JP2014529406A5 - - Google Patents
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- Publication number
- JP2014529406A5 JP2014529406A5 JP2014528501A JP2014528501A JP2014529406A5 JP 2014529406 A5 JP2014529406 A5 JP 2014529406A5 JP 2014528501 A JP2014528501 A JP 2014528501A JP 2014528501 A JP2014528501 A JP 2014528501A JP 2014529406 A5 JP2014529406 A5 JP 2014529406A5
- Authority
- JP
- Japan
- Prior art keywords
- bone
- pvmcs
- composition
- isolated
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000988 bone and bone Anatomy 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 15
- 210000001519 tissue Anatomy 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 8
- 210000001185 bone marrow Anatomy 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 239000006285 cell suspension Substances 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 230000006862 enzymatic digestion Effects 0.000 claims 3
- 229940088598 enzyme Drugs 0.000 claims 3
- 238000005119 centrifugation Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000004062 sedimentation Methods 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 108091005658 Basic proteases Proteins 0.000 claims 1
- 102100024210 CD166 antigen Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 108010005843 Cysteine Proteases Proteins 0.000 claims 1
- 102000005927 Cysteine Proteases Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- -1 GAGase Proteins 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000980840 Homo sapiens CD166 antigen Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 108090001092 clostripain Proteins 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 230000001502 supplementing effect Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 7
- 210000000056 organ Anatomy 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 101100022549 Mus musculus Cd46 gene Proteins 0.000 description 1
- 230000030120 acrosome reaction Effects 0.000 description 1
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 210000003668 pericyte Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000004786 perivascular cell Anatomy 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161528556P | 2011-08-29 | 2011-08-29 | |
| US201161528563P | 2011-08-29 | 2011-08-29 | |
| US201161528567P | 2011-08-29 | 2011-08-29 | |
| US61/528,563 | 2011-08-29 | ||
| US61/528,556 | 2011-08-29 | ||
| US61/528,567 | 2011-08-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014529406A JP2014529406A (ja) | 2014-11-13 |
| JP2014529406A5 true JP2014529406A5 (https=) | 2015-10-29 |
Family
ID=47756794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528501A Pending JP2014529406A (ja) | 2011-08-29 | 2012-08-27 | 血管周囲薬用細胞の単離および治療的使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140314869A1 (https=) |
| EP (1) | EP2751256A4 (https=) |
| JP (1) | JP2014529406A (https=) |
| AU (1) | AU2012300221A1 (https=) |
| CA (1) | CA2853910A1 (https=) |
| SG (1) | SG11201401038VA (https=) |
| WO (1) | WO2013033043A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10758573B2 (en) | 2015-06-09 | 2020-09-01 | President And Fellows Of Harvard College | Compositions and methods for enrichment of cells |
| CN105505862B (zh) * | 2015-12-29 | 2019-01-18 | 江苏省原子医学研究所 | 一种采用机械分离法提取骨组织中的成骨细胞的方法 |
| CA3067558A1 (en) | 2017-06-16 | 2018-12-20 | Avery Therapeutics, Inc. | Three dimensional tissue compositions and methods of use |
| US12233094B2 (en) | 2017-11-29 | 2025-02-25 | Spinalcyte, Llc | Interaction of fibroblasts and immune cells for activation and uses thereof |
| WO2020092321A1 (en) * | 2018-10-29 | 2020-05-07 | Avery Therapeutics, Inc. | Compositions and methods for cryopreservation and reconstitution of engineered tissues |
| US20220096600A1 (en) * | 2019-02-07 | 2022-03-31 | Baylor College Of Medicine | Periosteal skeletal stem cells in bone repair |
| CN115772494B (zh) * | 2021-09-06 | 2025-10-21 | 上海交通大学医学院附属第九人民医院 | 一种牙槽骨组织消化液及其在牙槽骨细胞分离中的用途和方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4619989A (en) * | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
| AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
| GB0600972D0 (en) * | 2006-01-18 | 2006-03-01 | Univ Leeds | Enrichment of cells |
| US20070264239A1 (en) * | 2006-05-10 | 2007-11-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Isolation of pericytes |
| BRPI0910686A2 (pt) * | 2008-04-21 | 2015-09-29 | Tissue Regeneration Therapeutics Inc | células perivasculares do cordão umbilical humano geneticamente modificadas para a profilaxia contra agentes biológicos e químicos ou para o tratamento dos mesmos. |
| US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
| WO2011021194A2 (en) * | 2009-08-17 | 2011-02-24 | Technion Research & Development Foundation Ltd. | Pericyte progenitor cells and methods of generating and using same |
-
2012
- 2012-08-27 US US14/241,872 patent/US20140314869A1/en not_active Abandoned
- 2012-08-27 AU AU2012300221A patent/AU2012300221A1/en not_active Abandoned
- 2012-08-27 JP JP2014528501A patent/JP2014529406A/ja active Pending
- 2012-08-27 CA CA2853910A patent/CA2853910A1/en not_active Abandoned
- 2012-08-27 EP EP12828001.3A patent/EP2751256A4/en not_active Withdrawn
- 2012-08-27 WO PCT/US2012/052575 patent/WO2013033043A1/en not_active Ceased
- 2012-08-27 SG SG11201401038VA patent/SG11201401038VA/en unknown
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