JP2014532688A5 - - Google Patents
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- JP2014532688A5 JP2014532688A5 JP2014539368A JP2014539368A JP2014532688A5 JP 2014532688 A5 JP2014532688 A5 JP 2014532688A5 JP 2014539368 A JP2014539368 A JP 2014539368A JP 2014539368 A JP2014539368 A JP 2014539368A JP 2014532688 A5 JP2014532688 A5 JP 2014532688A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- group
- solvate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 2
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 2
- QLSWIGRIBOSFMV-UHFFFAOYSA-N 1h-pyrrol-2-amine Chemical compound NC1=CC=CN1 QLSWIGRIBOSFMV-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- -1 oxadiazol-4-yl Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 0 *c1cc(N*)c(*)c2n[o]nc12 Chemical compound *c1cc(N*)c(*)c2n[o]nc12 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201131754A ES2396764B1 (es) | 2011-11-02 | 2011-11-02 | FÁRMACOS INHIBIDORES DE p38 Y APLICACIONES. |
| ESP201131754 | 2011-11-02 | ||
| PCT/ES2012/070762 WO2013064714A1 (es) | 2011-11-02 | 2012-10-31 | Fármacos inhibidores de p38 y aplicaciones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532688A JP2014532688A (ja) | 2014-12-08 |
| JP2014532688A5 true JP2014532688A5 (https=) | 2015-12-17 |
Family
ID=48191418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539368A Pending JP2014532688A (ja) | 2011-11-02 | 2012-10-31 | ｐ３８を阻害するための薬物およびそれらの用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9096554B2 (https=) |
| EP (1) | EP2774613A4 (https=) |
| JP (1) | JP2014532688A (https=) |
| KR (1) | KR20140085580A (https=) |
| AU (1) | AU2012331016A1 (https=) |
| BR (1) | BR112014010560A2 (https=) |
| CA (1) | CA2854349A1 (https=) |
| ES (1) | ES2396764B1 (https=) |
| WO (1) | WO2013064714A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2396764B1 (es) | 2011-11-02 | 2013-12-19 | Universidad Autónoma de Madrid | FÁRMACOS INHIBIDORES DE p38 Y APLICACIONES. |
| US9757379B2 (en) | 2012-11-14 | 2017-09-12 | The Board Of Regents Of The University Of Texas System | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) |
| WO2015054358A1 (en) * | 2013-10-11 | 2015-04-16 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2355470C (en) | 1999-01-13 | 2008-09-30 | Warner-Lambert Company | Benzoheterocycles and their use as mek inhibitors |
| CA2377092A1 (en) | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
| DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
| US20040110755A1 (en) | 2002-08-13 | 2004-06-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Combination therapy with p38 MAP kinase inhibitors and their pharmaceutical compositions |
| JP2006503025A (ja) | 2002-09-05 | 2006-01-26 | サイオス インク． | ｐ３８ＭＡＰキナーゼの抑制による疼痛治療 |
| US20080039461A1 (en) | 2002-09-05 | 2008-02-14 | Protter Andrew A | Treatment of pain by inhibition of p38 map kinase |
| WO2005032551A1 (en) | 2003-09-30 | 2005-04-14 | Scios Inc. | TREATMENT OF CARDIOVASCULAR DISEASE WITH INHIBITORS OF p38 KINASE |
| WO2006002284A1 (en) | 2004-06-22 | 2006-01-05 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| WO2006127678A2 (en) | 2005-05-23 | 2006-11-30 | Smithkline Beecham Corporation | Inhibition of p38 mark for treatment of obesity |
| WO2008124838A1 (en) | 2007-04-10 | 2008-10-16 | University Of Maryland, Baltimore | Compounds that inhibit human dna ligases and methods of treating cancer |
| GB0713311D0 (en) | 2007-07-10 | 2007-08-22 | Nene Group Plc | Pallet racking shield |
| DE102007060008A1 (de) | 2007-12-13 | 2009-06-18 | Technolas Gmbh Ophthalmologische Systeme | Bestimmung und Überwachumg von Laserenergie |
| WO2010083404A2 (en) | 2009-01-16 | 2010-07-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Linked myc-max small molecule inhibitors |
| US20120122896A1 (en) * | 2009-05-08 | 2012-05-17 | Pike Pharma Gmbh | 2,1,3-benzoxadiazol derivatives for the inhibition of influenza a and b virus and respiratory syncytial virus replication |
| ES2396764B1 (es) | 2011-11-02 | 2013-12-19 | Universidad Autónoma de Madrid | FÁRMACOS INHIBIDORES DE p38 Y APLICACIONES. |
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2011
- 2011-11-02 ES ES201131754A patent/ES2396764B1/es active Active
-
2012
- 2012-10-31 US US14/355,545 patent/US9096554B2/en not_active Expired - Fee Related
- 2012-10-31 WO PCT/ES2012/070762 patent/WO2013064714A1/es not_active Ceased
- 2012-10-31 CA CA2854349A patent/CA2854349A1/en not_active Abandoned
- 2012-10-31 EP EP12846045.8A patent/EP2774613A4/en not_active Withdrawn
- 2012-10-31 AU AU2012331016A patent/AU2012331016A1/en not_active Abandoned
- 2012-10-31 KR KR1020147014457A patent/KR20140085580A/ko not_active Withdrawn
- 2012-10-31 JP JP2014539368A patent/JP2014532688A/ja active Pending
- 2012-10-31 BR BR112014010560A patent/BR112014010560A2/pt not_active IP Right Cessation