JP2015067586A - Astringent composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a formulation technique for enhancing an astringent action of an astringent in an astringent composition containing an astringent.SOLUTION: An astringent composition combining an astringent which is at least one kind selected from the group consisting of (A) an allantoin derivative, Quercus salicina extract, and Betula alba extract with (B) Paeoniae radix extract, Angelica acutiloba extract, and/or Sapindus mukurossi extract synergistically enhances an astringent action of astringent.

Description

  The present invention relates to an astringent composition. More specifically, the present invention relates to an astringent composition that can enhance and exhibit the astringent action of an astringent.

  Astringents have a protective function against physical or chemical stimuli from the outside by tightening the tissue by temporarily denaturing and agglutinating proteins in the skin and mucous membranes or by exerting a dehydrating effect by osmotic pressure. It has an enhancing action and is blended in oral compositions and skin external compositions for the purpose of anti-inflammatory, hemostasis, antiperspirant and the like. Hitherto, intensive studies have been made on components having an astringent action, and various components that can be used as astringents have been reported (for example, see Patent Documents 1 and 2).

  On the other hand, in recent years, the pharmacological effects appealed to by consumers have diversified, and while some people prefer a stronger astringent action, some people prefer a milder astringent action, and the demands for the astringent action exhibited by astringents are also diverse. It has become. In order to follow such diversified demands, development of a formulation technique that enhances the astringent action of the astringent is required.

  Usually, in order to enhance the astringent action exhibited by the astringent, it can be realized by increasing the blending amount of the astringent, but the increase in the blending amount of the astringent causes white turbidity, precipitation, etc. It may be destabilized or the feeling of use may be impaired by the bitterness, astringency, saltiness, etc. of the astringent itself. In particular, in the case of a composition for oral cavity, a decrease in taste caused by an increase in the amount of astringent is accompanied by a significant deterioration in the feeling of use. Therefore, there is a demand for the development of a formulation technique that can enhance the astringent action without increasing the blending amount of the astringent.

  However, from the standpoint of enhancing the astringent action of astringents, however, the current situation is that sufficient studies have not been made.

JP 2007-302620 A JP 2006-104074 A

  An object of the present invention is to provide a preparation technique that enhances the astringent action of an astringent in an astringent composition containing the astringent.

  The present inventor has intensively studied to solve the above-mentioned problems. As a result, (B) peonies extract is combined with at least one astringent selected from the group consisting of (A) allantoin derivatives, vulgari extract, and birch extract. It has been found that an astringent composition combined with a Toki extract and / or Mukuroji extract exhibits synergistically enhancing the astringent action of an astringent. The present invention has been completed by further studies based on this finding.

That is, this invention provides the invention of the aspect hung up below.
Item 1. (A) at least one astringent selected from the group consisting of an allantoin derivative, jellyfish extract, and birch extract; and (B) at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract. A composition for converging, comprising:
Item 2. Item 2. The astringent composition according to Item 1, wherein the component (A) is at least one selected from the group consisting of an allantoin derivative and a jellyfish extract.
Item 3. Item 3. The astringent composition according to Item 1 or 2, wherein the component (B) is contained in an amount of 0.01 to 140 parts by weight per 1 part by weight of the total amount of the component (A).
Item 4. Item 3. The astringent composition according to Item 2, wherein the component (B) is contained in an amount of 2 to 140 parts by weight per 1 part by weight of the total amount of the component (A).
Item 5. Item 5. The converging composition according to any one of Items 1 to 4, which is an oral composition.
Item 6. Astringent action on at least one astringent selected from the group consisting of allantoin derivatives, radish extract, and birch extract, comprising at least one selected from the group consisting of peony extract, toki extract and mukuroji extract as an active ingredient Enhancer.
Item 7. An astringent composition containing at least one astringent selected from the group consisting of an allantoin derivative, a velvet extract, and a birch extract, and at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract A method for enhancing the convergence effect, comprising the step of blending.

  According to the astringent composition of the present invention, the astringent action exhibited by a specific astringent can be synergistically enhanced, so that it provides an excellent astringent effect on tissues such as the oral cavity and skin, and The protection function can be remarkably improved. Further, according to the astringent composition of the present invention, the astringent action can be enhanced without increasing the blending amount of the astringent, so the taste reduction caused by the increase in the blending amount of the astringent can be avoided, and the oral composition Even when used as a product, a good feeling of use can be obtained.

1. Astringent Composition The astringent composition of the present invention is at least one astringent selected from the group consisting of an allantoin derivative, a velvet extract, and a birch extract (hereinafter sometimes simply referred to as component (A)). And at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract (hereinafter sometimes simply referred to as component (B)). Hereinafter, the astringent composition of the present invention will be described in detail.

(A) Component The astringent composition of the present invention contains at least one astringent selected from the group consisting of an allantoin derivative, a velvet extract, and a birch extract as a component that exhibits an astringent action.

  The allantoin derivative used as an astringent in the present invention is not particularly limited as long as it can exert an action of temporarily denaturing and agglutinating proteins of skin and mucous membranes. For example, allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, etc. Is mentioned. These allantoin derivatives may be used individually by 1 type, and may be used in combination of 2 or more type.

  Vulgaris extract used as an astringent in the present invention is described in Japanese Pharmacopoeia Pharmaceutical Standards and is well known. More specifically, the extract of quercus salicina (Quercus salicina Blume (Fagaceae)) can be obtained by roughly cutting dry twig leaves and adding water to leach out.

  Moreover, the birch extract used as an astringent in this invention is described in the quasi-drug raw material specification, and is well-known. Specifically, birch extract can be obtained by subjecting leaves and / or sap of European birch (Betula alba linne (Betulaceae)) to extraction using an extraction solvent. Examples of the extraction solvent used for the extraction of birch extract include water; lower alcohols such as ethanol and propanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as a mixture thereof. Among these extraction solvents, ethanol or a mixed solvent of water and 1,3-butylene glycol is preferable.

  In the astringent composition of the present invention, as component (A), one of allantoin derivatives, jellyfish extract, and birch extract may be used alone, or two or more of these may be used in combination. Also good.

  Among these astringents, from the viewpoint of more effectively enhancing the astringent action, preferably an allantoin derivative, jellyfish extract, more preferably allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, urajirokashi extract, particularly preferably allantoinchlorohydroxy. Aluminum and allantoin dihydroxyaluminum are mentioned.

The content of the component (A) in the astringent composition of the present invention is not particularly limited, but for example 0.01 to 5% by weight, preferably 0.01 to 3% by weight, more preferably 0.01 to 2%. % By weight. From the viewpoint of enhancing the astringent action more effectively while imparting a good taste, the content of each type of component (A) includes the following ranges.
When component (A) is an allantoin derivative: preferably 0.01 to 1% by weight, more preferably 0.01 to 0.3% by weight.
When component (A) is birch extract: preferably 0.01 to 2% by weight, more preferably 0.2 to 2% by weight, still more preferably 1 to 2% by weight.
When the component (A) is a jellyfish extract: preferably 0.01 to 1% by weight, more preferably 0.01 to 0.3% by weight.

  In addition, in this specification, about the content of the velvet extract, when approximately 1.0 g of a sample is accurately weighed and dried at 105 ° C. for 3 hours, the weight loss is 3% by weight (loss on drying). With regard to the content of the velvet extract, the amount of the component contained will be substantially the same as in the case of the above criteria, taking into account the degree of concentration of the variegation extract used, etc. May be set as appropriate.

  In addition, in this specification, with respect to the content of birch extract, 10 ml of a sample is accurately weighed on an evaporating dish, evaporated to dryness on a water bath, and the residue is further dried at 105 ° C. for 3 hours and allowed to cool in a desiccator or the like. The value is based on the case of a liquid substance whose mass becomes 0.08 g (evaporation residue), and the content of the birch extract is based on the degree of concentration of the birch extract used. Thus, the amount of the component contained may be appropriately set so as to be the same as in the case of the standard.

(B) Component The astringent composition of the present invention contains at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract as a component that enhances the astringent action of the astringent. By using such a specific component (B) in combination with an astringent, it becomes possible to synergistically enhance the astringent action of the component (A).

  The peony extract used as the component (B) in the present invention is described in the quasi-drug raw material specifications and is publicly known. Specifically, a peony extract can be obtained by extracting the root of peony (Paeonia albiflora Pallas var. Trichocarpa Bunge) or other related plant (Paeoniaceae) using an extraction solvent. Examples of the extraction solvent used for the extraction treatment of peony extract include water; lower alcohols such as ethanol; polyhydric alcohols such as 1,3-butylene glycol; and polar solvents such as a mixture thereof. Water, ethanol, 1,3-butylene glycol, or a mixed solvent thereof.

  The toki extract used as the component (B) in the present invention is known in the Japanese Pharmacopoeia Pharmaceutical Standards, Quasi-drug Raw Material Standards, and the like. Specifically, the touki extract is extracted after removing the soluble part of n-hexane and / or n-butanol, if necessary, from roots of touki (Angera acutiloba Kitagawa) or other related plants (Umbelliferae). It can be obtained by an extraction treatment using a solvent. Examples of the extraction solvent used for the extraction process of Toki extract include water; lower alcohols such as ethanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol and propylene glycol; and polar solvents such as a mixture thereof. Preferably, water, ethanol, 1,3-butylene glycol, propylene glycol or a mixed solvent thereof is used.

  In addition, mukuroji extract used as the component (B) in the present invention is shown in the Japanese Pharmacopoeia Pharmaceutical Standards and is well known. Specifically, a mugwort extract can be obtained by subjecting the skin of mud crab (Sapindus mukurossi Gaetner (Sapindaceae)) to extraction using an extraction solvent. The extraction solvent used for the extraction process of mukuroji extract is water, ethanol, or a mixed solvent thereof, and is obtained by pulverization.

  In the astringent composition of the present invention, as the component (B), one of peony extract, toki extract and mukuroji extract may be used alone, or two or more of these may be used in combination. Also good.

  Among these components (B), peony extract and peony extract are preferable, and peony extract is more preferable from the viewpoint of further effectively enhancing the astringent action of the astringent.

The content of the component (B) in the astringent composition of the present invention is appropriately determined according to the type and content of the component (A) to be used, the type of the component (B) to be used, the degree of the convergence effect to be enhanced For example, 0.01 to 2% by weight, preferably 0.04 to 2% by weight, more preferably 0.04 to 1% by weight, and still more preferably 0.04 to 0.6% by weight. . From the viewpoint of effectively enhancing the astringent action of the component (A) while imparting a good taste, the content of each type of the component (B) includes the following ranges.
When the component (B) is a peony extract: preferably 0.04 to 0.3% by weight.
When component (B) is a touki extract: preferably 0.04 to 0.2% by weight.
When the component (B) is mukuroji extract: preferably 0.05 to 0.2% by weight.

  In this specification, for the content of peony extract, 10 ml of a sample is accurately weighed in an evaporating dish, evaporated to dryness on a water bath, and the residue is further dried at 105 ° C. for 6 hours, and then allowed to cool in a desiccator or the like. The value is based on the case of a liquid substance whose mass becomes 0.32 g (evaporation residue), and the content of the peony extract is based on the degree of concentration of the peony extract used. Thus, the amount of the component contained may be appropriately set so as to satisfy the content in the case of the above standard.

  In addition, in this specification, as for the content of the touki extract, 10 ml of a sample is accurately weighed on an evaporating dish, evaporated to dryness on a water bath, the residue is further dried at 105 ° C. for 6 hours, and then cooled in a desiccator or the like. The value is based on the case of a liquid substance having a mass of 0.35 g (evaporation residue) when it is applied, and the content of the toki extract is based on the degree of concentration of the toki extract used. Thus, the amount of the component contained may be appropriately set so as to be the same as in the case of the standard.

  In addition, in this specification, the content of mukuroji extract is about 1.0 g of a sample, and when dried at 105 ° C. for 4 hours, the weight loss is 2% by weight (loss on drying). It is a value on the basis of the case, and the content of the mugwort extract is substantially the same as the case of the above based on the degree of concentration of the mugwort extract to be used, etc. What is necessary is just to set suitably.

  In the astringent composition of the present invention, the ratio of the content of the component (B) to the content of the component (A) is appropriately set according to the type of the component (A) and the component (B) used. However, from the viewpoint of effectively enhancing the astringent action of the astringent, the amount of the component (B) is 0.01 to 140 parts by weight with respect to 1 part by weight of the component (A).

In particular, from the viewpoint of more effectively enhancing the astringent action of the astringent while giving a good taste, the content of the (A) component and the (B) component according to the type of the (A) component The following ranges are suitable for the ratio.
When the component (A) is an allantoin derivative : The component (B) is preferably 2-140 parts by weight, more preferably 2.5-140 parts by weight, still more preferably with respect to 1 part by weight of the total amount of the component (A). 2.5 to 70 parts by weight, particularly preferably 2.5 to 10 parts by weight.
When the component (A) is a velvet extract : The component (B) is preferably 2-140 parts by weight, more preferably 2-30 parts by weight, and still more preferably 2 parts per 1 part by weight of the total amount of the component (A). .5 to 20 parts by weight.
When the component (A) is a birch extract : The component (B) is preferably 0.01 to 100 parts by weight, more preferably 0.1 to 70 parts by weight with respect to 1 part by weight of the total amount of the component (A).

Formulation Form The form of the astringent composition of the present invention is not particularly limited, and may be any of liquid, solid, semi-solid (gel, ointment, paste) and the like.

  The astringent composition of the present invention is used as an oral composition, an external composition for skin, and the like, and is used for the purpose of converging the tissue by applying it to tissues such as oral mucosa and skin. In particular, the astringent composition of the present invention can enhance the astringent action without increasing the blending amount of the astringent, and can avoid a decrease in taste caused by an increase in the blending amount of the astringent. In view of such an effect of the present invention, the astringent composition of the present invention can be suitably used as an oral composition that is a preparation form in which taste is important.

  When the astringent composition of the present invention is used as an oral composition, the astringent composition of the present invention can be applied to the art according to the formulation form of the oral composition as long as the effects of the present invention are not impaired. You may contain the additive component normally used in the field | area. Examples of such additive components include abrasives, antiseptics, bactericides, antibacterial agents, anti-inflammatory agents, glucosyltransferase (GTase) inhibitors, plaque inhibitors, hypersensitivity inhibitors, tartar preventive agents, adhesives, viscosity agents. Examples include thickeners, excipients, lubricants, fragrances, sweeteners, cooling agents, pigments, deodorants, surfactants, pH adjusters, bases, solvents, stabilizers, and the like.

  When the astringent composition of the present invention is used as an oral composition, the oral composition is edible and non-edible as long as it is applied to the oral cavity and can stay in the oral cavity for a certain period of time. It does n’t matter. The oral composition is, for example, in any form such as an oral hygiene agent, food (including functional food, health health food, sick food, etc.), pharmaceutical (including quasi-drug), and cosmetics. There may be. Specific preparation forms for oral compositions include liquid dentifrices, toothpastes, moisturized dentifrices, powder dentifrices, mouthwashes (mouth wash), mouth rinses, mouthwashes, mouth fresheners (mouse) Oral hygiene agents such as spray, etc., oral paste, gum massage cream, oropharyngeal medicine (troche, etc.); edible films, chewing gum, candy, gummy candy, tablets, granules, fine granules, powders, capsules, etc. Examples include edible oral preparations. Among these, the oral hygiene agent is easy to impart an astringent action to the oral mucosa, and is a suitable preparation form.

  In addition, when the astringent composition of the present invention is used as a skin external composition, the astringent composition of the present invention is within a range that does not impair the effects of the present invention, depending on the formulation form of the skin external composition, You may contain the additive component normally used in the said technical field. Examples of such additive components include inorganic pigments, ultraviolet absorbers, whitening agents, surfactants, cell activators, anti-inflammatory agents, antibacterial agents, moisturizers, cooling agents, fragrances, colorants, deodorants, Surfactants, adhesives, thickeners, pH adjusters, bases, solvents, stabilizers and the like can be mentioned.

  When the astringent composition of the present invention is used as a skin external composition, the skin external composition is in any form such as cosmetics, pharmaceuticals, skin cleansing agents, etc. as long as it is applied to the skin. Also good. Specific preparation forms of the external composition for skin include, for example, cosmetics such as ointments, creams, emulsions, lotions, lotions, packs, gels; liquids, patches, aerosols, ointments, creams, gels, etc. Skin external preparations such as body shampoos, hair shampoos, rinses, and the like.

Manufacturing method The astringent composition of the present invention is prepared by blending the above-described component (A), component (B), and additive components blended as necessary, and preparing it in a predetermined shape according to the formulation form. Manufactured by. The astringent composition of the present invention can contain an edible carrier, a pharmaceutically acceptable carrier, or the like depending on the formulation form.

2. As described above astringent effect enhancer, peony extract, Japanese angelica root extract, and at least one selected from the group consisting of Sapindus extract has the effect of enhancing the convergence action of astringent which is the component (A). Therefore, the present invention further includes at least one selected from the group consisting of an allantoin derivative, jellyfish extract, and birch extract, which contains at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract. Provided is an astringent action enhancer for a kind of astringent.

  The astringent enhancing agent of the present invention is used for the purpose of enhancing the astringent action of the astringent by adding it to an oral composition or an external composition containing the astringent as the component (A). In the astringent action enhancer of the present invention, the type and amount of peony extract, toki extract and / or mugwort extract used as active ingredients, the type and amount of astringent targeted for enhancing the astringent action, applicable The composition for the oral cavity, the composition for external skin and the like are as described in the section of “1. Composition for convergence”.

  EXAMPLES The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples. In the following test examples and production examples, the birch extract is a product name “birch extract” (manufactured by Maruzen Pharmaceutical Co., Ltd.) (10 ml of a sample is accurately weighed in an evaporating dish, evaporated to dryness in a water bath, and further remained. When the product is dried at 105 ° C. for 3 hours and allowed to cool in a desiccator or the like, the mass becomes 0.08 g (evaporation residue), and the jellyfish extract is (manufactured by Nippon Shinyaku Co., Ltd.) (sample approximately 1 0.0 g was weighed and dried at 105 ° C. for 3 hours, and the weight loss was 3% by weight (loss on drying). Peony extract was named “peony extract BG / JC” (Maruzen Pharmaceutical Co., Ltd.) (Manufactured by the company) (10 ml of sample was accurately weighed in an evaporating dish, evaporated to dryness on a water bath, the residue was further dried at 105 ° C. for 6 hours, and when cooled in a desiccator or the like, its mass was 0.32 g (evaporated). Residue) ), Toki extract is a product name “Touki extract BG-J” (manufactured by Maruzen Pharmaceutical Co., Ltd.) (10 ml of sample is accurately measured in an evaporating dish, evaporated to dryness on a water bath, and the residue is further heated to 105 ° C. The product is dried for 6 hours and cooled in a desiccator, etc., and its mass becomes 0.35 g (evaporation residue). Mukuroji extract is the product name “Mukuroji extract powder” (manufactured by Maruzen Pharmaceutical Co., Ltd.) ( About 1.0 g of a sample was accurately weighed and a solid matter whose weight loss was 2 wt% (loss on drying) when dried at 105 ° C. for 4 hours was used.

Test example 1
In order to prepare test solutions having the compositions shown in Tables 1 to 5 and to evaluate the convergence effect, the following albumin aggregability test was performed.

<Albumin aggregation test>
First, an albumin-containing aqueous solution (albumin content 0.3% by weight, citric acid 1.5% by weight, pH 4.0) was prepared. Each test solution and an aqueous solution containing albumin were mixed at a volume ratio of 1: 2, and incubated at 37 ° C. for 30 minutes. Next, the turbidity at 650 nm was measured for the mixed solution after incubation. In this test, it is determined that the higher the turbidity value, the stronger the protein denaturation effect and the greater the convergence effect. Using the turbidity measured above, the enhancement rate (%) of the astringent action was calculated according to the following formula.
Convergence enhancement rate (%) = [{(turbidity when using each test solution) − (turbidity when using corresponding control test solution)} / (using corresponding control test solution) Turbidity in case of)] × 100

  The obtained results are shown in Tables 1-5. As is clear from Reference Examples 1 to 3, peony extract, toki extract, and mugwort extract alone did not show astringent action. On the other hand, when an astringent (allantoinchlorohydroxyaluminum, birch extract, or jellyfish extract) was combined with a peony extract, toki extract or mukuroji extract, an astringent action enhancing effect was observed. In particular, when allantoin chlorohydroxyaluminum is used as an astringent, the effect of enhancing the astringent action has become prominent when combined with peony extract, toki extract or mukuroji extract. On the other hand, glycyrrhetinic acid, l-menthol, cinnaaldehyde, and clove oil did not enhance the astringent action of the astringent, but rather attenuated the astringent action. From the above results, the astringent enhancing effect of the astringent is a unique effect recognized by selecting a specific component (peony extract, toki extract, and / or mukuroji extract) and coexisting with the astringent. Became clear.

Test example 2
Test solutions having the compositions shown in Table 6 were prepared and evaluated for use feeling when applied to the oral cavity. Specifically, taste was scored by 3 panelists according to the following criteria, with 10 ml of each test solution included in the mouth.
(Judgment criteria for taste)
Score 5: Taste suitable as an intraoral composition and good feeling in use.
4: It is a taste suitable as an intraoral composition, and a feeling of use is a little good.
3: It is a normal taste as an intraoral composition, and a feeling of use is also normal.
2: It is a taste which is not very suitable as an intraoral composition, and a feeling of use is a little bad.
1: It is a taste which is not suitable as an intraoral composition, and a usability | use_condition is bad.
Next, the scores determined by each panel were summed, and the feeling of use was evaluated according to the following classification criteria.
(Classification criteria for feeling of use)
++++: Total score is 12 points or more +++: Total score is 9 points or more and 11 points or less ++: Total score is 6 points or more and 8 points or less +: Total score is 5 points or less

  The results obtained are shown in Table 6. From these results, it was confirmed that when the peony extract, toki extract or mukuroji extract was used in combination with the astringent, the taste when applied in the oral cavity was good. In addition, in any of the test solutions shown in Table 6, the case of containing both the (A) component and the (B) component as compared with the case where each of the (A) component or the (B) component is contained alone. However, the convergence effect was increasing. That is, from this test result, the astringent composition using the astringent and the peony extract, toki extract, or mukuroji extract in combination has an increased astringent effect even when used as a composition for oral cavity, and is a point of taste. However, it was clear that it was good and excellent usability was obtained.

Production Example 1
Toothpastes having the compositions shown in Tables 7 to 10 were produced. In any of the toothpastes, a synergistic enhancing effect on the astringent action of the astringent was observed and the taste was good as compared with the case where the component (B) was not contained.

Production Example 2
Liquid dentifrices having the compositions shown in Table 11 were produced. The liquid dentifrice also showed a synergistic enhancing effect on the astringent action of the astringent compared with the case where the component (B) was not contained, and the taste was also good.

Production Example 3
Oral and throat drugs (troche: drop) having the composition shown in Table 12 were produced. Also in the oropharyngeal drug, a synergistic enhancing effect on the astringent action of the astringent was observed and the taste was good as compared with the case where the component (B) was not contained.

Claims (7)

  (A) at least one astringent selected from the group consisting of an allantoin derivative, jellyfish extract, and birch extract; and (B) at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract. A composition for converging, comprising:   The astringent composition according to claim 1, wherein the component (A) is at least one selected from the group consisting of an allantoin derivative and a jellyfish extract.   The astringent composition according to claim 1 or 2, wherein the component (B) is contained in an amount of 0.01 to 140 parts by weight per 1 part by weight of the total amount of the component (A).   The astringent composition according to claim 2, wherein the total amount of the component (B) is 2 to 140 parts by weight per 1 part by weight of the total amount of the component (A).   The astringent composition according to any one of claims 1 to 4, which is an oral composition.   Astringent action on at least one astringent selected from the group consisting of allantoin derivatives, radish extract, and birch extract, comprising at least one selected from the group consisting of peony extract, toki extract and mukuroji extract as an active ingredient Enhancer.   An astringent composition containing at least one astringent selected from the group consisting of an allantoin derivative, a velvet extract, and a birch extract, and at least one selected from the group consisting of peony extract, toki extract, and mukuroji extract A method for enhancing the convergence effect, comprising the step of blending.