JP2014532766A - 癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤 - Google Patents

癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤 Download PDF

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JP2014532766A
JP2014532766A JP2014541256A JP2014541256A JP2014532766A JP 2014532766 A JP2014532766 A JP 2014532766A JP 2014541256 A JP2014541256 A JP 2014541256A JP 2014541256 A JP2014541256 A JP 2014541256A JP 2014532766 A JP2014532766 A JP 2014532766A
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compound
formula
bone
maleate
acid
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Japanese (ja)
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デーナ ティー． アフタブ，
デーナ ティー． アフタブ，
フラウケ シュモラー，
フラウケ シュモラー，
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エクセリクシス， インク．
エクセリクシス， インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
JP2014541256A 2011-11-08 2012-11-08 癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤 Pending JP2014532766A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161557358P 2011-11-08 2011-11-08
US61/557,358 2011-11-08
PCT/US2012/064116 WO2013070890A1 (en) 2011-11-08 2012-11-08 Dual inhibitor of met and vegf for treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017193945A Division JP2018048154A (ja) 2011-11-08 2017-10-04 癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤

Publications (1)

Publication Number Publication Date
JP2014532766A true JP2014532766A (ja) 2014-12-08

Family

ID=47179011

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014541256A Pending JP2014532766A (ja) 2011-11-08 2012-11-08 癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤
JP2017193945A Pending JP2018048154A (ja) 2011-11-08 2017-10-04 癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤

Family Applications After (1)

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JP2017193945A Pending JP2018048154A (ja) 2011-11-08 2017-10-04 癌を治療する、ｍｅｔ及びｖｅｇｆの二重阻害剤

Country Status (15)

Country Link
US (1) US20140323522A1 (OSRAM)
EP (1) EP2776033A1 (OSRAM)
JP (2) JP2014532766A (OSRAM)
KR (1) KR20140088610A (OSRAM)
CN (1) CN104159585A (OSRAM)
AU (2) AU2012335737A1 (OSRAM)
BR (1) BR112014011009A2 (OSRAM)
CA (1) CA2854336A1 (OSRAM)
EA (1) EA201490944A1 (OSRAM)
HK (1) HK1202062A1 (OSRAM)
IL (1) IL232421A0 (OSRAM)
IN (1) IN2014CN04067A (OSRAM)
MX (1) MX2014005458A (OSRAM)
TW (2) TW201818937A (OSRAM)
WO (1) WO2013070890A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015515988A (ja) * 2012-05-02 2015-06-04 エクセリクシス， インク． 溶骨性骨転移を治療するためのｍｅｔ−ｖｅｇｆ二重調節剤
JP2019531354A (ja) * 2016-10-18 2019-10-31 ベイジン コンルンス ファーマシューティカル カンパニー リミテッド キノリル置換カルボン酸化合物又はその薬学的に許容される塩、その薬物組成物及び使用

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UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
US20140057943A1 (en) 2010-09-27 2014-02-27 Exelixix, Inc. Method of Treating Cancer
KR20230158644A (ko) 2011-02-10 2023-11-20 엑셀리시스, 인코포레이티드 퀴놀린 화합물들의 제조 방법들 및 상기 화합물들을 함유하는 약학 조성물들
US20120252840A1 (en) 2011-04-04 2012-10-04 Exelixis, Inc. Method of Treating Cancer
WO2012151326A1 (en) 2011-05-02 2012-11-08 Exelixis, Inc. Method of treating cancer and bone cancer pain
CA2848512A1 (en) 2011-09-22 2013-03-28 Exelixis, Inc. Method for treating osteoporosis
BR112014009302B1 (pt) 2011-10-20 2020-04-28 Exelis Inc Us/Us processo para preparar derivados de quinolina
GEP20196995B (en) 2013-03-15 2019-07-25 Inc Exelixis Metabolites of n-(4-{[6,7-bis (methyloxy)quinolin-4-yl] oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
ES2927651T3 (es) 2013-04-04 2022-11-10 Exelixis Inc Forma de dosificación de cabozantinib y uso en el tratamiento del cáncer
US9149471B2 (en) * 2013-09-30 2015-10-06 National University Corporation Tokyo University Of Agriculture And Technology Therapeutic agent for osteoporosis
EP3738952A1 (en) 2014-02-14 2020-11-18 Exelixis, Inc. Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
JP6666849B2 (ja) 2014-03-17 2020-03-18 エグゼリクシス， インコーポレイテッド カボザンチニブ製剤の投与
CN104788372B (zh) * 2014-07-25 2018-01-30 上海圣考医药科技有限公司 一种氘代卡博替尼衍生物、其制备方法、应用及其中间体
EP3174854B1 (en) 2014-07-31 2022-08-24 Exelixis, Inc. Method of preparing fluorine-18 labeled cabozantinib and its analogs
CN106573042A (zh) 2014-08-05 2017-04-19 埃克塞里艾克西斯公司 治疗多发性骨髓瘤的药物组合
CN105503717A (zh) * 2014-09-24 2016-04-20 江苏奥赛康药业股份有限公司 一种苹果酸卡博替尼化合物及其药物组合物
CN109069499A (zh) * 2016-04-15 2018-12-21 埃克塞里艾克西斯公司 使用 n-(4-(6,7-二甲氧基喹啉-4-基氧基)苯基)-n’-(4-氟苯基)环丙烷-1,1-二甲酰胺,(2s)-羟基丁二酸盐治疗肾细胞癌的方法
PT3630726T (pt) 2017-05-26 2022-03-02 Exelixis Inc Formas sólidas cristalinas de sais de n-{4-[(6,7-dimetoxiquinolin- 4-il)oxi]fenil}-n¿-(4-fluorfenil)ciclopropano-1,1- dicarboxamida, processos para a preparação e métodos de utilização
MA51673B1 (fr) 2018-01-26 2025-10-31 Exelixis, Inc. Composés pour le traitement des troubles dépendants de kinases
EP3806858A4 (en) 2018-06-15 2022-03-09 Handa Pharmaceuticals, Inc. KINA INHIBITOR SALTS AND COMPOSITIONS THEREOF
EP4658271A1 (en) 2023-01-31 2025-12-10 Handa Oncology, LLC Improved cabozantinib compositions and methods of use

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JP2013537916A (ja) * 2010-09-27 2013-10-07 エクセリクシス， インク． 去勢抵抗性前立腺癌および造骨性転移の治療のためのｍｅｔおよびｖｅｇｆの二元阻害薬

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WO2005030140A2 (en) 2003-09-26 2005-04-07 Exelixis, Inc. C-met modulators and methods of use
WO2008083319A1 (en) 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Solid state forms of enantiopure ilaprazole
UA108618C2 (uk) * 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
CN103391773A (zh) * 2010-09-27 2013-11-13 埃克塞里艾克西斯公司 用于治疗去势抵抗性前列腺癌和成骨性骨转移的met和vegf的双重抑制剂

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D. C. SMITH ET AL.: "Phase 2 study of XL184 in a cohort of patients (pts) with castration-resistant prostate cancer (CRPC", J CLIN ONCOL, vol. 29(7), JPN6016034807, 1 April 2011 (2011-04-01), pages 7 - 127, ISSN: 0003396621 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015515988A (ja) * 2012-05-02 2015-06-04 エクセリクシス， インク． 溶骨性骨転移を治療するためのｍｅｔ−ｖｅｇｆ二重調節剤
JP2019531354A (ja) * 2016-10-18 2019-10-31 ベイジン コンルンス ファーマシューティカル カンパニー リミテッド キノリル置換カルボン酸化合物又はその薬学的に許容される塩、その薬物組成物及び使用

Also Published As

Publication number Publication date
TW201322981A (zh) 2013-06-16
CN104159585A (zh) 2014-11-19
EP2776033A1 (en) 2014-09-17
EA201490944A1 (ru) 2014-10-30
BR112014011009A2 (pt) 2017-06-06
IL232421A0 (en) 2014-06-30
CA2854336A1 (en) 2013-05-16
US20140323522A1 (en) 2014-10-30
MX2014005458A (es) 2015-04-16
WO2013070890A1 (en) 2013-05-16
TW201818937A (zh) 2018-06-01
JP2018048154A (ja) 2018-03-29
IN2014CN04067A (OSRAM) 2015-10-23
KR20140088610A (ko) 2014-07-10
HK1202062A1 (en) 2015-09-18
AU2012335737A1 (en) 2014-06-05
AU2017225103A1 (en) 2017-09-28
TWI662962B (zh) 2019-06-21

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