JP2015063497A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition in which the unique odor and taste of placenta extract are masked.SOLUTION: An oral composition comprising placenta extract has alanine and phytic acid blended therewith. The oral composition is particularly useful for beverages and jelly compositions.

Description

  The present invention relates to an oral composition in which the unique odor and taste of placenta extract are masked. Specifically, the present invention relates to an oral composition containing placenta extract, alanine, and phytic acid.

  Placenta extract is actively used in the fields of beauty, health or medicine. For example, an oral composition characterized by containing a placenta extract, a collagen-derived component and a stress relieving agent (Patent Document 1), an intestinal environment improving composition characterized by a combination of oligosaccharide and placenta extract (Patent Document) 2) A health comprising a nerve cell activator containing a placenta extract (Patent Document 3), a collagen hydrolyzate, a porcine placenta extract, a low molecular weight polyphenol derived from lychee, and ascorbic acids as cosmetic ingredients. Food (patent document 4) etc. are known.

  However, placenta extract has a unique unpleasant taste and smell when taken orally because it originates from organisms, and masking has been a problem.

JP 2007-70316 A JP 2011-157335 A JP 2012-136448 A JP 2013-34423 A

  This invention makes it a subject to provide the composition for oral use which masked the peculiar smell and taste which a placenta extract has.

  Alanine and phytic acid are added to the oral composition containing placenta extract.

  By blending alanine and phytic acid into an oral composition containing placenta extract, the effect of masking the unique odor and taste of placenta extract is exhibited.

  Hereinafter, modes for carrying out the present invention will be described.

  The oral composition of the present invention contains a placenta extract. The origin of the placenta from which the placenta extract is obtained is not particularly limited, and examples thereof include humans, cows, horses, pigs, sheep, goats, salmon, herring, sturgeon, roses, and melons. Among these sources, it is preferable to use those derived from pigs from the viewpoint of commercial use. Moreover, there is a product already marketed as a placenta extract, and it may be used.

An example of a method for producing placenta extract is a method of treating pig placenta with a protease. Examples of the protease include papain, trypsin, pepsin, promeline, thermolysin and the like. Of these, papain is preferably used from the viewpoint of protease treatment efficiency. The protease treatment proceeds by reacting at about 3 to 75 ° C. for about 0.5 to 3 hours. The components obtained by the protease treatment are centrifuged, ultrafiltered, diatomaceous earth filtered, ion exchange resin, reverse osmosis filtered. The placenta extract can be obtained by purification by activated carbon treatment or the like.
The above placenta extract can be pulverized by conventional means such as spray drying and freeze drying. In the present specification, the placenta extract (powder) means a powdery placenta having a water content of about 10% or less.

  The content of the placenta extract is 0.01 to 5 g, more preferably 0.1 to 3 g as the daily intake. Ingestion of less than 0.01 g may not exhibit the effect of placenta extract. Moreover, even if it ingests exceeding 5g, the effect may not be recognized but it is inefficient.

  Any of D-form, L-form, and DL-form may be used for the alanine blended in the oral composition of the present invention. The intake of alanine is not particularly limited as long as it is an amount that masks the taste and smell of the raw material of placenta extract, but is preferably 0.1 to 10 g per 1 g of placenta extract.

  The oral composition of the present invention contains phytic acid. Although the compounding quantity of a phytic acid is not specifically limited, 0.01-10g is preferable per 1g of placenta extract.

The oral composition of the present invention may be in any form such as powder, granule, tablet, capsule, jelly, and liquid. Among such dosage forms, the effect of the present invention can be most exhibited in a liquid dosage form in which the smell and taste of the placenta extract are particularly worrisome.
When a liquid dosage form is employed, the pH is preferably adjusted to 5 or less, and more preferably to 3 to 4.

  It can be adjusted with phytic acid. Moreover, it can also adjust using pH adjusters other than a phytic acid. As such a pH adjuster, organic and inorganic edible acids can be used. The acids may be used in their undissociated form or in the form of their respective salts, such as potassium or sodium hydrogen phosphate, potassium dihydrogen phosphate or sodium salt. Preferred acids are edible organic acids including citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid or mixtures thereof. Bicarbonates can also be used.

  In order to produce the oral composition according to the present invention as a beverage whose pH is adjusted in this way, the beverage is preferably produced in a container form. There are no particular restrictions on the type of container, but any container such as a molded container (so-called PET bottle) mainly composed of polyethylene terephthalate, a metal can, a paper container combined with a metal foil or plastic film, or a bottle should be used. Can do.

  Furthermore, in order to improve palatability, you may select and mix | blend a sweetener suitably. For example, carbohydrates such as sucrose, glucose, and maltose, high-intensity sweeteners such as stevia, aspartame, thaumatin, and acesulfame K, sugar alcohols such as sorbitol, erythritol, and xylitol, and glycerols such as glycerin can be used. .

  In the preparation of the oral composition of the present invention, special additives such as surfactants are not essential, but other known additives, excipients, etc. may be added to an appropriate dosage form as necessary. And may be processed. For example, in the case of a liquid agent, an antioxidant, a colorant, a flavoring agent, a surfactant, a plasticizer, a pH adjuster, etc. can be mixed to obtain an oral product such as a dry syrup agent or a liquid agent. If it is a solid agent, an excipient, a disintegrant, a binder, a lubricant, an antioxidant, a coating agent, a coloring agent, a corrigent, a surfactant, a plasticizer, etc. are mixed in a conventional manner. Granules, powders, capsules, tablets and the like can be produced.

  Examples of the antioxidant include vitamin C, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHT), α-tocopherol, and citric acid.

  Examples of the colorant include caramel, safflower dye, silicon dye, turmeric dye, and tar dye.

  Examples of the surfactant include polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer, polysorbate, sodium lauryl sulfate, macrogol, and sucrose fatty acid ester. It is done.

  In addition to placenta extract, alanine, and phytic acid, various physiologically active ingredients can be blended as necessary. Such physiologically active ingredients include proteins and hydrolysates thereof, peptides, amino acids, vitamins, polysaccharides, oligosaccharides, herbal extracts and the like.

  Moreover, in order to give palatability to the oral composition of this invention, you may add various fragrance | flavors.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the scope of the present invention is not limited thereby.

  First, the preparation method of the placenta extract used for the Example is shown.

[Placenta extract 1]
The placenta extract obtained by hydrolyzing, filtering and drying the European porcine-derived placenta was used as placenta extract 1.

[Placenta extract 2]
Placenta extract obtained by hydrolyzing, filtering and drying Japanese SPF porcine placenta was used as placenta extract 2.

  With the formulation shown in Table 1, beverages were prepared by a conventional method, and the taste was evaluated. Taste evaluation was performed by 3 taste sensory sensory evaluation panels, and the taste was evaluated from the beginning to the end of drinking by consultation.

  In Example 1, the taste of the placenta extract was masked, and it was evaluated that it was delicious from the beginning to the aftertaste. On the other hand, Comparative Example 1 in which phytic acid was replaced with citric acid and sodium citrate was evaluated that it was too sour and difficult to drink. Moreover, the comparative example 2 which does not mix | blend alanine was evaluation that the masking of a placenta extract was not enough and the raw odor was strong.

  Examples of other beverages are shown.

[Example 11]
(1) Placenta extract 1 800mg
(2) Liquid sugar 3000mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.8
(4) Alanine 300mg
(Manufacturing method)
After dissolving the above components in purified water, the pH was adjusted to 3.8, and purified water was added to make up a total volume of 100 mL. A glass bottle was filled and a cap was applied to obtain an internal solution.

[Example 12]
(1) Placenta extract 1 1000mg
(2) Erythritol 1500mg
(3) Indigestible dextrin 100mg
(4) Fructose liquid sugar 600mg
(5) Alanine 300mg
(6) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.5
(Manufacturing method)
After the above components were dissolved in purified water, the pH was adjusted to 3.5, and purified water was further added to make up a total volume of 100 mL. A glass bottle was filled and a cap was applied to obtain an internal solution.

[Example 13]
(1) Placenta extract 2 1200mg
(2) Hydrolyzed collagen 1000mg
(3) Liquid sugar 3000mg
(4) Alanine 700mg
(5) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.7
(Manufacturing method)
After dissolving the above components in purified water, the pH was adjusted to 3.7, and further purified water was added to make up a total volume of 100 mL.

[Example 14]
(1) Placenta extract 2 300mg
(2) Alanine 400mg
(3) Phytic acid (50% aqueous solution) 100 mg
(4) Carnitine chloride 20mg
(5) Arginine hydrochloride 200mg
(6) Magnesium aspartate 250mg
(7) Calcium gluconate 300mg
(8) Benthiamine 10mg
(9) Riboflavin sodium phosphate 10mg
(10) Pyridoxine hydrochloride 10mg
(11) Ascorbic acid 1000mg
(12) Xylitol 4000mg
(13) Trehalose 5000mg
(14) Erythritol 5000mg
(15) Citric acid 800mg
(16) Sodium citrate pH 3.5
(17) Citrus flavor 100mg
(Manufacturing method)
After the above components were dissolved in purified water, the pH was adjusted to 3.5, and purified water was further added to make up a total volume of 100 mL.

[Example 15]
(1) Placenta extract 2 300mg
(2) Alanine 400mg
(3) Phytic acid (50% aqueous solution) 100 mg
(4) L-carnitine 20mg
(5) L-arginine 200mg
(6) Sodium aspartate 250mg
(7) Calcium gluconate 300mg
(8) Thiamine nitrate 10mg
(9) Riboflavin sodium phosphate 10mg
(10) Pyridoxine hydrochloride 10mg
(11) Ascorbic acid 1000mg
(12) Xylitol 4000mg
(13) Trehalose 5000mg
(14) Erythritol 5000mg
(15) Citric acid 800mg
(16) Sodium citrate pH 3.5
(17) Mango flavor 100mg
(Manufacturing method)
After the above components were dissolved in purified water, the pH was adjusted to 3.5, and purified water was further added to make up a total volume of 100 mL.

[Example 16]
(1) Placenta extract 1 5000mg
(2) Alanine 600mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.6
(4) Leucine 200mg
(5) Isoleucine 200mg
(6) Valine 200mg
(7) Histidine hydrochloride 100mg
(8) Arginine hydrochloride 200mg
(10) Magnesium aspartate 300mg
(11) Thiamine nitrate 10mg
(12) Riboflavin 10mg
(13) Pyridoxine hydrochloride 100mg
(14) Ascorbic acid 1000mg
(15) Aminoethylsulfonic acid 1000mg
(16) Sorbitol 4000mg
(17) Trehalose 5000mg
(18) Xylitol 4000mg
(19) Stevia extract 30mg
(20) Acesulfame potassium 3mg
(21) Guava flavor 100mg
(Manufacturing method)
After dissolving the above components in purified water, the pH was adjusted to 3.6, and further purified water was added to make up a total volume of 100 mL.

[Example 17]
(1) Placenta extract 1 5000mg
(2) Alanine 600mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.6
(4) Leucine 200mg
(5) Isoleucine 200mg
(6) Valine 200mg
(7) Histidine hydrochloride 100mg
(8) L-arginine 200mg
(10) Sodium aspartate 300mg
(11) Thiamine nitrate 10mg
(12) Riboflavin sodium phosphate 10mg
(13) Pyridoxine hydrochloride 100mg
(14) Ascorbic acid 1000mg
(15) Sorbitol 4000mg
(16) Trehalose 5000mg
(17) Xylitol 4000mg
(18) Stevia extract 30mg
(19) Acesulfame potassium 3mg
(20) Guava flavor 100mg
(Manufacturing method)
After dissolving the above components in purified water, the pH was adjusted to 3.6, and further purified water was added to make up a total volume of 100 mL.

[Example 18]
(1) Placenta extract 1 50mg
(2) Alanine 100mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.7
(4) Hyaluronic acid 10mg
(5) γ-aminobutyric acid 200 mg
(6) Indigestible dextrin 200mg
(7) Hydrolyzed elastin 500mg
(8) Riboflavin nitrate 10mg
(9) Pyridoxine hydrochloride 10mg
(10) Cyanocobalamin 60μg
(11) Panthenol 10mg
(12) Nicotinamide 50mg
(13) Aminoethylsulfonic acid 3000mg
(14) Sorbitol 5000mg
(15) Xylitol 4000mg
(16) Maltitol 2000mg
(17) Malic acid 100mg
(18) Guava flavor 50mg
(19) Peach flavor 50mg
(Manufacturing method)
After dissolving the above components in purified water, the pH was adjusted to 3.7, and further purified water was added to make up a total volume of 100 mL.

[Example 19]
(1) Placenta extract 1 50mg
(2) Alanine 100mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.7
(4) Hyaluronic acid 10mg
(5) γ-aminobutyric acid 200 mg
(6) Indigestible dextrin 200mg
(7) Hydrolyzed elastin 500mg
(8) Riboflavin sodium phosphate 10mg
(9) Pyridoxine hydrochloride 10mg
(10) Cyanocobalamin 60μg
(11) Calcium pantothenate 10mg
(12) Nicotinamide 50mg
(13) Sorbitol 5000mg
(14) Xylitol 4000mg
(15) Maltitol 2000mg
(16) Malic acid 100mg
(17) Guava flavor 50mg
(18) Peach flavor 50mg
(Manufacturing method)
After dissolving the above components in purified water, the pH was adjusted to 3.7, and purified water was further added to make up a total volume of 100 mL.

[Example 20]
(1) Placenta extract 2 500mg
(2) Alanine 400mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.5
(4) Chondroitin sulfate 50mg
(5) Astaxanthin 50mg
(6) Thiamine nitrate 10mg
(7) Sodium riboflavin phosphate 10mg
(8) Pyridoxine hydrochloride 10mg
(9) Nicotinamide 100mg
(10) Anhydrous caffeine 100mg
(11) Aminoethylsulfonic acid 2000mg
(12) 5000mg of glucose
(13) Indigestible dextrin 4000mg
(14) Erythritol 5000mg
(15) Xylitol 2000mg
(16) Stevia extract 20mg
(17) Acesulfame potassium 30mg
(18) Sucralose 5mg
(19) Mixed fruit flavor 100mg
(Manufacturing method)
After the above components were dissolved in purified water, the pH was adjusted to 3.5, and purified water was further added to make up a total volume of 100 mL.

[Example 21]
(1) Placenta extract 2 500mg
(2) Alanine 400mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.5
(4) Chondroitin sulfate 50mg
(5) Astaxanthin 50mg
(6) Thiamine nitrate 10mg
(7) Sodium riboflavin phosphate 10mg
(8) Pyridoxine hydrochloride 10mg
(9) Nicotinamide 100mg
(10) Anhydrous caffeine 100mg
(11) Aminoethylsulfonic acid 2000mg
(12) 5000mg of glucose
(13) Indigestible dextrin 4000mg
(14) Erythritol 5000mg
(15) Xylitol 2000mg
(16) Stevia extract 20mg
(17) Acesulfame potassium 30mg
(18) Sucralose 5mg
(19) Mixed fruit flavor 100mg
(Manufacturing method)
After the above components were dissolved in purified water, the pH was adjusted to 3.5, and purified water was further added to make up a total volume of 100 mL.

[Example 22] Jelly beverage
(1) Placenta extract 2 1400mg
(2) Alanine 800mg
(3) Phytic acid (50% aqueous solution) Amount to adjust pH to 3.4
(4) Collagen hydrolyzate 1000mg
(5) Elastin hydrolyzate 1000mg
(6) Hyaluronic acid 500mg
(7) Indigestible dextrin 1000mg
(8) γ-aminobutyric acid 100mg
(9) Astaxanthin 50mg
(10) Liquid sugar 3000mg
(11) Xanthan gum 3000mg
(12) Powdered agar 3000mg
(13) Carrageenan 500mg
(14) Gellan gum 500mg
(15) Flavor 100mg
(Manufacturing method)
After the above components were dissolved in purified water, the pH was adjusted to 3.5, and purified water was added to make the total amount 100 g.

  When it tasted regarding Examples 11-22, there was no product which was worried about the raw material smell of a placenta extract, and it was evaluation that all were delicious.

Claims (1)

An oral composition containing placenta extract, alanine and phytic acid.