light emitting means is masked using a sampling pulse for generating the fluctuation value by the CPU.
The first group of pulse lights includes the timing of the sampling pulse for generating the reference value by the CPU, and has a pulse width equal to or greater than the timing pulse,
A wristwatch-type blood sugar level watch device characterized in that the second group of pulsed lights includes a sampling pulse timing for generating the fluctuation value by the CPU and has a pulse width equal to or greater than the timing pulse.

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