JP2014532655A - ナノ懸濁過程 - Google Patents

ナノ懸濁過程 Download PDF

Info

Publication number
JP2014532655A
JP2014532655A JP2014539026A JP2014539026A JP2014532655A JP 2014532655 A JP2014532655 A JP 2014532655A JP 2014539026 A JP2014539026 A JP 2014539026A JP 2014539026 A JP2014539026 A JP 2014539026A JP 2014532655 A JP2014532655 A JP 2014532655A
Authority
JP
Japan
Prior art keywords
nanosuspension
acoustic energy
grinding
acoustic
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014539026A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014532655A5 (enExample
Inventor
リユウン，デニス
ネルソン，トツド，デイー
ローズ，テイモシー，エー
クオン，エリザベス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2014532655A publication Critical patent/JP2014532655A/ja
Publication of JP2014532655A5 publication Critical patent/JP2014532655A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/18—Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014539026A 2011-10-31 2012-10-26 ナノ懸濁過程 Pending JP2014532655A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161553508P 2011-10-31 2011-10-31
US61/553,508 2011-10-31
PCT/US2012/062026 WO2013066735A1 (en) 2011-10-31 2012-10-26 Nano-suspension process

Publications (2)

Publication Number Publication Date
JP2014532655A true JP2014532655A (ja) 2014-12-08
JP2014532655A5 JP2014532655A5 (enExample) 2015-11-19

Family

ID=48192642

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014539026A Pending JP2014532655A (ja) 2011-10-31 2012-10-26 ナノ懸濁過程

Country Status (6)

Country Link
US (1) US9381518B2 (enExample)
EP (1) EP2773323A4 (enExample)
JP (1) JP2014532655A (enExample)
AU (1) AU2012332894A1 (enExample)
CA (1) CA2853470A1 (enExample)
WO (1) WO2013066735A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2018061989A1 (ja) * 2016-09-30 2019-04-04 富士フイルム株式会社 分散物の製造方法、及びインクジェット記録方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160317391A1 (en) * 2013-12-17 2016-11-03 Merck Sharp & Dohme Corp. Media milling process for the manufacture of active pharmaceutical ingredients in propellants
CN108699253B (zh) * 2015-11-18 2022-01-25 阿瑞萨生物科技有限责任公司 用于制备细胞膜或病毒膜以及纳米颗粒的方法和系统
WO2019040346A1 (en) * 2017-08-25 2019-02-28 Merck Sharp & Dohme Corp. METHODS FOR PREPARING STORED AMORPHOUS MEDICATION FORMULATIONS USING ACOUSTIC FUSION
US12285731B2 (en) 2019-09-12 2025-04-29 United States Of America, As Represented By The Secretary Of The Army Acoustic mixing system for creating propellant mixture
WO2025096329A1 (en) * 2023-10-31 2025-05-08 Genentech, Inc. Method for preparing stable peptide nanoparticle formulations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591456A (en) * 1995-02-10 1997-01-07 Nanosystems L.L.C. Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer
WO2003090717A1 (en) * 2002-04-23 2003-11-06 Nanotherapeutics, Inc Process of forming and modifying particles and compositions produced thereby
JP2006504511A (ja) * 2002-07-18 2006-02-09 アストラゼネカ・アクチエボラーグ 結晶性ナノ−微粒子分散液の調製方法
JP2009533314A (ja) * 2005-04-13 2009-09-17 ファイザー・プロダクツ・インク ナノ粒子を含む貧溶性薬物を持続放出するための注射用デポ製剤および方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552160A (en) * 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
JP2000516244A (ja) 1996-08-22 2000-12-05 リサーチ・トライアングル・ファーマシューティカルズ 水不溶性物質の微粒子を含む組成物およびその製造方法
GB2339703B (en) 1998-07-22 2002-05-01 Univ Cardiff Particle manipulation device
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7188993B1 (en) * 2003-01-27 2007-03-13 Harold W Howe Apparatus and method for resonant-vibratory mixing
GB0302671D0 (en) 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
US20060086834A1 (en) * 2003-07-29 2006-04-27 Robert Pfeffer System and method for nanoparticle and nanoagglomerate fluidization
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
EP1802193B1 (en) 2004-10-19 2014-04-30 Regeneron Pharmaceuticals, Inc. Method for generating a mouse homozygous for a genetic modification
WO2006052712A1 (en) 2004-11-08 2006-05-18 Baxter International Inc. Nanoparticulate compositions of tubulin inhibitor
US20060134646A1 (en) 2004-12-17 2006-06-22 Ansari Aftab A Method for treatment of HIV infection
BRPI0519712A2 (pt) 2004-12-21 2009-03-10 Baxter Healthcare Sa modificador superficial de (polialcàxi)-sulfonatos
DE102005057333B4 (de) * 2005-11-28 2008-11-20 Dr. Hielscher Gmbh Verfahren und Vorrichtungen zur Beschallung von Flüssigkeiten mit Niederfrequenz-Leistungs-Ultraschall
WO2007078765A2 (en) * 2005-12-16 2007-07-12 Massachusetts Institute Of Technology High-throughput fabrication of microparticles
US20080033296A1 (en) 2006-02-17 2008-02-07 Florida Gulf Coast University Methods for delivering materials into biological systems using sonic energy
CN101809024A (zh) 2007-07-16 2010-08-18 铂雅制药公司 吡铂的口服制剂
TWI476280B (zh) 2008-03-07 2015-03-11 Regeneron Pharma 來自二倍體宿主胚胎注射之ｅｓ－細胞衍生的老鼠
US20110224312A1 (en) * 2008-11-17 2011-09-15 Wayne State University Engineering porous particles of water soluble therapeutics for pressurized metered-dose inhaler formulations

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591456A (en) * 1995-02-10 1997-01-07 Nanosystems L.L.C. Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer
WO2003090717A1 (en) * 2002-04-23 2003-11-06 Nanotherapeutics, Inc Process of forming and modifying particles and compositions produced thereby
JP2006504511A (ja) * 2002-07-18 2006-02-09 アストラゼネカ・アクチエボラーグ 結晶性ナノ−微粒子分散液の調製方法
JP2009533314A (ja) * 2005-04-13 2009-09-17 ファイザー・プロダクツ・インク ナノ粒子を含む貧溶性薬物を持続放出するための注射用デポ製剤および方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2018061989A1 (ja) * 2016-09-30 2019-04-04 富士フイルム株式会社 分散物の製造方法、及びインクジェット記録方法

Also Published As

Publication number Publication date
EP2773323A4 (en) 2015-04-22
US20140256818A1 (en) 2014-09-11
US9381518B2 (en) 2016-07-05
AU2012332894A1 (en) 2014-05-08
WO2013066735A1 (en) 2013-05-10
EP2773323A1 (en) 2014-09-10
CA2853470A1 (en) 2013-05-10

Similar Documents

Publication Publication Date Title
JP2014532655A (ja) ナノ懸濁過程
Peltonen et al. Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods
Lee et al. Characteristics of polymers enabling nano-comminution of water-insoluble drugs
Rao et al. Formulation of nanosuspensions of albendazole for oral administration
Sy et al. Pickering nano-emulsion as a nanocarrier for pH-triggered drug release
JP2010265324A (ja) ナノ粒子組成物
Bitterlich et al. Challenges in nanogrinding of active pharmaceutical ingredients
Zhang et al. Nanonization of megestrol acetate by liquid precipitation
Plakkot et al. Comminution of ibuprofen to produce nano-particles for rapid dissolution
JP2005504266A (ja) 小規模ミルまたは微小流体工学を用いる高スループットスクリーニング法
Imbrogno et al. Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes
Domenech et al. High loading capacity nanoencapsulation and release of hydrophobic drug nanocrystals from microgel particles
CA2604770A1 (en) Method for carefully producing ultrafine particle suspensions and ultrafine particles and use thereof
TW200826973A (en) Method of micronization
Konnerth et al. Impact of stressing conditions and polymer–surfactant interactions on product characteristics of organic nanoparticles produced by media milling
Chakravorty Nanosuspension as an emerging Nanotechnology and Techniques for its Development
Azad et al. Preparation of concentrated stable fenofibrate suspensions via liquid antisolvent precipitation
Paul et al. Progress in the Production of Nanocrystals through Miniaturised Milling Methods
Khanuja et al. Recent patents and potential applications of homogenisation techniques in drug delivery systems
AU2018283777B2 (en) Amorphous nanostructured pharmaceutical materials
CN101579335A (zh) 药剂的新制剂及其制备和应用方法
Patel et al. Improvement in the dissolution of poorly water soluble drug using media milling technique
Scheler Micro‐and Nanosizing of Poorly Soluble Drugs by Grinding Techniques
WO2015024759A1 (en) Process for preparing redispersible powders of water-insoluble, biodegradable polyesters
Parmar et al. Novel nano-technologies to enhance drug solubility, dissolution and bioavailability of poorly water-soluble drugs

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150930

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150930

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160617

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160628

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170307