JP2014530822A5 - - Google Patents
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- Publication number
- JP2014530822A5 JP2014530822A5 JP2014535952A JP2014535952A JP2014530822A5 JP 2014530822 A5 JP2014530822 A5 JP 2014530822A5 JP 2014535952 A JP2014535952 A JP 2014535952A JP 2014535952 A JP2014535952 A JP 2014535952A JP 2014530822 A5 JP2014530822 A5 JP 2014530822A5
- Authority
- JP
- Japan
- Prior art keywords
- phycocyanobilin
- meso
- amphoteric compound
- biliversin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 12
- NNMALANKTSRILL-ZUTFDUMMSA-N 3-[(2z,5z)-2-[[3-(2-carboxyethyl)-5-[(z)-[(3z,4r)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid Chemical compound O=C1C(CC)=C(C)C(\C=C/2C(=C(CCC(O)=O)C(=C/C3=C(C(C)=C(\C=C/4\C(\[C@@H](C)C(=O)N\4)=C/C)N3)CCC(O)=O)/N\2)C)=N1 NNMALANKTSRILL-ZUTFDUMMSA-N 0.000 claims 11
- INPDFIMLLXXDOQ-UHFFFAOYSA-N Phycocyanobilin Natural products CCC1=C(C)C(=CC2=NC(=C/c3[nH]c(C=C/4C(C(C(N4)=O)C)=CC)c(C)c3CCC(=O)O)C(=C2C)CCC(=O)O)NC1=O INPDFIMLLXXDOQ-UHFFFAOYSA-N 0.000 claims 11
- 108010072011 phycocyanobilin Proteins 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 6
- 241000192700 Cyanobacteria Species 0.000 claims 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 241000195493 Cryptophyta Species 0.000 claims 3
- 108010053210 Phycocyanin Proteins 0.000 claims 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 3
- 238000005406 washing Methods 0.000 claims 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 2
- QBUVFDKTZJNUPP-UHFFFAOYSA-N biliverdin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(C=C2C(=C(C)C(C=C3C(=C(C=C)C(=O)N3)C)=N2)CCC(O)=O)N1 QBUVFDKTZJNUPP-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- CXQHEXWJGZEPFP-BBROENKCSA-N mesobiliverdin Chemical compound N1C(=O)C(CC)=C(C)\C1=C\C(C(=C/1CCC(O)=O)C)=N\C\1=C/C1=C(CCC(O)=O)C(C)=C(\C=C/2C(=C(C)C(=O)N\2)CC)N1 CXQHEXWJGZEPFP-BBROENKCSA-N 0.000 claims 2
- ASWULEQKMHWPCL-UHFFFAOYSA-N mesobiliverdin IXalpha Natural products CCC1=C(C)C(=Cc2[nH]c(C=C3/N=C(C=C4/NC(=O)C(=C4CC)C)C(=C3CCC(=O)O)C)c(CCC(=O)O)c2C)NC1=O ASWULEQKMHWPCL-UHFFFAOYSA-N 0.000 claims 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229920001917 Ficoll Polymers 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 238000006317 isomerization reaction Methods 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 108090000195 villin Proteins 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161546442P | 2011-10-12 | 2011-10-12 | |
| US61/546,442 | 2011-10-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530822A JP2014530822A (ja) | 2014-11-20 |
| JP2014530822A5 true JP2014530822A5 (enExample) | 2015-11-26 |
Family
ID=48082770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535952A Pending JP2014530822A (ja) | 2011-10-12 | 2012-10-12 | メソ−ビリベルジン組成物および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9242932B2 (enExample) |
| EP (1) | EP2766357B1 (enExample) |
| JP (1) | JP2014530822A (enExample) |
| WO (1) | WO2013056142A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455222B2 (en) | 2009-11-04 | 2013-06-04 | Utah State University | Biliverdin from a non-animal source |
| US9119842B2 (en) | 2012-09-14 | 2015-09-01 | Utah State University | Therapeutic meso-biliverdin IXα compositions and associated methods |
| JP6694820B2 (ja) * | 2014-01-27 | 2020-05-20 | ユニヴァーシティ オヴ ニューカッスル アポン タインＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｅｗｃａｓｔｌｅ Ｕｐｏｎ Ｔｙｎｅ | フィコシアニン合成の改善 |
| CN109535057B (zh) * | 2018-11-07 | 2020-03-10 | 百顺药业有限公司 | 一种用胆绿素Ⅸα二酯制备高含量胆红素Ⅸα的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455222B2 (en) | 2009-11-04 | 2013-06-04 | Utah State University | Biliverdin from a non-animal source |
| US20110217764A1 (en) | 2010-03-04 | 2011-09-08 | Utah State University | Rotating Bioreactor and Spool Harvester Apparatus for Biomass Production |
-
2012
- 2012-10-12 WO PCT/US2012/060086 patent/WO2013056142A2/en not_active Ceased
- 2012-10-12 EP EP12839361.8A patent/EP2766357B1/en not_active Not-in-force
- 2012-10-12 JP JP2014535952A patent/JP2014530822A/ja active Pending
- 2012-10-12 US US13/650,842 patent/US9242932B2/en active Active
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