JP2014534956A5 - - Google Patents
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- JP2014534956A5 JP2014534956A5 JP2014533950A JP2014533950A JP2014534956A5 JP 2014534956 A5 JP2014534956 A5 JP 2014534956A5 JP 2014533950 A JP2014533950 A JP 2014533950A JP 2014533950 A JP2014533950 A JP 2014533950A JP 2014534956 A5 JP2014534956 A5 JP 2014534956A5
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- 239000000203 mixture Substances 0.000 claims description 104
- 238000000034 method Methods 0.000 claims description 103
- 239000003112 inhibitor Substances 0.000 claims description 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 13
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 12
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 9
- 102000015685 human GM-CSF receptor-alpha subunit Human genes 0.000 claims description 9
- 108010038879 human GM-CSF receptor-alpha subunit Proteins 0.000 claims description 9
- 229960000485 methotrexate Drugs 0.000 claims description 9
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 8
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 8
- 238000007920 subcutaneous administration Methods 0.000 claims description 7
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
- 239000003435 antirheumatic agent Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 238000006467 substitution reaction Methods 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 238000012360 testing method Methods 0.000 claims description 2
- 108010074051 C-Reactive Protein Proteins 0.000 claims 1
- 102100032752 C-reactive protein Human genes 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 26
- 238000003556 assay Methods 0.000 description 8
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 8
- 239000002988 disease modifying antirheumatic drug Substances 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 210000004602 germ cell Anatomy 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 241001385733 Aesculus indica Species 0.000 description 1
- 102220627452 Paired immunoglobulin-like type 2 receptor alpha_L95A_mutation Human genes 0.000 description 1
- KLAONOISLHWJEE-QWRGUYRKSA-N Phe-Gln Chemical group NC(=O)CC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=CC=C1 KLAONOISLHWJEE-QWRGUYRKSA-N 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545359P | 2011-10-10 | 2011-10-10 | |
| US61/545,359 | 2011-10-10 | ||
| US201161556974P | 2011-11-08 | 2011-11-08 | |
| US61/556,974 | 2011-11-08 | ||
| PCT/EP2012/070074 WO2013053767A1 (en) | 2011-10-10 | 2012-10-10 | Treatment for rheumatoid arthritis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534956A JP2014534956A (ja) | 2014-12-25 |
| JP2014534956A5 true JP2014534956A5 (https=) | 2015-11-26 |
| JP6239517B2 JP6239517B2 (ja) | 2017-11-29 |
Family
ID=47010599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014533950A Active JP6239517B2 (ja) | 2011-10-10 | 2012-10-10 | 関節リウマチの治療法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20140335081A1 (https=) |
| EP (1) | EP2766394B1 (https=) |
| JP (1) | JP6239517B2 (https=) |
| CN (1) | CN103906767A (https=) |
| AU (2) | AU2012322991B2 (https=) |
| CA (1) | CA2851322C (https=) |
| ES (1) | ES2660776T3 (https=) |
| RU (1) | RU2014117510A (https=) |
| WO (1) | WO2013053767A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10745475B2 (en) * | 2013-08-30 | 2020-08-18 | Takeda Gmbh | Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics |
| CN106456761A (zh) * | 2014-05-19 | 2017-02-22 | 免疫医疗有限公司 | 对类风湿关节炎的治疗 |
| AU2017270027B2 (en) | 2016-05-24 | 2024-07-11 | Medimmune Limited | Anti-PAD4 autoantibodies as clinical response biomarkers for the treatment of rheumatoid arthritis |
| WO2018144334A1 (en) * | 2017-02-02 | 2018-08-09 | Imclone Llc | Dosing regimen for anti-csf-1r antibody |
| US11078264B2 (en) | 2018-10-17 | 2021-08-03 | University Of Connecticut | Inhibiting granulocyte macrophage-colony stimulating factor (GM-CSF) prevents preterm birth |
| AU2019377515A1 (en) | 2018-11-09 | 2021-05-27 | Kiniksa Pharmaceuticals, Gmbh | Treatment for giant cell arteritis |
| WO2020096664A1 (en) | 2018-11-09 | 2020-05-14 | Kiniksa Pharmaceuticals, Ltd. | Treatment for giant cell arteritis |
| WO2020239090A1 (zh) * | 2019-05-31 | 2020-12-03 | 广州市雷德生物科技有限公司 | 一种类风湿关节炎相关的特异性多肽及其应用 |
| US20220331425A1 (en) | 2019-06-03 | 2022-10-20 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cancers with gm-csf antagonists |
| US20210284744A1 (en) | 2020-03-15 | 2021-09-16 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cytokine release syndrome with gm-csf antagonists |
| WO2022093855A1 (en) | 2020-10-26 | 2022-05-05 | Kiniksa Pharmaceuticals, Ltd. | Treatment of cancers with gm-csf antagonists |
| WO2025218746A1 (en) * | 2024-04-17 | 2025-10-23 | Sinomab Bioscience Limited | Methods of treating rheumatoid arthritis |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US565332A (en) | 1896-08-04 | Toy for making soap-bubbles | ||
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| DK1137941T4 (da) | 1998-12-10 | 2014-01-06 | Brystol Myers Squibb Company | Protein-scaffolds til antistof-mimetika og andre bindingsproteiner |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| MXPA04005080A (es) * | 2004-05-27 | 2005-11-30 | Aspid S A De C V | Una composicion moduladora de la inflamacion articular cronica a base de colagena-polivinilpirrolidona. |
| MX2008012291A (es) * | 2006-03-27 | 2009-01-12 | Medimmune Ltd | Miembro que enlaza al receptor gm-csf. |
| SI2049123T1 (sl) * | 2006-08-03 | 2013-04-30 | Horizon Pharma Ag | Zdravljenje revmatoznih bolezni z zadržanim sproščanjem glukokortikoida |
| US7915222B2 (en) * | 2008-05-05 | 2011-03-29 | Bristol-Myers Squibb Company | Method of preventing the development of rheumatoid arthritis in subjects with undifferentiated arthritis |
| JP2013518590A (ja) * | 2010-02-02 | 2013-05-23 | アボツト・バイオテクノロジー・リミテツド | ＴＮＦ−α阻害剤を用いる処置に対する応答性を予測するための方法および組成物 |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2012
- 2012-10-10 CA CA2851322A patent/CA2851322C/en active Active
- 2012-10-10 EP EP12770487.2A patent/EP2766394B1/en active Active
- 2012-10-10 JP JP2014533950A patent/JP6239517B2/ja active Active
- 2012-10-10 RU RU2014117510/15A patent/RU2014117510A/ru unknown
- 2012-10-10 AU AU2012322991A patent/AU2012322991B2/en not_active Ceased
- 2012-10-10 ES ES12770487.2T patent/ES2660776T3/es active Active
- 2012-10-10 WO PCT/EP2012/070074 patent/WO2013053767A1/en not_active Ceased
- 2012-10-10 CN CN201280048532.1A patent/CN103906767A/zh active Pending
- 2012-10-10 US US14/349,706 patent/US20140335081A1/en not_active Abandoned
-
2018
- 2018-01-24 AU AU2018200560A patent/AU2018200560A1/en not_active Abandoned
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